ZA200107834B - Method for making 2-(N-phenylamino)benzoic acids. - Google Patents
Method for making 2-(N-phenylamino)benzoic acids. Download PDFInfo
- Publication number
- ZA200107834B ZA200107834B ZA200107834A ZA200107834A ZA200107834B ZA 200107834 B ZA200107834 B ZA 200107834B ZA 200107834 A ZA200107834 A ZA 200107834A ZA 200107834 A ZA200107834 A ZA 200107834A ZA 200107834 B ZA200107834 B ZA 200107834B
- Authority
- ZA
- South Africa
- Prior art keywords
- benzoic acid
- aniline
- phenylamino
- alkaline metal
- lihmds
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 42
- ZWJINEZUASEZBH-UHFFFAOYSA-N fenamic acid Chemical class OC(=O)C1=CC=CC=C1NC1=CC=CC=C1 ZWJINEZUASEZBH-UHFFFAOYSA-N 0.000 title claims description 18
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 48
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 48
- 235000010233 benzoic acid Nutrition 0.000 claims description 25
- 239000005711 Benzoic acid Substances 0.000 claims description 24
- YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical group [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 claims description 23
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 16
- 229910052751 metal Inorganic materials 0.000 claims description 13
- 239000002184 metal Substances 0.000 claims description 13
- XGIUDIMNNMKGDE-UHFFFAOYSA-N bis(trimethylsilyl)azanide Chemical compound C[Si](C)(C)[N-][Si](C)(C)C XGIUDIMNNMKGDE-UHFFFAOYSA-N 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 8
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical group 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- MYDAOWXYGPEPJT-UHFFFAOYSA-N 2-chloro-4-iodoaniline Chemical group NC1=CC=C(I)C=C1Cl MYDAOWXYGPEPJT-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 239000011737 fluorine Substances 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 239000001257 hydrogen Substances 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 239000003880 polar aprotic solvent Substances 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 125000001475 halogen functional group Chemical group 0.000 claims 1
- 239000002585 base Substances 0.000 description 15
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- 238000005859 coupling reaction Methods 0.000 description 6
- 125000005843 halogen group Chemical group 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- OVEHNNQXLPJPPL-UHFFFAOYSA-N lithium;n-propan-2-ylpropan-2-amine Chemical compound [Li].CC(C)NC(C)C OVEHNNQXLPJPPL-UHFFFAOYSA-N 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- WEPXLRANFJEOFZ-UHFFFAOYSA-N 2,3,4-trifluorobenzoic acid Chemical compound OC(=O)C1=CC=C(F)C(F)=C1F WEPXLRANFJEOFZ-UHFFFAOYSA-N 0.000 description 2
- NSTREUWFTAOOKS-UHFFFAOYSA-N 2-fluorobenzoic acid Chemical class OC(=O)C1=CC=CC=C1F NSTREUWFTAOOKS-UHFFFAOYSA-N 0.000 description 2
- -1 Alkali metal hexamethyldisilazide Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- NNNDGNSOCBWTJG-UHFFFAOYSA-N aniline;benzoic acid Chemical compound NC1=CC=CC=C1.OC(=O)C1=CC=CC=C1 NNNDGNSOCBWTJG-UHFFFAOYSA-N 0.000 description 2
- 150000001448 anilines Chemical class 0.000 description 2
- 239000000010 aprotic solvent Substances 0.000 description 2
- 150000001559 benzoic acids Chemical class 0.000 description 2
- 125000002843 carboxylic acid group Chemical group 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 125000006575 electron-withdrawing group Chemical group 0.000 description 2
- 238000003818 flash chromatography Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BBYDXOIZLAWGSL-UHFFFAOYSA-N 4-fluorobenzoic acid Chemical compound OC(=O)C1=CC=C(F)C=C1 BBYDXOIZLAWGSL-UHFFFAOYSA-N 0.000 description 1
- BGKLFAQCHHCZRZ-UHFFFAOYSA-N 4-iodo-2-methylaniline Chemical compound CC1=CC(I)=CC=C1N BGKLFAQCHHCZRZ-UHFFFAOYSA-N 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 239000012820 MEK1 Inhibitor Substances 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical class C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- BHAAPTBBJKJZER-UHFFFAOYSA-N p-anisidine Chemical compound COC1=CC=C(N)C=C1 BHAAPTBBJKJZER-UHFFFAOYSA-N 0.000 description 1
- IUBQJLUDMLPAGT-UHFFFAOYSA-N potassium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([K])[Si](C)(C)C IUBQJLUDMLPAGT-UHFFFAOYSA-N 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13038499P | 1999-04-21 | 1999-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200107834B true ZA200107834B (en) | 2002-12-23 |
Family
ID=22444462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200107834A ZA200107834B (en) | 1999-04-21 | 2001-09-21 | Method for making 2-(N-phenylamino)benzoic acids. |
Country Status (34)
| Country | Link |
|---|---|
| EP (1) | EP1171418B1 (https=) |
| JP (1) | JP3769192B2 (https=) |
| KR (1) | KR20010108521A (https=) |
| CN (1) | CN1213997C (https=) |
| AP (1) | AP2001002328A0 (https=) |
| AT (1) | ATE286015T1 (https=) |
| AU (1) | AU773096B2 (https=) |
| BG (1) | BG106132A (https=) |
| BR (1) | BR0009886A (https=) |
| CA (1) | CA2368807A1 (https=) |
| CR (1) | CR6486A (https=) |
| CU (1) | CU22996A3 (https=) |
| DE (1) | DE60017109T2 (https=) |
| DK (1) | DK1171418T3 (https=) |
| EA (1) | EA004209B1 (https=) |
| EE (1) | EE200100546A (https=) |
| ES (1) | ES2235843T3 (https=) |
| GE (1) | GEP20033089B (https=) |
| HK (1) | HK1045682B (https=) |
| HR (1) | HRP20010850A2 (https=) |
| HU (1) | HUP0200932A3 (https=) |
| IL (1) | IL146056A0 (https=) |
| MA (1) | MA25412A1 (https=) |
| NO (1) | NO20015095D0 (https=) |
| NZ (1) | NZ515120A (https=) |
| OA (1) | OA11861A (https=) |
| PL (1) | PL351085A1 (https=) |
| PT (1) | PT1171418E (https=) |
| SK (1) | SK14732001A3 (https=) |
| TR (1) | TR200103015T2 (https=) |
| UA (1) | UA70995C2 (https=) |
| WO (1) | WO2000064856A1 (https=) |
| YU (1) | YU73701A (https=) |
| ZA (1) | ZA200107834B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK2072003A3 (en) * | 2000-08-25 | 2004-01-08 | Warner Lambert Co | Process for making N-aryl-anthranilic acids and their derivatives |
| ES2346998T3 (es) * | 2005-04-06 | 2010-10-22 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para la produccion de acido 2,3,4-trifluoro-5-(yodo o bromo)benzoico. |
| JPWO2007021001A1 (ja) * | 2005-08-18 | 2009-02-26 | 宇部興産株式会社 | ２，３，４−トリフルオロ−５−置換安息香酸化合物及びその製法 |
| CN102985399A (zh) * | 2010-02-19 | 2013-03-20 | 国家科学研究中心 | 通过对携带至少一个吸电子基团的芳香族羧酸衍生物进行亲核芳香族取代来制备目的化合物的方法 |
| JP2013519714A (ja) * | 2010-02-19 | 2013-05-30 | センター ナショナル デ ラ リシェルシェ サイエンティフィック | 芳香族求核置換によって目的の化学化合物を調製するための方法 |
| JP2016034900A (ja) * | 2012-11-26 | 2016-03-17 | 中外製薬株式会社 | ５−置換−２−フェニルアミノ−ベンズアミド類の製造方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ501276A (en) * | 1997-07-01 | 2000-10-27 | Warner Lambert Co | 4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders |
-
2000
- 2000-02-16 PT PT00913489T patent/PT1171418E/pt unknown
- 2000-02-16 AU AU34928/00A patent/AU773096B2/en not_active Ceased
- 2000-02-16 HU HU0200932A patent/HUP0200932A3/hu unknown
- 2000-02-16 CN CNB008064423A patent/CN1213997C/zh not_active Expired - Fee Related
- 2000-02-16 KR KR1020017013402A patent/KR20010108521A/ko not_active Ceased
- 2000-02-16 NZ NZ515120A patent/NZ515120A/en unknown
- 2000-02-16 PL PL00351085A patent/PL351085A1/xx not_active IP Right Cessation
- 2000-02-16 GE GEAP20006152A patent/GEP20033089B/en unknown
- 2000-02-16 OA OA1200100260A patent/OA11861A/en unknown
- 2000-02-16 AP APAP/P/2001/002328A patent/AP2001002328A0/en unknown
- 2000-02-16 HK HK02107069.9A patent/HK1045682B/zh not_active IP Right Cessation
- 2000-02-16 BR BR0009886-8A patent/BR0009886A/pt not_active IP Right Cessation
- 2000-02-16 DK DK00913489T patent/DK1171418T3/da active
- 2000-02-16 EP EP00913489A patent/EP1171418B1/en not_active Expired - Lifetime
- 2000-02-16 IL IL14605600A patent/IL146056A0/xx unknown
- 2000-02-16 TR TR2001/03015T patent/TR200103015T2/xx unknown
- 2000-02-16 JP JP2000613809A patent/JP3769192B2/ja not_active Expired - Fee Related
- 2000-02-16 EE EEP200100546A patent/EE200100546A/xx unknown
- 2000-02-16 ES ES00913489T patent/ES2235843T3/es not_active Expired - Lifetime
- 2000-02-16 SK SK1473-2001A patent/SK14732001A3/sk unknown
- 2000-02-16 HR HR20010850A patent/HRP20010850A2/hr not_active Application Discontinuation
- 2000-02-16 UA UA2001096639A patent/UA70995C2/uk unknown
- 2000-02-16 CA CA002368807A patent/CA2368807A1/en not_active Abandoned
- 2000-02-16 AT AT00913489T patent/ATE286015T1/de not_active IP Right Cessation
- 2000-02-16 WO PCT/US2000/003982 patent/WO2000064856A1/en not_active Ceased
- 2000-02-16 DE DE60017109T patent/DE60017109T2/de not_active Expired - Fee Related
- 2000-02-16 EA EA200101113A patent/EA004209B1/ru not_active IP Right Cessation
- 2000-02-16 YU YU73701A patent/YU73701A/sh unknown
-
2001
- 2001-09-21 ZA ZA200107834A patent/ZA200107834B/en unknown
- 2001-09-21 CU CU20010213A patent/CU22996A3/es unknown
- 2001-10-19 CR CR6486A patent/CR6486A/es not_active Application Discontinuation
- 2001-10-19 NO NO20015095A patent/NO20015095D0/no not_active Application Discontinuation
- 2001-11-16 MA MA26413A patent/MA25412A1/fr unknown
- 2001-11-21 BG BG106132A patent/BG106132A/xx unknown
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