JP2002513378A - 癌の治療および診断 - Google Patents
癌の治療および診断Info
- Publication number
- JP2002513378A JP2002513378A JP50699598A JP50699598A JP2002513378A JP 2002513378 A JP2002513378 A JP 2002513378A JP 50699598 A JP50699598 A JP 50699598A JP 50699598 A JP50699598 A JP 50699598A JP 2002513378 A JP2002513378 A JP 2002513378A
- Authority
- JP
- Japan
- Prior art keywords
- biopharmaceutical
- prostate
- antibody
- cells
- membrane antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 66
- 201000011510 cancer Diseases 0.000 title claims description 45
- 238000011282 treatment Methods 0.000 title abstract description 31
- 238000003745 diagnosis Methods 0.000 title description 9
- 210000004027 cell Anatomy 0.000 claims abstract description 204
- 229960000074 biopharmaceutical Drugs 0.000 claims abstract description 191
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims abstract description 101
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims abstract description 101
- 230000027455 binding Effects 0.000 claims abstract description 60
- 210000002307 prostate Anatomy 0.000 claims abstract description 49
- 239000000523 sample Substances 0.000 claims abstract description 47
- 210000001519 tissue Anatomy 0.000 claims abstract description 45
- 210000000064 prostate epithelial cell Anatomy 0.000 claims abstract description 40
- 210000003556 vascular endothelial cell Anatomy 0.000 claims abstract description 36
- 239000003446 ligand Substances 0.000 claims abstract description 31
- 230000002062 proliferating effect Effects 0.000 claims abstract description 28
- 238000001514 detection method Methods 0.000 claims abstract description 26
- 239000000126 substance Substances 0.000 claims abstract description 19
- 210000004408 hybridoma Anatomy 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims description 172
- 206010060862 Prostate cancer Diseases 0.000 claims description 43
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 42
- 230000002147 killing effect Effects 0.000 claims description 30
- 239000012472 biological sample Substances 0.000 claims description 25
- 210000002966 serum Anatomy 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 20
- 108090000623 proteins and genes Proteins 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 18
- 102000004169 proteins and genes Human genes 0.000 claims description 18
- 241000124008 Mammalia Species 0.000 claims description 16
- 239000003124 biologic agent Substances 0.000 claims description 16
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
- 239000003381 stabilizer Substances 0.000 claims description 15
- 229940127089 cytotoxic agent Drugs 0.000 claims description 14
- 239000002254 cytotoxic agent Substances 0.000 claims description 14
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 14
- 230000001394 metastastic effect Effects 0.000 claims description 14
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 239000012634 fragment Substances 0.000 claims description 13
- 210000004185 liver Anatomy 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 10
- 208000009956 adenocarcinoma Diseases 0.000 claims description 9
- 238000005481 NMR spectroscopy Methods 0.000 claims description 8
- 210000001072 colon Anatomy 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 8
- 210000004072 lung Anatomy 0.000 claims description 8
- 230000005855 radiation Effects 0.000 claims description 8
- 210000003734 kidney Anatomy 0.000 claims description 7
- 230000036963 noncompetitive effect Effects 0.000 claims description 7
- 230000002285 radioactive effect Effects 0.000 claims description 7
- 210000002700 urine Anatomy 0.000 claims description 7
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 6
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 6
- 238000007912 intraperitoneal administration Methods 0.000 claims description 6
- 238000007920 subcutaneous administration Methods 0.000 claims description 6
- 210000000481 breast Anatomy 0.000 claims description 5
- 238000007918 intramuscular administration Methods 0.000 claims description 5
- 238000001990 intravenous administration Methods 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 4
- 206010038389 Renal cancer Diseases 0.000 claims description 4
- 239000012190 activator Substances 0.000 claims description 4
- 230000001580 bacterial effect Effects 0.000 claims description 4
- 201000010982 kidney cancer Diseases 0.000 claims description 4
- 230000001404 mediated effect Effects 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 238000001574 biopsy Methods 0.000 claims description 3
- 230000017531 blood circulation Effects 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 230000003013 cytotoxicity Effects 0.000 claims description 3
- 231100000135 cytotoxicity Toxicity 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 230000036737 immune function Effects 0.000 claims 6
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 5
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 5
- 239000007850 fluorescent dye Substances 0.000 claims 4
- 210000004754 hybrid cell Anatomy 0.000 claims 4
- 238000001802 infusion Methods 0.000 claims 4
- 238000001361 intraarterial administration Methods 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 description 35
- 108091007433 antigens Proteins 0.000 description 35
- 102000036639 antigens Human genes 0.000 description 35
- 238000003384 imaging method Methods 0.000 description 19
- 235000018102 proteins Nutrition 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 239000002773 nucleotide Substances 0.000 description 14
- 125000003729 nucleotide group Chemical group 0.000 description 14
- 241000282414 Homo sapiens Species 0.000 description 13
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 12
- 108010051457 Acid Phosphatase Proteins 0.000 description 12
- 102000013563 Acid Phosphatase Human genes 0.000 description 12
- 241000699666 Mus <mouse, genus> Species 0.000 description 12
- 239000012528 membrane Substances 0.000 description 12
- 108091033380 Coding strand Proteins 0.000 description 11
- 210000004379 membrane Anatomy 0.000 description 11
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 description 10
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 10
- 238000011534 incubation Methods 0.000 description 10
- 229940002612 prodrug Drugs 0.000 description 9
- 239000000651 prodrug Substances 0.000 description 9
- 238000001959 radiotherapy Methods 0.000 description 9
- 238000002560 therapeutic procedure Methods 0.000 description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
- 102000004190 Enzymes Human genes 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 8
- 241000283973 Oryctolagus cuniculus Species 0.000 description 8
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000002953 phosphate buffered saline Substances 0.000 description 8
- 108010076504 Protein Sorting Signals Proteins 0.000 description 7
- 238000001727 in vivo Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 6
- 125000003275 alpha amino acid group Chemical group 0.000 description 6
- 230000000890 antigenic effect Effects 0.000 description 6
- 210000001124 body fluid Anatomy 0.000 description 6
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 6
- 238000002372 labelling Methods 0.000 description 6
- 239000006166 lysate Substances 0.000 description 6
- 230000009257 reactivity Effects 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 230000004927 fusion Effects 0.000 description 5
- 239000000499 gel Substances 0.000 description 5
- 238000001114 immunoprecipitation Methods 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 230000003834 intracellular effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000001000 micrograph Methods 0.000 description 5
- 210000005267 prostate cell Anatomy 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 229960003604 testosterone Drugs 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 201000009030 Carcinoma Diseases 0.000 description 4
- 229920002261 Corn starch Polymers 0.000 description 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
- 108010044467 Isoenzymes Proteins 0.000 description 4
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 4
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 4
- 102000007066 Prostate-Specific Antigen Human genes 0.000 description 4
- 108010072866 Prostate-Specific Antigen Proteins 0.000 description 4
- 229960002685 biotin Drugs 0.000 description 4
- 235000020958 biotin Nutrition 0.000 description 4
- 239000011616 biotin Substances 0.000 description 4
- 239000010839 body fluid Substances 0.000 description 4
- 239000000969 carrier Substances 0.000 description 4
- 210000000170 cell membrane Anatomy 0.000 description 4
- 238000012512 characterization method Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000008120 corn starch Substances 0.000 description 4
- 210000002919 epithelial cell Anatomy 0.000 description 4
- 210000002149 gonad Anatomy 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 230000003053 immunization Effects 0.000 description 4
- 230000000984 immunochemical effect Effects 0.000 description 4
- 238000010166 immunofluorescence Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 210000001165 lymph node Anatomy 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 238000011471 prostatectomy Methods 0.000 description 4
- 238000002271 resection Methods 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- 102000005853 Clathrin Human genes 0.000 description 3
- 108010019874 Clathrin Proteins 0.000 description 3
- 108010010803 Gelatin Proteins 0.000 description 3
- 206010027476 Metastases Diseases 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- 102000003992 Peroxidases Human genes 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- SXEHKFHPFVVDIR-UHFFFAOYSA-N [4-(4-hydrazinylphenyl)phenyl]hydrazine Chemical compound C1=CC(NN)=CC=C1C1=CC=C(NN)C=C1 SXEHKFHPFVVDIR-UHFFFAOYSA-N 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229930193282 clathrin Natural products 0.000 description 3
- 230000001268 conjugating effect Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 239000008273 gelatin Substances 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 235000011852 gelatine desserts Nutrition 0.000 description 3
- 238000001794 hormone therapy Methods 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 210000004698 lymphocyte Anatomy 0.000 description 3
- 230000003211 malignant effect Effects 0.000 description 3
- 238000000386 microscopy Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000011451 sequencing strategy Methods 0.000 description 3
- 230000001568 sexual effect Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 238000012546 transfer Methods 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 210000001635 urinary tract Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 238000001262 western blot Methods 0.000 description 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 2
- VPFUWHKTPYPNGT-UHFFFAOYSA-N 3-(3,4-dihydroxyphenyl)-1-(5-hydroxy-2,2-dimethylchromen-6-yl)propan-1-one Chemical compound OC1=C2C=CC(C)(C)OC2=CC=C1C(=O)CCC1=CC=C(O)C(O)=C1 VPFUWHKTPYPNGT-UHFFFAOYSA-N 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 108091035707 Consensus sequence Proteins 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- 102000016607 Diphtheria Toxin Human genes 0.000 description 2
- 108010053187 Diphtheria Toxin Proteins 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
- ZCYVEMRRCGMTRW-AHCXROLUSA-N Iodine-123 Chemical compound [123I] ZCYVEMRRCGMTRW-AHCXROLUSA-N 0.000 description 2
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
- 206010027452 Metastases to bone Diseases 0.000 description 2
- 241001529936 Murinae Species 0.000 description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 description 2
- 241000276498 Pollachius virens Species 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- 239000006180 TBST buffer Substances 0.000 description 2
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 229940009456 adriamycin Drugs 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 125000004429 atom Chemical group 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 2
- 229960004630 chlorambucil Drugs 0.000 description 2
- 238000003759 clinical diagnosis Methods 0.000 description 2
- 230000002860 competitive effect Effects 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 239000003636 conditioned culture medium Substances 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 210000001163 endosome Anatomy 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 229940011871 estrogen Drugs 0.000 description 2
- 239000000262 estrogen Substances 0.000 description 2
- -1 ethylin glycol Chemical class 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 125000001153 fluoro group Chemical group F* 0.000 description 2
- 229960002074 flutamide Drugs 0.000 description 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 230000000951 immunodiffusion Effects 0.000 description 2
- 238000011532 immunohistochemical staining Methods 0.000 description 2
- 230000009545 invasion Effects 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- 230000000155 isotopic effect Effects 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000000968 medical method and process Methods 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000009401 metastasis Effects 0.000 description 2
- 208000010658 metastatic prostate carcinoma Diseases 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 238000004264 monolayer culture Methods 0.000 description 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 2
- 201000000050 myeloid neoplasm Diseases 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 150000007523 nucleic acids Chemical group 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 201000001514 prostate carcinoma Diseases 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- KIWUVOGUEXMXSV-UHFFFAOYSA-N rhodanine Chemical compound O=C1CSC(=S)N1 KIWUVOGUEXMXSV-UHFFFAOYSA-N 0.000 description 2
- 102220201851 rs143406017 Human genes 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000003325 tomography Methods 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- 229910052722 tritium Inorganic materials 0.000 description 2
- 210000005166 vasculature Anatomy 0.000 description 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
- 108010066676 Abrin Proteins 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 208000003200 Adenoma Diseases 0.000 description 1
- 206010001233 Adenoma benign Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 101000669426 Aspergillus restrictus Ribonuclease mitogillin Proteins 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 101710158575 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical class O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 229910021555 Chromium Chloride Inorganic materials 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108700032819 Croton tiglium crotin II Proteins 0.000 description 1
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 1
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 101100001675 Emericella variicolor andJ gene Proteins 0.000 description 1
- 241001522296 Erithacus rubecula Species 0.000 description 1
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 208000015872 Gaucher disease Diseases 0.000 description 1
- 108700004714 Gelonium multiflorum GEL Proteins 0.000 description 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
- 101000893710 Homo sapiens Galactoside alpha-(1,2)-fucosyltransferase 2 Proteins 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 1
- 208000008771 Lymphadenopathy Diseases 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 108700020962 Peroxidase Proteins 0.000 description 1
- 101710132772 Peroxidase 1 Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 240000007643 Phytolacca americana Species 0.000 description 1
- 235000009074 Phytolacca americana Nutrition 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 208000007660 Residual Neoplasm Diseases 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 240000003946 Saponaria officinalis Species 0.000 description 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241001655798 Taku Species 0.000 description 1
- 208000006593 Urologic Neoplasms Diseases 0.000 description 1
- 240000001866 Vernicia fordii Species 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 208000013228 adenopathy Diseases 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 229960003896 aminopterin Drugs 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 230000001826 anti-prostatic effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- XFLVBMBRLSCJAI-ZKWXMUAHSA-N biotin amide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)N)SC[C@@H]21 XFLVBMBRLSCJAI-ZKWXMUAHSA-N 0.000 description 1
- XFLVBMBRLSCJAI-UHFFFAOYSA-N biotin amide Natural products N1C(=O)NC2C(CCCCC(=O)N)SCC21 XFLVBMBRLSCJAI-UHFFFAOYSA-N 0.000 description 1
- 238000007413 biotinylation Methods 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000007469 bone scintigraphy Methods 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- QSWDMMVNRMROPK-UHFFFAOYSA-K chromium(3+) trichloride Chemical compound [Cl-].[Cl-].[Cl-].[Cr+3] QSWDMMVNRMROPK-UHFFFAOYSA-K 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000009137 competitive binding Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000004624 confocal microscopy Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000002681 cryosurgery Methods 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 230000000120 cytopathologic effect Effects 0.000 description 1
- 238000011393 cytotoxic chemotherapy Methods 0.000 description 1
- 238000002784 cytotoxicity assay Methods 0.000 description 1
- 231100000263 cytotoxicity test Toxicity 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 1
- 229960000452 diethylstilbestrol Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000012202 endocytosis Effects 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 108010028531 enomycin Proteins 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000007236 host immunity Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011503 in vivo imaging Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
- APFVFJFRJDLVQX-UHFFFAOYSA-N indium atom Chemical compound [In] APFVFJFRJDLVQX-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 102000027411 intracellular receptors Human genes 0.000 description 1
- 108091008582 intracellular receptors Proteins 0.000 description 1
- 230000002083 iodinating effect Effects 0.000 description 1
- 230000026045 iodination Effects 0.000 description 1
- 238000006192 iodination reaction Methods 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- BJHIKXHVCXFQLS-OTWZMJIISA-N keto-L-sorbose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-OTWZMJIISA-N 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000011474 orchiectomy Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229960002695 phenobarbital Drugs 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 208000017497 prostate disease Diseases 0.000 description 1
- 108010043671 prostatic acid phosphatase Proteins 0.000 description 1
- 235000004252 protein component Nutrition 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000011472 radical prostatectomy Methods 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 238000011363 radioimmunotherapy Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940043267 rhodamine b Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012723 sample buffer Substances 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000007892 solid unit dosage form Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 230000036964 tight binding Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000036326 tumor accumulation Effects 0.000 description 1
- 210000003741 urothelium Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Reproductive Health (AREA)
- Biotechnology (AREA)
- Pregnancy & Childbirth (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.癌性細胞を切除または殺す方法であって、 前立腺特異的膜抗原の細胞外ドメインに接触したときに、前立腺特異的膜抗原 の細胞外ドメインに結合する生物薬剤を準備し、 癌性細胞に近接の血管性内皮細胞を生物薬剤に、癌性細胞に近接の血管性内皮 細胞に生物薬剤が結合することと癌性細胞を切除または殺すことの両方を可能に するのに効果的な条件で、接触せしめる、 ことを含む方法。 2.生物薬剤が癌性細胞に近接の血管性内皮細胞を殺すまたは切除し、それによ って癌性細胞への血流を減少して癌性細胞を殺すまたは切除する、請求項1の方 法。 3.癌性細胞が腎癌性細胞、尿路上皮癌性細胞、結腸癌性細胞、直腸癌性細胞、 肺癌性細胞、乳房癌性細胞または肝への転移性腺癌細胞である、請求項1の方法 。 4.生物薬剤が抗体、その結合部分、プローブまたはリガンドである、請求項1 の方法。 5.生物薬剤が、前立腺特異的膜抗原の細胞外ドメインに接触したときに、前立 腺特異的膜抗原で取り込まれる、請求項1の方法。 6.該接触が生きている哺乳動物で実施され、そして、 生物薬剤を哺乳動物に、癌性細胞に近接の血管性内皮細胞に生物薬剤を結合さ すことと癌性細胞を殺すことの両方を可能とするのに効果的な条件で、投与する ことを含む、請求項1の方法。 7.該投与が経口で、非経口で、皮下に、静脈内に、筋肉内に、腹腔内に、点鼻 で、空洞または小胞点滴で、点眼で、動脈内に、病巣内に、および粘膜になされ る、請求項6の方法。 8.抗体が請求項4の方法の実施において使用され、この抗体がモノクローナル およびポリクローナル抗体よりなる群から選ばれる抗体である、請求項4の方法 。 9.抗体がE99、J415、J533およびJ591モノクローナル抗体よりなる群から選ば れる、請求項8の方法。 10.抗体がHB-12101、HB-12109、HB-12127およびHB-12126抗体よりなる群から 選ばれるATCC受託番号を有するハイブリド細胞系により産生されるモノクローナ ル抗体である、請求項8の方法。 11.抗体の結合部分が請求項4の方法の実施において使用され、この結合部分 がFabフラグメント、F(ab')2フラグメントおよびFvフラグメントよりなる群から 選ばれる、請求項4の方法。 12.プローブまたはリガンドが請求項4の方法の実施において使用される、請 求項4の方法。 13.生物薬剤が、癌性細胞に近接の血管性内皮細胞に生物薬剤が結合する際に 癌性細胞を殺すまたは切除するのに効果的な物質に結合している、請求項1の方 法。 14.癌性細胞を殺すまたは切除するのに効果的な物質が細胞障害剤である、請 求項13の方法。 15.細胞障害剤が治療薬剤、放射化合物、植物、カビまたは細菌源の分子、生 物性タンパク質およびこれらの混合物よりなる群から選ばれる、請求項14の方 法。 16.抗体が内因性宿主免疫機能を開始するのに効果的である、請求項4の方法 。 17.内因性宿主免疫機能が補体媒介性細胞障害である、請求項16の方法。 18.内因性宿主免疫機能が抗体依存性細胞障害である、請求項16の方法。 19.生物薬剤が、生理的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項1の方法。 20.生物薬剤が、薬学的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項1の方法。 21.生物サンプルにおいて癌性組織を検出する方法であって、 前立腺特異的膜抗原の細胞外ドメインに接触したときに、前立腺特異的膜抗原 の細胞外ドメインに結合する生物薬剤を準備し、そのうち、生物薬剤は、癌性細 胞に近接または内在の血管性内皮細胞に生物薬剤が結合する際に癌性細胞に近接 または内在の血管性内皮細胞の検出を可能にするのに効果的な標識と結合してお り、 標識を有する生物薬剤に生物サンプルを、生物サンプルにおける癌性細胞に近 接または内在の血管性内皮細胞に生物薬剤が結合することを可能にするのに効果 的な条件で、接触せしめ、 標識の検出により生物サンプルにおける癌性組織の存在を検出する、ことを含 む方法。 22.癌性細胞が腎癌性細胞、尿路上皮癌性細胞、結腸癌性細胞、直腸癌性細胞 、肺癌性細胞、乳房癌性細胞または肝への転移性腺癌細胞である、請求項21の 方法。 23.生物薬剤が抗体、その結合部分、プローブまたはリガンドである、請求項 21の方法。 24.生物薬剤が、前立腺特異的膜抗原の細胞外ドメインに接触したときに、前 立腺特異的膜抗原で取り込まれる、請求項21の方法。 25.該接触が生きている哺乳動物で実施され、そして、 生物薬剤を哺乳動物に、癌性細胞に近接の血管性内皮細胞に生物薬剤を結合さ すことと癌性細胞を殺すことの両方を可能とするのに効果的な条件で、投与する ことを含む、請求項21の方法。 26.標識が短射程放射放出体である、請求項25の方法。 27.該投与が経口で、非経口で、皮下に、静脈内に、筋肉内に、腹腔内に、点 鼻で、空洞または小胞点滴で、点眼で、動脈内に、病巣内に、および粘膜になさ れる、請求項25の方法。 28.抗体が請求項23の方法の実施において使用され、この抗体がモノクロー ナルおよびポリクローナル抗体よりなる群から選ばれる抗体である、請求項23 の方法。 29.抗体がE99、J415、J533およびJ591モノクローナル抗体よりなる群から選 ばれる、請求項28の方法。 30.抗体がHB-12101、HB-12109、HB-12127およびHB-12126抗体よりなる群から 選ばれるATCC受託番号を有するハイブリド細胞系により産生されるモノクローナ ル抗体である、請求項28の方法。 31.抗体の結合部分が請求項23の方法の実施において使用され、この結合部 分がFabフラグメント、F(ab')2フラグメントおよびFvフラグメントよりなる群か ら選ばれる、請求項23の方法。 32.プローブまたはリガンドが請求項23の方法の実施において使用される、 請求項23の方法。 33.標識が蛍光標識、放射標識、核磁気共鳴活性標識、発光体および発光団よ りなる群から選ばれる、請求項21の方法。 34.生物薬剤が、生理的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項21の方法。 35.生物薬剤が、薬学的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項21の方法。 36.該接触がサンプルの血清または尿において行われる、請求項21の方法。 37.該接触が組織生検サンプルにおいて行われる、請求項21の方法。 38.正常、良性増殖性および癌性前立腺上皮細胞を切除または殺す方法であっ て、 前立腺特異的膜抗原の細胞外ドメインに結合する生物薬剤を準備し、 該細胞を生物薬剤に、前立腺特異的膜抗原の細胞外ドメインに生物薬剤が結合 することと該細胞を切除または殺すことの両方を可能にするのに効果的な条件で 、接触せしめる、 ことを含む方法。 39.生物薬剤が抗体、その結合部分、プローブまたはリガンドである、請求項 38の方法。 40.生物薬剤が、前立腺特異的膜抗原の細胞外ドメインに接触したときに、前 立腺特異的膜抗原で取り込まれる、請求項38の方法。 41.該接触が生きている哺乳動物で実施され、そして、 生物薬剤を哺乳動物に、前立腺特異的膜抗原の細胞外ドメインに生物薬剤を結 合さすことと該細胞を殺すことの両方を可能とするのに効果的な条件で、投与す る、 ことを含む請求項38の方法。 42.生物薬剤が前立腺特異的膜抗原で取り込まれる、請求項41の方法。 43.該投与が経口で、非経口で、皮下に、静脈内に、筋肉内に、腹腔内に、点 鼻で、空洞または小胞点滴で、点眼で、動脈内に、病巣内に、および粘膜になさ れる、請求項41の方法。 44.抗体が請求項39の方法の実施において使用され、この抗体がモノクロー ナルおよびポリクローナル抗体よりなる群から選ばれる抗体である、請求項39 の方法。 45.抗体がE99、J415、J533およびJ591モノクローナル抗体よりなる群から選 ばれる、請求項44の方法。 46.抗体がHB-12101、HB-12109、HB-12127およびHB-12126抗体よりなる群から 選ばれるATCC受託番号を有するハイブリド細胞系により産生されるモノクローナ ル抗体である、請求項44の方法。 47.抗体の結合部分が請求項39の方法の実施において使用され、この結合部 分がFabフラグメント、F(ab')2フラグメントおよびFvフラグメントよりなる群か ら選ばれる、請求項39の方法。 48.プローブまたはリガンドが請求項39の方法の実施において使用される、 請求項39の方法。 49.生物薬剤が、癌性細胞に近接の血管性内皮細胞に生物薬剤が結合する際に 癌性細胞を殺すまたは切除するのに効果的な物質に結合している、請求項38の 方法。 50.癌性細胞を殺すまたは切除するのに効果的な物質が細胞障害剤である、請 求項49の方法。 51.細胞障害剤が治療薬剤、放射化合物、植物、カビまたは細菌源の分子、生 物性タンパク質およびこれらの混合物よりなる群から選ばれる、請求項50の方 法。 52.抗体が内因性宿主免疫機能を開始するのに効果的である、請求項39の方 法。 53.内因性宿主免疫機能が補体媒介性細胞障害である、請求項52の方法。 54.内因性宿主免疫機能が抗体依存性細胞障害である、請求項52の方法。 55.生物薬剤が、生理的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項38の方法。 56.生物薬剤が、薬学的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項38の方法。 57.さらに、 前立腺特異的膜抗原の細胞外ドメインに結合する第2生物薬剤を準備し、 該細胞を第2生物薬剤に、前立腺特異的膜抗原の細胞外ドメインに第2生物薬 剤が結合することを可能にするのに効果的な条件で、接触せしめる、 ことを含む、請求項38の方法。 58.生物薬剤および第2生物薬剤が前立腺特異的膜抗原の細胞外ドメイン上の 非競合の結合部位に結合する、請求項57の方法。 59.抗体がE99、J415、J533およびJ591モノクローナル抗体よりなる群から選 ばれる、請求項57の方法。 60.生物薬剤が該細胞を殺すまたは切除するのに効果的な物質に、生物薬剤が 該細胞の前立腺特異的膜抗原の細胞外ドメインに結合する際および活性化剤によ り活性化される際に結合しており、第2生物薬剤が活性化剤に結合している、請 求項57の方法。 61.生物サンプルにおいて正常、良性増殖性および癌性の前立腺上皮細胞また はその部分を検出する方法であって、 前立腺特異的膜抗原の細胞外ドメインに結合する生物薬剤を準備し、そのうち 、生物薬剤は、該細胞またはその部分に生物薬剤が結合する際に該細胞またはそ の部分の検出を可能にするのに効果的な標識と結合しており、 標識を有する生物薬剤に生物サンプルを、生物サンプルにおける該細胞または その部分の前立腺特異的膜抗原の細胞外ドメインに生物薬剤が結合することを可 能にするのに効果的な条件で、接触せしめ、 標識の検出により生物サンプルにおける該細胞またはその部分の存在を検出す る、 ことを含む方法。 62.生物薬剤が抗体、その結合部分、プローブまたはリガンドである、請求項 61の方法。 63.生物薬剤が、前立腺特異的膜抗原の細胞外ドメインに接触したときに、前 立腺特異的膜抗原で取り込まれる、請求項61の方法。 64.該接触が生きている哺乳動物で行われ、そして生物薬剤を哺乳動物に、生 物サンプルにおける該細胞またはその部分の前立腺特異的膜抗原の細胞外ドメイ ンに生物薬剤が結合することを可能にするのに効果的な条件で、投与することを 含む、請求項61の方法。 65.標識が短射程放射放出体である、請求項64の方法。 66.該検出が経直腸で行われる、請求項64の方法。 67.生物サンプルが哺乳動物の前立腺窩である、請求項64の方法。 68.該検出が前立腺除去後に行われる、64の方法。 69.生物薬剤が前立腺特異的膜抗原で取り込まれる、請求項64の方法。 70.該投与が経口で、非経口で、皮下に、静脈内に、筋肉内に、腹腔内に、点 鼻で、空洞または小胞点滴で、点眼で、動脈内に、病巣内に、および粘膜になさ れる、請求項64の方法。 71.抗体が請求項62の方法の実施において使用され、この抗体がモノクロー ナルおよびポリクローナル抗体よりなる群から選ばれる抗体である、請求項23 の方法。 72.抗体がE99、J415、J533およびJ591モノクローナル抗体よりなる群から選 ばれる、請求項71の方法。 73.抗体がHB-12101、HB-12109、HB-12127およびHB-12126抗体よりなる群から 選ばれるATCC受託番号を有するハイブリド細胞系により産生されるモノクローナ ル抗体である、請求項71の方法。 74.抗体の結合部分が請求項62の方法の実施において使用され、この結合部 分がFabフラグメント、F(ab')2フラグメントおよびFvフラグメントよりなる群か ら選ばれる、請求項62の方法。 75.プローブまたはリガンドが請求項62の方法の実施において使用される、 請求項62の方法。 76.標識が蛍光標識、放射標識、核磁気共鳴活性標識、発光体および発光団よ りなる群から選ばれる、請求項61の方法。 77.生物薬剤が、生理的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項61の方法。 78.生物薬剤が、薬学的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項61の方法。 79.該接触がサンプルの血清または尿において行われる、請求項61の方法。 80.前立腺特異的膜抗原の細胞外ドメインに結合する単離された生物薬剤。 81.該単離された生物薬剤が単離された抗体、その結合部分、プローブまたは リガンドである、請求項80の生物薬剤。 82.生物薬剤が前立腺特異的膜抗原で取り込まれる、請求項80の単離された 生物薬剤。 83.単離された生物薬剤がモノクローナル抗体およびポリクローナル抗体より なる群から選ばれる抗体である、請求項81の単離された生物薬剤。 84.抗体がE99、J415、J533およびJ591モノクローナル抗体よりなる群から選 ばれる、請求項83の単離された生物薬剤。 85.抗体がHB-12101、HB-12109、HB-12127およびHB-12126抗体よりなる群から 選ばれるATCC受託番号を有するハイブリドーマ細胞系により産生されるモノクロ ーナル抗体である、請求項83の単離された生物薬剤。 86.単離された生物薬剤がFabフラグメント、F(ab')2フラグメントおよびFvフ ラグメントよりなる群から選ばれる抗体の結合部分である、請求項81の単離さ れた生物薬剤。 87.単離された生物薬剤がプローブまたはリガンドである、請求項81の単離 された生物薬剤。 88.生物薬剤が細胞障害剤と結合している、請求項80の単離された生物薬剤 。 89.細胞障害剤が治療薬剤、放射化合物、植物、かび、細菌源の分子、生物的 タンパク質およびこれらの混合物よりなる群から選ばれる、請求項88の単離さ れた生物薬剤。 90.請求項88の生物薬剤および 生物薬剤と混合した生理的に許容される担体、賦形剤または安定剤 を含有する組成物。 91.請求項88の生物薬剤および 生物薬剤と混合した薬学的に許容される担体、賦形剤または安定剤 を含有する組成物。 92.該生物薬剤が標識に結合している、請求項80の単離された生物薬剤。 93.標識が蛍光標識、放射標識、核磁気共鳴活性標識、発光体および発光団よ りなる群から選ばれる、請求項92の単離された生物薬剤。 94.請求項92の生物薬剤および 生物薬剤と混合した生理的に許容される担体、賦形剤または安定剤 を含有する組成物。 95.請求項92の生物薬剤および 生物薬剤と混合した薬学的に許容される担体、賦形剤または安定剤 を含有する組成物。 96.請求項92の生物薬剤および標識を検出する手段を含む、癌検出キット。 97.標識が蛍光標識、放射標識、核磁気共鳴活性標識、発光体および発光団よ りなる群から選ばれる、請求項96のキット。 98.抗体がE99、J415、J533およびJ591モノクローナル抗体よりなる群から選 ばれる、請求項96のキット。 99.生物薬剤が、生理的に許容される担体、賦形剤または安定剤をさらに含有 する組成物に含まれる、請求項96のキット。 100.生物薬剤が、薬学的に許容される担体、賦形剤または安定剤をさらに含 有する組成物に含まれる、請求項96のキット。 101.癌性細胞が前立腺癌、腎癌性細胞、尿路上皮癌性細胞、結腸癌性細胞、 直腸癌性細胞、肺癌性細胞、乳房癌性細胞または肝への転移性腺癌細胞である、 請求項96のキット。 102.前立腺特異的膜抗原の細胞外ドメインに結合するモノクローナル抗体を 産生するハイブリドーマ細胞系。 103.抗体が前立腺特異的膜抗原で取り込まれる、請求項102のハイブリド ーマ細胞系。 104.モノクローナル抗体がE99、J415、J533またはJ591モノクローナル抗体 である、請求項102のハイブリドーマ細胞系。 105.ハイブリドーマ細胞系がHB-12101、HB-12109、HB-12127およびHB-12126 抗体よりなる群から選ばれるATCC受託番号を有する、請求項102のハイブリド ーマ細胞系。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2212596P | 1996-07-18 | 1996-07-18 | |
US60/022,125 | 1997-04-09 | ||
US08/838,682 | 1997-04-09 | ||
US08/838,682 US6107090A (en) | 1996-05-06 | 1997-04-09 | Treatment and diagnosis of prostate cancer with antibodies to extracellur PSMA domains |
PCT/US1997/012035 WO1998003873A1 (en) | 1996-07-18 | 1997-07-17 | Treatment and diagnosis of cancer |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009092429A Division JP5627191B2 (ja) | 1996-07-18 | 2009-04-06 | 癌の治療および診断 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2002513378A true JP2002513378A (ja) | 2002-05-08 |
JP2002513378A5 JP2002513378A5 (ja) | 2004-12-09 |
JP4503102B2 JP4503102B2 (ja) | 2010-07-14 |
Family
ID=26695548
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50699598A Expired - Lifetime JP4503102B2 (ja) | 1996-07-18 | 1997-07-17 | 癌の治療および診断 |
JP2009092429A Expired - Lifetime JP5627191B2 (ja) | 1996-07-18 | 2009-04-06 | 癌の治療および診断 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009092429A Expired - Lifetime JP5627191B2 (ja) | 1996-07-18 | 2009-04-06 | 癌の治療および診断 |
Country Status (16)
Country | Link |
---|---|
US (4) | US6107090A (ja) |
EP (2) | EP1655605A3 (ja) |
JP (2) | JP4503102B2 (ja) |
CN (2) | CN100344970C (ja) |
AT (1) | ATE319089T1 (ja) |
AU (1) | AU733544C (ja) |
BR (1) | BR9710487A (ja) |
CA (1) | CA2261018C (ja) |
DE (1) | DE69735368T2 (ja) |
EA (2) | EA004634B1 (ja) |
ES (1) | ES2255723T3 (ja) |
HK (1) | HK1025631A1 (ja) |
IL (2) | IL127979A0 (ja) |
NZ (2) | NZ333683A (ja) |
PT (1) | PT956506E (ja) |
WO (1) | WO1998003873A1 (ja) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003504306A (ja) * | 1999-03-30 | 2003-02-04 | ピエール・ファーブル・メディカマン | 前立腺がん治療用薬剤の製造へのセレノア・レペンス抽出物の使用 |
US7045605B2 (en) | 2001-06-01 | 2006-05-16 | Cornell Research Foundation, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
JP2008529556A (ja) * | 2005-02-18 | 2008-08-07 | メダレックス, インク. | 前立腺特異的膜抗原(psma)に対するヒトモノクローナル抗体 |
JP2008530243A (ja) * | 2005-02-18 | 2008-08-07 | メダレックス, インク. | フコシル残基を欠く前立腺特異的膜抗原(psma)に対するモノクローナル抗体 |
JP2008541711A (ja) * | 2005-05-27 | 2008-11-27 | ユニベルシテーツクリニクム フライブルグ | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2009509497A (ja) * | 2005-06-15 | 2009-03-12 | モノクローナル アンチボディーズ セラピューティックス | 抗cd71モノクローナル抗体および悪性腫瘍細胞を治療するためのその使用 |
US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
Families Citing this family (135)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US7105159B1 (en) | 1992-11-05 | 2006-09-12 | Sloan-Kettering Institute For Cancer Research | Antibodies to prostate-specific membrane antigen |
US7070782B1 (en) | 1992-11-05 | 2006-07-04 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US6953668B1 (en) | 1992-11-05 | 2005-10-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
US6569432B1 (en) | 1995-02-24 | 2003-05-27 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
ATE317435T1 (de) | 1995-02-24 | 2006-02-15 | Sloan Kettering Inst Cancer | Prostataspezifisches membranes antigen und seine anwendungen |
US20040253246A1 (en) * | 1996-02-23 | 2004-12-16 | Israeli Ron S. | Prostate-specific membrane antigen and uses thereof |
US7381407B1 (en) | 1996-03-25 | 2008-06-03 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US6962981B1 (en) | 1996-03-25 | 2005-11-08 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US6150508A (en) * | 1996-03-25 | 2000-11-21 | Northwest Biotherapeutics, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US6759515B1 (en) * | 1997-02-25 | 2004-07-06 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
US20060269532A1 (en) * | 1997-02-25 | 2006-11-30 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
US20060024301A1 (en) * | 1997-02-25 | 2006-02-02 | Corixa Corporation | Prostate-specific polypeptides and fusion polypeptides thereof |
US6207805B1 (en) * | 1997-07-18 | 2001-03-27 | University Of Iowa Research Foundation | Prostate cell surface antigen-specific antibodies |
US6232287B1 (en) * | 1998-03-13 | 2001-05-15 | The Burnham Institute | Molecules that home to various selected organs or tissues |
US6200765B1 (en) | 1998-05-04 | 2001-03-13 | Pacific Northwest Cancer Foundation | Non-invasive methods to detect prostate cancer |
EP1710256A1 (en) * | 1999-07-29 | 2006-10-11 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen |
ATE342282T1 (de) * | 1999-07-29 | 2006-11-15 | Medarex Inc | Humane monoklonale antikörper gegen prostata spezifisches membranantigen |
AU7351800A (en) * | 1999-09-13 | 2001-04-17 | Neil H. Bander | A method for isolation of prostatic epithelial cells from semen |
US20080153119A1 (en) * | 1999-09-24 | 2008-06-26 | Schebo Biotech Ag | Detecting the presence of pyruvate kinase isoenzyme in feces |
AU3679801A (en) | 2000-02-08 | 2001-08-20 | Rice University | Optically-active nanoparticles for use in therapeutic and diagnostic methods |
US6379550B1 (en) * | 2000-07-24 | 2002-04-30 | Health Research, Inc. | Method for detecting PSA and its molecular forms using thiophilic gel |
US7048931B1 (en) | 2000-11-09 | 2006-05-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
US7468354B2 (en) | 2000-12-01 | 2008-12-23 | Genspera, Inc. | Tissue specific prodrugs |
WO2002096460A1 (en) * | 2001-05-30 | 2002-12-05 | Cornell Research Foundation, Inc. | Endopeptidase/anti-psma antibody fusion proteins for treatment of cancer |
US7666414B2 (en) * | 2001-06-01 | 2010-02-23 | Cornell Research Foundation, Inc. | Methods for treating prostate cancer using modified antibodies to prostate-specific membrane antigen |
US20060073530A1 (en) * | 2001-08-15 | 2006-04-06 | Olaf Schneewind | Methods and compositions involving sortase B |
AU2002359244A1 (en) * | 2001-09-05 | 2003-04-28 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of | Imaging the activity of extracellular proteases in cells using mutant anthrax toxin protective antigens that are cleaved by specific extracellular proteases |
WO2003024388A2 (en) * | 2001-09-20 | 2003-03-27 | Cornell Research Foundation, Inc. | Methods and compositions for treating and preventing skin disorders using binding agents specific for psma |
US20030139374A1 (en) * | 2001-09-27 | 2003-07-24 | Board Of Regents, The University Of Texas System And Peregrine Pharmaceuticals, Inc. | Combined methods for tumor vasculature coagulation and treatment |
US20050215472A1 (en) * | 2001-10-23 | 2005-09-29 | Psma Development Company, Llc | PSMA formulations and uses thereof |
EP3184539A3 (en) | 2001-10-23 | 2017-09-13 | PSMA Development Company L.L.C. | Psma antibodies |
US20040161776A1 (en) * | 2001-10-23 | 2004-08-19 | Maddon Paul J. | PSMA formulations and uses thereof |
US7591994B2 (en) | 2002-12-13 | 2009-09-22 | Immunomedics, Inc. | Camptothecin-binding moiety conjugates |
US7767803B2 (en) * | 2002-06-18 | 2010-08-03 | Archemix Corp. | Stabilized aptamers to PSMA and their use as prostate cancer therapeutics |
MX337052B (es) | 2002-07-15 | 2016-02-11 | Univ Texas | Peptidos que se enlazan a fosfatidiletanolamina y sus usos en el tratamiento de infecciones virales y del cancer. |
US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
WO2004063701A2 (en) * | 2003-01-10 | 2004-07-29 | Millennium Pharmaceuticals, Inc. | Methods of diagnosing and treating cancer |
US7811564B2 (en) * | 2003-01-28 | 2010-10-12 | Proscan Rx Pharma | Prostate cancer diagnosis and treatment |
EP1610818A4 (en) * | 2004-03-03 | 2007-09-19 | Millennium Pharm Inc | MODIFIED ANTIBODIES AGAINST A PROSTATE-SPECIFIC MEMBRANE-ANTIGEN AND USE THEREOF |
WO2005092286A2 (en) * | 2004-03-29 | 2005-10-06 | The University Of Houston System | Metallic nano-particles and discrete polymer-coated nano-particles |
EP1756166A4 (en) * | 2004-04-19 | 2008-08-27 | Proscan Rx Pharma | DIAGNOSIS AND TREATMENT OF PROSTATE CANCER |
EP1819277A4 (en) * | 2004-11-12 | 2010-05-05 | Ltd Kpe | NANOTE PARTICLE-MEDIATED ULTRASOUND THERAPY AND DIAGNOSTIC IMAGE DISPLAY |
EP1864134A4 (en) * | 2005-02-07 | 2010-10-20 | Univ Columbia | METHODS OF TREATING OR PREVENTING HORMONE-RESISTANT PROSTATE CANCER USING SMALL INTERFERING RNA SPECIFIC TO PROTOCADHERINE-PC, OR OTHER INHIBITORS OF PROTOCADHERINE-PC EXPRESSION OR ACTIVITY |
WO2006096754A2 (en) * | 2005-03-07 | 2006-09-14 | Archemix Corp. | Stabilized aptamers to psma and their use as prostate cancer therapeutics |
CA2612762C (en) * | 2005-06-20 | 2013-12-10 | Psma Development Company, Llc | Psma antibody-drug conjugates |
CA2623236A1 (en) * | 2005-09-26 | 2007-04-05 | Medarex, Inc. | Human monoclonal antibodies to cd70 |
SG10201602095PA (en) * | 2005-12-20 | 2016-05-30 | Sbi Biotech Co Ltd | Anti-Ilt7 Antibody |
AU2007274738B2 (en) * | 2006-07-18 | 2013-11-28 | Sanofi-Aventis | Antagonist antibody against EphA2 for the treatment of cancer |
NZ578354A (en) * | 2006-12-14 | 2012-01-12 | Medarex Inc | Antibody-partner molecule conjugates that bind cd70 and uses thereof |
WO2009015263A2 (en) * | 2007-07-25 | 2009-01-29 | Wyeth | Methods for characterizing cell proximity |
EP3714906A1 (en) | 2007-10-03 | 2020-09-30 | Cornell University | Treatment of proliferative disorders using radiolabelled antibodies to psma |
CN101861278B (zh) | 2007-11-14 | 2013-10-09 | 因温特奥股份公司 | 用于驱动和保持电梯轿厢的电梯驱动装置和方法,相应的方法以及制动装置和用于减速和保持电梯轿厢的方法和附属的方法 |
CA2721169A1 (en) * | 2008-04-14 | 2009-10-22 | Proscan Rx Pharma Inc. | Prostate specific membrane antigen antibodies and antigen binding fragments |
EP2727606A3 (en) | 2008-09-08 | 2015-09-23 | Psma Development Company, L.L.C. | Compounds for killing psma-expressing, taxane-resistant cancer cells |
US20100082438A1 (en) * | 2008-10-01 | 2010-04-01 | Ronnie Jack Garmon | Methods and systems for customer performance scoring |
MD24Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare |
MD35Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare |
MD36Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare |
MD23Z (ro) * | 2008-12-02 | 2010-01-31 | Василе ЖОВМИР | Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare |
DK3903829T3 (da) | 2009-02-13 | 2023-06-26 | Immunomedics Inc | Immunkonjugater med en intracellulær spaltelig binding |
EP2398504B1 (en) | 2009-02-17 | 2018-11-28 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
US20120183847A1 (en) | 2009-05-19 | 2012-07-19 | Aic Blab | Composite current collector and methods therefor |
US8221753B2 (en) | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
MX354143B (es) | 2009-12-02 | 2018-02-14 | Imaginab Inc | Minicuerpos j591 y diacuerpos-cys para apuntar con especificidad de objetivo a un antígeno de membrana específico para próstata de humano (psma) y métodos para su uso. |
IN2012DN03354A (ja) | 2009-12-02 | 2015-10-23 | Immunomedics Inc | |
CA3188287A1 (en) | 2010-03-26 | 2011-09-29 | Memorial Sloan-Kettering Cancer Center | Antibodies to muc16 and methods of use thereof |
JP5702944B2 (ja) * | 2010-03-31 | 2015-04-15 | 独立行政法人国立がん研究センター | バイオマーカー |
US9133239B2 (en) | 2010-04-20 | 2015-09-15 | The Research Foundation For The State University Of New York | Compositions and methods for inhibiting matrix metalloproteinase (MMP)-mediated cell migration |
RU2012148816A (ru) * | 2010-05-07 | 2014-06-20 | Ф. Хоффманн-Ля Рош Аг | Метод диагностики для определения клеток ex vivo |
US20120148559A1 (en) | 2010-12-01 | 2012-06-14 | Board Of Regents The University Of Texas System | Compositions and method for deimmunization of proteins |
WO2012106368A2 (en) | 2011-01-31 | 2012-08-09 | The Regents Of The University Of California | Methods for inhibiting prostate cancer |
US8314566B2 (en) * | 2011-02-22 | 2012-11-20 | Quarkstar Llc | Solid state lamp using light emitting strips |
EP2704751B1 (en) | 2011-05-02 | 2019-04-17 | Immunomedics, Inc. | Ultrafiltration concentration of allotype selected antibodies for small-volume administration |
NZ703298A (en) | 2012-06-07 | 2016-04-29 | Ambrx Inc | Prostate-specific membrane antigen antibody drug conjugates |
MX2014015205A (es) | 2012-06-14 | 2015-08-14 | Ambrx Inc | Anticuerpos anti-psma conjugados a polipeptidos de ligando de receptor nuclear. |
EP2885002A4 (en) | 2012-08-14 | 2016-04-20 | Ibc Pharmaceuticals Inc | BISPECIFIC ANTIBODIES REDIRECTED AGAINST T CELLS FOR THE TREATMENT OF DISEASES |
UA115789C2 (uk) | 2012-09-05 | 2017-12-26 | Трейкон Фармасутікалз, Інк. | Композиція антитіла до cd105 та її застосування |
EP2839860B1 (en) | 2012-10-12 | 2019-05-01 | MedImmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
CA3177936A1 (en) | 2012-12-13 | 2014-06-19 | Immunomedics, Inc. | Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity |
US11242399B2 (en) | 2013-02-19 | 2022-02-08 | Adienne S.A. | Anti-CD26 antibodies |
JP6444902B2 (ja) | 2013-03-13 | 2018-12-26 | メドイミューン・リミテッドMedImmune Limited | ピロロベンゾジアゼピン及びその結合体 |
CN110041427B (zh) | 2013-03-15 | 2023-05-23 | 本质生命科学有限公司 | 抗铁调素抗体及其用途 |
JP6908964B2 (ja) | 2013-10-18 | 2021-07-28 | ピーエスエムエー ディベロップメント カンパニー,エルエルシー | Psmaリガンドコンジュゲートによる併用療法 |
US20150147339A1 (en) | 2013-11-15 | 2015-05-28 | Psma Development Company, Llc | Biomarkers for psma targeted therapy for prostate cancer |
CN106132436B (zh) | 2014-02-21 | 2021-06-15 | Ibc药品公司 | 通过诱导对trop-2表达细胞的免疫应答的疾病疗法 |
US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
KR102419766B1 (ko) | 2014-05-22 | 2022-07-13 | 비온디스 비.브이. | 항체에 대한 링커 약물의 부위 특이적 접합 및 그 결과로 얻어지는 adc |
US9580495B2 (en) | 2014-06-24 | 2017-02-28 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
US10188746B2 (en) | 2014-09-10 | 2019-01-29 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
AU2015321462B2 (en) | 2014-09-22 | 2020-04-30 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
CN106999517A (zh) | 2014-10-07 | 2017-08-01 | 免疫医疗公司 | 抗体‑药物缀合物的新辅助剂用途 |
US9926375B2 (en) | 2014-11-12 | 2018-03-27 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
JP2017537084A (ja) | 2014-11-12 | 2017-12-14 | トラコン ファーマシューティカルズ、インコーポレイテッド | 抗エンドグリン抗体及びその用途 |
CN104447955B (zh) * | 2014-11-23 | 2018-04-20 | 南京市第一医院 | 一种与psma膜外区靶向性结合的多肽及其应用 |
EP3064507A1 (en) | 2015-03-06 | 2016-09-07 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15ra and therapeutic uses thereof |
US10722523B2 (en) | 2015-03-17 | 2020-07-28 | The Regents Of The University Of California | Chemoimmunotherapy for epithelial cancer |
IL296062A (en) | 2015-03-17 | 2022-10-01 | Memorial Sloan Kettering Cancer Center | Antibodies against muc16 and their uses |
EP3286224A4 (en) | 2015-04-22 | 2018-11-14 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
EP3297672B1 (en) | 2015-05-21 | 2021-09-01 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
PL3313443T3 (pl) | 2015-06-25 | 2023-11-06 | Immunomedics, Inc. | Łączenie przeciwciał anty-hla-dr lub anty-trop-2 z inhibitorami mikrotubuli, inhibitorami parp, 5 inhibitorami kinazy brutona lub inhibitorami 3-kinazy fosfoinozytydu istotnie poprawia wynik terapeutyczny nowotworu |
SI3316885T1 (sl) | 2015-07-01 | 2021-09-30 | Immunomedics, Inc. | Imunokonjugati protitelo-SN-38 z linkerjem CL2A |
JOP20160154B1 (ar) | 2015-07-31 | 2021-08-17 | Regeneron Pharma | أجسام ضادة مضاد لل psma، وجزيئات رابطة لمستضد ثنائي النوعية الذي يربط psma و cd3، واستخداماتها |
KR20180050321A (ko) | 2015-08-07 | 2018-05-14 | 이미지냅 인코포레이티드 | 분자를 표적화하기 위한 항원 결합 구조체 |
EP3192810A1 (en) * | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum | Psma binding antibody and uses thereof |
AU2017267793B2 (en) | 2016-05-20 | 2024-01-25 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
JP7101621B2 (ja) | 2016-05-20 | 2022-07-15 | ハープーン セラピューティクス,インク. | 単一ドメイン血清アルブミン結合タンパク質 |
US11485792B2 (en) | 2016-06-06 | 2022-11-01 | Polytherics Limited | Antibodies, uses thereof and conjugates thereof |
GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
EP3525829A1 (en) | 2016-10-11 | 2019-08-21 | Medimmune Limited | Antibody-drug conjugates with immune-mediated therapy agents |
CN110198955A (zh) | 2016-11-23 | 2019-09-03 | 哈普恩治疗公司 | 前列腺特异性膜抗原结合蛋白质 |
US10844134B2 (en) | 2016-11-23 | 2020-11-24 | Harpoon Therapeutics, Inc. | PSMA targeting trispecific proteins and methods of use |
WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
EP3589662A4 (en) | 2017-02-28 | 2020-12-30 | Harpoon Therapeutics, Inc. | INDUCTIBLE MONOVALENT ANTIGBINDING PROTEIN |
CA3063362A1 (en) | 2017-05-12 | 2018-11-15 | Harpoon Therapeutics, Inc. | Msln targeting trispecific proteins and methods of use |
AU2018265856B2 (en) | 2017-05-12 | 2023-04-27 | Harpoon Therapeutics, Inc. | Mesothelin binding proteins |
SG11202003341UA (en) | 2017-10-13 | 2020-05-28 | Harpoon Therapeutics Inc | B cell maturation antigen binding proteins |
CR20200196A (es) | 2017-10-13 | 2020-06-05 | Harpoon Therapeutics Inc | Proteínas trispecìficas y mètodos de uso |
EP3703886A4 (en) | 2017-11-04 | 2021-05-05 | Sona Nanotech | METAL NANOPARTICLES AND METHOD FOR MANUFACTURING THEREOF |
CA3093078A1 (en) | 2018-03-06 | 2019-09-12 | The Trustees Of The University Of Pennsylvania | Prostate-specific membrane antigen cars and methods of use thereof |
JP2021519076A (ja) * | 2018-03-29 | 2021-08-10 | アンブルックス, インコーポレイテッドAmbrx, Inc. | ヒト化抗前立腺特異的膜抗原(psma)抗体薬物複合体 |
CN113286616A (zh) | 2018-05-23 | 2021-08-20 | Adc治疗有限公司 | 分子佐剂 |
EP3587454A1 (en) * | 2018-06-27 | 2020-01-01 | Albert-Ludwigs-Universität Freiburg | Chimeric antigen receptors that bind to prostate specific membrane antigen |
JP2021532778A (ja) | 2018-07-31 | 2021-12-02 | ハイデルベルク ファルマ リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング | Psmaに対するヒト化抗体 |
US10815311B2 (en) | 2018-09-25 | 2020-10-27 | Harpoon Therapeutics, Inc. | DLL3 binding proteins and methods of use |
USD925928S1 (en) | 2019-03-01 | 2021-07-27 | Simplehuman, Llc | Vanity mirror |
JP2023527609A (ja) | 2020-02-21 | 2023-06-30 | ハープーン セラピューティクス,インク. | Flt3結合タンパク質および使用方法 |
WO2022010797A2 (en) | 2020-07-07 | 2022-01-13 | Bionecure Therapeutics, Inc. | Novel maytansinoids as adc payloads and their use for the treatment of cancer |
US20230372528A1 (en) | 2020-10-16 | 2023-11-23 | University Of Georgia Research Foundation, Inc. | Glycoconjugates |
CN112285082A (zh) * | 2020-10-28 | 2021-01-29 | 上海睿钰生物科技有限公司 | 一种基于细胞直径评价细胞杀伤效力的方法及其应用 |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
WO2022239720A1 (ja) | 2021-05-10 | 2022-11-17 | 公益財団法人川崎市産業振興財団 | 抗原への結合親和性を低減させた抗体 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62215870A (ja) * | 1985-12-17 | 1987-09-22 | イ−スタン・バ−ジニア・メデイカル・オ−ソリテイ | ヒト前立腺腫瘍関連抗原に対する結合特異性を有するモノクロ−ナル抗体類およびそれらを使用する方法 |
JPH08506005A (ja) * | 1992-11-05 | 1996-07-02 | スローン ー ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 前立腺に特異的な膜抗原 |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4472509A (en) | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4454106A (en) | 1982-06-07 | 1984-06-12 | Gansow Otto A | Use of metal chelate conjugated monoclonal antibodies |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4824986A (en) | 1985-04-26 | 1989-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Metal chelate protein conjugate |
US4814275A (en) * | 1985-05-13 | 1989-03-21 | E.I. Dupont De Nemours And Company | Monoclonal hybridoma antibody specific for a human epithelial antigen |
US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
US5525338A (en) | 1992-08-21 | 1996-06-11 | Immunomedics, Inc. | Detection and therapy of lesions with biotin/avidin conjugates |
US4735210A (en) | 1985-07-05 | 1988-04-05 | Immunomedics, Inc. | Lymphographic and organ imaging method and kit |
US4863854A (en) * | 1985-08-12 | 1989-09-05 | Sloan-Kettering Institute For Cancer Research | Monoclonal antibodies to mucin-like human differentiation antigens |
MX174467B (es) | 1986-01-23 | 1994-05-17 | Squibb & Sons Inc | 1,4,7-triscarboximetil-1,4,7,10-tetraazaciclodo decano substituido en 1 y compuestos analogos |
US4885363A (en) | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
DE3772785D1 (de) | 1986-01-23 | 1991-10-17 | Squibb & Sons Inc | 1-substituiertes-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecan und analoga. |
DK172629B1 (da) | 1986-02-14 | 1999-03-22 | Nihon Mediphysics Co Ltd | Reaktive højmolekylære forbindelser med mindst én fri aminogruppe, højmolekylære forbindelser kombineret med et fysiologisk |
ZA877727B (en) | 1986-10-17 | 1988-06-29 | Cytogen Corp | Method for preparation of protein-chelator-metal ion compositions suitable for injection |
US4863851A (en) * | 1986-10-20 | 1989-09-05 | The Upjohn Company | Monoclonal antibody to prostate secretory protein |
US5057302A (en) | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
MX171769B (es) | 1987-02-16 | 1993-11-15 | Sumitomo Chemical Co | Base catalitica solida y procedimiento para obtenerla |
US5013645A (en) * | 1987-04-14 | 1991-05-07 | Abbott Laboratories | Immunological methods and materials for detection of tumor associated antigens |
US5531978A (en) | 1987-07-16 | 1996-07-02 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
DE3855239T2 (de) | 1987-07-16 | 1996-10-31 | Nycomed Imaging As | Aminocarbonsäure und Derivate |
GB9007965D0 (en) | 1990-04-09 | 1990-06-06 | Nycomed As | Compounds |
AU619218B2 (en) | 1987-11-06 | 1992-01-23 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
US5130118A (en) | 1987-11-06 | 1992-07-14 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
US5217704A (en) | 1987-11-06 | 1993-06-08 | Abbott Laboratories | Methods and materials for the preparation of metal labelled antibody solutions |
US5342924A (en) * | 1987-12-31 | 1994-08-30 | Tanox Biosystems, Inc. | Extracellular segments of human ε immunoglobulin anchoring peptides and antibodies specific therefor |
GB8801646D0 (en) | 1988-01-26 | 1988-02-24 | Nycomed As | Chemical compounds |
US5229289A (en) * | 1988-03-11 | 1993-07-20 | The Biomembrane Institute | Monoclonal antibodies and vaccine development directed to human cancer-associated antigens by immunization with animal and human and with synthetic carbohydrate-carrier conjugates |
US5162504A (en) | 1988-06-03 | 1992-11-10 | Cytogen Corporation | Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients |
US5118611A (en) * | 1988-07-25 | 1992-06-02 | Adeza Biomedical Corporation | Adenocarcinoma antigen binding methods and reagents |
ATE133165T1 (de) | 1989-02-10 | 1996-02-15 | Celltech Therapeutics Ltd | Aza-macrozyklen und verfahren zu deren herstellung |
US5053503A (en) | 1989-02-17 | 1991-10-01 | Centocor | Chelating agents |
DE3911816A1 (de) | 1989-04-11 | 1990-10-25 | Hoechst Ag | Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden |
US5244816A (en) | 1989-10-11 | 1993-09-14 | Akzo N.V. | Method for purifying chelator conjugated compounds |
EP0453554A4 (en) | 1989-11-13 | 1993-02-17 | Xoma Corporation | Chimeric mouse human antibodies with specificity to hiv antigens |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9115192D0 (en) | 1991-07-12 | 1991-08-28 | Antisoma Ltd | Cancer treatment |
US5227471A (en) * | 1992-01-30 | 1993-07-13 | Eastern Virginia Medical School Of The Medical College Of Hampton Roads | Monoclonal antibody PD41 that binds to a prostate mucin antigen that is expressed in human prostatic carcinoma |
US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
US5965132A (en) | 1992-03-05 | 1999-10-12 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
EP1306095A3 (en) | 1992-03-05 | 2003-06-25 | Board Of Regents, The University Of Texas System | Methods and compositions for targeting the vasculature of solid tumors |
US6036955A (en) | 1992-03-05 | 2000-03-14 | The Scripps Research Institute | Kits and methods for the specific coagulation of vasculature |
US5877289A (en) | 1992-03-05 | 1999-03-02 | The Scripps Research Institute | Tissue factor compositions and ligands for the specific coagulation of vasculature |
US6093399A (en) | 1992-03-05 | 2000-07-25 | Board Of Regents, The University Of Texas System | Methods and compositions for the specific coagulation of vasculature |
US5489525A (en) * | 1992-10-08 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies to prostate cells |
US5428156A (en) | 1993-04-02 | 1995-06-27 | Associated Universities, Inc. | Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging |
KR100220864B1 (ko) | 1993-05-17 | 1999-09-15 | 오트리브 데이비스 더블유 | 비오틴/아비딘-금속 단백질 콘쥬게이트로 병변을 검출 및 치료하기 위한 조성물 |
US5935818A (en) | 1995-02-24 | 1999-08-10 | Sloan-Kettering Institute For Cancer Research | Isolated nucleic acid molecule encoding alternatively spliced prostate-specific membrane antigen and uses thereof |
US5599677A (en) * | 1993-12-29 | 1997-02-04 | Abbott Laboratories | Immunoassays for prostate specific antigen |
WO1995026206A1 (en) | 1994-03-28 | 1995-10-05 | The Regents Of The University Of California | Method for preparing radionuclide-labeled chelating agent-ligand complexes |
US6693190B1 (en) | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
ATE317435T1 (de) | 1995-02-24 | 2006-02-15 | Sloan Kettering Inst Cancer | Prostataspezifisches membranes antigen und seine anwendungen |
US5773292A (en) | 1995-06-05 | 1998-06-30 | Cornell University | Antibodies binding portions, and probes recognizing an antigen of prostate epithelial cells but not antigens circulating in the blood |
ATE458499T1 (de) | 1995-06-07 | 2010-03-15 | Immunomedics Inc | Verbesserte abgabe von diagnostischen und therapeutischen stoffen an einem zielort |
IT1283218B1 (it) | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
US6150508A (en) | 1996-03-25 | 2000-11-21 | Northwest Biotherapeutics, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
US6962981B1 (en) * | 1996-03-25 | 2005-11-08 | Medarex, Inc. | Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen |
ATE318147T1 (de) | 1996-03-25 | 2006-03-15 | Medarex Inc | Spezifische monoklonale antikörperfür die extrazelluläre domäne von protasta-spezifischem membranantigen |
US6136311A (en) | 1996-05-06 | 2000-10-24 | Cornell Research Foundation, Inc. | Treatment and diagnosis of cancer |
US5804602A (en) | 1996-06-17 | 1998-09-08 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
US5958474A (en) | 1996-08-21 | 1999-09-28 | Nestec S.A. | Process for preparing food flavor precursors |
IT1291623B1 (it) | 1997-04-18 | 1999-01-11 | Bracco Spa | Procedimento per la coniugazione di chelanti con molecole contenenti gruppi amminici |
WO1999043710A1 (en) | 1998-02-26 | 1999-09-02 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
WO2000050457A1 (en) | 1999-02-22 | 2000-08-31 | Beckman Coulter, Inc. | Prostate-specific membrane antigens and methods of making and using |
US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
JP2004510683A (ja) | 1999-06-07 | 2004-04-08 | センター・フォー・モレキュラー・メディシン・アンド・イムノロジー | 放射免疫療法において断片に付着されるα線エミッタまたはβ線エミッタ |
AU1123202A (en) | 2000-09-15 | 2002-03-26 | Sloan Kettering Inst Cancer | Targeted alpha particle therapy using actinium-225 conjugates |
WO2002098897A2 (en) | 2001-06-01 | 2002-12-12 | Cornell Research Foundation, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
-
1997
- 1997-04-09 US US08/838,682 patent/US6107090A/en not_active Expired - Lifetime
- 1997-07-17 AU AU37976/97A patent/AU733544C/en not_active Expired
- 1997-07-17 DE DE69735368T patent/DE69735368T2/de not_active Expired - Lifetime
- 1997-07-17 NZ NZ333683A patent/NZ333683A/en not_active IP Right Cessation
- 1997-07-17 CN CNB2004100544223A patent/CN100344970C/zh not_active Expired - Lifetime
- 1997-07-17 CN CNB97197912XA patent/CN1165764C/zh not_active Expired - Lifetime
- 1997-07-17 PT PT97934922T patent/PT956506E/pt unknown
- 1997-07-17 CA CA002261018A patent/CA2261018C/en not_active Expired - Lifetime
- 1997-07-17 JP JP50699598A patent/JP4503102B2/ja not_active Expired - Lifetime
- 1997-07-17 AT AT97934922T patent/ATE319089T1/de active
- 1997-07-17 IL IL12797997A patent/IL127979A0/xx not_active IP Right Cessation
- 1997-07-17 EA EA199900033A patent/EA004634B1/ru not_active IP Right Cessation
- 1997-07-17 ES ES97934922T patent/ES2255723T3/es not_active Expired - Lifetime
- 1997-07-17 EP EP05021545A patent/EP1655605A3/en not_active Withdrawn
- 1997-07-17 EA EA200400179A patent/EA200400179A1/ru unknown
- 1997-07-17 EP EP97934922A patent/EP0956506B1/en not_active Expired - Lifetime
- 1997-07-17 WO PCT/US1997/012035 patent/WO1998003873A1/en active IP Right Grant
- 1997-07-17 NZ NZ524036A patent/NZ524036A/xx not_active IP Right Cessation
- 1997-07-17 BR BR9710487A patent/BR9710487A/pt not_active Application Discontinuation
-
1999
- 1999-07-20 US US09/357,704 patent/US7666425B1/en not_active Expired - Fee Related
- 1999-07-20 US US09/357,709 patent/US7112412B1/en not_active Expired - Fee Related
-
2000
- 2000-08-08 HK HK00104938A patent/HK1025631A1/xx not_active IP Right Cessation
-
2001
- 2001-08-13 US US09/929,665 patent/US20030003101A1/en not_active Abandoned
-
2004
- 2004-05-30 IL IL162230A patent/IL162230A/en not_active IP Right Cessation
-
2009
- 2009-04-06 JP JP2009092429A patent/JP5627191B2/ja not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62215870A (ja) * | 1985-12-17 | 1987-09-22 | イ−スタン・バ−ジニア・メデイカル・オ−ソリテイ | ヒト前立腺腫瘍関連抗原に対する結合特異性を有するモノクロ−ナル抗体類およびそれらを使用する方法 |
JPH08506005A (ja) * | 1992-11-05 | 1996-07-02 | スローン ー ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 前立腺に特異的な膜抗原 |
Non-Patent Citations (1)
Title |
---|
JPN4007019035, MURPHY, G.P. et al., The Prostate, 199604, Vol.28, pp.266−271 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003504306A (ja) * | 1999-03-30 | 2003-02-04 | ピエール・ファーブル・メディカマン | 前立腺がん治療用薬剤の製造へのセレノア・レペンス抽出物の使用 |
US7045605B2 (en) | 2001-06-01 | 2006-05-16 | Cornell Research Foundation, Inc. | Modified antibodies to prostate-specific membrane antigen and uses thereof |
US7514078B2 (en) | 2001-06-01 | 2009-04-07 | Cornell Research Foundation, Inc. | Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies |
JP2008529556A (ja) * | 2005-02-18 | 2008-08-07 | メダレックス, インク. | 前立腺特異的膜抗原(psma)に対するヒトモノクローナル抗体 |
JP2008530243A (ja) * | 2005-02-18 | 2008-08-07 | メダレックス, インク. | フコシル残基を欠く前立腺特異的膜抗原(psma)に対するモノクローナル抗体 |
JP2008541711A (ja) * | 2005-05-27 | 2008-11-27 | ユニベルシテーツクリニクム フライブルグ | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2012197278A (ja) * | 2005-05-27 | 2012-10-18 | Universitaetsklinikum Freiburg | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2014141491A (ja) * | 2005-05-27 | 2014-08-07 | Universitaetsklinikum Freiburg | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2016190839A (ja) * | 2005-05-27 | 2016-11-10 | ユニベルシテーツクリニクム フライブルグ | 細胞表面の前立腺特異的膜抗原に対するモノクローナル抗体および単鎖抗体フラグメント |
JP2009509497A (ja) * | 2005-06-15 | 2009-03-12 | モノクローナル アンチボディーズ セラピューティックス | 抗cd71モノクローナル抗体および悪性腫瘍細胞を治療するためのその使用 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2002513378A (ja) | 癌の治療および診断 | |
US8951737B2 (en) | Treatment and diagnosis of cancer | |
JPH11507509A (ja) | 前立腺癌の治療および診断 | |
JP4229591B2 (ja) | 前立腺特異的膜抗原の細胞外ドメインに対して特異的なモノクローナル抗体 | |
JP4295826B2 (ja) | 前立腺特異的膜抗原の細胞外ドメインに対して特異的なモノクローナル抗体 | |
US8512702B2 (en) | Prostate cancer diagnosis and treatment | |
WO1998003873A9 (en) | Treatment and diagnosis of cancer | |
JP5847755B2 (ja) | 細胞を検出する方法、およびこれに有用な薬剤 | |
JPH0249596A (ja) | ヒト前立腺上皮細胞の表面に特異的に反応するモノクローナル抗体 | |
JPH08506801A (ja) | Cd44エキソン6に対応するペプチド、そのペプチドに特異的な抗体、および、腫瘍診断にそれらの抗体を使用する方法 | |
US5424192A (en) | Markers for invasive prostatic neoplasia | |
MXPA99000642A (en) | Derivatized rodamine tint and its copolime | |
Dan et al. | Immunoreactivity of human MAb BT32/A6 with neuroepithelial tumors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20040413 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040413 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070724 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20071023 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20071203 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080124 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090106 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090406 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090623 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090918 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100323 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100421 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130430 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140430 Year of fee payment: 4 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
EXPY | Cancellation because of completion of term |