JP2004538237A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004538237A5 JP2004538237A5 JP2000587803A JP2000587803A JP2004538237A5 JP 2004538237 A5 JP2004538237 A5 JP 2004538237A5 JP 2000587803 A JP2000587803 A JP 2000587803A JP 2000587803 A JP2000587803 A JP 2000587803A JP 2004538237 A5 JP2004538237 A5 JP 2004538237A5
- Authority
- JP
- Japan
- Prior art keywords
- ige
- binding
- allergen
- allergens
- fab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000013566 allergen Substances 0.000 description 70
- 238000009739 binding Methods 0.000 description 51
- 150000001875 compounds Chemical class 0.000 description 50
- 239000003153 chemical reaction reagent Substances 0.000 description 33
- 229960004784 allergens Drugs 0.000 description 31
- 230000000873 masking effect Effects 0.000 description 28
- 206010020751 Hypersensitivity Diseases 0.000 description 25
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 25
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 25
- 238000000034 method Methods 0.000 description 24
- 239000000427 antigen Substances 0.000 description 23
- 108091007433 antigens Proteins 0.000 description 23
- 102000036639 antigens Human genes 0.000 description 23
- 235000018102 proteins Nutrition 0.000 description 23
- 102000004169 proteins and genes Human genes 0.000 description 23
- 108090000623 proteins and genes Proteins 0.000 description 23
- 239000000126 substance Substances 0.000 description 22
- 229920000126 latex Polymers 0.000 description 21
- 208000026935 allergic disease Diseases 0.000 description 18
- 239000000203 mixture Substances 0.000 description 18
- 241001465754 Metazoa Species 0.000 description 15
- 230000007815 allergy Effects 0.000 description 13
- 239000000463 material Substances 0.000 description 12
- 108090000765 processed proteins & peptides Proteins 0.000 description 12
- 239000004816 latex Substances 0.000 description 11
- 238000010561 standard procedure Methods 0.000 description 10
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 9
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 9
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 150000001413 amino acids Chemical group 0.000 description 8
- 238000003556 assay Methods 0.000 description 8
- 210000003630 histaminocyte Anatomy 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000012216 screening Methods 0.000 description 7
- 238000011282 treatment Methods 0.000 description 7
- 241000238631 Hexapoda Species 0.000 description 6
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 6
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 6
- 208000030961 allergic reaction Diseases 0.000 description 6
- 235000001014 amino acid Nutrition 0.000 description 6
- 239000002981 blocking agent Substances 0.000 description 6
- 230000000903 blocking effect Effects 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 239000002299 complementary DNA Substances 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 210000003491 skin Anatomy 0.000 description 6
- 241000282326 Felis catus Species 0.000 description 5
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 description 5
- 230000000172 allergic effect Effects 0.000 description 5
- 208000010668 atopic eczema Diseases 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 241000238876 Acari Species 0.000 description 4
- 208000001840 Dandruff Diseases 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 210000004209 hair Anatomy 0.000 description 4
- 238000009169 immunotherapy Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 108020004635 Complementary DNA Proteins 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 101800002189 Hevein Proteins 0.000 description 3
- 102000009438 IgE Receptors Human genes 0.000 description 3
- 108010073816 IgE Receptors Proteins 0.000 description 3
- 241000258242 Siphonaptera Species 0.000 description 3
- 230000002009 allergenic effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 210000001616 monocyte Anatomy 0.000 description 3
- 238000004091 panning Methods 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241001674044 Blattodea Species 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- 244000043261 Hevea brasiliensis Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 241000257303 Hymenoptera Species 0.000 description 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 2
- 101710194991 Pro-hevein Proteins 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000000428 dust Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- WKMZPSWMEXVKKG-XITFREQTSA-N hevein Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CS)C(=O)NCC(=O)OC(=O)CC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CO)[C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1N=CN=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(O)=O)CC1=CNC2=CC=CC=C12 WKMZPSWMEXVKKG-XITFREQTSA-N 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 238000002823 phage display Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000003259 recombinant expression Methods 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000009261 transgenic effect Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 101800000263 Acidic protein Proteins 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 108700021041 Disintegrin Proteins 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 238000012286 ELISA Assay Methods 0.000 description 1
- 206010051841 Exposure to allergen Diseases 0.000 description 1
- 241000724791 Filamentous phage Species 0.000 description 1
- 108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
- 102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 108010060231 Insect Proteins Proteins 0.000 description 1
- 206010023644 Lacrimation increased Diseases 0.000 description 1
- 208000009481 Laryngeal Edema Diseases 0.000 description 1
- 206010023845 Laryngeal oedema Diseases 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108010052285 Membrane Proteins Proteins 0.000 description 1
- 102000018697 Membrane Proteins Human genes 0.000 description 1
- 101000952180 Morus alba Mulatexin Proteins 0.000 description 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000037656 Respiratory Sounds Diseases 0.000 description 1
- 208000036071 Rhinorrhea Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 241000282485 Vulpes vulpes Species 0.000 description 1
- 206010047924 Wheezing Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940074608 allergen extract Drugs 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 229940125715 antihistaminic agent Drugs 0.000 description 1
- 239000000739 antihistaminic agent Substances 0.000 description 1
- 229940127218 antiplatelet drug Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000003651 basophil Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 229920003211 cis-1,4-polyisoprene Polymers 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 150000001945 cysteines Chemical class 0.000 description 1
- 239000000850 decongestant Substances 0.000 description 1
- 229940124581 decongestants Drugs 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 229940046528 grass pollen Drugs 0.000 description 1
- 239000005090 green fluorescent protein Substances 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000008348 humoral response Effects 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 238000003119 immunoblot Methods 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 231100001039 immunological change Toxicity 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000002917 insecticide Substances 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- XMBWDFGMSWQBCA-RNFDNDRNSA-M iodine-131(1-) Chemical compound [131I-] XMBWDFGMSWQBCA-RNFDNDRNSA-M 0.000 description 1
- 208000001875 irritant dermatitis Diseases 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000004317 lacrimation Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 244000144972 livestock Species 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000000163 radioactive labelling Methods 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- -1 scents Substances 0.000 description 1
- 238000003345 scintillation counting Methods 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000000539 two dimensional gel electrophoresis Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21611798A | 1998-12-18 | 1998-12-18 | |
| PCT/US1999/030238 WO2000035484A2 (en) | 1998-12-18 | 1999-12-17 | Methods and compositions for decreasing allergic reactions to surface allergens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004538237A JP2004538237A (ja) | 2004-12-24 |
| JP2004538237A5 true JP2004538237A5 (enExample) | 2005-03-17 |
Family
ID=22805772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000587803A Withdrawn JP2004538237A (ja) | 1998-12-18 | 1999-12-17 | 表面アレルゲンに対するアレルギー反応を減少させるための方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20010051155A1 (enExample) |
| EP (1) | EP1140169A2 (enExample) |
| JP (1) | JP2004538237A (enExample) |
| AU (1) | AU2196500A (enExample) |
| CA (1) | CA2355650A1 (enExample) |
| WO (1) | WO2000035484A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020019009A1 (en) * | 1999-12-09 | 2002-02-14 | Roggen Erwin Ludo | High throughput screening (HTS) assays |
| US7060687B2 (en) | 2001-02-07 | 2006-06-13 | Genmont Biotechnology Co. | Live vaccines for allergy treatment |
| US20020197268A1 (en) * | 2001-06-08 | 2002-12-26 | Hsu Ching-Hsaing | Allergen-containing milk for allergy treatment |
| JP3642340B2 (ja) * | 2003-03-28 | 2005-04-27 | ダイキン工業株式会社 | 有害物質除去方法、並びに、それに用いる空気浄化用フィルタ、拭き取りシートなどの有害物質除去材、及び、その保管方法 |
| CA2693416C (en) * | 2007-07-09 | 2018-01-09 | Nestec S.A. | Methods for reducing allergies caused by environmental allergens |
| US9388236B2 (en) | 2007-07-09 | 2016-07-12 | Nestec Sa | Methods for reducing allergies caused by environmental allergens |
| EP2022507A1 (en) * | 2007-08-07 | 2009-02-11 | Universität Hamburg | Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy |
| US8962241B2 (en) * | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
| US9597385B2 (en) | 2012-04-23 | 2017-03-21 | Allertein Therapeutics, Llc | Nanoparticles for treatment of allergy |
| EP3760223A1 (en) | 2013-04-03 | 2021-01-06 | N-Fold Llc | Nanoparticle composition for desensitizing a subject to peanut allergens |
| EP3631464A1 (en) * | 2017-05-25 | 2020-04-08 | Société des Produits Nestlé S.A. | Methods for enabling pet ownership |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5512283A (en) * | 1990-07-06 | 1996-04-30 | Allergene, Inc. | Methods for the selective suppression of an immune response to dust mite der Pi |
| JPH08501799A (ja) * | 1992-12-21 | 1996-02-27 | タノックス バイオシステムズ インコーポレイテッド | アレルゲン特異的ＩｇＡモノクローナル抗体及びアレルギー治療のための関連物質 |
| WO1995012420A1 (en) * | 1993-11-04 | 1995-05-11 | Bsi Corporation | Barrier coatings for surfaces |
-
1999
- 1999-12-17 JP JP2000587803A patent/JP2004538237A/ja not_active Withdrawn
- 1999-12-17 WO PCT/US1999/030238 patent/WO2000035484A2/en not_active Ceased
- 1999-12-17 EP EP99966427A patent/EP1140169A2/en not_active Withdrawn
- 1999-12-17 AU AU21965/00A patent/AU2196500A/en not_active Abandoned
- 1999-12-17 CA CA002355650A patent/CA2355650A1/en not_active Abandoned
-
2001
- 2001-07-02 US US09/897,864 patent/US20010051155A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69931377T2 (de) | Verfahren zur behandlung von ig-e assozierten krankheiten und zusammensetzungen zur verwendung in diesen verfahren | |
| CA2319437C (en) | Methods and reagents for decreasing allergic reactions | |
| US5670626A (en) | Allergen-specific human IgA monoclonal antibodies for mucosal administration | |
| US20020009453A1 (en) | Polyclonal antibody composition for treating allergy | |
| JP2005518367A (ja) | 免疫療法および系 | |
| JP2004538237A5 (enExample) | ||
| US20010051155A1 (en) | Methods and compositions for decreasing allergic reactions to surface allergens | |
| DE69901569T2 (de) | Humane antikörper gegen faktor ix/ixa | |
| Thomas | The advent of recombinant allergens and allergen cloning | |
| Chippaux et al. | Production and use of snake antivenin | |
| JP2004537991A (ja) | アレルギー及び喘息治療用Ｆｃε融合タンパク質 | |
| KR100831118B1 (ko) | 알레르기를 치료하기 위한 재조합 폴리클로날 항체 또는정제된 폴리클로날 항체 | |
| Zinkhan et al. | On the role of allergen-specific IgG subclasses for blocking human basophil activation | |
| JP6073239B2 (ja) | 抗原隠蔽剤としての使用のための、ヒトラクトフェリン誘導ペプチド | |
| De Silva et al. | The hevein domain of the major latex‐glove allergen Hev b 6.01 contains dominant T cell reactive sites | |
| Edlmayr et al. | Allergen-specific immunotherapy: towards combination vaccines for allergic and infectious diseases | |
| Özdemir | Cockroach allergy, respiratory allergic diseases and its immunotherapy | |
| Yang et al. | Allergen Preparation in AIT, Now and in the Future | |
| Corthésy et al. | Efficacy of a therapeutic treatment using gas‐filled microbubble‐associated phospholipase A2 in a mouse model of honeybee venom allergy | |
| EP2431381B1 (en) | Synthetic oligopeptides designed from mite cysteine proteases and methods for the production of igy polyclonal antibodies for the detection of intradomiciliary mites | |
| US8343504B2 (en) | Methods of administering IGBPMA to treat type 1 hypersensitivity | |
| Meenatchisundaram et al. | Comparison of antivenom potential of chicken egg yolk antibodies generated against bentonite and adjuvent coated venomes of common poisonous snake in india | |
| JP2918795B2 (ja) | アレルギー疾患治療のための植物自己不和合性受容体蛋白（ｓｌｇおよびｓｒｋ）組成物 | |
| Gamboa et al. | Allergic rhinitis to turtle food | |
| Chapman et al. | Cockroach allergens, environmental exposure, and asthma |