JP2002522399A5 - - Google Patents

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Publication number
JP2002522399A5
JP2002522399A5 JP2000563311A JP2000563311A JP2002522399A5 JP 2002522399 A5 JP2002522399 A5 JP 2002522399A5 JP 2000563311 A JP2000563311 A JP 2000563311A JP 2000563311 A JP2000563311 A JP 2000563311A JP 2002522399 A5 JP2002522399 A5 JP 2002522399A5
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JP
Japan
Prior art keywords
uricase
conjugate
peg
kda
liver
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JP2000563311A
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English (en)
Japanese (ja)
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JP2002522399A (ja
JP5183836B2 (ja
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Priority claimed from PCT/US1999/017514 external-priority patent/WO2000007629A2/en
Publication of JP2002522399A publication Critical patent/JP2002522399A/ja
Publication of JP2002522399A5 publication Critical patent/JP2002522399A5/ja
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Publication of JP5183836B2 publication Critical patent/JP5183836B2/ja
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JP2000563311A 1998-08-06 1999-08-02 Ｐｅｇ−尿酸酸化酵素結合体およびその使用 Expired - Fee Related JP5183836B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13039298A 1998-08-06 1998-08-06
US09/130,392 1998-08-06
PCT/US1999/017514 WO2000007629A2 (en) 1998-08-06 1999-08-02 Peg-urate oxidase conjugates and use thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2009173148A Division JP5290901B2 (ja) 1998-08-06 2009-07-24 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2012248770A Division JP5291235B2 (ja) 1998-08-06 2012-11-12 Ｐｅｇ−尿酸酸化酵素結合体およびその使用

Publications (3)

Publication Number Publication Date
JP2002522399A JP2002522399A (ja) 2002-07-23
JP2002522399A5 true JP2002522399A5 (https=) 2008-05-08
JP5183836B2 JP5183836B2 (ja) 2013-04-17

Family

ID=22444494

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2000563311A Expired - Fee Related JP5183836B2 (ja) 1998-08-06 1999-08-02 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2009173148A Expired - Fee Related JP5290901B2 (ja) 1998-08-06 2009-07-24 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2012248770A Expired - Fee Related JP5291235B2 (ja) 1998-08-06 2012-11-12 Ｐｅｇ−尿酸酸化酵素結合体およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009173148A Expired - Fee Related JP5290901B2 (ja) 1998-08-06 2009-07-24 Ｐｅｇ−尿酸酸化酵素結合体およびその使用
JP2012248770A Expired - Fee Related JP5291235B2 (ja) 1998-08-06 2012-11-12 Ｐｅｇ−尿酸酸化酵素結合体およびその使用

Country Status (13)

Country Link
EP (1) EP1100542B1 (https=)
JP (3) JP5183836B2 (https=)
KR (2) KR100488848B1 (https=)
AU (1) AU770014B2 (https=)
BR (2) BRPI9917760B8 (https=)
CZ (1) CZ303751B6 (https=)
HU (2) HU228916B1 (https=)
IL (3) IL141220A0 (https=)
NZ (1) NZ509595A (https=)
PL (2) PL202799B1 (https=)
RU (3) RU2278680C2 (https=)
TW (1) TW570981B (https=)
WO (1) WO2000007629A2 (https=)

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PL202799B1 (pl) * 1998-08-06 2009-07-31 Mountain View Pharmaceuticals Sposób izolowania urykazy w postaci tetramerycznej oraz wyizolowana tetrameryczna urykaza
JP2002524053A (ja) 1998-08-06 2002-08-06 デューク・ユニバーシティー 尿酸オキシダーゼ
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
ES2245114T3 (es) 1998-08-06 2005-12-16 Mountain View Pharmaceuticals, Inc. Conjugados de peg-oxidasa de urato y su uso.
AU2006203252B8 (en) * 2000-02-10 2009-06-18 Duke University Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
EP1279406A4 (en) 2000-04-03 2007-10-24 Santen Pharmaceutical Co Ltd TRANSPORTERS AND DRUG DISPENSING SYSTEMS USING THESE
JP2004517804A (ja) 2000-06-28 2004-06-17 メルク・アンド・カンパニー・インコーポレーテッド 心臓血管病の治療法
AU2002345938A1 (en) 2001-06-28 2003-03-03 Mountain View Pharmaceuticals, Inc. Polymer stabilized proteinases
US6913915B2 (en) * 2001-08-02 2005-07-05 Phoenix Pharmacologics, Inc. PEG-modified uricase
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2004100997A2 (en) 2003-05-12 2004-11-25 Affymax, Inc. Spacer moiety for poly(ethylene glycol) -modified peptides
SI1625156T1 (sl) 2003-05-12 2013-02-28 Affymax, Inc. Peptidi, ki se veĹľejo k eritropoetinskemu receptorju
KR101146160B1 (ko) * 2004-06-30 2012-07-16 넥타르 테라퓨틱스 중합체­인자 ｉｘ 부분의 접합체
US8148123B2 (en) 2005-04-11 2012-04-03 Savient Pharmaceuticals, Inc. Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
WO2006110761A2 (en) * 2005-04-11 2006-10-19 Savient Pharmaceuticals, Inc. A variant form of urate oxidase and use thereof
HUE052976T2 (hu) 2005-04-11 2021-06-28 Horizon Pharma Rheumatology Llc Urát-oxidáz variáns formái és azok alkalmazása
EP1883405A4 (en) 2005-05-09 2010-01-27 Takeda Pharmaceuticals North A METHODS OF TREATING NEPHROLITHIASIS
US7550433B2 (en) 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
CN101622270B (zh) 2006-04-12 2014-01-01 萨文特医药公司 用阳离子表面活性剂纯化蛋白质的方法
JP4890132B2 (ja) * 2006-07-20 2012-03-07 東洋紡績株式会社 ウリカーゼの比活性を向上させる方法、および比活性の向上した改変型ウリカーゼ
RU2382048C1 (ru) * 2008-12-25 2010-02-20 Общество С Ограниченной Ответственностью "Фармапарк" Лекарственное средство на основе модифицированного интерферона альфа с пролонгированным терапевтическим действием
HUP1200205A3 (en) 2009-06-25 2012-09-28 Savient Pharmaceuticals Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy
CA2812034C (en) 2010-09-10 2018-10-23 Takeda Pharmaceuticals U.S.A., Inc. Methods for concomitant treatment of theophylline and febuxostat
CN102634492B (zh) 2011-02-14 2015-06-10 重庆富进生物医药有限公司 聚乙二醇化犬源尿酸氧化酶类似物及其制备方法和应用
CA2869557A1 (en) 2012-04-06 2013-10-10 Indus Pharmaceuticals, Inc. Novel compositions of combinations of non-covalent dna binding agents and anti-cancer and/or anti-inflammatory agents and their use in disease treatment
HUE052599T2 (hu) 2013-05-03 2021-05-28 Selecta Biosciences Inc CD4+ szabályozó T-sejtek fokozására szolgáló eljárások és készítmények
CN107614007B (zh) 2015-05-15 2022-03-25 免疫医疗有限责任公司 改进的尿酸酶序列和治疗方法
CN105412942B (zh) * 2015-12-23 2019-02-26 沈阳三生制药有限责任公司 聚乙二醇化的重组产朊假丝酵母尿酸氧化酶冻干注射剂
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
CN110234340A (zh) 2016-11-11 2019-09-13 好利恩风湿病制药有限责任公司 泼尼松和尿酸酶分子的组合疗法及其用途
WO2018169811A1 (en) 2017-03-11 2018-09-20 Selecta Biosciences, Inc. Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant
CN114207440A (zh) 2019-06-04 2022-03-18 西莱克塔生物科技公司 聚乙二醇化尿酸酶的制剂和剂量
CN112980808B (zh) * 2019-12-12 2024-10-29 深圳迈瑞生物医疗电子股份有限公司 尿酸酶、及其制备方法和用途
EP4240423A1 (en) 2020-11-03 2023-09-13 Protalix Ltd. Modified uricase and uses thereof
CN114438048B (zh) * 2020-11-05 2024-10-22 重庆派金生物科技有限公司 尿酸氧化酶制剂及其应用
CN114438047B (zh) * 2020-11-05 2024-11-22 重庆派金生物科技有限公司 制备聚乙二醇修饰的尿酸氧化酶的方法
US20240060063A1 (en) 2021-02-10 2024-02-22 Oriental Yeast Co., Ltd. Uricase activator and uric acid measurement reagent
CN114181917B (zh) * 2022-02-14 2022-06-03 潍坊华卓生物科技有限公司 一种改造尿酸酶、基因序列、制备方法及应用
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

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US3616231A (en) * 1968-11-14 1971-10-26 Boehringer Mannheim Gmbh Process for the production of uricase
US4179337A (en) * 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6031472B2 (ja) * 1978-12-14 1985-07-22 協和醗酵工業株式会社 酸性ウリカ−ゼ
JPS55135590A (en) * 1979-04-05 1980-10-22 Mihama Hisaharu Modified asparaginase and uricase and their preparation
JPS57192435A (en) * 1981-05-20 1982-11-26 Toyobo Co Ltd Modified polypeptide
JPS6255079A (ja) * 1986-04-23 1987-03-10 Mihama Hisaharu 修飾ウリカ−ゼ
NZ234453A (en) * 1989-07-13 1993-01-27 Sanofi Sa Recombinant dna encoding urate oxidase, and vector, host, protein and pharmaceutical compositions associated therewith
JP2002524053A (ja) * 1998-08-06 2002-08-06 デューク・ユニバーシティー 尿酸オキシダーゼ
PL202799B1 (pl) * 1998-08-06 2009-07-31 Mountain View Pharmaceuticals Sposób izolowania urykazy w postaci tetramerycznej oraz wyizolowana tetrameryczna urykaza
US6783965B1 (en) * 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates

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