CN1176941C - Caspase抑制剂及其应用 - Google Patents

Caspase抑制剂及其应用

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Publication number
CN1176941C
CN1176941C CNB008070202A CN00807020A CN1176941C CN 1176941 C CN1176941 C CN 1176941C CN B008070202 A CNB008070202 A CN B008070202A CN 00807020 A CN00807020 A CN 00807020A CN 1176941 C CN1176941 C CN 1176941C
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CN
China
Prior art keywords
asp
val
fmk
compound
cell death
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008070202A
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English (en)
Chinese (zh)
Other versions
CN1349496A (zh
Inventor
蔡遂雄
E·维比尔
王炎
G·B·密勒斯
D·R·格林
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Cytovia Therapeutics LLC
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Cytovia Inc
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Publication date
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Publication of CN1349496A publication Critical patent/CN1349496A/zh
Application granted granted Critical
Publication of CN1176941C publication Critical patent/CN1176941C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
CNB008070202A 1999-04-09 2000-04-07 Caspase抑制剂及其应用 Expired - Fee Related CN1176941C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12854599P 1999-04-09 1999-04-09
US60/128,545 1999-04-09
US15837099P 1999-10-12 1999-10-12
US60/158,370 1999-10-12

Publications (2)

Publication Number Publication Date
CN1349496A CN1349496A (zh) 2002-05-15
CN1176941C true CN1176941C (zh) 2004-11-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008070202A Expired - Fee Related CN1176941C (zh) 1999-04-09 2000-04-07 Caspase抑制剂及其应用

Country Status (12)

Country Link
US (3) US6355618B1 (https=)
EP (1) EP1177168B1 (https=)
JP (1) JP2002541237A (https=)
KR (1) KR20020005665A (https=)
CN (1) CN1176941C (https=)
AT (1) ATE363465T1 (https=)
AU (1) AU4213500A (https=)
BR (1) BR0009610A (https=)
CA (1) CA2369619A1 (https=)
DE (1) DE60035037T2 (https=)
MX (1) MXPA01010127A (https=)
WO (1) WO2000061542A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106317161A (zh) * 2015-06-29 2017-01-11 深圳翰宇药业股份有限公司 一种氟甲基酮肽系列化合物的制备方法
CN107207421A (zh) * 2015-02-25 2017-09-26 豪夫迈·罗氏有限公司 新的三氟甲基丙酰胺衍生物

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EP0476916A1 (en) * 1990-09-13 1992-03-25 Westinghouse Electric Corporation Aluminum-silver oxide battery system
US6184210B1 (en) * 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
ATE276754T1 (de) * 1998-07-21 2004-10-15 Cytovia Inc Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung
AU3876600A (en) * 1999-03-16 2000-10-04 Cytovia, Inc. Substituted 2-aminobenzamide caspase inhibitors and the use thereof
US6355618B1 (en) * 1999-04-09 2002-03-12 Cytovia, Inc. Caspase inhibitors and the use thereof
US6495522B1 (en) 1999-08-27 2002-12-17 Cytovia, Inc. Substituted alpha-hydroxy acid caspase inhibitors and the use thereof
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
AU2001249619B2 (en) 2000-03-29 2006-08-17 Vertex Pharmaceuticals Incorporated Carbamate caspase inhibitors and uses thereof
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
CA2418720A1 (en) * 2000-09-13 2002-03-21 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
FR2815541B1 (fr) * 2000-10-24 2008-02-29 Lipha Utilisation d'inhibiteurs de l'apoptose des pericytes pour le traitement et/ou la prevention de la retinopathie diabetique
CN1326562C (zh) * 2001-01-29 2007-07-18 应用研究系统Ars股份公司 Il－18抑制剂制造治疗和/或预防心脏病的药物的应用
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