JP2002501015A - リーシュマニア症の治療における経口投与のためのミルテフォシンを含有する固形医薬品 - Google Patents
リーシュマニア症の治療における経口投与のためのミルテフォシンを含有する固形医薬品Info
- Publication number
- JP2002501015A JP2002501015A JP2000528271A JP2000528271A JP2002501015A JP 2002501015 A JP2002501015 A JP 2002501015A JP 2000528271 A JP2000528271 A JP 2000528271A JP 2000528271 A JP2000528271 A JP 2000528271A JP 2002501015 A JP2002501015 A JP 2002501015A
- Authority
- JP
- Japan
- Prior art keywords
- active ingredient
- miltefosine
- solid pharmaceutical
- pharmaceutical product
- dosage regimen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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Classifications
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP1998/000345 WO1999037289A1 (en) | 1998-01-22 | 1998-01-22 | Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis |
Publications (2)
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| JP2002501015A true JP2002501015A (ja) | 2002-01-15 |
| JP2002501015A5 JP2002501015A5 (enExample) | 2005-12-22 |
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| JP2000528271A Pending JP2002501015A (ja) | 1998-01-22 | 1998-01-22 | リーシュマニア症の治療における経口投与のためのミルテフォシンを含有する固形医薬品 |
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|---|---|
| US (1) | US6544551B1 (enExample) |
| EP (1) | EP1051159B1 (enExample) |
| JP (1) | JP2002501015A (enExample) |
| KR (1) | KR100517399B1 (enExample) |
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| AT (1) | ATE215817T1 (enExample) |
| AU (1) | AU756805B2 (enExample) |
| BR (1) | BR9814772A (enExample) |
| CA (1) | CA2318260C (enExample) |
| CZ (1) | CZ299229B6 (enExample) |
| DE (1) | DE69804865T2 (enExample) |
| DK (1) | DK1051159T3 (enExample) |
| ES (1) | ES2175663T3 (enExample) |
| HU (1) | HUP0004363A3 (enExample) |
| IL (1) | IL136196A (enExample) |
| NO (1) | NO20003674L (enExample) |
| NZ (1) | NZ505648A (enExample) |
| PL (1) | PL189654B1 (enExample) |
| PT (1) | PT1051159E (enExample) |
| SI (1) | SI1051159T1 (enExample) |
| SK (1) | SK284839B6 (enExample) |
| TR (1) | TR200001717T2 (enExample) |
| UA (1) | UA68372C2 (enExample) |
| WO (1) | WO1999037289A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005515244A (ja) * | 2002-01-25 | 2005-05-26 | ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 原虫症の予防的処置のためのアルキルホスホコリンの使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7887817B2 (en) * | 2002-01-25 | 2011-02-15 | Aeterna Zentaris Gmbh | Process for preventing protozoal diseases |
| WO2003090757A1 (en) * | 2002-04-26 | 2003-11-06 | Rudolf Perl | Pharmaceutical compositions of phospholipid derivatives |
| US8383605B2 (en) | 2002-07-30 | 2013-02-26 | Aeterna Zentaris Gmbh | Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals |
| UA82322C2 (uk) * | 2002-07-30 | 2008-04-10 | Центаріс Гмбх | Застосування алкілфосфохолінів в комбінації з протипухлинними лікарськими засобами |
| DK1663197T3 (da) | 2003-09-09 | 2008-01-07 | Fumapharm Ag | Anvendelse af fumarsyrederivater til behandling af hjerteinsuffiens og astma |
| SI1799196T1 (sl) | 2004-10-08 | 2016-10-28 | Forward Pharma A/S | Farmacevtski sestavki z nadzorovanim sproščanjem, obsegajoči ester fumarne kisline |
| US8703179B2 (en) * | 2006-05-11 | 2014-04-22 | Kimberly-Clark Worldwide, Inc. | Mucosal formulation |
| WO2010020276A1 (en) * | 2008-08-19 | 2010-02-25 | Orphanidis Pharma Research Gmbh | Treatment of coccidian parasites |
| US8383607B2 (en) | 2010-03-31 | 2013-02-26 | Aeterna Zentaris Gmbh | Perifosine and capecitabine as a combined treatment for cancer |
| BR112013012652A2 (pt) | 2010-11-22 | 2016-09-06 | Dafra Pharma Res & Dev Bvba | forma de dosagem sólida de oleil fosfocolina para administração oral, forma de dosagem sólida, e método para a preparação de uma forma de dosagem sólida |
| CN111298120A (zh) | 2011-06-24 | 2020-06-19 | 格里生物公司 | 炎性病症的预防和治疗 |
| EP2983709A1 (en) * | 2013-04-08 | 2016-02-17 | Academisch Medisch Centrum | Miltefosin or perifosin for use in the treatment of ibd |
| WO2016042372A1 (en) | 2014-09-17 | 2016-03-24 | Steer Engineering Private Limited | Effervescent composition and method of making it |
| CN104473941A (zh) * | 2014-12-20 | 2015-04-01 | 长沙佰顺生物科技有限公司 | 一种含有米替福新的药物制剂及其制备方法 |
| US11219594B2 (en) | 2015-12-12 | 2022-01-11 | Steerlife India Private Limited | Effervescent compositions of metformin and processes for preparation thereof |
| BR112021020389A2 (pt) * | 2019-04-12 | 2021-12-07 | Oblita Therapeutics Bvba | Formulações de dosagem em comprimidos de oleil fosfocolina |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE888444C (de) * | 1951-11-10 | 1953-08-31 | Benckiser Gmbh Joh A | Verfahren zum Tablettieren von hygroskopischen Praeparaten |
| IE59778B1 (en) * | 1985-12-04 | 1994-04-06 | Max Planck Gesellschaft | Medicament with anti-tumour action containing hexadecylphosphocholine |
| US4762658A (en) * | 1986-10-08 | 1988-08-09 | Central Soya Company, Inc. | Method of tableting of de-oiled phosphatides (lecithin) |
| US5290769A (en) * | 1989-09-27 | 1994-03-01 | Asta Pharma Aktiengesellschaft | Use of hexadecylphosphocholine for the treatment of psoriasis |
| EP0419998A3 (en) * | 1989-09-27 | 1991-10-23 | Asta Pharma Aktiengesellschaft | Use of alkylphosphonic acid derivatives for the treatment of psoriasis |
| DE4132344A1 (de) * | 1991-09-27 | 1993-04-01 | Max Planck Gesellschaft | Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis |
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1998
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- 1998-01-22 EP EP98904121A patent/EP1051159B1/en not_active Expired - Lifetime
- 1998-01-22 DE DE69804865T patent/DE69804865T2/de not_active Expired - Lifetime
- 1998-01-22 KR KR10-2000-7008029A patent/KR100517399B1/ko not_active Expired - Fee Related
- 1998-01-22 PL PL98342838A patent/PL189654B1/pl not_active IP Right Cessation
- 1998-01-22 UA UA2000084909A patent/UA68372C2/uk unknown
- 1998-01-22 CN CNB988125714A patent/CN100413492C/zh not_active Expired - Fee Related
- 1998-01-22 SK SK986-2000A patent/SK284839B6/sk unknown
- 1998-01-22 AT AT98904121T patent/ATE215817T1/de not_active IP Right Cessation
- 1998-01-22 HU HU0004363A patent/HUP0004363A3/hu unknown
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- 1998-01-22 JP JP2000528271A patent/JP2002501015A/ja active Pending
- 1998-01-22 ES ES98904121T patent/ES2175663T3/es not_active Expired - Lifetime
- 1998-01-22 DK DK98904121T patent/DK1051159T3/da active
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- 1998-01-22 AU AU62121/98A patent/AU756805B2/en not_active Ceased
- 1998-01-22 CZ CZ20002596A patent/CZ299229B6/cs not_active IP Right Cessation
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- 1998-01-22 BR BR9814772-2A patent/BR9814772A/pt not_active Application Discontinuation
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005515244A (ja) * | 2002-01-25 | 2005-05-26 | ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 原虫症の予防的処置のためのアルキルホスホコリンの使用 |
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