|
WO1985000831A1
(en)
|
1983-08-10 |
1985-02-28 |
Amgen |
Microbial expression of insulin-like growth factor
|
|
EP0394827A1
(en)
|
1989-04-26 |
1990-10-31 |
F. Hoffmann-La Roche Ag |
Chimaeric CD4-immunoglobulin polypeptides
|
|
US5155038A
(en)
|
1990-02-22 |
1992-10-13 |
W. R. Grace & Co.-Conn. |
Use of thrombospondin to promote wound healing
|
|
WO1991014438A1
(en)
|
1990-03-20 |
1991-10-03 |
The Trustees Of Columbia University In The City Of New York |
Chimeric antibodies with receptor binding ligands in place of their constant region
|
|
US5061620A
(en)
|
1990-03-30 |
1991-10-29 |
Systemix, Inc. |
Human hematopoietic stem cell
|
|
SE9101840L
(sv)
|
1991-06-14 |
1992-12-15 |
Kabi Pharmacia |
Ny medicinsk anvaendning
|
|
AU2368892A
(en)
|
1991-07-29 |
1993-03-02 |
British Bio-Technology Limited |
Igf-ii analogues
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
DK0661990T3
(da)
|
1992-08-26 |
2002-06-17 |
Celtrix Pharma |
Fremgangsmåde til systemisk behandling af kataboliske tilstande og systemisk vævsbeskadigelse
|
|
US5843780A
(en)
|
1995-01-20 |
1998-12-01 |
Wisconsin Alumni Research Foundation |
Primate embryonic stem cells
|
|
US5622932A
(en)
|
1995-05-05 |
1997-04-22 |
Eli Lilly And Company |
IGF-1 superagonists
|
|
GB9608130D0
(en)
|
1996-04-19 |
1996-06-26 |
Univ Sheffield |
Adam proteins and uses thereof
|
|
EP2213743A1
(en)
|
2000-04-12 |
2010-08-04 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
TWI233361B
(en)
|
2001-04-13 |
2005-06-01 |
Gen Hospital Corp |
Methods of preventing UVB-induced skin damage
|
|
US20030072761A1
(en)
|
2001-10-16 |
2003-04-17 |
Lebowitz Jonathan |
Methods and compositions for targeting proteins across the blood brain barrier
|
|
CN101172091B
(zh)
|
2007-09-25 |
2011-04-27 |
北京美福源生物医药科技有限公司 |
含人血清白蛋白与皮肤细胞生长因子的融合蛋白护肤产品制备工艺和用途
|
|
US7355018B2
(en)
|
2003-09-30 |
2008-04-08 |
Regeneron Pharmaceuticals, Inc. |
Modified IGF1 polypeptides with increased stability and potency
|
|
US7837993B2
(en)
|
2004-03-19 |
2010-11-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and compositions for regeneration of aged skeletal muscle tissues
|
|
JP4988599B2
(ja)
|
2005-01-07 |
2012-08-01 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Igf−1融合ポリペプチドおよびその治療的使用
|
|
DE602006017071D1
(de)
|
2005-01-25 |
2010-11-04 |
Five Prime Therapeutics Inc |
Zusammensetzungen und verfahren zur behandlung von herzkrankheiten
|
|
US7521211B2
(en)
|
2005-04-05 |
2009-04-21 |
Regeneron Pharmaceuticals, Inc |
IGF-1 and IGF-2 chimeric polypeptides and therapeutic uses thereof
|
|
WO2007146038A2
(en)
*
|
2006-06-07 |
2007-12-21 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
US9226965B2
(en)
|
2007-10-05 |
2016-01-05 |
U.S. Department Of Veterans Affairs |
Method and composition for treating heart failure
|
|
JP5627571B2
(ja)
|
2008-05-07 |
2014-11-19 |
バイオマリン ファーマシューティカル インコーポレイテッド |
リソソーム標的化ペプチドおよびその使用
|
|
KR20100119437A
(ko)
|
2009-04-30 |
2010-11-09 |
충북대학교 산학협력단 |
인슐린 유사 성장 인자 ⅱ를 이용하여 세포 분화를 조절하는 방법
|
|
WO2011028952A1
(en)
*
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
|
PT3103469T
(pt)
|
2010-06-25 |
2021-03-04 |
Shire Human Genetic Therapies |
Administração de agentes terapêuticos no snc
|
|
WO2012037687A1
(en)
|
2010-09-23 |
2012-03-29 |
Angiochem Inc. |
Therapeutic polypeptides and uses thereof
|
|
WO2012140650A2
(en)
|
2011-04-12 |
2012-10-18 |
Hepacore Ltd. |
Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
|
|
CN110947002A
(zh)
|
2012-05-01 |
2020-04-03 |
约翰霍普金斯大学 |
治疗或预防骨关节炎的组合物和方法
|
|
EP2851429B1
(en)
|
2012-05-18 |
2019-07-24 |
Adda Biotech Inc. |
Protein and protein conjugate for diabetes treatment, and applications thereof
|
|
WO2014082080A2
(en)
|
2012-11-26 |
2014-05-30 |
Callidus Biopharma, Inc. |
Methods for coupling targeting peptides onto recombinant lysosomal enzymes for improved treatments of lysosomal storage diseases
|
|
ES2729997T3
(es)
|
2012-11-27 |
2019-11-07 |
Biomarin Pharm Inc |
Proteínas de fusión terapéuticas dirigidas de enzima lisosómica y usos de las mismas
|
|
PL2935320T3
(pl)
|
2012-12-18 |
2020-03-31 |
Novartis Ag |
Stabilizowane polipeptydy insulinopodobnego czynnika wzrostu
|
|
US9605084B2
(en)
*
|
2013-03-15 |
2017-03-28 |
Xencor, Inc. |
Heterodimeric proteins
|
|
WO2014152440A2
(en)
|
2013-03-15 |
2014-09-25 |
Trustees Of Boston University |
Polymorphism of thrombospondin-1 as a biomarker for susceptibility to dry eye
|
|
US9758763B2
(en)
|
2013-05-29 |
2017-09-12 |
The Regents Of The University Of California |
Methods and compositions for somatic cell proliferation and viability
|
|
US20160271265A1
(en)
|
2013-10-02 |
2016-09-22 |
Novartis Ag |
Insulin-like growth factor mimetics for use in therapy
|
|
US10265372B2
(en)
|
2014-08-12 |
2019-04-23 |
The Regents Of The University Of California |
Molecular composition for enhancing and rejuvenating maintenance and repair of mammalian tissues
|
|
CA2964857A1
(en)
|
2014-10-20 |
2016-04-28 |
Nestec S.A. |
Methods for prediction of anti-tnf alpha drug levels and autoantibody formation
|
|
CA3183289A1
(en)
|
2015-09-08 |
2017-03-16 |
Jcr Pharmaceuticals Co., Ltd. |
Novel human serum albumin mutant
|
|
CN108367048B
(zh)
|
2015-10-02 |
2022-08-12 |
银溪制药股份有限公司 |
用于组织修复的双特异性治疗性蛋白质
|
|
CN115491373A
(zh)
*
|
2015-10-30 |
2022-12-20 |
爱迪塔斯医药公司 |
治疗单纯疱疹病毒的crispr/cas相关方法及组合物
|
|
TWI767915B
(zh)
|
2016-06-27 |
2022-06-21 |
加州大學董事會 |
Ror-1與btk拮抗劑的組合
|
|
CN106317226B
(zh)
|
2016-08-19 |
2017-09-05 |
安源医药科技(上海)有限公司 |
用于构建融合蛋白的连接肽
|
|
GB201620119D0
(en)
|
2016-11-29 |
2017-01-11 |
Pharmafox Therapeutics Ag |
Compounds
|
|
WO2018189661A2
(en)
|
2017-04-10 |
2018-10-18 |
Palti Yoram Prof |
Methods and compounds for treating diabetes
|
|
JP7308151B2
(ja)
|
2017-04-27 |
2023-07-13 |
イーライ リリー アンド カンパニー |
ヒトbmp7タンパク質のバリアント
|
|
US20190240156A1
(en)
|
2018-02-06 |
2019-08-08 |
Agency For Science, Technology And Research (A*Star) |
Therapeutic Compositions Comprising Mesenchymal Stem Cell Particles And Related Methods
|
|
BR112020021962A2
(pt)
|
2018-04-30 |
2021-01-26 |
Amicus Therapeutics, Inc. |
construtos para terapia gênica e métodos de uso
|
|
EP4606428A3
(en)
|
2018-06-27 |
2025-11-05 |
Juvena Therapeutics, Inc. |
Heparin-associated polypeptides and uses thereof
|
|
AU2019404061A1
(en)
|
2018-12-19 |
2021-07-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
Bifunctional molecules for lysosomal targeting and related compositions and methods
|
|
KR20220077921A
(ko)
|
2019-10-10 |
2022-06-09 |
아미쿠스 세라퓨틱스, 인코포레이티드 |
변이체 igf2 작제물
|
|
US20240189397A1
(en)
|
2019-12-24 |
2024-06-13 |
Juvena Therapeutics, Inc. |
Heparin-Associated Polypeptides and Uses Thereof
|
|
CN115379850A
(zh)
|
2019-12-24 |
2022-11-22 |
裘美娜治疗公司 |
再生性多肽及其用途
|
|
EP4171658A4
(en)
|
2020-06-24 |
2025-04-09 |
Lycia Therapeutics, Inc. |
Modified viral compositions for viral transduction
|
|
US20220031812A1
(en)
|
2020-07-30 |
2022-02-03 |
Silver Creek Pharmaceuticals, Inc. |
Chimeric Proteins and Methods of Use for Treatment of Central Nervous System Disorders
|
|
GEAP202416351A
(en)
|
2021-02-17 |
2024-02-12 |
Dr Falk Pharma Gmbh |
Anti-cd30l antibodies and uses thereof
|
|
WO2022271466A1
(en)
|
2021-06-21 |
2022-12-29 |
Juvena Therapeutics, Inc. |
Regenerative polypeptides and uses thereof
|
|
WO2022271981A2
(en)
|
2021-06-23 |
2022-12-29 |
Lycia Therapeutics, Inc. |
Bifunctional compounds containing igf-2 polypeptides
|
|
US20230405089A1
(en)
|
2022-06-17 |
2023-12-21 |
Juvena Therapeutics, Inc. |
Heparin-Associated Polypeptides and Uses Thereof
|