JP2002543055A5 - - Google Patents
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- Publication number
- JP2002543055A5 JP2002543055A5 JP2000613809A JP2000613809A JP2002543055A5 JP 2002543055 A5 JP2002543055 A5 JP 2002543055A5 JP 2000613809 A JP2000613809 A JP 2000613809A JP 2000613809 A JP2000613809 A JP 2000613809A JP 2002543055 A5 JP2002543055 A5 JP 2002543055A5
- Authority
- JP
- Japan
- Prior art keywords
- benzoic acid
- aniline
- alkyl
- phenylamino
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 10
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 239000005711 Benzoic acid Substances 0.000 description 5
- 235000010233 benzoic acid Nutrition 0.000 description 5
- -1 alkali metal hexamethyldisilazide Chemical class 0.000 description 4
- ZWJINEZUASEZBH-UHFFFAOYSA-N fenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC=C1 ZWJINEZUASEZBH-UHFFFAOYSA-N 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical group 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 0 Cc1c(*)c(*)c(*)c(*)c1C(O)=[U-] Chemical compound Cc1c(*)c(*)c(*)c(*)c1C(O)=[U-] 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- 239000003880 polar aprotic solvent Substances 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- WEPXLRANFJEOFZ-UHFFFAOYSA-N 2,3,4-trifluorobenzoic acid Chemical compound OC(=O)C1=CC=C(F)C(F)=C1F WEPXLRANFJEOFZ-UHFFFAOYSA-N 0.000 description 1
- MYDAOWXYGPEPJT-UHFFFAOYSA-N 2-chloro-4-iodoaniline Chemical group NC1=CC=C(I)C=C1Cl MYDAOWXYGPEPJT-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 125000005265 dialkylamine group Chemical group 0.000 description 1
- 125000006575 electron-withdrawing group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical group [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13038499P | 1999-04-21 | 1999-04-21 | |
| US60/130,384 | 1999-04-21 | ||
| PCT/US2000/003982 WO2000064856A1 (en) | 1999-04-21 | 2000-02-16 | Method for making 2-(n-phenylamino)benzoic acids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002543055A JP2002543055A (ja) | 2002-12-17 |
| JP2002543055A5 true JP2002543055A5 (https=) | 2006-01-05 |
| JP3769192B2 JP3769192B2 (ja) | 2006-04-19 |
Family
ID=22444462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000613809A Expired - Fee Related JP3769192B2 (ja) | 1999-04-21 | 2000-02-16 | ２−（ｎ−フェニルアミノ）安息香酸の製造方法 |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1171418B1 (https=) |
| JP (1) | JP3769192B2 (https=) |
| KR (1) | KR20010108521A (https=) |
| CN (1) | CN1213997C (https=) |
| AP (1) | AP2001002328A0 (https=) |
| AT (1) | ATE286015T1 (https=) |
| AU (1) | AU773096B2 (https=) |
| BG (1) | BG106132A (https=) |
| BR (1) | BR0009886A (https=) |
| CA (1) | CA2368807A1 (https=) |
| CR (1) | CR6486A (https=) |
| CU (1) | CU22996A3 (https=) |
| DE (1) | DE60017109T2 (https=) |
| DK (1) | DK1171418T3 (https=) |
| EA (1) | EA004209B1 (https=) |
| EE (1) | EE200100546A (https=) |
| ES (1) | ES2235843T3 (https=) |
| GE (1) | GEP20033089B (https=) |
| HK (1) | HK1045682B (https=) |
| HR (1) | HRP20010850A2 (https=) |
| HU (1) | HUP0200932A3 (https=) |
| IL (1) | IL146056A0 (https=) |
| MA (1) | MA25412A1 (https=) |
| NO (1) | NO20015095D0 (https=) |
| NZ (1) | NZ515120A (https=) |
| OA (1) | OA11861A (https=) |
| PL (1) | PL351085A1 (https=) |
| PT (1) | PT1171418E (https=) |
| SK (1) | SK14732001A3 (https=) |
| TR (1) | TR200103015T2 (https=) |
| UA (1) | UA70995C2 (https=) |
| WO (1) | WO2000064856A1 (https=) |
| YU (1) | YU73701A (https=) |
| ZA (1) | ZA200107834B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030059115A (ko) * | 2000-08-25 | 2003-07-07 | 워너-램버트 캄파니 엘엘씨 | Ｎ-아릴-안트라닐산 및 그의 유도체의 제조 방법 |
| WO2006109661A1 (ja) | 2005-04-06 | 2006-10-19 | Chugai Seiyaku Kabushiki Kaisha | ２，３，４－トリフルオロ－５－（ヨード又はブロモ）安息香酸の製造方法 |
| WO2007021001A1 (ja) * | 2005-08-18 | 2007-02-22 | Ube Industries, Ltd. | ２，３，４－トリフルオロ－５－置換安息香酸化合物及びその製法 |
| CN102958892A (zh) * | 2010-02-19 | 2013-03-06 | 国家科学研究中心 | 通过芳香族亲核取代来制备目的化合物的方法 |
| CA2789373A1 (en) * | 2010-02-19 | 2011-08-25 | Centre National De La Recherche Scientifique | Process for preparing chemical compounds of interest by nucleophilic aromatic substitution of aromatic carboxylic acid derivatives supporting at least one electro-attractive group |
| JP2016034900A (ja) * | 2012-11-26 | 2016-03-17 | 中外製薬株式会社 | ５−置換−２−フェニルアミノ−ベンズアミド類の製造方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ501276A (en) * | 1997-07-01 | 2000-10-27 | Warner Lambert Co | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders |
-
2000
- 2000-02-16 DE DE60017109T patent/DE60017109T2/de not_active Expired - Fee Related
- 2000-02-16 GE GEAP20006152A patent/GEP20033089B/en unknown
- 2000-02-16 IL IL14605600A patent/IL146056A0/xx unknown
- 2000-02-16 KR KR1020017013402A patent/KR20010108521A/ko not_active Ceased
- 2000-02-16 PL PL00351085A patent/PL351085A1/xx not_active IP Right Cessation
- 2000-02-16 HK HK02107069.9A patent/HK1045682B/zh not_active IP Right Cessation
- 2000-02-16 EA EA200101113A patent/EA004209B1/ru not_active IP Right Cessation
- 2000-02-16 ES ES00913489T patent/ES2235843T3/es not_active Expired - Lifetime
- 2000-02-16 AT AT00913489T patent/ATE286015T1/de not_active IP Right Cessation
- 2000-02-16 WO PCT/US2000/003982 patent/WO2000064856A1/en not_active Ceased
- 2000-02-16 YU YU73701A patent/YU73701A/sh unknown
- 2000-02-16 CN CNB008064423A patent/CN1213997C/zh not_active Expired - Fee Related
- 2000-02-16 TR TR2001/03015T patent/TR200103015T2/xx unknown
- 2000-02-16 UA UA2001096639A patent/UA70995C2/uk unknown
- 2000-02-16 JP JP2000613809A patent/JP3769192B2/ja not_active Expired - Fee Related
- 2000-02-16 HU HU0200932A patent/HUP0200932A3/hu unknown
- 2000-02-16 DK DK00913489T patent/DK1171418T3/da active
- 2000-02-16 SK SK1473-2001A patent/SK14732001A3/sk unknown
- 2000-02-16 AP APAP/P/2001/002328A patent/AP2001002328A0/en unknown
- 2000-02-16 PT PT00913489T patent/PT1171418E/pt unknown
- 2000-02-16 OA OA1200100260A patent/OA11861A/en unknown
- 2000-02-16 AU AU34928/00A patent/AU773096B2/en not_active Ceased
- 2000-02-16 CA CA002368807A patent/CA2368807A1/en not_active Abandoned
- 2000-02-16 NZ NZ515120A patent/NZ515120A/en unknown
- 2000-02-16 EE EEP200100546A patent/EE200100546A/xx unknown
- 2000-02-16 BR BR0009886-8A patent/BR0009886A/pt not_active IP Right Cessation
- 2000-02-16 EP EP00913489A patent/EP1171418B1/en not_active Expired - Lifetime
- 2000-02-16 HR HR20010850A patent/HRP20010850A2/hr not_active Application Discontinuation
-
2001
- 2001-09-21 ZA ZA200107834A patent/ZA200107834B/en unknown
- 2001-09-21 CU CU20010213A patent/CU22996A3/es unknown
- 2001-10-19 NO NO20015095A patent/NO20015095D0/no not_active Application Discontinuation
- 2001-10-19 CR CR6486A patent/CR6486A/es not_active Application Discontinuation
- 2001-11-16 MA MA26413A patent/MA25412A1/fr unknown
- 2001-11-21 BG BG106132A patent/BG106132A/xx unknown
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