JP2002501532A - 新規血管形成阻害薬 - Google Patents

新規血管形成阻害薬

Info

Publication number
JP2002501532A
JP2002501532A JP50079099A JP50079099A JP2002501532A JP 2002501532 A JP2002501532 A JP 2002501532A JP 50079099 A JP50079099 A JP 50079099A JP 50079099 A JP50079099 A JP 50079099A JP 2002501532 A JP2002501532 A JP 2002501532A
Authority
JP
Japan
Prior art keywords
pyrazolo
compound
pyrimidine
pyridyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP50079099A
Other languages
English (en)
Japanese (ja)
Inventor
ビロデユウ，マーク・テイ
ハンゲイト，ランドル・ダブリユ
ケンドル，リチヤード・エル
ルートリツジ，ルース
トーマス，ケニス・エイ，ジユニア
ルビーノ，ロバート
フレイリー，マーク・イー
Original Assignee
メルク エンド カンパニー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9800681.0A external-priority patent/GB9800681D0/en
Application filed by メルク エンド カンパニー インコーポレーテッド filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JP2002501532A publication Critical patent/JP2002501532A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50079099A 1997-05-30 1998-05-26 新規血管形成阻害薬 Pending JP2002501532A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4807697P 1997-05-30 1997-05-30
GBGB9800681.0A GB9800681D0 (en) 1998-01-14 1998-01-14 Novel angiogenesis inhibitors
GB60/048,076 1998-01-14
GB9800681.0 1998-01-14
PCT/US1998/010590 WO1998054093A1 (fr) 1997-05-30 1998-05-26 Nouveaux inhibiteurs d'angiogenese

Publications (1)

Publication Number Publication Date
JP2002501532A true JP2002501532A (ja) 2002-01-15

Family

ID=26312935

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50079099A Pending JP2002501532A (ja) 1997-05-30 1998-05-26 新規血管形成阻害薬

Country Status (5)

Country Link
EP (1) EP0984692A4 (fr)
JP (1) JP2002501532A (fr)
AU (1) AU734009B2 (fr)
CA (1) CA2291709A1 (fr)
WO (1) WO1998054093A1 (fr)

Cited By (8)

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JP2006507278A (ja) * 2002-10-25 2006-03-02 ツェンティバ，エー．エス ザレプロンの製造方法
JP2008519059A (ja) * 2004-11-04 2008-06-05 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼのインヒビターとして有用なピラゾロ［１，５−α］ピリミジン
JP2009511479A (ja) * 2005-10-06 2009-03-19 シェーリング コーポレイション プロテインキナーゼインヒビターとしてのピラゾロ［１，５−ａ］ピリミジン
WO2009041663A1 (fr) * 2007-09-28 2009-04-02 Kyowa Hakko Kirin Co., Ltd. Agent destiné à la prévention et/ou au traitement de maladies cutanées
JP2010513447A (ja) * 2006-12-22 2010-04-30 アステックス、セラピューティックス、リミテッド Ｆｇｆｒインヒビターとしての二環式ヘテロ環式化合物
JP2013538838A (ja) * 2010-09-27 2013-10-17 プロクシマゲン リミテッド ７−ヒドロキシ−ピラゾロ［１，５−ａ］ピリミジン化合物およびｃｃｒ２レセプターアンタゴニストとしてのその使用
JP2016515119A (ja) * 2013-03-14 2016-05-26 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． Ｂｍｐ阻害剤およびその使用方法
JP2022536188A (ja) * 2019-06-14 2022-08-12 メッドシャイン ディスカバリー インコーポレイテッド Ｆｇｆｒとｖｅｇｆｒ二重阻害剤としての縮合環系化合物

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JP2022536188A (ja) * 2019-06-14 2022-08-12 メッドシャイン ディスカバリー インコーポレイテッド Ｆｇｆｒとｖｅｇｆｒ二重阻害剤としての縮合環系化合物
JP7343622B2 (ja) 2019-06-14 2023-09-12 シージーンテック （スーチョウ， チャイナ） カンパニー リミテッド Ｆｇｆｒとｖｅｇｆｒ二重阻害剤としての縮合環系化合物

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WO1998054093A1 (fr) 1998-12-03
AU734009B2 (en) 2001-05-31

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