JP2002536442A5 - - Google Patents
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- JP2002536442A5 JP2002536442A5 JP2000598492A JP2000598492A JP2002536442A5 JP 2002536442 A5 JP2002536442 A5 JP 2002536442A5 JP 2000598492 A JP2000598492 A JP 2000598492A JP 2000598492 A JP2000598492 A JP 2000598492A JP 2002536442 A5 JP2002536442 A5 JP 2002536442A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
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- salts
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 description 49
- 0 C*c1c*(C)*c(*)c1 Chemical compound C*c1c*(C)*c(*)c1 0.000 description 23
- 150000003839 salts Chemical class 0.000 description 22
- 239000012453 solvate Substances 0.000 description 16
- -1 1-azetidinyl Chemical group 0.000 description 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 14
- 150000004677 hydrates Chemical class 0.000 description 10
- 150000007522 mineralic acids Chemical class 0.000 description 10
- 150000007524 organic acids Chemical class 0.000 description 10
- 239000002253 acid Substances 0.000 description 9
- 235000005985 organic acids Nutrition 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- 125000001309 chloro group Chemical group Cl* 0.000 description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- 229910052801 chlorine Inorganic materials 0.000 description 5
- 239000003638 chemical reducing agent Substances 0.000 description 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 125000003944 tolyl group Chemical group 0.000 description 2
- 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- RKSAOWDQSWIQGU-TWGQIWQCSA-N CC(C/C(/C)=C\C(C)=C)NC Chemical compound CC(C/C(/C)=C\C(C)=C)NC RKSAOWDQSWIQGU-TWGQIWQCSA-N 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 206010046543 Urinary incontinence Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9901593A FR2789389B3 (fr) | 1999-02-10 | 1999-02-10 | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
| FR99/01593 | 1999-02-10 | ||
| FR9904429A FR2789390B3 (fr) | 1999-02-10 | 1999-04-07 | Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
| FR99/04429 | 1999-04-07 | ||
| PCT/FR2000/000284 WO2000047572A1 (fr) | 1999-02-10 | 2000-02-08 | Derives de (1-phenacy-3-phenyl-3-piperidylethyl)piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536442A JP2002536442A (ja) | 2002-10-29 |
| JP2002536442A5 true JP2002536442A5 (https=) | 2007-03-22 |
| JP4648544B2 JP4648544B2 (ja) | 2011-03-09 |
Family
ID=26234812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000598492A Expired - Fee Related JP4648544B2 (ja) | 1999-02-10 | 2000-02-08 | （１−フェナシル−３−フェニル−３−ピペリジルエチル）ピペリジン誘導体、その製造方法およびそれを含有する医薬組成物 |
Country Status (36)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050009798A1 (en) * | 2002-02-20 | 2005-01-13 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids in combination with B2 adrenergic agonists |
| WO2003070745A2 (en) * | 2002-02-20 | 2003-08-28 | Sepracor Inc. | Carbonate and carbamate modified forms of glucocorticoids |
| EP1713506A1 (en) * | 2004-01-30 | 2006-10-25 | Pfizer Products Incorporated | Pharmaceutical compositions of neurokinin receptor antagonists and cyclodextrin and methods for improved injection site toleration |
| FR2873373B1 (fr) * | 2004-07-23 | 2006-09-08 | Sanofi Synthelabo | Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique |
| GB2452696B (en) * | 2007-08-02 | 2009-09-23 | Cambridge Entpr Ltd | 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions |
| DE102008015428A1 (de) * | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende Zubereitungen für den humanen Haut- und/oder Schleimhautkontakt mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid |
| DE102008015425A1 (de) * | 2008-03-20 | 2010-01-21 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen zur Verringerung von Juckreiz und anderen dermatologischen Missempfindungen, die insbesondere bei Altershaut auftreten können, mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid |
| DE102008015426A1 (de) * | 2008-03-20 | 2009-09-24 | Beiersdorf Ag | Kühlende kosmetische oder dermatologische Zubereitungen mit einem Gehalt an (1R,2S,5R)-2-Isopropyl-5-methyl-N-(2-(pyridyn-2-yl)ethyl-cyclohexancarboxamid und/oder (1R,2S,5R)-N-(4-(Cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexancarboxamid zu Reduktion von Hautrötungen |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US512901A (en) * | 1894-01-16 | Folding bed | ||
| GB821012A (en) * | 1957-01-15 | 1959-09-30 | Rhone Poulenc Sa | New phenthiazine derivatives and processes for their preparation |
| FR2676055B1 (fr) | 1991-05-03 | 1993-09-03 | Sanofi Elf | Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| MX9701305A (es) * | 1994-08-25 | 1998-05-31 | Merrell Pharma Inc | Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas. |
| EP0714891A1 (en) * | 1994-11-22 | 1996-06-05 | Eli Lilly And Company | Heterocyclic tachykinin receptor antagonists |
-
1999
- 1999-04-07 FR FR9904429A patent/FR2789390B3/fr not_active Expired - Lifetime
-
2000
- 2000-02-08 SI SI200030968T patent/SI1150970T1/sl unknown
- 2000-02-08 ID IDW00200101651A patent/ID29219A/id unknown
- 2000-02-08 EP EP00903744A patent/EP1150970B1/fr not_active Expired - Lifetime
- 2000-02-08 TR TR2001/02331T patent/TR200102331T2/xx unknown
- 2000-02-08 CA CA002360894A patent/CA2360894C/en not_active Expired - Fee Related
- 2000-02-08 SK SK1139-2001A patent/SK286401B6/sk not_active IP Right Cessation
- 2000-02-08 JP JP2000598492A patent/JP4648544B2/ja not_active Expired - Fee Related
- 2000-02-08 NZ NZ513053A patent/NZ513053A/xx not_active IP Right Cessation
- 2000-02-08 EE EEP200100417A patent/EE04437B1/xx not_active IP Right Cessation
- 2000-02-08 PT PT00903744T patent/PT1150970E/pt unknown
- 2000-02-08 AT AT00903744T patent/ATE370942T1/de not_active IP Right Cessation
- 2000-02-08 UA UA2001075184A patent/UA70986C2/uk unknown
- 2000-02-08 RU RU2001121989/04A patent/RU2220956C2/ru not_active IP Right Cessation
- 2000-02-08 US US09/913,106 patent/US6642233B1/en not_active Expired - Fee Related
- 2000-02-08 DE DE60036081T patent/DE60036081T2/de not_active Expired - Lifetime
- 2000-02-08 HU HU0201281A patent/HUP0201281A3/hu unknown
- 2000-02-08 PL PL350243A patent/PL198561B1/pl not_active IP Right Cessation
- 2000-02-08 AU AU25531/00A patent/AU763716B2/en not_active Ceased
- 2000-02-08 WO PCT/FR2000/000284 patent/WO2000047572A1/fr not_active Ceased
- 2000-02-08 HR HR20010566A patent/HRP20010566A2/hr not_active Application Discontinuation
- 2000-02-08 IL IL14436300A patent/IL144363A0/xx not_active IP Right Cessation
- 2000-02-08 RS YUP-564/01A patent/RS50210B/sr unknown
- 2000-02-08 CZ CZ20012888A patent/CZ300765B6/cs not_active IP Right Cessation
- 2000-02-08 ME MEP-119/08A patent/MEP11908A/xx unknown
- 2000-02-08 KR KR1020017009983A patent/KR100611261B1/ko not_active Expired - Fee Related
- 2000-02-08 BR BR0008067-5A patent/BR0008067A/pt not_active Application Discontinuation
- 2000-02-08 ES ES00903744T patent/ES2291187T3/es not_active Expired - Lifetime
- 2000-02-08 DK DK00903744T patent/DK1150970T3/da active
- 2000-02-08 CN CNB008058261A patent/CN1273463C/zh not_active Expired - Fee Related
- 2000-02-09 TW TW089102106A patent/TWI254712B/zh active
- 2000-02-09 AR ARP000100555A patent/AR028813A1/es active IP Right Grant
- 2000-02-10 CO CO00008757A patent/CO4980896A1/es unknown
- 2000-02-10 PE PE2000000102A patent/PE20001463A1/es not_active Application Discontinuation
-
2001
- 2001-08-08 NO NO20013878A patent/NO321149B1/no not_active IP Right Cessation
- 2001-08-08 BG BG105794A patent/BG65031B1/bg unknown
-
2003
- 2003-09-16 US US10/663,124 patent/US6951940B2/en not_active Expired - Fee Related
-
2005
- 2005-04-21 NO NO20051958A patent/NO20051958L/no unknown
-
2007
- 2007-01-07 IL IL180579A patent/IL180579A0/en unknown
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