DE69734601D1 - Zusammensetzungen von kollagenbindungsprotein und verfahren zur deren verwendungen - Google Patents
Zusammensetzungen von kollagenbindungsprotein und verfahren zur deren verwendungenInfo
- Publication number
- DE69734601D1 DE69734601D1 DE69734601T DE69734601T DE69734601D1 DE 69734601 D1 DE69734601 D1 DE 69734601D1 DE 69734601 T DE69734601 T DE 69734601T DE 69734601 T DE69734601 T DE 69734601T DE 69734601 D1 DE69734601 D1 DE 69734601D1
- Authority
- DE
- Germany
- Prior art keywords
- compositions
- binding protein
- prevention
- cna
- dna segments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 102100027287 Serpin H1 Human genes 0.000 title 1
- 108050008290 Serpin H1 Proteins 0.000 title 1
- 102000014914 Carrier Proteins Human genes 0.000 abstract 3
- 101150043616 cna gene Proteins 0.000 abstract 3
- 230000002265 prevention Effects 0.000 abstract 3
- 108091008324 binding proteins Proteins 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 208000034309 Bacterial disease carrier Diseases 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 230000010065 bacterial adhesion Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1767896P | 1996-05-16 | 1996-05-16 | |
US17678P | 1996-05-16 | ||
PCT/US1997/008210 WO1997043314A2 (en) | 1996-05-16 | 1997-05-14 | Collagen binding protein compositions and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69734601D1 true DE69734601D1 (de) | 2005-12-15 |
DE69734601T2 DE69734601T2 (de) | 2006-08-03 |
Family
ID=21783969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69734601T Expired - Fee Related DE69734601T2 (de) | 1996-05-16 | 1997-05-14 | Zusammensetzung von kollagenbindungsprotein und verfahren zu deren verwendungen |
Country Status (9)
Country | Link |
---|---|
US (2) | US6288214B1 (de) |
EP (1) | EP0950068B1 (de) |
AT (1) | ATE309271T1 (de) |
AU (1) | AU3126097A (de) |
CA (1) | CA2255669A1 (de) |
DE (1) | DE69734601T2 (de) |
DK (1) | DK0950068T3 (de) |
ES (1) | ES2252785T3 (de) |
WO (1) | WO1997043314A2 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE309271T1 (de) * | 1996-05-16 | 2005-11-15 | Texas A & M Univ Sys | Zusammensetzungen von kollagenbindungsprotein und verfahren zur deren verwendungen |
US6610293B1 (en) * | 1997-06-16 | 2003-08-26 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria |
WO2000012132A1 (en) * | 1998-08-31 | 2000-03-09 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
US6703025B1 (en) | 1998-08-31 | 2004-03-09 | Inhibitex, Inc. | Multicomponent vaccines |
US6692739B1 (en) * | 1998-08-31 | 2004-02-17 | Inhibitex, Inc. | Staphylococcal immunotherapeutics via donor selection and donor stimulation |
ES2322409T3 (es) * | 1998-08-31 | 2009-06-19 | Inhibitex, Inc. | Vacunas multicomponentes contra staphylococcus aureus. |
US20020092987A1 (en) * | 1998-09-05 | 2002-07-18 | Taehee Cho | Photo detect device using quantum dots and materialization method thereof |
CA2503110A1 (en) | 1999-05-10 | 2000-11-16 | Rebecca L. Rich | Collagen-binding proteins from enterococcal bacteria |
US6908994B1 (en) | 1999-05-10 | 2005-06-21 | The Texas A&M University System | Collagen-binding proteins from enterococcal bacteria |
AU4933799A (en) | 1999-08-02 | 2001-02-19 | E-Mark Systems Inc. | Electronic settlement system, settlement device, and terminal |
US20070077256A1 (en) * | 1999-11-19 | 2007-04-05 | Los Angeles Biomedical Research Institute | Pharmaceutical compositions and methods to vaccinate against disseminated candidiasis and other infectious agents |
AU2001256958A1 (en) | 2000-03-17 | 2001-10-03 | Inhibitex, Inc. | Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use |
GB0014907D0 (en) * | 2000-06-20 | 2000-08-09 | Univ Sheffield | Antigenic polypeptides |
ATE524195T1 (de) * | 2001-01-26 | 2011-09-15 | Inhibitex Inc | Monoklonale antikörper gegen das clfa-protein und verfahren zur verwendung bei der behandlung bzw. pr vention von infektionen |
JP2002253712A (ja) * | 2001-03-02 | 2002-09-10 | Endo Mfg Co Ltd | ゴルフクラブ |
EP1443957A4 (de) * | 2001-05-08 | 2005-10-12 | Texas A & M Univ Sys | Oberflächenproteine aus grampositiven bakterien mit hochkonservierten motiven sowie diese erkennende antikörper |
EP1395272A4 (de) | 2001-05-11 | 2005-10-26 | Texas A & M Univ Sys | Verfahren und zusammensetzungen zur hemmung der durch thrombin induzierten blutgerinnung |
CN100359327C (zh) * | 2001-06-15 | 2008-01-02 | 英希比泰克斯公司 | 识别凝血酶阴性的葡萄球菌和金黄色葡萄球菌的表面蛋白的交叉反应性单克隆抗体和多克隆抗体 |
US7115264B2 (en) * | 2001-11-05 | 2006-10-03 | Inhibitex | Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections |
US20030153026A1 (en) * | 2002-01-04 | 2003-08-14 | Javier Alarcon | Entrapped binding protein as biosensors |
US6855556B2 (en) | 2002-01-04 | 2005-02-15 | Becton, Dickinson And Company | Binding protein as biosensors |
WO2003072607A1 (en) * | 2002-02-21 | 2003-09-04 | Università Degli Studi Di Pavia | Monoclonal antibodies that are cross-reactive against bacterial collagen binding proteins |
WO2003076470A1 (en) * | 2002-03-05 | 2003-09-18 | Inhibitex, Inc. | Monoclonal and polyclonal antibodies recognizing coagulase-negative staphylococcal proteins |
AU2004220590B2 (en) * | 2003-03-07 | 2010-02-18 | Inhibitex, Inc. | Polysaccharide - Staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
WO2005124348A1 (en) * | 2004-06-09 | 2005-12-29 | Becton, Dickinson And Company | Multianalyte sensor |
EP2305294B1 (de) | 2004-09-22 | 2015-04-01 | GlaxoSmithKline Biologicals SA | Immunogene Zusammensetzung zur Verwendung zur Impfung gegen Staphylokokken |
PL1838341T3 (pl) | 2005-01-20 | 2014-04-30 | Isconova Ab | Kompozycja szczepionki obejmująca białko wiążące fibronektynę lub peptyd wiążący fibronektynę |
JP4726109B2 (ja) * | 2005-02-10 | 2011-07-20 | 昭和電工株式会社 | 皮膚外用剤、それを用いる皮膚有害微生物の付着予防方法及び増殖防止方法 |
JP2008532935A (ja) * | 2005-02-14 | 2008-08-21 | エピトピックス,リミティド ライアビリティ カンパニー | 黄色ブドウ球菌由来のポリペプチド及び使用方法 |
WO2006138627A2 (en) * | 2005-06-16 | 2006-12-28 | Inhibitex, Inc. | Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein |
JP2009502261A (ja) * | 2005-07-25 | 2009-01-29 | ナノテクノロジー ビクトリア ピーティーワイ リミテッド | マイクロアレイデバイス |
WO2007030012A2 (en) * | 2005-09-05 | 2007-03-15 | Stichting Voor De Technische Wetenscahappen | Extracellular matrix imaging |
WO2007100580A2 (en) * | 2006-02-22 | 2007-09-07 | The Texas A & M University System | Antibodies recognizing a highly expressed putative antigen of ca-mrsa and methods of use |
EP2476434A1 (de) | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Immunogene Zusammensetzung |
ES2391908T3 (es) | 2006-04-20 | 2012-11-30 | Becton,Dickinson And Company | Proteinas termoestables y procedimientos de obtención y uso de las mismas |
US20180221466A9 (en) * | 2006-06-12 | 2018-08-09 | Glaxosmithkline Biologicals S.A. | Use of alpha-toxin for treating and preventing staphylococcus infections |
CA2697538C (en) * | 2007-08-31 | 2019-02-12 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
WO2010014304A1 (en) * | 2008-07-29 | 2010-02-04 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
WO2010042481A1 (en) | 2008-10-06 | 2010-04-15 | University Of Chicago | Compositions and methods related to bacterial eap, emp, and/or adsa proteins |
AU2010204139A1 (en) | 2009-01-12 | 2011-08-11 | Novartis Ag | Cna_B domain antigens in vaccines against gram positive bacteria |
US9932373B2 (en) | 2009-03-23 | 2018-04-03 | Epitopix, Llc | Polypeptides and immunizing compositions containing gram positive polypeptides and methods of use |
JP5747370B2 (ja) * | 2009-03-31 | 2015-07-15 | 国立大学法人浜松医科大学 | 高病原性口腔細菌の高感度検出法 |
KR20170102039A (ko) | 2009-04-03 | 2017-09-06 | 유니버시티 오브 시카고 | 단백질 A(SpA) 변이체와 관련된 조성물 및 방법 |
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
EP2284193A1 (de) * | 2009-08-10 | 2011-02-16 | Kenta Biotech AG | Menschlicher monoklonaler Antikörper gegen S.aureus aus Alpha-Toxin und seine Verwendung bei der Behandlung oder Vorbeugung der Abszessbildung |
US9297811B2 (en) | 2010-03-10 | 2016-03-29 | National University Corporation Hamamatsu University School Of Medicine | Production of enteritis evoking causal factor by highly pathogenic oral bacteria and high sensitivity detection method therefor |
US8808699B2 (en) | 2010-04-05 | 2014-08-19 | The University Of Chicago | Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response |
AU2011274367B2 (en) | 2010-07-02 | 2015-04-23 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
WO2012034067A1 (en) | 2010-09-09 | 2012-03-15 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
US8182842B1 (en) | 2010-11-10 | 2012-05-22 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Physico-chemical-managed killing of penicillin-resistant static and growing gram-positive and gram-negative vegetative bacteria |
US8440618B2 (en) * | 2011-01-19 | 2013-05-14 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Composition for the attachment of implants to collagen or other components of biological tissue |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
JP2014521605A (ja) | 2011-07-22 | 2014-08-28 | ノバダイム セラピューティクス, インコーポレイテッド | Staphylococcusaureusに対してワクチン接種するための方法および組成物 |
CA2845259A1 (en) | 2011-08-15 | 2013-02-21 | The University Of Chicago | Compositions and methods related to antibodies to staphylococcal protein a |
JP6251730B2 (ja) | 2012-04-26 | 2017-12-20 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | 黄色ブドウ球菌(staphylococcusaureus)疾患の間にコアグラーゼ活性を中和する抗体に関連した組成物および方法 |
NZ702285A (en) | 2012-04-26 | 2016-07-29 | Univ Chicago | Staphylococcal coagulase antigens and methods of their use |
MD20150098A2 (ro) | 2013-03-15 | 2016-02-29 | Los Angeles Biomedical Research Institute At Harbor - Ucla Medical Center | Compoziţii şi procedee de tratare a agenţilor patogeni fungici şi bacterieni |
US11531028B2 (en) | 2013-05-10 | 2022-12-20 | Nordic Bioscience A/S | Collagen type X alpha-1 assay |
US10260111B1 (en) | 2014-01-20 | 2019-04-16 | Brett Eric Etchebarne | Method of detecting sepsis-related microorganisms and detecting antibiotic-resistant sepsis-related microorganisms in a fluid sample |
WO2017087838A2 (en) * | 2015-11-19 | 2017-05-26 | George Mason University | Dual inhibitory action peptidomimetic inhibitor for il-33 and il-1beta |
EP3426287A4 (de) | 2016-03-09 | 2020-03-11 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | Verfahren und kits zur verwendung bei der vorbeugung und behandlung von vulvovaginaler candidose |
EP3870598A1 (de) | 2018-10-23 | 2021-09-01 | Dragonfly Therapeutics, Inc. | Heterodimere fc-kondensierte proteine |
KR20220107166A (ko) | 2019-10-02 | 2022-08-02 | 얀센 백신스 앤드 프리벤션 비.브이. | 스타필로코커스 펩티드 및 사용 방법 |
IL297495A (en) | 2020-04-22 | 2022-12-01 | Dragonfly Therapeutics Inc | Dosing regimen, formulation and manufacturing process for fc fusion heterodimeric proteins |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5189015A (en) * | 1984-05-30 | 1993-02-23 | Alfa-Laval Agri International Ab | Method for prophylactic treatment of the colonization of a Staphylococcus aureus bacterial strain by bacterial cell surface protein with fibronectin and fibrinogen binding ability |
GB8516421D0 (en) | 1985-06-28 | 1985-07-31 | Biotechnology Interface Ltd | Fibronectins |
US5300434A (en) * | 1987-11-06 | 1994-04-05 | Washington Research Foundation | Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide |
US5270030A (en) * | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
SE9003374D0 (sv) | 1990-10-22 | 1990-10-22 | Alfa Laval Agri Int | A collagen binding protein as well as its preparation |
US5851794A (en) * | 1990-10-22 | 1998-12-22 | Alfa Laval Ab | Collagen binding protein as well as its preparation |
US5980908A (en) * | 1991-12-05 | 1999-11-09 | Alfa Laval Ab | Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment |
US5491130A (en) | 1992-11-10 | 1996-02-13 | The United States Of America As Represented By The Department Of Health And Human Services | Peptide inhibitors of fibronectin and related collagen-binding proteins |
US5624904A (en) * | 1993-11-17 | 1997-04-29 | Massachusetts Institute Of Technology | Method for treating gram positive septicemia |
US6008341A (en) * | 1994-08-22 | 1999-12-28 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | S. aureus fibrinogen binding protein gene |
US5858709A (en) * | 1996-10-15 | 1999-01-12 | Smithkline Beecham P.L.C. | Fibronectin binding protein B compounds |
US6013482A (en) * | 1996-10-15 | 2000-01-11 | Smithkline Beecham Plc | Cell surface protein compounds |
ATE309271T1 (de) * | 1996-05-16 | 2005-11-15 | Texas A & M Univ Sys | Zusammensetzungen von kollagenbindungsprotein und verfahren zur deren verwendungen |
US5789171A (en) * | 1996-06-20 | 1998-08-04 | Board Of Trustees Of The University Of Arkansas | Use of cna, fnba, fnbb, and hlb, gene probes for the strain-specific identification of Staphylococcus aureus |
-
1997
- 1997-05-14 AT AT97926514T patent/ATE309271T1/de not_active IP Right Cessation
- 1997-05-14 ES ES97926514T patent/ES2252785T3/es not_active Expired - Lifetime
- 1997-05-14 CA CA002255669A patent/CA2255669A1/en not_active Abandoned
- 1997-05-14 US US08/856,253 patent/US6288214B1/en not_active Expired - Fee Related
- 1997-05-14 DE DE69734601T patent/DE69734601T2/de not_active Expired - Fee Related
- 1997-05-14 WO PCT/US1997/008210 patent/WO1997043314A2/en active IP Right Grant
- 1997-05-14 EP EP97926514A patent/EP0950068B1/de not_active Expired - Lifetime
- 1997-05-14 DK DK97926514T patent/DK0950068T3/da active
- 1997-05-14 AU AU31260/97A patent/AU3126097A/en not_active Abandoned
-
2001
- 2001-03-22 US US09/813,820 patent/US20020102262A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6288214B1 (en) | 2001-09-11 |
AU3126097A (en) | 1997-12-05 |
EP0950068A2 (de) | 1999-10-20 |
WO1997043314A2 (en) | 1997-11-20 |
ATE309271T1 (de) | 2005-11-15 |
WO1997043314A3 (en) | 1997-12-24 |
DK0950068T3 (da) | 2006-02-13 |
CA2255669A1 (en) | 1997-11-20 |
EP0950068B1 (de) | 2005-11-09 |
ES2252785T3 (es) | 2006-05-16 |
DE69734601T2 (de) | 2006-08-03 |
US20020102262A1 (en) | 2002-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69734601D1 (de) | Zusammensetzungen von kollagenbindungsprotein und verfahren zur deren verwendungen | |
RU94046367A (ru) | Днк, хозяйская клетка, способ получения белка, белок, фармацевтический препарат, антитело, применение антитела | |
DE69032484T4 (de) | Zusammensetzungen und deren verwendung zur förderung der immunopotentiation | |
DE60130468D1 (de) | Zusammensetzungen und verfahren zur behandlung von chlamydia-infektionen | |
CA2340304A1 (en) | Multicomponent vaccines | |
DE69934967D1 (de) | Verfahren zur verminderung der immunogenität von proteinen | |
GEP20022695B (en) | Moraxella Catarrhalis Outer Membrane Protein-106 Polypeptide, Gene Sequence and Uses Thereof | |
NZ524888A (en) | Nucleic acids and proteins from streptococcus groups A & B | |
ATE461709T1 (de) | Choline-bindende proteine derivate aus pneumokoken als impfstoff | |
ATE251464T1 (de) | Verwendung natriuretischer peptide als antibiotisch wirksame substanzen zur behandlung von bakteriellen infektionen | |
WO1998008542A3 (en) | Compounds and methods for treatment and diagnosis of mycobacterial infections | |
ATE17082T1 (de) | Verfahren zur herstellung von polysaccharidprotein-komplexenaus bakterienhuellen, die hergestellten produkte und dieselben enthaltende immunogenische zusammensetzungen. | |
EA200000860A1 (ru) | Выделенный полинуклеотид (варианты), полинуклеотид (варианты), вектор (варианты), клетка-хозяин (варианты), выделенный полипептид (варианты), способ его получения (варианты), вакцинная композиция (варианты), способ терапевтического или профилактического лечения стрептококковой бактериальной инфекции у животного (варианты), применение (варианты) | |
PT750672E (pt) | Sequencias de adn para metaloproteases matriciais, sua preparacao e utilizacao. | |
BR0010155A (pt) | Proteìnas isolada, e quimérica, composição, molécula de ácido nucleico, plasmìdeo, vacina recombinante ou vacina atenuada, composição de vacina recombinante ou composição de vacina atenuada, composição farmacêutica, métodos de imunizar um indivìduo contra um imunógeno, proteìna não-cd80 isolada, molécula de ácido nucleico, e, método de imunossuprimir um indivìduo | |
DE69841073D1 (de) | Fibronektinbindungsprotein abgeleitete peptide, die nicht an fibronektin binden, antikörper dagegen und therapeutische anwendung | |
ATE237691T1 (de) | Rekombinantes pockenvirus der infektiösen peritonitis der katze, dessen zusammensetzungen und methoden zur herstellung und verwendung | |
WO2001040313A3 (en) | Feline immunoregulatory proteins, nucleic acid molecules, and uses thereof | |
RU94040393A (ru) | Синтетические пептиды для вакцины против краснухи | |
DE60035485D1 (de) | IDENTIFIZIERUNG VON SPEZIFISCHEN DIFFERENZIELL EXPRIMIERTEN ANTIGENEN AUS MYCOBACTERIUM UND MEDIZINISCHE VERWENDUNG DER MYCOBAKTERIUMPROTEINE Rv0068 UND Rv3407 | |
DE69833568D1 (de) | Isolierte stämme von staphylococcus aureus und daraus hergestellte impfstoffe | |
FR2792639B1 (fr) | Nouveaux immunogenes anti-vih (toxoides), nouveaux procedes de preparation et application a la prevention et au traitement du sida | |
ATE401349T1 (de) | Monoklonale antikörper gegen das map-protein und verfahren zu dessen anwendung bei der behandlung bzw. prävention von infektionen | |
TH64256A3 (th) | องค์ประกอบของโปรตีนที่ถูกทำให้เสถียร | |
TH14996EX (th) | วัคซีนป้องกันโรคติดเชื้อสเตร็ปโตคอคคัส ซูอิส |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |