JP2001526902A5 - - Google Patents
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- Publication number
- JP2001526902A5 JP2001526902A5 JP2000525570A JP2000525570A JP2001526902A5 JP 2001526902 A5 JP2001526902 A5 JP 2001526902A5 JP 2000525570 A JP2000525570 A JP 2000525570A JP 2000525570 A JP2000525570 A JP 2000525570A JP 2001526902 A5 JP2001526902 A5 JP 2001526902A5
- Authority
- JP
- Japan
- Prior art keywords
- capsular polysaccharide
- chromatography
- polysaccharide
- group
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 46
- 150000004676 glycans Chemical class 0.000 description 39
- 229920001282 polysaccharide Polymers 0.000 description 39
- 239000005017 polysaccharide Substances 0.000 description 39
- 239000003153 chemical reaction reagent Substances 0.000 description 14
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical group CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 12
- 238000004587 chromatography analysis Methods 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 150000007523 nucleic acids Chemical class 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 108091005461 Nucleic proteins Proteins 0.000 description 3
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 3
- 239000012346 acetyl chloride Substances 0.000 description 3
- YBADLXQNJCMBKR-UHFFFAOYSA-N (4-nitrophenyl)acetic acid Chemical compound OC(=O)CC1=CC=C([N+]([O-])=O)C=C1 YBADLXQNJCMBKR-UHFFFAOYSA-N 0.000 description 2
- SMWZGZIZOHNWBH-UHFFFAOYSA-N 3-bromo-5-phenyl-1,2-oxazole Chemical compound O1N=C(Br)C=C1C1=CC=CC=C1 SMWZGZIZOHNWBH-UHFFFAOYSA-N 0.000 description 2
- 125000003047 N-acetyl group Chemical group 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 241000588650 Neisseria meningitidis Species 0.000 description 2
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 239000003636 conditioned culture medium Substances 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 150000007529 inorganic bases Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 108010060123 Conjugate Vaccines Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 229940031670 conjugate vaccine Drugs 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 150000002009 diols Chemical group 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6860897P | 1997-12-23 | 1997-12-23 | |
| US60/068,608 | 1997-12-23 | ||
| PCT/US1998/027375 WO1999032653A1 (en) | 1997-12-23 | 1998-12-23 | Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009206304A Division JP5144613B2 (ja) | 1997-12-23 | 2009-09-07 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001526902A JP2001526902A (ja) | 2001-12-25 |
| JP2001526902A5 true JP2001526902A5 (enExample) | 2006-02-16 |
| JP4435413B2 JP4435413B2 (ja) | 2010-03-17 |
Family
ID=22083630
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525570A Expired - Lifetime JP4435413B2 (ja) | 1997-12-23 | 1998-12-23 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
| JP2009206304A Expired - Lifetime JP5144613B2 (ja) | 1997-12-23 | 2009-09-07 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009206304A Expired - Lifetime JP5144613B2 (ja) | 1997-12-23 | 2009-09-07 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6248570B1 (enExample) |
| EP (3) | EP1051506B2 (enExample) |
| JP (2) | JP4435413B2 (enExample) |
| KR (2) | KR100757630B1 (enExample) |
| AT (1) | ATE468403T2 (enExample) |
| AU (1) | AU754256C (enExample) |
| CA (1) | CA2316975C (enExample) |
| CZ (1) | CZ302615B6 (enExample) |
| DE (1) | DE69841676D1 (enExample) |
| DK (1) | DK1051506T4 (enExample) |
| ES (2) | ES2346022T3 (enExample) |
| HU (1) | HUP0100623A3 (enExample) |
| NO (1) | NO331100B1 (enExample) |
| WO (1) | WO1999032653A1 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU66103A (sh) | 2001-01-23 | 2006-05-25 | Aventis Pasteur | Vakcina multivalentnog konjugata meningokokalnog polisaharid-proteina |
| US8222232B2 (en) * | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
| US7816514B2 (en) | 2001-02-16 | 2010-10-19 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| US6693188B2 (en) | 2001-08-08 | 2004-02-17 | Cargill Incorporated | N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine |
| US7923437B2 (en) * | 2001-02-16 | 2011-04-12 | Cargill, Incorporated | Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same |
| US20020115639A1 (en) * | 2001-02-16 | 2002-08-22 | Weiyu Fan | Glucosamine and method of making glucosamine from microbial blomass |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| ATE419278T1 (de) * | 2002-03-26 | 2009-01-15 | Novartis Vaccines & Diagnostic | Modifizierte saccharide mit verbesserter stabilität in wasser |
| US20040096461A1 (en) * | 2002-07-30 | 2004-05-20 | Baxter Healthcare Corporation | Chimeric multivalent polysaccharide conjugate vaccines |
| US20060058263A1 (en) * | 2002-11-01 | 2006-03-16 | Rogers Brent D | Heat pasturized liquids containing glucosamine |
| US20060003965A1 (en) * | 2002-11-01 | 2006-01-05 | Fosdick Lawrence D | N-acetyl-d-glucosamine (nag) supplemented food products and beverages |
| CN102319427A (zh) | 2003-01-30 | 2012-01-18 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
| US20070020293A1 (en) * | 2003-06-23 | 2007-01-25 | Michon Francis J | Vaccines against group neisseria meningitidis and meningococcal combinations thereof |
| GB0406013D0 (en) * | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| WO2006016161A1 (en) * | 2004-08-12 | 2006-02-16 | Lipoxen Technologies Limited | Fractionation of charged polysaccharide |
| GB0502096D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
| GB0502095D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| CN104815327A (zh) | 2005-04-08 | 2015-08-05 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| AU2011253684B8 (en) * | 2005-04-08 | 2013-07-11 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| CA2620416A1 (en) * | 2005-08-24 | 2007-03-01 | Novartis Vaccines And Diagnostics S.R.L. | Zwitterionization of capsular saccharides |
| GB0522303D0 (en) | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| JP5286089B2 (ja) * | 2006-01-13 | 2013-09-11 | バクスター・インターナショナル・インコーポレイテッド | ポリサッカライドを精製する方法 |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| US10543265B2 (en) | 2006-03-22 | 2020-01-28 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| EP1872791A1 (en) | 2006-06-30 | 2008-01-02 | Institut Pasteur | Use of bacterial polysaccharides for biofilm inhibition |
| PL2115010T3 (pl) | 2007-02-28 | 2012-07-31 | Lipoxen Tech Limited | Zmniejszanie zawartości endotoksyny w kwasach polisialowych |
| HUE038598T2 (hu) | 2007-03-05 | 2018-10-29 | Om Pharma | Bakteriális extraktum légzési rendellenességekhez, és eljárás ennek elõállítására |
| DK2436700T5 (en) * | 2007-03-23 | 2018-09-03 | Wyeth Llc | BRIEF PURIFICATION PROCEDURE FOR THE PREPARATION OF STREPTOCOCCUS PNEUMONIAE-Capsule POLYACCHARIDES |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| JP5339243B2 (ja) * | 2008-04-24 | 2013-11-13 | 株式会社微生物化学研究所 | ストレプトコッカス・スイス感染症予防用ワクチン |
| WO2011005587A1 (en) * | 2009-06-24 | 2011-01-13 | University Of Dubuque | Vaccine compositions and methods of use to protect against infectious disease |
| JP5944480B2 (ja) * | 2011-03-22 | 2016-07-05 | セルム・インスティテュート・オブ・インディア・ピーブイティー．・リミテッド | 多糖を調製するための新規な方法 |
| US9400250B2 (en) | 2013-09-30 | 2016-07-26 | Han Sheng Biotech Co., Ltd. | Method for analyzing mushrooms |
| MY186874A (en) * | 2014-02-25 | 2021-08-26 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | A novel downstream process for purifying polysaccharides |
| EP2942396A1 (en) | 2014-05-07 | 2015-11-11 | Novartis AG | Polysaccharides produced by CPSC mutants |
| EP3034516A1 (en) * | 2014-12-19 | 2016-06-22 | Novartis AG | Purification of streptococcal capsular polysaccharide |
| KR102045663B1 (ko) | 2015-05-04 | 2019-11-15 | 화이자 인코포레이티드 | B군 스트렙토코쿠스 폴리사카라이드-단백질 접합체, 접합체를 생산하는 방법, 접합체를 포함하는 면역원성 조성물, 및 그의 용도 |
| WO2018104889A1 (en) * | 2016-12-06 | 2018-06-14 | Glaxosmithkline Biologicals Sa | Purification process for capsular polysaccharide |
| KR102565771B1 (ko) * | 2017-05-05 | 2023-08-10 | 세럼 인스티튜트 오브 인디아 프라이비트 리미티드 | 박테리아 협막 폴리사카라이드 기반 제제로부터의 불순물의 제거 방법 |
| JP7111799B2 (ja) * | 2017-07-05 | 2022-08-02 | インベントプライズ リミテッド ライアビリティ カンパニー | 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製 |
| SI3678654T1 (sl) | 2017-09-07 | 2024-10-30 | Merck Sharp & Dohme Llc | Pnevmokokni polisaharidi in njihova uporaba v imunogenih polisaharidnih nosilnih proteinskih konjugatih |
| FR3078977B1 (fr) | 2018-03-16 | 2023-03-17 | Biomerieux Sa | Procede d'extraction d'acides nucleiques |
| EP4232593A1 (en) * | 2020-10-22 | 2023-08-30 | Pfizer Inc. | Methods for purifying bacterial polysaccharides |
| CN117512031B (zh) * | 2023-10-16 | 2024-06-25 | 江苏金迪克生物技术股份有限公司 | 一种肺炎球菌荚膜多糖的纯化方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3523801A (en) | 1966-01-13 | 1970-08-11 | Kyowa Hakko Kogyo Kk | Process for the preparation of seasonings |
| US3577527A (en) * | 1969-01-27 | 1971-05-04 | Us Navy | Neisseria meningitidis antigen |
| US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
| US4413057A (en) | 1980-04-14 | 1983-11-01 | Merck & Co., Inc. | Group B streptococcal capsular polysaccharides |
| US4356170A (en) | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4644059A (en) * | 1982-07-06 | 1987-02-17 | Connaught Laboratories, Inc. | Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine |
| AU586857B2 (en) * | 1986-03-27 | 1989-07-27 | Swiss Serum And Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
| EP0238739B1 (en) * | 1986-03-27 | 1992-02-05 | Swiss Serum and Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5190746A (en) | 1989-05-10 | 1993-03-02 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Plaque inhibiting oligosaccharide |
| DK0504202T3 (da) | 1989-12-14 | 1995-10-02 | Ca Nat Research Council | Forbedret meningokok-polysaccharid-konjugat vaccine |
| NZ239643A (en) | 1990-09-17 | 1996-05-28 | North American Vaccine Inc | Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group. |
| ZA937034B (en) * | 1992-09-24 | 1995-06-23 | Brigham & Womens Hospital | Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines |
| US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
-
1998
- 1998-12-23 CZ CZ20002373A patent/CZ302615B6/cs not_active IP Right Cessation
- 1998-12-23 EP EP98966468.5A patent/EP1051506B2/en not_active Expired - Lifetime
- 1998-12-23 WO PCT/US1998/027375 patent/WO1999032653A1/en not_active Ceased
- 1998-12-23 KR KR1020067013976A patent/KR100757630B1/ko not_active Expired - Fee Related
- 1998-12-23 CA CA002316975A patent/CA2316975C/en not_active Expired - Lifetime
- 1998-12-23 HU HU0100623A patent/HUP0100623A3/hu unknown
- 1998-12-23 ES ES98966468T patent/ES2346022T3/es not_active Expired - Lifetime
- 1998-12-23 EP EP10005184.6A patent/EP2226336B1/en not_active Expired - Lifetime
- 1998-12-23 JP JP2000525570A patent/JP4435413B2/ja not_active Expired - Lifetime
- 1998-12-23 KR KR1020007006995A patent/KR100641490B1/ko not_active Expired - Lifetime
- 1998-12-23 US US09/221,630 patent/US6248570B1/en not_active Expired - Lifetime
- 1998-12-23 DK DK98966468.5T patent/DK1051506T4/da active
- 1998-12-23 ES ES10005184.6T patent/ES2611464T3/es not_active Expired - Lifetime
- 1998-12-23 AU AU23071/99A patent/AU754256C/en not_active Expired
- 1998-12-23 EP EP16182410.7A patent/EP3118225A1/en not_active Withdrawn
- 1998-12-23 AT AT98966468T patent/ATE468403T2/de active
- 1998-12-23 DE DE69841676T patent/DE69841676D1/de not_active Expired - Lifetime
-
2000
- 2000-06-21 NO NO20003226A patent/NO331100B1/no not_active IP Right Cessation
-
2009
- 2009-09-07 JP JP2009206304A patent/JP5144613B2/ja not_active Expired - Lifetime
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