JP2002501748A - アレルギー反応を減少させるための方法および試薬 - Google Patents

アレルギー反応を減少させるための方法および試薬

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Publication number
JP2002501748A
JP2002501748A JP2000529437A JP2000529437A JP2002501748A JP 2002501748 A JP2002501748 A JP 2002501748A JP 2000529437 A JP2000529437 A JP 2000529437A JP 2000529437 A JP2000529437 A JP 2000529437A JP 2002501748 A JP2002501748 A JP 2002501748A
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JP
Japan
Prior art keywords
allergen
ige
modified
binding
modified allergen
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Pending
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JP2000529437A
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English (en)
Japanese (ja)
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JP2002501748A5 (enExample
Inventor
ハワード ソシン,
ゲーリー エイ. バノン,
エイ. ウェスリー ジュニア バークス,
ヒュー エイ. サンプソン,
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Publication of JP2002501748A publication Critical patent/JP2002501748A/ja
Publication of JP2002501748A5 publication Critical patent/JP2002501748A5/ja
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806Antigenic peptides or proteins
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2000529437A 1998-01-31 1999-01-29 アレルギー反応を減少させるための方法および試薬 Pending JP2002501748A (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US7328398P 1998-01-31 1998-01-31
US60/073,283 1998-01-31
US7462498P 1998-02-13 1998-02-13
US7459098P 1998-02-13 1998-02-13
US7463398P 1998-02-13 1998-02-13
US60/074,624 1998-02-13
US60/074,633 1998-02-13
US60/074,590 1998-02-13
US14122098A 1998-08-27 1998-08-27
US09/141,220 1998-08-27
PCT/US1999/002031 WO1999038978A1 (en) 1998-01-31 1999-01-29 Methods and reagents for decreasing allergic reactions

Publications (2)

Publication Number Publication Date
JP2002501748A true JP2002501748A (ja) 2002-01-22
JP2002501748A5 JP2002501748A5 (enExample) 2007-01-11

Family

ID=27535962

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000529437A Pending JP2002501748A (ja) 1998-01-31 1999-01-29 アレルギー反応を減少させるための方法および試薬

Country Status (8)

Country Link
US (1) US7485708B2 (enExample)
EP (1) EP1051494B1 (enExample)
JP (1) JP2002501748A (enExample)
AT (1) ATE430199T1 (enExample)
AU (1) AU743647B2 (enExample)
CA (1) CA2319437C (enExample)
DE (1) DE69940805D1 (enExample)
WO (1) WO1999038978A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505410A (ja) * 2007-12-03 2011-02-24 デベヴェ・テクノロジーズ 被験者のグラウンドナッツに対する寛容を増大させる免疫治療法
KR20210142000A (ko) * 2019-03-13 2021-11-23 소마젠 인크 알레르기 치료를 위한 에피토프-기반 접근법 및 크론병에 대한 억제제

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69940805D1 (de) 1998-01-31 2009-06-10 Sinai School Medicine Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie
NZ506665A (en) * 1998-03-16 2003-08-29 Alk Abello As Mutant recombinant allergens
ATE390441T1 (de) * 1998-10-30 2008-04-15 Novozymes As Niedrigallergene proteinvarianten
US6686164B1 (en) 1998-10-30 2004-02-03 Novozymes A/S Low allergenic protein variants
US20020009452A1 (en) * 1999-02-10 2002-01-24 Michael Caplan Method for altering undesirable immune responses to polypeptides
AU3717600A (en) * 1999-03-02 2000-09-21 Board Of Trustees Of The University Of Arkansas, The Methods and reagents for decreasing clinical reaction to allergy
AU3865400A (en) * 1999-03-03 2000-09-21 Mount Sinai School Of Medicine Of The City University Of New York, The Animal model of allergies
AU1921601A (en) * 1999-11-19 2001-05-30 Alabama A & M University Down-regulation and silencing of allergen genes in transgenic peanut seeds
US6943010B1 (en) 1999-11-19 2005-09-13 Hortense W. Dodo Down-regulation and silencing of allergen genes in transgenic peanut seeds
WO2001040264A2 (en) * 1999-12-06 2001-06-07 Panacea Pharmaceuticals, Llc. Peptide antigens
CA2394377A1 (en) * 1999-12-09 2001-05-10 Novozymes A/S High throughput screening (hts) assays for protein variants with reducedantibody binding capacity
WO2001049834A2 (en) 2000-01-06 2001-07-12 Monsanto Technology Llc Preparation of deallergenized patatin proteins and patatin permutein proteins
GB0006437D0 (en) * 2000-03-17 2000-05-10 Leuven Res & Dev Vzw Compounds for the modulation of allergen sensitivity by antigens sharing T cell epitopes with allergens
ES2260078T3 (es) * 2000-04-06 2006-11-01 Seer Pharmaceuticals, Llc. Sistema de administracion microbiana.
AU2001254620A1 (en) * 2000-04-28 2001-11-12 Novozymes A/S Lipolytic enzyme variant
IT1318692B1 (it) * 2000-09-12 2003-08-27 Consiglio Nazionale Ricerche Varianti di proteine allergeniche di phleum pratense.
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US20030175312A1 (en) * 2000-11-16 2003-09-18 Alk-Abello A/S Novel mutant allergens
KR100919914B1 (ko) * 2000-11-16 2009-10-06 알크-아벨로 에이/에스 신규한 돌연변이체 알레르겐
WO2002074250A2 (en) * 2001-03-16 2002-09-26 Panacea Pharmaceuticals Methods and reagents for decreasing clinical reaction to allergy
US7265208B2 (en) * 2001-05-01 2007-09-04 The Regents Of The University Of California Fusion molecules and treatment of IgE-mediated allergic diseases
PT1403280E (pt) 2002-09-27 2005-11-30 Biomay Prod & Handel Vacinas hipoalergenicas baseadas no alergenio ph1 p 7 de polen de capim timoteo
WO2005121166A1 (en) * 2004-06-10 2005-12-22 Monash University Novel immunointeractive molecules and uses thereof
AU2005252268B2 (en) * 2004-06-10 2012-06-28 Aravax Pty Limited Novel immunointeractive molecules and uses thereof
EP2243791A1 (en) 2009-03-03 2010-10-27 PLS-Design GmbH Cloning and recombinant production of Vespula venom protease and methods of use thereof
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
EP2664624A1 (en) 2012-05-15 2013-11-20 Biomay Ag Allergen variants
DK2914286T3 (da) 2012-10-30 2021-11-08 Aravax Pty Ltd Hidtil ukendte immunterapeutiske molekyler og anvendelser deraf
EP3760223A1 (en) 2013-04-03 2021-01-06 N-Fold Llc Nanoparticle composition for desensitizing a subject to peanut allergens
KR20160075532A (ko) 2013-09-25 2016-06-29 아라백스 피티와이 엘티디 신규한 면역치료제 조성물 및 이의 용도
CN104280555B (zh) * 2014-10-24 2017-09-26 江南大学 一种快速检测花生过敏原Ara h 2的胶体金试纸条及其制备方法
US9920100B2 (en) 2015-06-05 2018-03-20 The Chinese University Of Hong Kong Mimotopes of tropomyosin for use in immunotherapy for shellfish and/or arthropod allergy
CN109295250B (zh) * 2018-10-31 2022-03-22 四川华汉三创生物科技有限公司 一种食源性植物过敏原成分的检测试剂盒和方法
WO2025212530A1 (en) 2024-04-01 2025-10-09 N-Fold Llc Nanoparticle manufacturing

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US580862A (en) * 1897-04-20 Cloth computing and measuring machine
US569345A (en) * 1896-10-13 Albert p
US576149A (en) * 1897-02-02 Gustavus a
US548972A (en) * 1895-10-29 Weed-cutter
SE337223B (enExample) * 1967-05-23 1971-08-02 Pharmacia Ab
US3720760A (en) * 1968-09-06 1973-03-13 Pharmacia Ab Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples
US4171299A (en) * 1975-04-04 1979-10-16 The Regents Of The University Of California Polypeptide agents for blocking the human allergic response
US4469677A (en) * 1980-02-19 1984-09-04 Michael J Gabriel Polypeptide active immunosuppressant fraction
US4338297A (en) * 1980-02-19 1982-07-06 Michael Jacob G Polypeptide active pollen immunosuppressant fraction
FI76888C (fi) * 1981-04-29 1988-12-12 Ciba Geigy Ag Nya medel och foerpackningar foer immunologiska analyser.
US4888170A (en) 1981-10-22 1989-12-19 Research Corporation Vaccines obtained from antigenic gene products of recombinant genes
US4659678A (en) * 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
SE8205908D0 (sv) * 1982-10-18 1982-10-18 Pharmacia Diagnostics Ab Sett att bilda polymerskikt
US4849337A (en) * 1983-01-31 1989-07-18 Minnesota Mining And Manufacturing Company Assaying allergen specific IgE levels with fluorogenic enzyme labeled antibody
CA1260828A (en) 1983-07-04 1989-09-26 Masakazu Iwai Therapeutic and prophylactic agent for gastrointestinal ulcers
US4579840A (en) * 1983-08-12 1986-04-01 Immunetech Pharmaceuticals Method of blocking immune complex binding to immunoglobulin Fc receptors
US4816449A (en) * 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents
US4696915A (en) * 1984-05-25 1987-09-29 Hoffmann-La Roche Inc. Parathymosin alpha
US5026545A (en) * 1984-09-17 1991-06-25 Baxter International, Inc. Treatment of allergy and composition therefor
US4658022A (en) 1985-08-08 1987-04-14 Molecular Diagnostics, Inc. Binding of antibody reagents to denatured protein analytes
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
US4900556A (en) * 1985-04-26 1990-02-13 Massachusetts Institute Of Technology System for delayed and pulsed release of biologically active substances
IL86583A0 (en) 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
US5843710A (en) * 1987-07-07 1998-12-01 Biotech Australia Pty. Limited And Csiro Vaccines against animal parasitic nematodes
US5049390A (en) * 1987-09-02 1991-09-17 Allergy Immuno Technologies, Inc. Liposome containing immunotherapy agents for treating IgE mediated allergies
US5449760A (en) * 1987-12-31 1995-09-12 Tanox Biosystems, Inc. Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils
US5169933A (en) * 1988-08-15 1992-12-08 Neorx Corporation Covalently-linked complexes and methods for enhanced cytotoxicity and imaging
AT393137B (de) * 1988-10-14 1991-08-26 Biomay Biotech Prod Verfahren zum screenen einer expressions-cdna- klonbank zur auffindung von polynukleotiden
US5061790A (en) 1989-07-10 1991-10-29 Molecular Diagnostics, Inc. Oxidative denaturation of protein analytes
JP2787162B2 (ja) * 1989-08-24 1998-08-13 フマキラー株式会社 精製ダニアレルゲン
AU650249B2 (en) 1989-11-03 1994-06-16 Immulogic Pharmaceutical Corporation A human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
US5547669A (en) * 1989-11-03 1996-08-20 Immulogic Pharma Corp Recombinant peptides comprising T cell epitopes of the cat allergen, Fel d I
US5328991A (en) * 1989-11-03 1994-07-12 Immulogic Pharmaceutical Corp. Preparation of alkali-modified cat dander allergen (Fel d I) for immunotherapeutic purposes
US5804604A (en) * 1989-12-21 1998-09-08 Biogen, Inc. Tat-derived transport polypeptides and fusion proteins
US5674980A (en) * 1989-12-21 1997-10-07 Biogen Inc Fusion protein comprising tat-derived transport moiety
AU7259691A (en) 1990-01-31 1991-08-21 Board Of Regents Of The University Of Oklahoma, The Assays and treatments for autoimmune diseases
US6897287B1 (en) * 1990-01-31 2005-05-24 Oklahoma Medical Research Foundation Ro/SSA peptide reagents for diagnosis of autoantibodies
US5091318A (en) * 1990-04-13 1992-02-25 Abbott Laboratories Binding of allergens to a solid phase
US5888762A (en) 1990-06-05 1999-03-30 Centre National De La Recherche Scientifique (Cnrs) Neurotropic growth factors comprising a homeobox peptide
US5512283A (en) 1990-07-06 1996-04-30 Allergene, Inc. Methods for the selective suppression of an immune response to dust mite der Pi
WO1992002621A2 (en) 1990-08-08 1992-02-20 Biomay Biotechnik Produktions- Und Handelsgesellschaft M.B.H. Allergens of alder pollen and applications thereof
WO1992003551A1 (en) 1990-08-13 1992-03-05 Biomay Biotechnik Produktions- Und Handelsgesellschaft M.B.H. Birch pollen allergen p14 for diagnosis and therapy of allergic diseases
AT401180B (de) * 1990-08-13 1996-07-25 Biomay Biotech Prod Für das baumpollenallergen p14 codierende rekombinante dna-moleküle, daraus hergestellte und abgeleitete polypeptide und deren verwendung
JP3139777B2 (ja) * 1990-08-27 2001-03-05 フマキラー株式会社 組換えダニアレルゲン
WO1992011859A1 (en) 1991-01-08 1992-07-23 Immulogic Pharmaceutical Corporation Peptide-mediated hyposensitization of the human t cell response to dermatophagoides spp. (house dust mite)
US5219990A (en) * 1991-01-28 1993-06-15 Biogen, Inc. Papillomavirus e2 trans-activation repressors
WO1994024281A1 (en) 1993-04-14 1994-10-27 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
US5350835A (en) * 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
JP3156237B2 (ja) * 1991-12-24 2001-04-16 雪印乳業株式会社 抗ヒトIgE モノクローナル抗体
AU679443B2 (en) 1992-04-13 1997-07-03 Oklahoma Medical Research Foundation Methods and reagents for diagnosis of autoantibodies
US5719064A (en) 1992-08-31 1998-02-17 Oklahoma Medical Research Foundation Peptide diagnostics and therapeutics for spondyloarthropathies
AU5411594A (en) 1992-10-27 1994-05-24 Biomay Produktions- Und Handelsgesellschaft M.B.H. Molecule fragments (peptides) of the main allergens contained in the pollen of trees of the (fagales) order
US5480972A (en) 1992-10-30 1996-01-02 The University Of Melbourne Allergenic proteins from Johnson grass pollen
ES2095001T5 (es) * 1992-12-22 2001-03-16 Univ Cincinnati Una composicion terapeutica administrable oralmente y su metodo de obtencion.
US5558869A (en) * 1992-12-30 1996-09-24 University Of Arkansas Major peanut allergen ara h II
US5939283A (en) * 1992-12-31 1999-08-17 Immulogic Pharmaceutical Corporation Allergenic proteins and peptides from dog dander and uses therefor
ES2114184T3 (es) 1993-02-12 1998-05-16 Mayo Foundation Composicion a base de microparticulas en fase condensada y procedimiento.
JP3451572B2 (ja) 1993-03-04 2003-09-29 アサヒビール株式会社 改変したダニ主要アレルゲン及びその製造方法
US5710126A (en) * 1993-03-12 1998-01-20 Immulogic Pharmaceutical Corporation T cell epitopes of ryegrass pollen allergen
US6849427B1 (en) 1993-03-12 2005-02-01 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
FI954269A0 (fi) 1993-03-12 1995-09-12 Immunologic Pharma Corp Raiheinäsiitepölyallergeenin T-soluepitoopit
AT401937B (de) 1993-04-01 1996-12-27 Biomay Prod & Handel Rekombinantes lieschgras pollen allergen phl p ii
US5830463A (en) 1993-07-07 1998-11-03 University Technology Corporation Yeast-based delivery vehicles
JP3350794B2 (ja) 1993-09-29 2002-11-25 アサヒビール株式会社 改変したダニ主要アレルゲン
JP2828391B2 (ja) 1993-10-29 1998-11-25 東燃株式会社 オリゴ糖を表面に有するリポソーム
US5449669A (en) * 1993-11-10 1995-09-12 The United States Of America As Represented By The Department Of Health And Human Services IgE-binding epitopes of a major heat-stable crustacean allergen derived from shrimp
US5731157A (en) * 1993-12-30 1998-03-24 The Procter And Gamble Company Two-site allergen immunoassay
US5820862A (en) 1994-04-14 1998-10-13 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
JPH07285875A (ja) 1994-04-19 1995-10-31 Mineo Hayazaki ノミアレルゲンの製造方法および該方法により製造されるノミアレルゲン
US5807746A (en) * 1994-06-13 1998-09-15 Vanderbilt University Method for importing biologically active molecules into cells
SE9402089D0 (sv) 1994-06-14 1994-06-14 Rudolf Valenta Recombinant allergen, fragments thereof, corresponding recombinant DNA molecules, vectors and hosts containing the DNA molecules, diagnostic and therapeutic uses of said allergens and fragments
EP0819763B1 (en) 1995-03-28 2004-11-17 Asahi Breweries, Ltd. Engineered acarid allergen and process for producing the same
US5840307A (en) * 1995-03-31 1998-11-24 Immulogic Pharmacuetical Corp. Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation
BE1009359A7 (fr) 1995-05-19 1997-02-04 Univ Bruxelles Procede de detection et/ou de quantification de ligands specifiques d'une pathologie liee a une reponse allergique.
US5820880A (en) 1995-06-07 1998-10-13 The United States Of America As Represented By The Secretary Of The Army Liposomal formulation
US5869040A (en) * 1995-06-07 1999-02-09 Biogen, Inc Gene therapy methods and compositions
AU705563B2 (en) 1995-07-28 1999-05-27 Marie Curie Cancer Care Transport proteins and their uses
JPH11507840A (ja) * 1995-12-29 1999-07-13 ユニバーシティ オブ アーカンソー ピーナッツアレルゲンおよび方法
US5955593A (en) * 1996-09-09 1999-09-21 Washington University BH3 interacting domain death agonist
US6017735A (en) 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses
BE1011033A6 (fr) 1997-03-05 1999-04-06 Univ Bruxelles Composition pharmaceutique et/ou alimentaire pour le traitement de pathologies liees a un rejet de greffe, une reaction allergique ou auto-immune ou du cancer.
DE19713001A1 (de) 1997-03-27 1998-10-01 Merck Patent Gmbh Graminaenpollenallergenmutanten zur spezifischen Immuntherapie, deren Herstellung und Verwendung
US5989814A (en) * 1997-04-01 1999-11-23 Reagents Of The University Of California Screening methods in eucaryotic cells
US5888760A (en) * 1997-04-10 1999-03-30 Dade Microscan Inc. Universal test systems and methods of use thereof for identifying multiple families of microorganisms
US6060082A (en) * 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
DE69738124T2 (de) 1997-05-08 2008-06-12 Amarnath Maitra Verfahren zur Herstellung von hochmonodisperser, Polymeren, hydrophiler Nanopartikel
US5891432A (en) * 1997-07-29 1999-04-06 The Immune Response Corporation Membrane-bound cytokine compositions comprising GM=CSF and methods of modulating an immune response using same
SE9703531D0 (sv) 1997-09-30 1997-09-30 Rudolf Valenta Non-anaphlactic forms of allergens and their use
US6024961A (en) 1997-11-14 2000-02-15 Washington University Recombinant avirulent immunogenic S typhi having rpos positive phenotype
JP2002500198A (ja) 1998-01-09 2002-01-08 サーカシア リミテッド 脱感作のための方法及び組成物
DE69940805D1 (de) 1998-01-31 2009-06-10 Sinai School Medicine Verfahren und reagenzien zur verminderung der klinischen reaktion zur allergie
US6248558B1 (en) 1998-03-31 2001-06-19 Vanderbilt University Sequence and method for genetic engineering of proteins with cell membrane translocating activity
ES2284247T3 (es) 1998-04-03 2007-11-01 University Of Iowa Research Foundation Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos.
AU3760100A (en) 1999-03-16 2000-10-04 Panacea Pharmaceuticals, Llc Immunostimulatory nucleic acids and antigens
AU1921601A (en) 1999-11-19 2001-05-30 Alabama A & M University Down-regulation and silencing of allergen genes in transgenic peanut seeds
DE60032250T2 (de) * 2000-12-28 2007-03-15 Biomay Produktions- Und Handels-Aktiengesellschaft Behandlung von Allergien

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011505410A (ja) * 2007-12-03 2011-02-24 デベヴェ・テクノロジーズ 被験者のグラウンドナッツに対する寛容を増大させる免疫治療法
KR20210142000A (ko) * 2019-03-13 2021-11-23 소마젠 인크 알레르기 치료를 위한 에피토프-기반 접근법 및 크론병에 대한 억제제
JP2022524757A (ja) * 2019-03-13 2022-05-10 プソマーゲン, インコーポレイテッド アレルギー治療のためのエピトープベースアプローチ及びクローン病のための阻害薬
JP7266700B2 (ja) 2019-03-13 2023-04-28 プソマーゲン, インコーポレイテッド アレルギー治療のためのエピトープベースアプローチ及びクローン病のための阻害薬
KR102811748B1 (ko) * 2019-03-13 2025-05-26 주식회사 마크로젠 알레르기 치료를 위한 에피토프-기반 접근법 및 크론병에 대한 억제제

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US7485708B2 (en) 2009-02-03
CA2319437A1 (en) 1999-08-05
DE69940805D1 (de) 2009-06-10
AU743647B2 (en) 2002-01-31
EP1051494A1 (en) 2000-11-15
EP1051494B1 (en) 2009-04-29
AU2350599A (en) 1999-08-16

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