JP2002541237A5 - - Google Patents

Download PDF

Info

Publication number
JP2002541237A5
JP2002541237A5 JP2000610819A JP2000610819A JP2002541237A5 JP 2002541237 A5 JP2002541237 A5 JP 2002541237A5 JP 2000610819 A JP2000610819 A JP 2000610819A JP 2000610819 A JP2000610819 A JP 2000610819A JP 2002541237 A5 JP2002541237 A5 JP 2002541237A5
Authority
JP
Japan
Prior art keywords
composition
prodrug
pharmaceutically acceptable
acceptable salt
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000610819A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002541237A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/009319 external-priority patent/WO2000061542A1/en
Publication of JP2002541237A publication Critical patent/JP2002541237A/ja
Publication of JP2002541237A5 publication Critical patent/JP2002541237A5/ja
Pending legal-status Critical Current

Links

JP2000610819A 1999-04-09 2000-04-07 カスパーゼインヒビターおよびその使用 Pending JP2002541237A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12854599P 1999-04-09 1999-04-09
US60/128,545 1999-04-09
US15837099P 1999-10-12 1999-10-12
US60/158,370 1999-10-12
PCT/US2000/009319 WO2000061542A1 (en) 1999-04-09 2000-04-07 Caspase inhibitors and the use thereof

Publications (2)

Publication Number Publication Date
JP2002541237A JP2002541237A (ja) 2002-12-03
JP2002541237A5 true JP2002541237A5 (https=) 2007-06-14

Family

ID=26826691

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000610819A Pending JP2002541237A (ja) 1999-04-09 2000-04-07 カスパーゼインヒビターおよびその使用

Country Status (12)

Country Link
US (3) US6355618B1 (https=)
EP (1) EP1177168B1 (https=)
JP (1) JP2002541237A (https=)
KR (1) KR20020005665A (https=)
CN (1) CN1176941C (https=)
AT (1) ATE363465T1 (https=)
AU (1) AU4213500A (https=)
BR (1) BR0009610A (https=)
CA (1) CA2369619A1 (https=)
DE (1) DE60035037T2 (https=)
MX (1) MXPA01010127A (https=)
WO (1) WO2000061542A1 (https=)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0476916A1 (en) * 1990-09-13 1992-03-25 Westinghouse Electric Corporation Aluminum-silver oxide battery system
US6184210B1 (en) * 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
ATE276754T1 (de) * 1998-07-21 2004-10-15 Cytovia Inc Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung
AU3876600A (en) * 1999-03-16 2000-10-04 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
US6355618B1 (en) * 1999-04-09 2002-03-12 Cytovia, Inc. Caspase inhibitors and the use thereof
US6495522B1 (en) 1999-08-27 2002-12-17 Cytovia, Inc. Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
AU2001249619B2 (en) 2000-03-29 2006-08-17 Vertex Pharmaceuticals Incorporated Carbamate caspase inhibitors and uses thereof
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
CA2418720A1 (en) * 2000-09-13 2002-03-21 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
FR2815541B1 (fr) * 2000-10-24 2008-02-29 Lipha Utilisation d'inhibiteurs de l'apoptose des pericytes pour le traitement et/ou la prevention de la retinopathie diabetique
CN1326562C (zh) * 2001-01-29 2007-07-18 应用研究系统Ars股份公司 Il－18抑制剂制造治疗和/或预防心脏病的药物的应用
CA2439415C (en) * 2001-03-02 2011-09-20 Merck Frosst Canada & Co. Cathepsin cysteine protease inhibitors
US20030096737A1 (en) 2001-04-19 2003-05-22 Anita Diu-Hercend Caspase inhibitors and uses thereof
KR100446961B1 (ko) * 2001-10-09 2004-09-01 주식회사 엘지생명과학 캐스파제 저해제를 이용하여 조혈모세포를 체외에서다량으로 증식시키는 세포배양 방법 및 배지 조성물
WO2003072528A2 (en) * 2002-02-08 2003-09-04 Idun Pharmaceuticals, Inc. (substituted)acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
AU2003272189A1 (en) * 2002-04-05 2004-01-19 Cytovia, Inc. Caspase inhibitors for the treatment of diseases and conditions caused by exposure to radionuclides, biological agents, or chemical agents
GB0208579D0 (en) * 2002-04-13 2002-05-22 British Biotech Pharm Antibacterial agents
AU2003225088A1 (en) 2002-04-19 2003-11-03 Vertex Pharmaceuticals Incorporated Regulation of tnf-alpha
JP2005536462A (ja) * 2002-04-30 2005-12-02 ユン ジン ファーマスーチカル インダストリーズ カンパニー リミテッド カスパーゼ−３阻害剤としてのキノリン誘導体、この製造方法及びこれを含む薬剤学的組成物
US7195884B2 (en) * 2002-07-19 2007-03-27 Promega Corp. Methods and kits for transferases
EP1549224A1 (en) * 2002-10-10 2005-07-06 Becton Dickinson and Company Sample collection system with caspase inhibitor
EP1628674A2 (en) * 2003-05-06 2006-03-01 Cytovia, Inc. Protease inhibitors for coronaviruses and sars-cov and the use thereof
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
US20090232866A1 (en) * 2003-10-07 2009-09-17 Mariann Pavone-Gyongyosi Oligopeptides as coating material for medical products
US7297714B2 (en) 2003-10-21 2007-11-20 Irm Llc Inhibitors of cathepsin S
EP1715866A2 (en) * 2004-02-05 2006-11-02 The General Hospital Corporation Protease inhibitors for treatment of wrinkles
EP2399916B1 (en) * 2004-03-12 2014-12-10 Vertex Pharmaceuticals Incorporated Process and intermediates for the preparation of aspartic acetal caspase ihnhibitors
WO2005115362A1 (en) 2004-05-15 2005-12-08 Vertex Pharmaceuticals Incorporated Treating seizures using ice inhibitors
CA2567080A1 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
EP1791535B1 (en) * 2004-09-17 2008-07-30 BioMAS Ltd. Novel tellurium compounds and their use as immunomodulators
ATE543803T1 (de) 2004-11-24 2012-02-15 Vertex Pharma 3-ä2-(3-azylamino-2-oxo-2h-pyridin-1- yl)acetylaminoü-4-oxopentansäurederivate und deren verwendung als caspase-inhibitoren
WO2008070579A2 (en) * 2006-12-01 2008-06-12 Loma Linda University Medical Center Inhibition of brain enzymes involved in cerebral amyloid angiopathy and macular degeneration
CN101544688B (zh) * 2009-05-06 2012-09-19 河北科技大学 环五肽细胞凋亡酶抑制剂及其制备方法
US20110165143A1 (en) * 2010-01-06 2011-07-07 The Regents Of The University Of Colorado, A Body Corporate Modulation of caspases and therapeutical applications
WO2012061786A1 (en) 2010-11-05 2012-05-10 Brandeis University Ice cleaved alpha-synuclein a biomarker
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS
WO2014164703A1 (en) * 2013-03-11 2014-10-09 University Of Florida Research Foundation, Inc. Delivery of card protein as therapy for occular inflammation
US11053291B2 (en) 2014-02-19 2021-07-06 University Of Florida Research Foundation, Incorporated Delivery of Nrf2 as therapy for protection against reactive oxygen species
AU2015229381B2 (en) 2014-03-11 2019-11-07 University Of Florida Research Foundation, Inc. Use of AAV-expressed M013 protein as an anti-inflammatory therapeutic
CN107207421B (zh) * 2015-02-25 2021-04-20 豪夫迈·罗氏有限公司 新的三氟甲基丙酰胺衍生物
CN106317161B (zh) * 2015-06-29 2020-05-15 深圳翰宇药业股份有限公司 一种氟甲基酮肽系列化合物的制备方法
WO2017148964A1 (en) * 2016-03-04 2017-09-08 F. Hoffmann-La Roche Ag New trifluoromethylpropanamide derivatives as htra1 inhibitors
CN108699105A (zh) 2016-03-04 2018-10-23 豪夫迈·罗氏有限公司 作为htra1抑制剂的新型二氟酮酰胺衍生物
US11186541B2 (en) * 2016-03-28 2021-11-30 The University Of Toledo Potent inhibitors of aspartate N-acetyl-transferase for the treatment of Canavan disease
EP3484859B1 (en) 2016-07-18 2021-09-15 F. Hoffmann-La Roche AG New difluoroketamide derivatives as htra1 inhibitors
JP2019526564A (ja) 2016-08-23 2019-09-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｈｔｒａ１阻害剤としての新規なトリフルオロメチルプロパンアミド誘導体
CN109661389A (zh) 2016-08-23 2019-04-19 豪夫迈·罗氏有限公司 作为htra1抑制剂的新型二氟酮酰胺衍生物
US12383700B2 (en) 2019-06-13 2025-08-12 Hollister Incorporated Reusable urinary catheter products
EP4628107A3 (en) 2019-06-25 2025-12-17 Hollister Incorporated Reusable urinary catheter products
CN114569702B (zh) * 2022-03-07 2022-10-18 上海揽微赛尔生物科技有限公司 含有抗衰老活性肽与干细胞的药物组合物

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2381023A1 (fr) 1977-02-18 1978-09-15 Delalande Sa Nouveaux oligopeptides trifluoromethyles derives de la l-alanine, leur procede de preparation et leur application en therapeutique
US4518528A (en) 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
US5416013A (en) 1990-04-04 1995-05-16 Sterling Winthrop Inc. Interleukin 1β protease and interleukin 1β protease inhibitors
US5252463A (en) 1990-06-22 1993-10-12 The Du Pont Merck Pharmaceutical Company Clipsin, a chymotrypsin-like protease and method of using same
US5824297A (en) 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
DE69226820T2 (de) 1991-06-21 1999-05-12 Merck & Co., Inc., Rahway, N.J. Peptidylderivate als Inhibitoren von Interleukin-1B-konvertierenden Enzymen
AU657701B2 (en) 1991-08-30 1995-03-23 Vertex Pharmaceuticals Incorporated Interleukin 1beta protease and interleukin 1beta protease inhibitors
GB9123326D0 (en) * 1991-11-04 1991-12-18 Sandoz Ltd Improvements in or relating to organic compounds
AU3666893A (en) 1992-02-21 1993-09-13 Merck & Co., Inc. Peptidyl derivatives as inhibitors of interleukin-1beta converting enzyme
EP0618223A3 (en) 1993-03-08 1996-06-12 Sandoz Ltd Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents.
US5462939A (en) 1993-05-07 1995-10-31 Sterling Winthrop Inc. Peptidic ketones as interleukin-1β-converting enzyme inhibitors
JPH0789951A (ja) 1993-06-03 1995-04-04 Sterling Winthrop Inc インターロイキン−１β転換酵素阻害剤
US6087160A (en) 1993-06-24 2000-07-11 The General Hospital Corporation Programmed cell death genes and proteins
US5866545A (en) 1993-08-13 1999-02-02 Merck & Co., Inc. Substituted ketone derivatives as inhibitors of interleukin-1β converting enzyme
US5759548A (en) 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
US5565430A (en) 1994-08-02 1996-10-15 Sterling Winthrop Inc. Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors
US5798442A (en) 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases
US5744451A (en) 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
US5843904A (en) 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
NZ330451A (https=) 1996-09-12 2000-01-28 Idun Pharmaceuticals Inc
AU738048B2 (en) 1996-09-12 2001-09-06 Idun Pharmaceuticals, Inc. Inhibition of apoptosis using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors
US5869519A (en) 1996-12-16 1999-02-09 Idun Pharmaceuticals, Inc. C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6200969B1 (en) 1996-09-12 2001-03-13 Idun Pharmaceuticals, Inc. Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
AU738341B2 (en) * 1996-10-11 2001-09-13 Abbott Gmbh & Co. Kg Asparate ester inhibitors of interleukin-1beta converting enzyme
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US5877197A (en) 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
SK122199A3 (en) 1997-03-18 2000-12-11 Basf Ag Methods and compositions for modulating responsiveness to corticosteroids
JPH111491A (ja) 1997-04-18 1999-01-06 Takeda Chem Ind Ltd ペプチド類及びその剤
US6184210B1 (en) * 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
CN1138472C (zh) * 1997-10-10 2004-02-18 西托维亚公司 二肽型编程性细胞死亡抑制剂及其用途
JPH11180891A (ja) 1997-12-25 1999-07-06 Dai Ichi Seiyaku Co Ltd 抗細胞死剤
KR20010041905A (ko) * 1998-03-16 2001-05-25 시토비아 인크. 디펩티드 카스파제 억제제 및 이의 용도
ES2242394T3 (es) 1998-05-05 2005-11-01 Warner-Lambert Company Llc Inhibidores de tipo succinamida de la enzima convertidora de la interleuquina 1 beta.
US6197750B1 (en) 1998-07-02 2001-03-06 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6201118B1 (en) 1998-08-19 2001-03-13 Vertex Pharmaceuticals Inc. Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
CA2353079A1 (en) 1998-12-02 2000-06-08 Merck Frosst Canada Inc. Gamma-ketoacid tetrapeptides as inhibitors of caspase-3
JP2002539193A (ja) * 1999-03-16 2002-11-19 メルク フロスト カナダ アンド カンパニー カスパーゼ−３阻害薬としてのγ−ケト酸ジペプチド類
AU3876600A (en) * 1999-03-16 2000-10-04 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
US6355618B1 (en) 1999-04-09 2002-03-12 Cytovia, Inc. Caspase inhibitors and the use thereof
DE60010675T2 (de) 1999-08-06 2005-06-16 Vertex Pharmaceuticals Inc., Cambridge Caspase inhibitoren und deren verwendung
US6495522B1 (en) 1999-08-27 2002-12-17 Cytovia, Inc. Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
US6566338B1 (en) * 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
AR026748A1 (es) 1999-12-08 2003-02-26 Vertex Pharma Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis
AU2001249619B2 (en) 2000-03-29 2006-08-17 Vertex Pharmaceuticals Incorporated Carbamate caspase inhibitors and uses thereof
KR20020025959A (ko) 2000-05-23 2002-04-04 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 및 이의 용도
WO2001094351A1 (en) 2000-06-07 2001-12-13 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof

Similar Documents

Publication Publication Date Title
JP2002541237A5 (https=)
ES2546378T3 (es) Moduladores de propiedades farmacocinéticas de agentes terapéuticos
AU2014224111B2 (en) Positively charged water-soluble prodrugs of 1H-imidazo[4,5-c]quinolin-4-amines and related compounds with very high skin penetration rates
KR101291643B1 (ko) 신규한 화합물 및 조성물과 사용 방법
ES2661850T3 (es) Moduladores de receptores del tipo toll
US10808007B2 (en) Desacetoxytubulysin H and analogs thereof
US7459473B2 (en) N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
KR20200037876A (ko) Egfr 및/또는 her2의 저해제 및 사용 방법
BRPI0413930A (pt) composto oligomérico ou sal farmaceuticamente aceitável deste, composição farmacêutica ou veterinária, métodos para inibir a expressão de eif4e em uma célula, tecido ou órgão, para diminuir a proliferação de uma célula em que eif4e é expressado, e para prevenir ou tratar uma condição ou doença métodos para prevenir ou diminuir a angiogênese, e o crescimento de tumor em um paciente, oligonucleotìdeo de anti-sentido, composição farmacêutica ou veterinária, e, uso de um composto oligomérico ou sal farmaceuticamente aceitável deste
CA2306692A1 (en) Dipeptide apoptosis inhibitors and the use thereof
KR20020028865A (ko) 복소환식 화합물, 그의 제조 및 용도
RU95113966A (ru) Пиразолопиримидины, фармацевтическая композиция и способ лечения
EP3143038B1 (de) Peptid-nukleinsäuren-monomere und -oligomere
WO2005033282A2 (en) Polyamide compositions and therapeutic methods for treatment of human papilloma virus
RU96122779A (ru) Производные бензоциклоалкилазолотиона
CA2321149A1 (en) Antitumor agents
JP2002516905A (ja) 神経学上の傷害および毛髪損失を治療するために使用されるａｚａ−複素環式化合物
US20240124491A1 (en) Methods and compounds for treating friedreich's ataxia
AU1708299A (en) Aza-heterocyclic compounds used to treat neurological disorders and hair loss
CA1340957C (en) Nikkomycin derivatives, antimycotic compositions of nikkomycin derivatives and azole antimycotics
SK18292000A3 (sk) Močoviny a karbamáty n-heterocyklických karboxylových kyselín a izosterov karboxylových kyselín, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
JP5561956B2 (ja) カルボキシアミド誘導体及び／またはその塩を活性成分とするｓｃｃａ−１産生抑制剤
CA2551167A1 (en) Aminoalcohol derivatives
WO2019143192A1 (ko) 듀니온을 유효성분으로 포함하는 탈모의 예방 또는 개선용 조성물
CA2517450A1 (en) 7-imino derivatives of camptothecin having antitumor activity