JP2005503763A5 - - Google Patents
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- Publication number
- JP2005503763A5 JP2005503763A5 JP2002561497A JP2002561497A JP2005503763A5 JP 2005503763 A5 JP2005503763 A5 JP 2005503763A5 JP 2002561497 A JP2002561497 A JP 2002561497A JP 2002561497 A JP2002561497 A JP 2002561497A JP 2005503763 A5 JP2005503763 A5 JP 2005503763A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- amino acid
- fusion protein
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 150000001413 amino acids Chemical group 0.000 claims 18
- 235000001014 amino acid Nutrition 0.000 claims 17
- 229940024606 amino acid Drugs 0.000 claims 16
- 102000037865 fusion proteins Human genes 0.000 claims 11
- 108020001507 fusion proteins Proteins 0.000 claims 11
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 4
- 229960001230 asparagine Drugs 0.000 claims 4
- 235000009582 asparagine Nutrition 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229920001515 polyalkylene glycol Polymers 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- 239000004472 Lysine Substances 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 102100026376 Artemin Human genes 0.000 claims 2
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 2
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 230000006576 neuronal survival Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 231100000915 pathological change Toxicity 0.000 claims 1
- 230000036285 pathological change Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26607101P | 2001-02-01 | 2001-02-01 | |
| PCT/US2002/002319 WO2002060929A2 (en) | 2001-02-01 | 2002-01-25 | Polymer conjugates of neublastin and methods of using same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008277469A Division JP4423338B2 (ja) | 2001-02-01 | 2008-10-28 | ニューブラスチンのポリマー結合体および同様の使用方法。 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503763A JP2005503763A (ja) | 2005-02-10 |
| JP2005503763A5 true JP2005503763A5 (https=) | 2005-12-22 |
| JP4259868B2 JP4259868B2 (ja) | 2009-04-30 |
Family
ID=23013042
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002561497A Expired - Fee Related JP4259868B2 (ja) | 2001-02-01 | 2002-01-25 | ニューブラスチンのポリマー結合体および同様の使用方法。 |
| JP2008277469A Expired - Fee Related JP4423338B2 (ja) | 2001-02-01 | 2008-10-28 | ニューブラスチンのポリマー結合体および同様の使用方法。 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008277469A Expired - Fee Related JP4423338B2 (ja) | 2001-02-01 | 2008-10-28 | ニューブラスチンのポリマー結合体および同様の使用方法。 |
Country Status (35)
| Country | Link |
|---|---|
| EP (2) | EP1862475A1 (https=) |
| JP (2) | JP4259868B2 (https=) |
| KR (2) | KR100872807B1 (https=) |
| CN (1) | CN1500095B (https=) |
| AR (1) | AR035077A1 (https=) |
| AT (1) | ATE365748T1 (https=) |
| AU (1) | AU2002247037B2 (https=) |
| BG (1) | BG66393B1 (https=) |
| BR (1) | BR0206852A (https=) |
| CA (1) | CA2436407C (https=) |
| CY (1) | CY1106886T1 (https=) |
| CZ (1) | CZ20032080A3 (https=) |
| DE (1) | DE60220879T2 (https=) |
| DK (1) | DK1355936T3 (https=) |
| EA (1) | EA009771B1 (https=) |
| EE (1) | EE05537B1 (https=) |
| ES (1) | ES2289091T3 (https=) |
| GE (1) | GEP20063916B (https=) |
| HU (1) | HU228973B1 (https=) |
| IL (2) | IL156941A0 (https=) |
| IS (1) | IS2867B (https=) |
| MX (1) | MXPA03006805A (https=) |
| MY (1) | MY143685A (https=) |
| NO (1) | NO332150B1 (https=) |
| NZ (1) | NZ527863A (https=) |
| PL (1) | PL211162B1 (https=) |
| PT (1) | PT1355936E (https=) |
| RS (1) | RS50857B (https=) |
| SG (1) | SG149685A1 (https=) |
| SI (1) | SI1355936T1 (https=) |
| SK (1) | SK288123B6 (https=) |
| TR (1) | TR200301208T2 (https=) |
| UA (2) | UA100967C2 (https=) |
| WO (1) | WO2002060929A2 (https=) |
| ZA (1) | ZA200305733B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7442370B2 (en) | 2001-02-01 | 2008-10-28 | Biogen Idec Ma Inc. | Polymer conjugates of mutated neublastin |
| DK1355936T3 (da) * | 2001-02-01 | 2007-10-29 | Biogen Idec Inc | Polymerkonjugater af neublastin og fremgangsmåder til anvendelse af samme |
| US7276580B2 (en) | 2001-03-12 | 2007-10-02 | Biogen Idec Ma Inc. | Neurotrophic factors |
| CN1525866B (zh) * | 2001-03-28 | 2013-05-29 | 比奥根艾迪克Ma公司 | 神经胚活素多肽的治疗作用 |
| PT3025726T (pt) * | 2002-01-18 | 2020-01-09 | Biogen Ma Inc | Compostos do polímero polialquileno e utilizações dos mesmos |
| EA008743B1 (ru) * | 2003-01-31 | 2007-08-31 | Байоджен Айдек Ма Инк. | Полимерные конъюгаты мутантного неубластина |
| WO2004094592A2 (en) | 2003-04-18 | 2004-11-04 | Biogen Idec Ma Inc. | Polymer-conjugated glycosylated neublastin |
| NZ544263A (en) | 2003-06-10 | 2009-04-30 | Nsgene As | Improved secretion of neublastin |
| US7598059B2 (en) | 2003-10-02 | 2009-10-06 | Biogen Idec Ma Inc. | Neublastin expression constructs |
| CA2577690C (en) * | 2004-08-19 | 2013-08-06 | Biogen Idec Ma Inc. | Refolding transforming growth factor beta family proteins |
| DK1786454T3 (da) | 2004-08-19 | 2010-09-06 | Biogen Idec Inc | Neublastinvarianter |
| TWI501774B (zh) | 2006-02-27 | 2015-10-01 | Biogen Idec Inc | 神經性病症之治療 |
| ES2450065T3 (es) * | 2006-03-01 | 2014-03-21 | Biogen Idec Ma Inc. | Composiciones y métodos para la administración de proteínas de la familia de ligandos del GDNF |
| CA2663300C (en) | 2006-09-15 | 2014-10-07 | Creabilis Therapeutics S.P.A. | Polymer conjugates of box-a of hmgb1 and box-a variants of hmgb1 |
| EP2142205B1 (en) * | 2007-05-01 | 2014-04-02 | Biogen Idec MA Inc. | Neublastin peptides for use in increasing vascularisation in tissue with impaired blood flow |
| HUE035685T2 (en) * | 2011-11-02 | 2018-05-28 | Hoffmann La Roche | Overload and elute chromatography |
| RU2488635C1 (ru) * | 2012-03-22 | 2013-07-27 | Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития | Способ получения рекомбинантного антиангиогенного полипептида |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472178B1 (en) * | 1998-02-27 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof |
| US5770577A (en) * | 1994-11-14 | 1998-06-23 | Amgen Inc. | BDNF and NT-3 polypeptides selectively linked to polyethylene glycol |
| US6593133B1 (en) * | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
| WO2000034475A2 (en) * | 1998-12-09 | 2000-06-15 | Amgen Inc. | Grnf4, a gdnf-related neurotrophic factor |
| DK1355936T3 (da) * | 2001-02-01 | 2007-10-29 | Biogen Idec Inc | Polymerkonjugater af neublastin og fremgangsmåder til anvendelse af samme |
-
2002
- 2002-01-25 DK DK02714792T patent/DK1355936T3/da active
- 2002-01-25 KR KR1020037010127A patent/KR100872807B1/ko not_active Expired - Fee Related
- 2002-01-25 EP EP07110666A patent/EP1862475A1/en not_active Withdrawn
- 2002-01-25 EE EEP200300355A patent/EE05537B1/xx not_active IP Right Cessation
- 2002-01-25 HU HU0500637A patent/HU228973B1/hu not_active IP Right Cessation
- 2002-01-25 TR TR2003/01208T patent/TR200301208T2/xx unknown
- 2002-01-25 DE DE60220879T patent/DE60220879T2/de not_active Expired - Lifetime
- 2002-01-25 BR BR0206852-4A patent/BR0206852A/pt not_active Application Discontinuation
- 2002-01-25 CZ CZ20032080A patent/CZ20032080A3/cs unknown
- 2002-01-25 KR KR1020087022638A patent/KR100960063B1/ko not_active Expired - Fee Related
- 2002-01-25 CA CA2436407A patent/CA2436407C/en not_active Expired - Fee Related
- 2002-01-25 NZ NZ527863A patent/NZ527863A/en not_active IP Right Cessation
- 2002-01-25 CN CN028077539A patent/CN1500095B/zh not_active Expired - Fee Related
- 2002-01-25 IL IL15694102A patent/IL156941A0/xx unknown
- 2002-01-25 JP JP2002561497A patent/JP4259868B2/ja not_active Expired - Fee Related
- 2002-01-25 PL PL372101A patent/PL211162B1/pl unknown
- 2002-01-25 SG SG200504719-6A patent/SG149685A1/en unknown
- 2002-01-25 EP EP02714792A patent/EP1355936B1/en not_active Expired - Lifetime
- 2002-01-25 GE GE5240A patent/GEP20063916B/en unknown
- 2002-01-25 UA UAA200802148A patent/UA100967C2/ru unknown
- 2002-01-25 UA UA2003088104A patent/UA82983C2/ru unknown
- 2002-01-25 AR ARP020100279A patent/AR035077A1/es not_active Application Discontinuation
- 2002-01-25 ES ES02714792T patent/ES2289091T3/es not_active Expired - Lifetime
- 2002-01-25 SK SK971-2003A patent/SK288123B6/sk not_active IP Right Cessation
- 2002-01-25 AT AT02714792T patent/ATE365748T1/de active
- 2002-01-25 EA EA200300852A patent/EA009771B1/ru not_active IP Right Cessation
- 2002-01-25 RS YUP-610/03A patent/RS50857B/sr unknown
- 2002-01-25 PT PT02714792T patent/PT1355936E/pt unknown
- 2002-01-25 WO PCT/US2002/002319 patent/WO2002060929A2/en not_active Ceased
- 2002-01-25 SI SI200230580T patent/SI1355936T1/sl unknown
- 2002-01-25 MX MXPA03006805A patent/MXPA03006805A/es active IP Right Grant
- 2002-01-25 AU AU2002247037A patent/AU2002247037B2/en not_active Ceased
- 2002-02-04 MY MYPI20020368A patent/MY143685A/en unknown
-
2003
- 2003-07-15 IL IL156941A patent/IL156941A/en not_active IP Right Cessation
- 2003-07-17 IS IS6879A patent/IS2867B/is unknown
- 2003-07-24 ZA ZA2003/05733A patent/ZA200305733B/en unknown
- 2003-08-01 NO NO20033441A patent/NO332150B1/no not_active IP Right Cessation
- 2003-08-19 BG BG108111A patent/BG66393B1/bg unknown
-
2007
- 2007-09-21 CY CY20071101225T patent/CY1106886T1/el unknown
-
2008
- 2008-10-28 JP JP2008277469A patent/JP4423338B2/ja not_active Expired - Fee Related
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