CN1361760A - 新的白介素－1和肿瘤坏死因子－α调节剂、所述调节剂的合成以及使用所述调节剂的方法 - Google Patents

新的白介素－1和肿瘤坏死因子－α调节剂、所述调节剂的合成以及使用所述调节剂的方法 Download PDF

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CN1361760A
CN1361760A CN00810323A CN00810323A CN1361760A CN 1361760 A CN1361760 A CN 1361760A CN 00810323 A CN00810323 A CN 00810323A CN 00810323 A CN00810323 A CN 00810323A CN 1361760 A CN1361760 A CN 1361760A
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compound
alkyl
alkenyl
hydrogen
substituted
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M·帕拉蒂诺
Ea·特奥多拉基斯
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Nereus Pharmaceuticals Inc
University of California San Diego UCSD
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Nereus Pharmaceuticals Inc
University of California San Diego UCSD
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    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B2200/05—Isotopically modified compounds, e.g. labelled
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

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  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
CN00810323A 1999-05-14 2000-05-12 新的白介素－1和肿瘤坏死因子－α调节剂、所述调节剂的合成以及使用所述调节剂的方法 Pending CN1361760A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13429599P 1999-05-14 1999-05-14
US60/134,295 1999-05-14
US18685300P 2000-03-03 2000-03-03
US60/186,853 2000-03-03

Publications (1)

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CN1361760A true CN1361760A (zh) 2002-07-31

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CN00810323A Pending CN1361760A (zh) 1999-05-14 2000-05-12 新的白介素－1和肿瘤坏死因子－α调节剂、所述调节剂的合成以及使用所述调节剂的方法

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CN (1) CN1361760A (enExample)
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PT1591437E (pt) 2010-03-04
CA2372962A1 (en) 2000-12-07
IL182272A0 (en) 2007-07-24
HK1084657A1 (en) 2006-08-04
BR0011522A (pt) 2002-06-04
KR20060135080A (ko) 2006-12-28
EP1178952B1 (en) 2007-08-22
DK1178952T3 (da) 2008-01-28
NZ540001A (en) 2007-06-29
AU2006200240B2 (en) 2009-05-28
DE60036101D1 (de) 2007-10-04
IL182272A (en) 2010-05-31
AU5013300A (en) 2000-12-18
EP1178952A1 (en) 2002-02-13
IL146221A (en) 2007-07-04
US20030040640A1 (en) 2003-02-27
US6365768B1 (en) 2002-04-02
US20050209325A1 (en) 2005-09-22
ATE370928T1 (de) 2007-09-15
JP2012211162A (ja) 2012-11-01
ES2337264T3 (es) 2010-04-22
US7342125B2 (en) 2008-03-11
MXPA01011613A (es) 2003-10-14
CA2372962C (en) 2008-04-08
ES2295031T3 (es) 2008-04-16
DE60036101T2 (de) 2008-05-15
KR100856353B1 (ko) 2008-09-04
AU2006200240A1 (en) 2006-02-16
WO2000073253A1 (en) 2000-12-07
AU783372B2 (en) 2005-10-20
KR20020028878A (ko) 2002-04-17
KR100840925B1 (ko) 2008-06-24
US6881857B2 (en) 2005-04-19
DK1178952T5 (da) 2008-03-17
JP2003500464A (ja) 2003-01-07
EP1591437A3 (en) 2006-03-08
EP1591437A2 (en) 2005-11-02
KR20060110013A (ko) 2006-10-23
NZ515675A (en) 2004-06-25
ATE449754T1 (de) 2009-12-15
JP5059996B2 (ja) 2012-10-31
PT1178952E (pt) 2007-12-04
DE60043400D1 (de) 2010-01-07
EP1591437B1 (en) 2009-11-25
NZ529505A (en) 2005-09-30

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