JP2001526242A5 - - Google Patents
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- Publication number
- JP2001526242A5 JP2001526242A5 JP2000525131A JP2000525131A JP2001526242A5 JP 2001526242 A5 JP2001526242 A5 JP 2001526242A5 JP 2000525131 A JP2000525131 A JP 2000525131A JP 2000525131 A JP2000525131 A JP 2000525131A JP 2001526242 A5 JP2001526242 A5 JP 2001526242A5
- Authority
- JP
- Japan
- Prior art keywords
- ifn
- type
- ifnar
- biological activity
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014150 Interferons Human genes 0.000 description 65
- 108010050904 Interferons Proteins 0.000 description 65
- 229940079322 interferon Drugs 0.000 description 65
- 101000852870 Homo sapiens Interferon alpha/beta receptor 1 Proteins 0.000 description 47
- 102100036714 Interferon alpha/beta receptor 1 Human genes 0.000 description 43
- 230000004071 biological effect Effects 0.000 description 32
- 108091028043 Nucleic acid sequence Proteins 0.000 description 18
- 238000000034 method Methods 0.000 description 13
- 230000000295 complement effect Effects 0.000 description 9
- 239000012634 fragment Substances 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 102000006992 Interferon-alpha Human genes 0.000 description 8
- 108010047761 Interferon-alpha Proteins 0.000 description 8
- 102000012740 beta Adrenergic Receptors Human genes 0.000 description 8
- 108010079452 beta Adrenergic Receptors Proteins 0.000 description 8
- 108090000765 processed proteins & peptides Proteins 0.000 description 8
- 102000002227 Interferon Type I Human genes 0.000 description 6
- 108010014726 Interferon Type I Proteins 0.000 description 6
- 108020001507 fusion proteins Proteins 0.000 description 6
- 102000037865 fusion proteins Human genes 0.000 description 6
- 102000054261 human IFNAR1 Human genes 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 229920001184 polypeptide Polymers 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 101000852865 Homo sapiens Interferon alpha/beta receptor 2 Proteins 0.000 description 3
- 102100036718 Interferon alpha/beta receptor 2 Human genes 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 238000012258 culturing Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6829597P | 1997-12-19 | 1997-12-19 | |
| US60/068,295 | 1997-12-19 | ||
| PCT/US1998/026926 WO1999032141A1 (en) | 1997-12-19 | 1998-12-18 | Ifnar2/ifn complex |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001526242A JP2001526242A (ja) | 2001-12-18 |
| JP2001526242A5 true JP2001526242A5 (https=) | 2006-01-19 |
| JP4601163B2 JP4601163B2 (ja) | 2010-12-22 |
Family
ID=22081665
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525131A Expired - Fee Related JP4601163B2 (ja) | 1997-12-19 | 1998-12-18 | Ｉｆｎａｒ２／ｉｆｎ複合体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6372207B1 (https=) |
| EP (1) | EP1037658B1 (https=) |
| JP (1) | JP4601163B2 (https=) |
| KR (1) | KR100593981B1 (https=) |
| CN (1) | CN1241638C (https=) |
| AR (1) | AR020315A1 (https=) |
| AT (1) | ATE218362T1 (https=) |
| AU (1) | AU755078B2 (https=) |
| BG (1) | BG64920B1 (https=) |
| BR (1) | BR9813753A (https=) |
| CA (1) | CA2311648C (https=) |
| DE (1) | DE69805844T2 (https=) |
| DK (1) | DK1037658T3 (https=) |
| EA (1) | EA003635B1 (https=) |
| EE (1) | EE200000355A (https=) |
| ES (1) | ES2174530T3 (https=) |
| HU (1) | HUP0100456A3 (https=) |
| IL (2) | IL136855A0 (https=) |
| NO (1) | NO20002691L (https=) |
| NZ (1) | NZ504771A (https=) |
| PL (1) | PL197568B1 (https=) |
| PT (1) | PT1037658E (https=) |
| SK (1) | SK9222000A3 (https=) |
| TR (1) | TR200001961T2 (https=) |
| UA (1) | UA74132C2 (https=) |
| WO (1) | WO1999032141A1 (https=) |
| ZA (1) | ZA9811634B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL122818A0 (en) * | 1997-07-10 | 1998-08-16 | Yeda Res & Dev | Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof |
| AUPP670698A0 (en) * | 1998-10-23 | 1998-11-19 | Monash University | A method of regulation |
| US7138379B2 (en) * | 2000-07-26 | 2006-11-21 | Schering Aktiengesellschaft | Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons |
| IL147414A0 (en) | 2001-12-31 | 2002-08-14 | Yeda Res & Dev | Ifnar2 mutants, their production and use |
| US20040175359A1 (en) * | 2002-11-12 | 2004-09-09 | Desjarlais John Rudolph | Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity |
| AU2004266969B2 (en) * | 2003-08-25 | 2010-02-25 | Taniguchi, Tadatsugu | Interferon-beta composite |
| CN100400664C (zh) * | 2005-09-06 | 2008-07-09 | 中国人民解放军第四军医大学 | 肿瘤血管导向肽与人干扰素α-2b的融合蛋白的制备方法 |
| EP2091568A2 (en) | 2006-10-31 | 2009-08-26 | East Carolina University | Fusion proteins comprising a anti-inflammatory cytokine and an antigen for treatment of immune disorders |
| GB0715383D0 (en) * | 2007-08-08 | 2007-09-19 | Asterion Ltd | Interferon |
| GB0815216D0 (en) * | 2008-08-21 | 2008-09-24 | Asterion Ltd | Interleukin |
| CA2757287C (en) | 2009-03-31 | 2019-09-10 | East Carolina University | Cytokines and neuroantigens for treatment of immune disorders |
| KR101293363B1 (ko) * | 2011-02-28 | 2013-08-05 | 성균관대학교산학협력단 | 인터페론 수용체 유전자를 포함하는 조류독감 예방용 조성물 |
| KR20150128849A (ko) * | 2013-03-15 | 2015-11-18 | 얀센 바이오테크 인코포레이티드 | 인터페론 알파 및 오메가 항체 길항제 |
| LT6164B (lt) | 2013-10-15 | 2015-06-25 | Uab Biotechnologinės Farmacijos Centras "Biotechpharma" | Sulieti interferono-alfa 5 baltymai su kitu citokinu ir jų gamybos būdas |
| CA3029627A1 (en) | 2016-07-01 | 2018-01-04 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| JP2020528878A (ja) * | 2017-06-20 | 2020-10-01 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | がん治療用インターフェロンプロドラッグ |
| CA3073537A1 (en) | 2017-08-22 | 2019-02-28 | Sanabio, Llc | Soluble interferon receptors and uses thereof |
| CN112646783B (zh) * | 2020-12-30 | 2023-12-01 | 广州医科大学附属市八医院 | 表达基因、经基因修饰的受精卵的构建方法和小鼠模型的构建方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106591A (en) | 1992-09-03 | 2008-03-20 | Yeda Res & Dev | Interferon alpha/beta binding protein, its preparation and pharmaceutical compositions containing it |
| US5821078A (en) * | 1992-09-03 | 1998-10-13 | Yeda Research And Development Co. Ltd. | Nucleic acid encoding interferon-α/β binding protein |
| IL107378A (en) * | 1993-10-24 | 2005-05-17 | Yeda Res & Dev | SOLUBLE INTERFERON alpha-RECEPTOR, ITS PREPARATION AND USE |
-
1998
- 1998-12-18 NZ NZ504771A patent/NZ504771A/xx unknown
- 1998-12-18 WO PCT/US1998/026926 patent/WO1999032141A1/en not_active Ceased
- 1998-12-18 PT PT98964071T patent/PT1037658E/pt unknown
- 1998-12-18 PL PL341423A patent/PL197568B1/pl not_active IP Right Cessation
- 1998-12-18 ZA ZA9811634A patent/ZA9811634B/xx unknown
- 1998-12-18 DK DK98964071T patent/DK1037658T3/da active
- 1998-12-18 UA UA2000074350A patent/UA74132C2/uk unknown
- 1998-12-18 US US09/215,212 patent/US6372207B1/en not_active Expired - Lifetime
- 1998-12-18 KR KR1020007006160A patent/KR100593981B1/ko not_active Expired - Fee Related
- 1998-12-18 CN CNB988123924A patent/CN1241638C/zh not_active Expired - Fee Related
- 1998-12-18 HU HU0100456A patent/HUP0100456A3/hu unknown
- 1998-12-18 DE DE69805844T patent/DE69805844T2/de not_active Expired - Lifetime
- 1998-12-18 SK SK922-2000A patent/SK9222000A3/sk unknown
- 1998-12-18 EE EEP200000355A patent/EE200000355A/xx unknown
- 1998-12-18 EA EA200000685A patent/EA003635B1/ru not_active IP Right Cessation
- 1998-12-18 BR BR9813753-0A patent/BR9813753A/pt not_active Application Discontinuation
- 1998-12-18 TR TR2000/01961T patent/TR200001961T2/xx unknown
- 1998-12-18 AR ARP980106515A patent/AR020315A1/es active IP Right Grant
- 1998-12-18 AU AU19269/99A patent/AU755078B2/en not_active Ceased
- 1998-12-18 EP EP98964071A patent/EP1037658B1/en not_active Expired - Lifetime
- 1998-12-18 JP JP2000525131A patent/JP4601163B2/ja not_active Expired - Fee Related
- 1998-12-18 IL IL13685598A patent/IL136855A0/xx active IP Right Grant
- 1998-12-18 CA CA2311648A patent/CA2311648C/en not_active Expired - Fee Related
- 1998-12-18 AT AT98964071T patent/ATE218362T1/de not_active IP Right Cessation
- 1998-12-18 ES ES98964071T patent/ES2174530T3/es not_active Expired - Lifetime
-
2000
- 2000-05-25 NO NO20002691A patent/NO20002691L/no not_active Application Discontinuation
- 2000-06-15 BG BG104539A patent/BG64920B1/bg unknown
- 2000-06-18 IL IL136855A patent/IL136855A/en not_active IP Right Cessation
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