IL146221A0 - NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS - Google Patents

NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS

Info

Publication number
IL146221A0
IL146221A0 IL14622100A IL14622100A IL146221A0 IL 146221 A0 IL146221 A0 IL 146221A0 IL 14622100 A IL14622100 A IL 14622100A IL 14622100 A IL14622100 A IL 14622100A IL 146221 A0 IL146221 A0 IL 146221A0
Authority
IL
Israel
Prior art keywords
modulators
necrosis factor
tumor necrosis
syntheses
methods
Prior art date
Application number
IL14622100A
Other languages
English (en)
Original Assignee
Nereus Pharmaceuticals Inc
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nereus Pharmaceuticals Inc, Univ California filed Critical Nereus Pharmaceuticals Inc
Publication of IL146221A0 publication Critical patent/IL146221A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/28—Unsaturated compounds polycyclic
    • C07C61/29—Unsaturated compounds polycyclic having a carboxyl group bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/35—Unsaturated compounds having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Otolaryngology (AREA)
  • Transplantation (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
IL14622100A 1999-05-14 2000-05-12 NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS IL146221A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13429599P 1999-05-14 1999-05-14
US18685300P 2000-03-03 2000-03-03
PCT/US2000/013202 WO2000073253A1 (en) 1999-05-14 2000-05-12 NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS

Publications (1)

Publication Number Publication Date
IL146221A0 true IL146221A0 (en) 2002-07-25

Family

ID=26832188

Family Applications (3)

Application Number Title Priority Date Filing Date
IL14622100A IL146221A0 (en) 1999-05-14 2000-05-12 NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS
IL146221A IL146221A (en) 1999-05-14 2001-10-29 Interloquin-1 regulators and α-tissue necrosis factors, preparation of these regulators and methods of using them
IL182272A IL182272A (en) 1999-05-14 2007-03-28 Derivatives of tricyclic diterpene compounds

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL146221A IL146221A (en) 1999-05-14 2001-10-29 Interloquin-1 regulators and α-tissue necrosis factors, preparation of these regulators and methods of using them
IL182272A IL182272A (en) 1999-05-14 2007-03-28 Derivatives of tricyclic diterpene compounds

Country Status (17)

Country Link
US (3) US6365768B1 (enExample)
EP (2) EP1591437B1 (enExample)
JP (2) JP5059996B2 (enExample)
KR (3) KR20060110013A (enExample)
CN (1) CN1361760A (enExample)
AT (2) ATE449754T1 (enExample)
AU (2) AU783372B2 (enExample)
BR (1) BR0011522A (enExample)
CA (1) CA2372962C (enExample)
DE (2) DE60043400D1 (enExample)
DK (1) DK1178952T5 (enExample)
ES (2) ES2337264T3 (enExample)
IL (3) IL146221A0 (enExample)
MX (1) MXPA01011613A (enExample)
NZ (3) NZ540001A (enExample)
PT (2) PT1591437E (enExample)
WO (1) WO2000073253A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037600A1 (en) * 1998-01-26 1999-07-29 Sae Han Pharm. Co., Ltd. Diterpene derivatives and anti-inflammatory analgesic agents comprising the same
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
CN1361760A (zh) 1999-05-14 2002-07-31 尼瑞斯药品公司 新的白介素－1和肿瘤坏死因子－α调节剂、所述调节剂的合成以及使用所述调节剂的方法
US7119223B2 (en) * 1999-05-14 2006-10-10 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-α modulators, synthesis of said modulators and their enantiomers and methods of using said modulators
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
WO2002079137A1 (en) * 2001-03-28 2002-10-10 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use
US20030087334A1 (en) * 2001-04-02 2003-05-08 Libraria, Inc. Method of flexibly generating diverse reaction chemistries
AU2003235676A1 (en) 2002-01-15 2003-07-30 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
WO2003061553A2 (en) * 2002-01-25 2003-07-31 Korea Research Institute Of Bioscience And Biotechnology An extract of acanthopanax koreanum for the treatment or prevention of hepatitis or the liver protective drug
US7517542B2 (en) * 2004-03-03 2009-04-14 Korea Research Institute Of Bioscience Abietane diterpenoid compound, and composition comprising extract of torreya nucifera, or abietane diterpenoid compounds or terpenoid compounds isolated from them for prevention and treatment of cardiovascular disease
JP2009505954A (ja) 2005-07-21 2009-02-12 ネレアス ファーマシューティカルズ インコーポレイテッド インターロイキン−１及び腫瘍壊死因子−ａ修飾因子、このような修飾因子の合成及びこのような修飾因子の使用方法
EP2094651A1 (en) 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
EP1925301A1 (en) * 2006-11-24 2008-05-28 DSMIP Assets B.V. Use of tricyclic diterpenes and their derivatives for the treatment, co-treatment or prevention of inflammatory disorders and/or joint disorders
US7875853B2 (en) * 2007-07-23 2011-01-25 Honeywell International Inc. Low-cost PIR scanning mechanism
ME03529B (me) 2008-01-11 2020-04-20 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
EP2279197B1 (en) 2008-04-18 2014-11-05 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
CN102083442B (zh) 2008-04-18 2014-08-13 里亚塔医药公司 抗氧化剂炎症调节剂：在c-17具有氨基和其它修饰的齐墩果酸衍生物
SI2271658T1 (sl) 2008-04-18 2017-03-31 Reata Pharmaceuticals, Inc. Antioksidantni modulatorji vnetja: C-17 homologirani derivati oleanolne kisline
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
CA2721665C (en) 2008-04-18 2017-01-24 Reata Pharmaceuticals, Inc. Compounds including an anti-inflammatory pharmacore and methods of use
ES2449396T3 (es) 2008-07-22 2014-03-19 Trustees Of Dartmouth College Cianoenonas monocíclicas y métodos de uso de las mismas
US20110293653A1 (en) * 2010-03-11 2011-12-01 University Of Massachusetts Antagonists of mir-155 for the treatment of inflammatory liver disease
EP2558105B1 (en) 2010-04-12 2019-11-20 Reata Pharmaceuticals, Inc. Bardoxolone methyl for the treatment of obesity
MY158661A (en) * 2010-10-27 2016-10-31 Sigma Tau Ind Farmaceutieche Riunite S P A Diterpenoid derivatives endowed of biological properties
EP2648706A4 (en) 2010-12-06 2014-07-23 Penn State Res Found COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES
CA2822071C (en) 2010-12-17 2019-07-16 Reata Pharmaceuticals, Inc. Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators
HUE044081T2 (hu) 2011-03-11 2019-09-30 Reata Pharmaceuticals Inc C4 Monometil-triterpenoid-származékok, és módszerek azok alkalmazására
BR112014026640B1 (pt) 2012-04-27 2021-05-18 Reata Pharmaceuticals, Inc compostos derivados de 2,2-difluoropropionamida de metil bardoxolona, formas polimórficas, composição farmacêutica, e uso dos mesmos
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US9556222B2 (en) 2012-06-15 2017-01-31 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
RS59194B1 (sr) 2012-09-10 2019-10-31 Reata Pharmaceuticals Inc C17-alkandiilni i alkendiilni derivati oleanolne kiseline i metode za njihovu upotrebu
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
WO2014040073A1 (en) 2012-09-10 2014-03-13 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
BR112018005861B1 (pt) 2015-09-23 2022-11-22 Reata Pharmaceuticals, Inc Compostos derivados de ácido oleanólico modificado com c4 para a inibição de il-17, composição farmacêutica e usos terapêuticos dos ditos compostos
CA3042123A1 (en) 2016-11-08 2018-05-17 Reata Pharmaceuticals, Inc. Methods of treating alport syndrome using bardoxolone methyl or analogs thereof
CN106928095A (zh) * 2017-03-14 2017-07-07 华东师范大学 氰基烯酮类三环二萜类似物及其制备方法和应用
US10463631B2 (en) * 2017-06-12 2019-11-05 University Of South Carolina Pimarane diterpenoids for use in wound healing and angiogenesis
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
CN120248001A (zh) 2019-07-19 2025-07-04 里亚塔医药公司 C17极性的-取代的杂芳族合成三萜类化合物及其使用方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5212708B2 (enExample) 1974-05-14 1977-04-08
JPS522910B2 (enExample) 1974-05-17 1977-01-25
GB1452053A (en) 1974-08-28 1976-10-06 Nippon Shinyaku Co Ltd Abietamide derivatives and a method for the preparation thereof
US4874891A (en) 1986-05-01 1989-10-17 Washington University Open "D" ring hormone analogs
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
EP0472733B1 (en) 1990-03-06 1994-12-28 Otsuka Pharmaceutical Co., Ltd. Phenanthrene derivative
US5276182A (en) 1990-07-09 1994-01-04 The Dow Chemical Company Process for preparing polyurea oligomers
DE4039602A1 (de) 1990-12-12 1992-06-17 Bauer Kurt Heinz Prof Dr Pharmazeutische formulierungen
KR100221695B1 (ko) 1991-08-12 1999-09-15 그린 마틴, 브라이언 쥐 테슬리 약학적 구상 제형
US5683676A (en) 1991-12-12 1997-11-04 Glaxo Group Limited Canister containing aerosol formulations containing P134a and particulate medicaments
DK0674510T3 (da) 1992-11-27 1999-05-10 Napro Biotherapeutics Inc Injicerbart præparat omfattende paclitaxel
US5654286A (en) 1993-05-12 1997-08-05 Hostetler; Karl Y. Nucleotides for topical treatment of psoriasis, and methods for using same
CZ301771B6 (cs) 1993-10-01 2010-06-16 Syntex (U.S.A.) Llc. Farmaceutický prostredek ve forme suchého granulátu obsahující mofetil mykofenolát nebo kyselinu mykofenolovou a zpusob jeho prípravy
KR0145941B1 (ko) * 1994-06-13 1998-08-17 김은영 인터루킨-1과 종양 괴사 인자-알파의 생산 억제에 유용한 아칸토산을 포함하는 약학적 조성물
US5707641A (en) 1994-10-13 1998-01-13 Pharmaderm Research & Development Ltd. Formulations comprising therapeutically-active proteins or polypeptides
IE80468B1 (en) 1995-04-04 1998-07-29 Elan Corp Plc Controlled release biodegradable nanoparticles containing insulin
US5653987A (en) 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5726181A (en) 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US5667809A (en) 1995-06-07 1997-09-16 Alliance Pharmaceutical Corp. Continuous fluorochemical microdispersions for the delivery of lipophilic pharmaceutical agents
FR2741262B1 (fr) 1995-11-20 1999-03-05 Oreal Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
WO1999037600A1 (en) * 1998-01-26 1999-07-29 Sae Han Pharm. Co., Ltd. Diterpene derivatives and anti-inflammatory analgesic agents comprising the same
US6051590A (en) 1999-05-13 2000-04-18 Merck & Co., Inc. Immunosuppressant tricyclic compounds
CN1361760A (zh) * 1999-05-14 2002-07-31 尼瑞斯药品公司 新的白介素－1和肿瘤坏死因子－α调节剂、所述调节剂的合成以及使用所述调节剂的方法
WO2002079137A1 (en) 2001-03-28 2002-10-10 Nereus Pharmaceuticals, Inc. Interleukin-1 and tumor necrosis factor-alpha modulators and their enantiomers, their synthesis and use

Also Published As

Publication number Publication date
PT1178952E (pt) 2007-12-04
KR100840925B1 (ko) 2008-06-24
ATE449754T1 (de) 2009-12-15
AU2006200240A1 (en) 2006-02-16
KR20060135080A (ko) 2006-12-28
CN1361760A (zh) 2002-07-31
DK1178952T3 (da) 2008-01-28
US6365768B1 (en) 2002-04-02
KR100856353B1 (ko) 2008-09-04
AU2006200240B2 (en) 2009-05-28
EP1591437A2 (en) 2005-11-02
EP1178952B1 (en) 2007-08-22
US7342125B2 (en) 2008-03-11
EP1591437A3 (en) 2006-03-08
EP1178952A1 (en) 2002-02-13
NZ529505A (en) 2005-09-30
HK1084657A1 (en) 2006-08-04
KR20060110013A (ko) 2006-10-23
PT1591437E (pt) 2010-03-04
US6881857B2 (en) 2005-04-19
DE60043400D1 (de) 2010-01-07
NZ515675A (en) 2004-06-25
AU5013300A (en) 2000-12-18
AU783372B2 (en) 2005-10-20
KR20020028878A (ko) 2002-04-17
CA2372962A1 (en) 2000-12-07
WO2000073253A1 (en) 2000-12-07
BR0011522A (pt) 2002-06-04
CA2372962C (en) 2008-04-08
ES2337264T3 (es) 2010-04-22
ES2295031T3 (es) 2008-04-16
DE60036101D1 (de) 2007-10-04
MXPA01011613A (es) 2003-10-14
JP5059996B2 (ja) 2012-10-31
DK1178952T5 (da) 2008-03-17
US20050209325A1 (en) 2005-09-22
JP2003500464A (ja) 2003-01-07
DE60036101T2 (de) 2008-05-15
JP2012211162A (ja) 2012-11-01
IL182272A0 (en) 2007-07-24
IL182272A (en) 2010-05-31
EP1591437B1 (en) 2009-11-25
NZ540001A (en) 2007-06-29
US20030040640A1 (en) 2003-02-27
IL146221A (en) 2007-07-04
ATE370928T1 (de) 2007-09-15

Similar Documents

Publication Publication Date Title
IL146221A0 (en) NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-α MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS
USD443082S1 (en) Mixed peppers candle jar
IL147037A0 (en) Peptide acceptor ligation methods
EP1591462A3 (en) Temperature-responsive polymer compound and process for producing the same
AU3293399A (en) High efficiency synthetic filter medium
EP1022283A4 (en) NOVEL LIGNIN DERIVATIVE, MOLDINGS PRODUCED USING THIS DERIVATIVE AND PREPARATION METHOD
AU3403299A (en) Reversible driven pulley
AU1751100A (en) Surface modified nozzle plate
AU2001215528A1 (en) Base materials for tissue regeneration, transplant materials and process for producing the same
IL131758A (en) Oligomeric bromine-containing flame retardants, polymeric compositions containing the same and methods utilizing the same
AU6994594A (en) Electroactive materials, a process for their preparation as well as the use thereof
SG102056A1 (en) Growing medium for plants
AU1802100A (en) Floating pesticide compositions for paddy fields, method for the utilization thereof and process for producing the same
HUP0104979A3 (en) Tack free surface cures of polymers by organic peroxides in the presence of air
FR2770454B1 (fr) Procede de fabrication d'un panneau decoratif d'imitation de carrelages, et panneau obtenu selon le procede
WO2000034285A3 (en) Substituted benzofuranoindoles and indenoindoles as novel potassium channel openers
WO2001042250A3 (en) Process for production of diphenyl-dialkoxysilane, phenylalkyl-dialkoxysilane, octaphenylcyclotetrasiloxane and sym-tetraalkyltetraphenyl-cyclotetrasiloxane
AU4122901A (en) Novel 7,8-dihydro-xanthenone-8-carboxylic acid derivative and novel microbe producing the same
AU5124500A (en) Tumor necrosis factor-gamma
AU2003216424A1 (en) Phosphorus-containing compounds with polymeric chains, and methods of making and using the same
AU4403099A (en) Surface hardening by particle injection into high energy beam melted surface
AU4437299A (en) Improved polymeric nozzle plate
AU1201995A (en) Fixture comprising bryothyte for greening, process for producing the fixture, and use thereof
AU4710800A (en) Methods of software driven flow sorting for reiterative synthesis cycles
EP1158006A4 (en) POLYMER, PROCESS FOR PREPARING THE POLYMER, AND CURABLE COMPOSITION CONTAINING THE POLYMER

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed