DK1051506T4 - Fremgangsmåder til ekstraktion og isolering af bakterielle kapselpolysaccharider til anvendelse som vacciner eller bundet til proteiner som konjugatvacciner - Google Patents

Fremgangsmåder til ekstraktion og isolering af bakterielle kapselpolysaccharider til anvendelse som vacciner eller bundet til proteiner som konjugatvacciner Download PDF

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Publication number
DK1051506T4
DK1051506T4 DK98966468.5T DK98966468T DK1051506T4 DK 1051506 T4 DK1051506 T4 DK 1051506T4 DK 98966468 T DK98966468 T DK 98966468T DK 1051506 T4 DK1051506 T4 DK 1051506T4
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DK
Denmark
Prior art keywords
vaccines
extraction
polyaccharides
cps
projects
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DK98966468.5T
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Danish (da)
English (en)
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DK1051506T3 (da
Inventor
Francis Michon
Milan Blake
Original Assignee
Pfizer Ireland Pharmaceuticals
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Application filed by Pfizer Ireland Pharmaceuticals filed Critical Pfizer Ireland Pharmaceuticals
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Publication of DK1051506T3 publication Critical patent/DK1051506T3/da
Publication of DK1051506T4 publication Critical patent/DK1051506T4/da

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
DK98966468.5T 1997-12-23 1998-12-23 Fremgangsmåder til ekstraktion og isolering af bakterielle kapselpolysaccharider til anvendelse som vacciner eller bundet til proteiner som konjugatvacciner DK1051506T4 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6860897P 1997-12-23 1997-12-23
PCT/US1998/027375 WO1999032653A1 (en) 1997-12-23 1998-12-23 Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines

Publications (2)

Publication Number Publication Date
DK1051506T3 DK1051506T3 (da) 2010-09-13
DK1051506T4 true DK1051506T4 (da) 2019-10-21

Family

ID=22083630

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98966468.5T DK1051506T4 (da) 1997-12-23 1998-12-23 Fremgangsmåder til ekstraktion og isolering af bakterielle kapselpolysaccharider til anvendelse som vacciner eller bundet til proteiner som konjugatvacciner

Country Status (14)

Country Link
US (1) US6248570B1 (enExample)
EP (3) EP1051506B2 (enExample)
JP (2) JP4435413B2 (enExample)
KR (2) KR100757630B1 (enExample)
AT (1) ATE468403T2 (enExample)
AU (1) AU754256C (enExample)
CA (1) CA2316975C (enExample)
CZ (1) CZ302615B6 (enExample)
DE (1) DE69841676D1 (enExample)
DK (1) DK1051506T4 (enExample)
ES (2) ES2346022T3 (enExample)
HU (1) HUP0100623A3 (enExample)
NO (1) NO331100B1 (enExample)
WO (1) WO1999032653A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU66103A (sh) 2001-01-23 2006-05-25 Aventis Pasteur Vakcina multivalentnog konjugata meningokokalnog polisaharid-proteina
US8222232B2 (en) * 2001-02-16 2012-07-17 Cargill, Incorporated Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass
US7816514B2 (en) 2001-02-16 2010-10-19 Cargill, Incorporated Glucosamine and method of making glucosamine from microbial biomass
US6693188B2 (en) 2001-08-08 2004-02-17 Cargill Incorporated N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine
US7923437B2 (en) * 2001-02-16 2011-04-12 Cargill, Incorporated Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same
US20020115639A1 (en) * 2001-02-16 2002-08-22 Weiyu Fan Glucosamine and method of making glucosamine from microbial blomass
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
ATE419278T1 (de) * 2002-03-26 2009-01-15 Novartis Vaccines & Diagnostic Modifizierte saccharide mit verbesserter stabilität in wasser
US20040096461A1 (en) * 2002-07-30 2004-05-20 Baxter Healthcare Corporation Chimeric multivalent polysaccharide conjugate vaccines
US20060058263A1 (en) * 2002-11-01 2006-03-16 Rogers Brent D Heat pasturized liquids containing glucosamine
US20060003965A1 (en) * 2002-11-01 2006-01-05 Fosdick Lawrence D N-acetyl-d-glucosamine (nag) supplemented food products and beverages
CN102319427A (zh) 2003-01-30 2012-01-18 诺华疫苗和诊断有限公司 抗多种脑膜炎球菌血清组的可注射性疫苗
US20070020293A1 (en) * 2003-06-23 2007-01-25 Michon Francis J Vaccines against group neisseria meningitidis and meningococcal combinations thereof
GB0406013D0 (en) * 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
WO2006016161A1 (en) * 2004-08-12 2006-02-16 Lipoxen Technologies Limited Fractionation of charged polysaccharide
GB0502096D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Purification of streptococcal capsular polysaccharide
GB0502095D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
CN104815327A (zh) 2005-04-08 2015-08-05 惠氏有限责任公司 多价肺炎球菌多糖-蛋白质缀合物组合物
AU2011253684B8 (en) * 2005-04-08 2013-07-11 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CA2620416A1 (en) * 2005-08-24 2007-03-01 Novartis Vaccines And Diagnostics S.R.L. Zwitterionization of capsular saccharides
GB0522303D0 (en) 2005-11-01 2005-12-07 Chiron Srl Culture method
JP5286089B2 (ja) * 2006-01-13 2013-09-11 バクスター・インターナショナル・インコーポレイテッド ポリサッカライドを精製する方法
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
GB0605757D0 (en) * 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
US10543265B2 (en) 2006-03-22 2020-01-28 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
EP1872791A1 (en) 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
PL2115010T3 (pl) 2007-02-28 2012-07-31 Lipoxen Tech Limited Zmniejszanie zawartości endotoksyny w kwasach polisialowych
HUE038598T2 (hu) 2007-03-05 2018-10-29 Om Pharma Bakteriális extraktum légzési rendellenességekhez, és eljárás ennek elõállítására
DK2436700T5 (en) * 2007-03-23 2018-09-03 Wyeth Llc BRIEF PURIFICATION PROCEDURE FOR THE PREPARATION OF STREPTOCOCCUS PNEUMONIAE-Capsule POLYACCHARIDES
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
JP5339243B2 (ja) * 2008-04-24 2013-11-13 株式会社微生物化学研究所 ストレプトコッカス・スイス感染症予防用ワクチン
WO2011005587A1 (en) * 2009-06-24 2011-01-13 University Of Dubuque Vaccine compositions and methods of use to protect against infectious disease
JP5944480B2 (ja) * 2011-03-22 2016-07-05 セルム・インスティテュート・オブ・インディア・ピーブイティー．・リミテッド 多糖を調製するための新規な方法
US9400250B2 (en) 2013-09-30 2016-07-26 Han Sheng Biotech Co., Ltd. Method for analyzing mushrooms
MY186874A (en) * 2014-02-25 2021-08-26 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd A novel downstream process for purifying polysaccharides
EP2942396A1 (en) 2014-05-07 2015-11-11 Novartis AG Polysaccharides produced by CPSC mutants
EP3034516A1 (en) * 2014-12-19 2016-06-22 Novartis AG Purification of streptococcal capsular polysaccharide
KR102045663B1 (ko) 2015-05-04 2019-11-15 화이자 인코포레이티드 B군 스트렙토코쿠스 폴리사카라이드-단백질 접합체, 접합체를 생산하는 방법, 접합체를 포함하는 면역원성 조성물, 및 그의 용도
WO2018104889A1 (en) * 2016-12-06 2018-06-14 Glaxosmithkline Biologicals Sa Purification process for capsular polysaccharide
KR102565771B1 (ko) * 2017-05-05 2023-08-10 세럼 인스티튜트 오브 인디아 프라이비트 리미티드 박테리아 협막 폴리사카라이드 기반 제제로부터의 불순물의 제거 방법
JP7111799B2 (ja) * 2017-07-05 2022-08-02 インベントプライズ リミテッド ライアビリティ カンパニー 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製
SI3678654T1 (sl) 2017-09-07 2024-10-30 Merck Sharp & Dohme Llc Pnevmokokni polisaharidi in njihova uporaba v imunogenih polisaharidnih nosilnih proteinskih konjugatih
FR3078977B1 (fr) 2018-03-16 2023-03-17 Biomerieux Sa Procede d'extraction d'acides nucleiques
EP4232593A1 (en) * 2020-10-22 2023-08-30 Pfizer Inc. Methods for purifying bacterial polysaccharides
CN117512031B (zh) * 2023-10-16 2024-06-25 江苏金迪克生物技术股份有限公司 一种肺炎球菌荚膜多糖的纯化方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523801A (en) 1966-01-13 1970-08-11 Kyowa Hakko Kogyo Kk Process for the preparation of seasonings
US3577527A (en) * 1969-01-27 1971-05-04 Us Navy Neisseria meningitidis antigen
US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
US4413057A (en) 1980-04-14 1983-11-01 Merck & Co., Inc. Group B streptococcal capsular polysaccharides
US4356170A (en) 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4644059A (en) * 1982-07-06 1987-02-17 Connaught Laboratories, Inc. Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine
AU586857B2 (en) * 1986-03-27 1989-07-27 Swiss Serum And Vaccine Institute Berne Klebsiella capsular polysaccharide vaccine
EP0238739B1 (en) * 1986-03-27 1992-02-05 Swiss Serum and Vaccine Institute Berne Klebsiella capsular polysaccharide vaccine
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5190746A (en) 1989-05-10 1993-03-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Plaque inhibiting oligosaccharide
DK0504202T3 (da) 1989-12-14 1995-10-02 Ca Nat Research Council Forbedret meningokok-polysaccharid-konjugat vaccine
NZ239643A (en) 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
ZA937034B (en) * 1992-09-24 1995-06-23 Brigham & Womens Hospital Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines
US5811102A (en) * 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines

Also Published As

Publication number Publication date
JP4435413B2 (ja) 2010-03-17
CZ302615B6 (cs) 2011-08-03
NO20003226D0 (no) 2000-06-21
EP3118225A1 (en) 2017-01-18
EP1051506A1 (en) 2000-11-15
CZ20002373A3 (cs) 2000-12-13
KR100641490B1 (ko) 2006-10-31
JP2001526902A (ja) 2001-12-25
EP2226336A1 (en) 2010-09-08
EP1051506B1 (en) 2010-05-19
US6248570B1 (en) 2001-06-19
CA2316975C (en) 2009-03-24
JP2010011862A (ja) 2010-01-21
AU754256C (en) 2004-05-20
AU754256B2 (en) 2002-11-07
ES2346022T3 (es) 2010-10-07
DE69841676D1 (de) 2010-07-01
EP1051506B2 (en) 2019-08-21
CA2316975A1 (en) 1999-07-01
EP2226336B1 (en) 2016-10-19
NO331100B1 (no) 2011-10-03
KR100757630B1 (ko) 2007-09-10
AU2307199A (en) 1999-07-12
WO1999032653A1 (en) 1999-07-01
KR20060086978A (ko) 2006-08-01
EP1051506B8 (en) 2010-09-01
HUP0100623A2 (hu) 2001-06-28
HUP0100623A3 (en) 2003-11-28
HK1147506A1 (en) 2011-08-12
ES2611464T3 (es) 2017-05-09
JP5144613B2 (ja) 2013-02-13
WO1999032653A9 (en) 1999-10-28
KR20010033494A (ko) 2001-04-25
DK1051506T3 (da) 2010-09-13
ATE468403T2 (de) 2010-06-15

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