DE69841676D1 - Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine - Google Patents

Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine

Info

Publication number
DE69841676D1
DE69841676D1 DE69841676T DE69841676T DE69841676D1 DE 69841676 D1 DE69841676 D1 DE 69841676D1 DE 69841676 T DE69841676 T DE 69841676T DE 69841676 T DE69841676 T DE 69841676T DE 69841676 D1 DE69841676 D1 DE 69841676D1
Authority
DE
Germany
Prior art keywords
vaccine
polysaccharides
extraction
cps
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69841676T
Other languages
English (en)
Inventor
Francis Michon
Milan Blake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter Healthcare SA
Original Assignee
Baxter Healthcare SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22083630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69841676(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Healthcare SA filed Critical Baxter Healthcare SA
Application granted granted Critical
Publication of DE69841676D1 publication Critical patent/DE69841676D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
DE69841676T 1997-12-23 1998-12-23 Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine Expired - Lifetime DE69841676D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6860897P 1997-12-23 1997-12-23
PCT/US1998/027375 WO1999032653A1 (en) 1997-12-23 1998-12-23 Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines

Publications (1)

Publication Number Publication Date
DE69841676D1 true DE69841676D1 (de) 2010-07-01

Family

ID=22083630

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69841676T Expired - Lifetime DE69841676D1 (de) 1997-12-23 1998-12-23 Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine

Country Status (15)

Country Link
US (1) US6248570B1 (de)
EP (3) EP1051506B2 (de)
JP (2) JP4435413B2 (de)
KR (2) KR100641490B1 (de)
AT (1) ATE468403T2 (de)
AU (1) AU754256C (de)
CA (1) CA2316975C (de)
CZ (1) CZ302615B6 (de)
DE (1) DE69841676D1 (de)
DK (1) DK1051506T4 (de)
ES (2) ES2611464T3 (de)
HK (1) HK1147506A1 (de)
HU (1) HUP0100623A3 (de)
NO (1) NO331100B1 (de)
WO (1) WO1999032653A1 (de)

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US7816514B2 (en) 2001-02-16 2010-10-19 Cargill, Incorporated Glucosamine and method of making glucosamine from microbial biomass
US6693188B2 (en) 2001-08-08 2004-02-17 Cargill Incorporated N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine
US8222232B2 (en) * 2001-02-16 2012-07-17 Cargill, Incorporated Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass
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US20060058263A1 (en) * 2002-11-01 2006-03-16 Rogers Brent D Heat pasturized liquids containing glucosamine
US20060003965A1 (en) * 2002-11-01 2006-01-05 Fosdick Lawrence D N-acetyl-d-glucosamine (nag) supplemented food products and beverages
WO2004067030A2 (en) 2003-01-30 2004-08-12 Chiron Srl Injectable vaccines against multiple meningococcal serogroups
CA2530364C (en) * 2003-06-23 2014-03-18 Baxter International Inc. Vaccines against group y neisseria meningitidis and meningococcal combinations thereof
GB0406013D0 (en) * 2004-03-17 2004-04-21 Chiron Srl Analysis of saccharide vaccines without interference
ES2640767T3 (es) 2004-08-12 2017-11-06 Lipoxen Technologies Limited Fraccionamientodepolisacáridos cargados
GB0502095D0 (en) 2005-02-01 2005-03-09 Chiron Srl Conjugation of streptococcal capsular saccharides
GB0502096D0 (en) * 2005-02-01 2005-03-09 Chiron Srl Purification of streptococcal capsular polysaccharide
AU2011253684B8 (en) * 2005-04-08 2013-07-11 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
CN102716480B (zh) 2005-04-08 2023-03-21 惠氏有限责任公司 多价肺炎球菌多糖-蛋白质缀合物组合物
WO2007023386A2 (en) * 2005-08-24 2007-03-01 Novartis Vaccines And Diagnostics Srl Zwitterionization of capsular saccharides
GB0522303D0 (en) 2005-11-01 2005-12-07 Chiron Srl Culture method
EP1976857A4 (de) * 2006-01-13 2011-08-03 Baxter Int Verfahren zur reinigung von polysacchariden
US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
NZ572054A (en) 2006-03-22 2011-12-22 Novartis Ag Regimens for immunisation with meningococcal conjugates
GB0605757D0 (en) * 2006-03-22 2006-05-03 Chiron Srl Separation of conjugated and unconjugated components
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
EP1872791A1 (de) 2006-06-30 2008-01-02 Institut Pasteur Verwendung von Polysacchariden bakteriellen Ursprungs zur Hemmung der Bildung von Biofilmen
JP2010520320A (ja) 2007-02-28 2010-06-10 リポクセン テクノロジーズ リミテッド ポリシアル酸におけるエンドトキシンの低減
DK2114421T3 (en) 2007-03-05 2018-04-23 Om Pharma BACTERIA EXTRACTS FOR RESPIRATORY DISORDERS AND PROCEDURES FOR PREPARING THEREOF
HUE039169T2 (hu) * 2007-03-23 2018-12-28 Wyeth Llc Rövidített tisztítási eljárás Streptococcus pneumoniae tok-poliszacharidok elõállítására
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
JP5339243B2 (ja) * 2008-04-24 2013-11-13 株式会社微生物化学研究所 ストレプトコッカス・スイス感染症予防用ワクチン
WO2011005587A1 (en) * 2009-06-24 2011-01-13 University Of Dubuque Vaccine compositions and methods of use to protect against infectious disease
CA2830879C (en) * 2011-03-22 2018-10-30 Serum Institute Of India Ltd. A novel process for preparation of polysaccharides
US9400250B2 (en) 2013-09-30 2016-07-26 Han Sheng Biotech Co., Ltd. Method for analyzing mushrooms
MY186874A (en) * 2014-02-25 2021-08-26 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd A novel downstream process for purifying polysaccharides
EP2942396A1 (de) 2014-05-07 2015-11-11 Novartis AG Durch CPSC-Mutanten hergestellte Polysaccharide
EP3034516A1 (de) 2014-12-19 2016-06-22 Novartis AG Reinigung von Streptokokkenkapselpolysaccharid
IL297740A (en) 2015-05-04 2022-12-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses
US20210108002A1 (en) * 2016-12-06 2021-04-15 Glaxosmithkline Biologicals Sa Purification Process For Capsular Polysaccharide
BR112019022868A2 (pt) * 2017-05-05 2020-05-19 Serum Institute Of India Private Limited método para remoção de impurezas de preparações à base de polissacarídeo capsular bacteriano
EP3649247A4 (de) * 2017-07-05 2021-03-31 Inventprise, LLC. Reinigung von polysacchariden zur herstellung von impfstoffen unter verwendung lytischer enzyme, tangentialer strömungsfiltration und multimodaler chromatographie
CN111093650B (zh) 2017-09-07 2024-03-01 默沙东有限责任公司 肺炎球菌多糖及其在免疫原性多糖-载体蛋白缀合物中的用途
EP4232593A1 (de) * 2020-10-22 2023-08-30 Pfizer Inc. Verfahren zur reinigung von bakteriellen polysacchariden
CN117512031B (zh) * 2023-10-16 2024-06-25 江苏金迪克生物技术股份有限公司 一种肺炎球菌荚膜多糖的纯化方法

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US4258029A (en) 1979-04-23 1981-03-24 Connaught Laboratories Limited Synthetic adjuvants for stimulation of antigenic responses
US4413057A (en) 1980-04-14 1983-11-01 Merck & Co., Inc. Group B streptococcal capsular polysaccharides
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
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AU586857B2 (en) * 1986-03-27 1989-07-27 Swiss Serum And Vaccine Institute Berne Klebsiella capsular polysaccharide vaccine
EP0238739B1 (de) * 1986-03-27 1992-02-05 Swiss Serum and Vaccine Institute Berne Impfstoff des Klebsiella Kapsulpolysaccharids
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US5190746A (en) 1989-05-10 1993-03-02 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Plaque inhibiting oligosaccharide
DK0504202T3 (da) 1989-12-14 1995-10-02 Ca Nat Research Council Forbedret meningokok-polysaccharid-konjugat vaccine
NZ239643A (en) 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
ZA937034B (en) * 1992-09-24 1995-06-23 Brigham & Womens Hospital Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines
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Also Published As

Publication number Publication date
ATE468403T2 (de) 2010-06-15
DK1051506T3 (da) 2010-09-13
KR100641490B1 (ko) 2006-10-31
JP4435413B2 (ja) 2010-03-17
CA2316975A1 (en) 1999-07-01
JP5144613B2 (ja) 2013-02-13
CZ20002373A3 (cs) 2000-12-13
AU2307199A (en) 1999-07-12
KR20060086978A (ko) 2006-08-01
ES2611464T3 (es) 2017-05-09
KR20010033494A (ko) 2001-04-25
AU754256B2 (en) 2002-11-07
CA2316975C (en) 2009-03-24
JP2010011862A (ja) 2010-01-21
WO1999032653A1 (en) 1999-07-01
AU754256C (en) 2004-05-20
EP1051506B2 (de) 2019-08-21
JP2001526902A (ja) 2001-12-25
EP1051506B1 (de) 2010-05-19
EP1051506B8 (de) 2010-09-01
DK1051506T4 (da) 2019-10-21
CZ302615B6 (cs) 2011-08-03
NO331100B1 (no) 2011-10-03
EP2226336A1 (de) 2010-09-08
NO20003226D0 (no) 2000-06-21
HUP0100623A2 (hu) 2001-06-28
HK1147506A1 (zh) 2011-08-12
EP2226336B1 (de) 2016-10-19
ES2346022T3 (es) 2010-10-07
EP1051506A1 (de) 2000-11-15
US6248570B1 (en) 2001-06-19
KR100757630B1 (ko) 2007-09-10
EP3118225A1 (de) 2017-01-18
HUP0100623A3 (en) 2003-11-28
WO1999032653A9 (en) 1999-10-28

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8363 Opposition against the patent