ATE468403T2 - Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine - Google Patents

Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine Download PDF

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Publication number
ATE468403T2
ATE468403T2 AT98966468T AT98966468T ATE468403T2 AT E468403 T2 ATE468403 T2 AT E468403T2 AT 98966468 T AT98966468 T AT 98966468T AT 98966468 T AT98966468 T AT 98966468T AT E468403 T2 ATE468403 T2 AT E468403T2
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AT
Austria
Prior art keywords
vaccine
extraction
cps
proteins
isolation
Prior art date
Application number
AT98966468T
Other languages
English (en)
Inventor
Francis Michon
Milan Blake
Original Assignee
Baxter Healthcare Sa
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Application filed by Baxter Healthcare Sa filed Critical Baxter Healthcare Sa
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Publication of ATE468403T2 publication Critical patent/ATE468403T2/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
AT98966468T 1997-12-23 1998-12-23 Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine ATE468403T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6860897P 1997-12-23 1997-12-23
PCT/US1998/027375 WO1999032653A1 (en) 1997-12-23 1998-12-23 Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines

Publications (1)

Publication Number Publication Date
ATE468403T2 true ATE468403T2 (de) 2010-06-15

Family

ID=22083630

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98966468T ATE468403T2 (de) 1997-12-23 1998-12-23 Verfahren zur extraktion und isolierung von bakteriellen hüllpolysacchariden zur verwendung als vakzine oder, an proteine gekoppelt, als konjugierte vakzine

Country Status (15)

Country Link
US (1) US6248570B1 (de)
EP (3) EP3118225A1 (de)
JP (2) JP4435413B2 (de)
KR (2) KR100757630B1 (de)
AT (1) ATE468403T2 (de)
AU (1) AU754256C (de)
CA (1) CA2316975C (de)
CZ (1) CZ302615B6 (de)
DE (1) DE69841676D1 (de)
DK (1) DK1051506T4 (de)
ES (2) ES2611464T3 (de)
HK (1) HK1147506A1 (de)
HU (1) HUP0100623A3 (de)
NO (1) NO331100B1 (de)
WO (1) WO1999032653A1 (de)

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US8222232B2 (en) * 2001-02-16 2012-07-17 Cargill, Incorporated Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass
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AU2011253684B8 (en) * 2005-04-08 2013-07-11 Wyeth Llc Multivalent pneumococcal polysaccharide-protein conjugate composition
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US10828361B2 (en) 2006-03-22 2020-11-10 Glaxosmithkline Biologicals Sa Regimens for immunisation with meningococcal conjugates
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SI2004225T1 (sl) 2006-03-22 2012-08-31 Novartis Ag Reĺ˝imi za imunizacijo z meningokoknimi konjugati
US8808707B1 (en) 2006-05-08 2014-08-19 Wyeth Llc Pneumococcal dosing regimen
EP1872791A1 (de) * 2006-06-30 2008-01-02 Institut Pasteur Verwendung von Polysacchariden bakteriellen Ursprungs zur Hemmung der Bildung von Biofilmen
DK2115010T3 (da) 2007-02-28 2012-02-06 Lipoxen Technologies Ltd Mindskelse af endotoksin i polysialinsyrer
PL2114421T3 (pl) 2007-03-05 2018-07-31 Om Pharma Ekstrakt bakteryjny do stosowania względem zaburzeń oddechowych i sposób jego wytwarzania
CA2681570C (en) * 2007-03-23 2016-05-03 Wyeth Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides
GB0818453D0 (en) 2008-10-08 2008-11-12 Novartis Ag Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom
JP5339243B2 (ja) * 2008-04-24 2013-11-13 株式会社微生物化学研究所 ストレプトコッカス・スイス感染症予防用ワクチン
US8647640B2 (en) * 2009-06-24 2014-02-11 Richard E. COWART Vaccine compositions and methods of use to protect against infectious disease
JP5944480B2 (ja) * 2011-03-22 2016-07-05 セルム・インスティテュート・オブ・インディア・ピーブイティー．・リミテッド 多糖を調製するための新規な方法
US9400250B2 (en) 2013-09-30 2016-07-26 Han Sheng Biotech Co., Ltd. Method for analyzing mushrooms
MY186874A (en) * 2014-02-25 2021-08-26 Msd Wellcome Trust Hilleman Laboratories Pvt Ltd A novel downstream process for purifying polysaccharides
EP2942396A1 (de) 2014-05-07 2015-11-11 Novartis AG Durch CPSC-Mutanten hergestellte Polysaccharide
EP3034516A1 (de) * 2014-12-19 2016-06-22 Novartis AG Reinigung von Streptokokkenkapselpolysaccharid
IL297740A (en) * 2015-05-04 2022-12-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses
WO2018104889A1 (en) * 2016-12-06 2018-06-14 Glaxosmithkline Biologicals Sa Purification process for capsular polysaccharide
EA201992636A1 (ru) * 2017-05-05 2020-04-17 Серум Инститьют Оф Индия Прайват Лимитед Способ удаления примесей из препаратов на основе бактериальных капсулярных полисахаридов
JP7111799B2 (ja) * 2017-07-05 2022-08-02 インベントプライズ リミテッド ライアビリティ カンパニー 溶菌酵素、接線流濾過、及びマルチモードクロマトグラフィを用いたワクチン生産のための多糖精製
DK3678654T3 (da) 2017-09-07 2024-09-02 Merck Sharp & Dohme Llc Pneumokokpolysaccharider og anvendelse deraf i immunogene polysaccharid-bærerprotein-konjugater
JP2023546446A (ja) * 2020-10-22 2023-11-02 ファイザー・インク 細菌多糖を精製する方法
CN117512031B (zh) * 2023-10-16 2024-06-25 江苏金迪克生物技术股份有限公司 一种肺炎球菌荚膜多糖的纯化方法

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Also Published As

Publication number Publication date
EP3118225A1 (de) 2017-01-18
CZ20002373A3 (cs) 2000-12-13
KR100757630B1 (ko) 2007-09-10
KR20010033494A (ko) 2001-04-25
EP1051506B8 (de) 2010-09-01
JP2010011862A (ja) 2010-01-21
CA2316975A1 (en) 1999-07-01
HUP0100623A3 (en) 2003-11-28
ES2611464T3 (es) 2017-05-09
KR20060086978A (ko) 2006-08-01
JP5144613B2 (ja) 2013-02-13
EP2226336A1 (de) 2010-09-08
CA2316975C (en) 2009-03-24
AU2307199A (en) 1999-07-12
WO1999032653A1 (en) 1999-07-01
HUP0100623A2 (hu) 2001-06-28
JP2001526902A (ja) 2001-12-25
EP2226336B1 (de) 2016-10-19
AU754256C (en) 2004-05-20
JP4435413B2 (ja) 2010-03-17
HK1147506A1 (zh) 2011-08-12
DE69841676D1 (de) 2010-07-01
DK1051506T4 (da) 2019-10-21
EP1051506A1 (de) 2000-11-15
EP1051506B1 (de) 2010-05-19
WO1999032653A9 (en) 1999-10-28
EP1051506B2 (de) 2019-08-21
NO20003226D0 (no) 2000-06-21
KR100641490B1 (ko) 2006-10-31
DK1051506T3 (da) 2010-09-13
CZ302615B6 (cs) 2011-08-03
AU754256B2 (en) 2002-11-07
ES2346022T3 (es) 2010-10-07
NO331100B1 (no) 2011-10-03
US6248570B1 (en) 2001-06-19

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