JP2001525322A5 - - Google Patents
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- Publication number
- JP2001525322A5 JP2001525322A5 JP2000523214A JP2000523214A JP2001525322A5 JP 2001525322 A5 JP2001525322 A5 JP 2001525322A5 JP 2000523214 A JP2000523214 A JP 2000523214A JP 2000523214 A JP2000523214 A JP 2000523214A JP 2001525322 A5 JP2001525322 A5 JP 2001525322A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- embedded image
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 description 15
- 150000003839 salts Chemical class 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 125000001475 halogen functional group Chemical group 0.000 description 4
- 150000002367 halogens Chemical class 0.000 description 4
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 125000005031 thiocyano group Chemical group S(C#N)* 0.000 description 2
- 0 *Cc1c(*)cc(*)cc1* Chemical compound *Cc1c(*)cc(*)cc1* 0.000 description 1
- PXZLZJICBRRFDD-UHFFFAOYSA-N 8-[(2,6-dimethylphenyl)methoxy]-2,3-dimethylimidazo[1,2-a]pyrazine Chemical compound N=1C=CN2C(C)=C(C)N=C2C=1OCC1=C(C)C=CC=C1C PXZLZJICBRRFDD-UHFFFAOYSA-N 0.000 description 1
- 125000005905 mesyloxy group Chemical group 0.000 description 1
- LZFXMIHHUPVZFQ-UHFFFAOYSA-N n-[(2,6-dimethylphenyl)methyl]-2,3-dimethylimidazo[1,2-a]pyrazin-8-amine Chemical compound N=1C=CN2C(C)=C(C)N=C2C=1NCC1=C(C)C=CC=C1C LZFXMIHHUPVZFQ-UHFFFAOYSA-N 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704404A SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | New compounds |
| SE9704404-4 | 1997-11-28 | ||
| PCT/SE1998/002091 WO1999028322A1 (en) | 1997-11-28 | 1998-11-18 | Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001525322A JP2001525322A (ja) | 2001-12-11 |
| JP2001525322A5 true JP2001525322A5 (cg-RX-API-DMAC7.html) | 2006-01-12 |
Family
ID=20409181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000523214A Pending JP2001525322A (ja) | 1997-11-28 | 1998-11-18 | 胃酸分泌を抑制する複素環式化合物、それらの製造法およびそれらの医薬組成物 |
Country Status (32)
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0909323T3 (da) | 1996-01-04 | 2007-05-21 | Novartis Vaccines & Diagnostic | Helicobacter pylori-bakterioferritin |
| SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
| UY26380A1 (es) | 1999-10-08 | 2001-04-30 | Smithkline Beecham Corp | Inhibidores de fab i |
| AU2002367773A1 (en) * | 2001-04-06 | 2003-11-03 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| JP2003119140A (ja) * | 2001-08-08 | 2003-04-23 | Sankyo Co Ltd | ピロロピリダジン化合物を含有する医薬 |
| JP2005530739A (ja) * | 2002-04-19 | 2005-10-13 | セルラー ジェノミクス，インコーポレーテッド | イミダゾ［１，２−ａ］ピラジン−８−イルアミン、生成方法、および使用方法 |
| AU2003270489A1 (en) | 2002-09-09 | 2004-03-29 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
| WO2004029057A1 (ja) * | 2002-09-25 | 2004-04-08 | Sankyo Company, Limited | 内臓痛の治療または予防のための医薬組成物 |
| WO2004029058A1 (ja) * | 2002-09-25 | 2004-04-08 | Sankyo Company, Limited | 血中ガストリン濃度上昇の抑制のための医薬組成物 |
| EP1575951B1 (en) | 2002-12-06 | 2014-06-25 | Debiopharm International SA | Heterocyclic compounds, methods of making them and their use in therapy |
| US7160885B2 (en) | 2003-02-10 | 2007-01-09 | Cgi Pharmaceuticals, Inc. | Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity |
| AR043002A1 (es) * | 2003-02-18 | 2005-07-13 | Altana Pharma Ag | Imidazopirazinas 6-substituidos |
| JP4880448B2 (ja) * | 2003-03-17 | 2012-02-22 | アフィナム ファーマシューティカルズ，インコーポレーテッド | 複数の抗生物質を含む組成物、及びそれを用いる方法 |
| WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
| WO2005019220A2 (en) | 2003-08-11 | 2005-03-03 | Cellular Genomics Inc. | Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity |
| EP1974730A1 (en) | 2003-11-03 | 2008-10-01 | AstraZeneca AB | Imidazo[1,2-a]pyridine derivatives for use in the treatment of sleep disturbance due to silent gastro-esophageal reflux |
| KR101299399B1 (ko) * | 2004-06-04 | 2013-08-22 | 아피늄 파마슈티컬스, 인크. | 치료제, 및 그의 제조 및 사용 방법 |
| KR101764575B1 (ko) * | 2004-07-28 | 2017-08-03 | 다케다 야쿠힌 고교 가부시키가이샤 | 피롤로〔2,3-ｃ〕피리딘 화합물, 그 제조 방법 및 용도 |
| JP2008508347A (ja) * | 2004-08-02 | 2008-03-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５置換された１Ｈ−ピロロ［３，２−ｂ］ピリジン |
| US8148529B2 (en) * | 2004-09-03 | 2012-04-03 | Yuhan Corporation | Pyrrolo[3,2-C] pyridine derivatives and processes for the preparation thereof |
| PL1784404T3 (pl) | 2004-09-03 | 2012-04-30 | Yuhan Corp | Pochodne pirolo[2,3-c]pirydyny i sposoby ich wytwarzania |
| JP4989477B2 (ja) * | 2004-09-03 | 2012-08-01 | ユーハン・コーポレイション | ピロロ［３，２−ｃ］ピリジン誘導体及びその製造方法 |
| EP1784403B1 (en) * | 2004-09-03 | 2013-07-17 | Yuhan Corporation | Pyrrolo[3,2-b]pyridine derivatives and processes for the preparation thereof |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| JP2009507032A (ja) | 2005-09-02 | 2009-02-19 | アボット・ラボラトリーズ | 新規なイミダゾ系複素環 |
| WO2007067416A2 (en) * | 2005-12-05 | 2007-06-14 | Affinium Pharmaceuticals, Inc. | Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| WO2007145921A1 (en) * | 2006-06-06 | 2007-12-21 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
| JP5468899B2 (ja) * | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ， インク． | Ｆａｂｉインヒビターとしてのアクリルアミド誘導体 |
| EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
| JP5496915B2 (ja) | 2008-02-13 | 2014-05-21 | シージーアイ ファーマシューティカルズ，インコーポレーテッド | ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法 |
| SG10201707798SA (en) | 2008-12-08 | 2017-10-30 | Gilead Connecticut Inc | Imidazopyrazine syk inhibitors |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| ES2590804T3 (es) | 2008-12-08 | 2016-11-23 | Gilead Connecticut, Inc. | Inhibidores de Imidazopyrazine Syk |
| AU2011226689B2 (en) | 2010-03-11 | 2016-09-01 | Kronos Bio, Inc. | Imidazopyridines Syk inhibitors |
| KR101720885B1 (ko) | 2012-06-19 | 2017-03-28 | 데비오팜 인터네셔날 에스 에이 | (e)-n-메틸-n-((3-메틸벤조푸란-2-일)메틸)-3-(7-옥소-5,6,7,8-테트라히드로-1,8-나프티리딘-3-일)아크릴아미드의전구약물 유도체 |
| KR20170116203A (ko) | 2013-07-30 | 2017-10-18 | 질레드 코네티컷 인코포레이티드 | Ｓｙｋ 억제제의 제제 |
| NZ715776A (en) | 2013-07-30 | 2017-04-28 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
| DK3076976T3 (da) | 2013-12-04 | 2020-12-07 | Kronos Bio Inc | Fremgangsmåder til behandling af cancer |
| GB201321738D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| EA201790086A1 (ru) | 2014-07-14 | 2017-07-31 | Джилид Сайэнс, Инк. | Комбинации для лечения раковых заболеваний |
| US10751351B2 (en) | 2016-02-26 | 2020-08-25 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
| WO2019040298A1 (en) | 2017-08-25 | 2019-02-28 | Gilead Sciences, Inc. | SYK INHIBITORY POLYMORPHS |
| LT3923914T (lt) | 2019-02-14 | 2023-07-25 | Debiopharm International S.A. | Afabicino kompozicija, jos gamybos būdas |
| US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
| US12414958B2 (en) | 2019-06-14 | 2025-09-16 | Debiopharm International S.A. | Medicament and use thereof for treating bacterial infections involving biofilm |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507294A (en) | 1982-03-08 | 1985-03-26 | Schering Corp. | Imidazo[1,2-a]pyrazines |
| EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| IL97931A0 (en) * | 1990-04-27 | 1992-06-21 | Byk Gulden Lomberg Chem Fab | Pyridazine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
| US5041442A (en) * | 1990-07-31 | 1991-08-20 | Syntex (U.S.A.) Inc. | Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion |
| WO1992006979A1 (de) * | 1990-10-15 | 1992-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue diazine |
| DE59209687D1 (de) * | 1991-10-25 | 1999-06-02 | Byk Gulden Lomberg Chem Fab | Pyrrolo-pyridazine mit magen- und darmschutzwirkungen |
| CN1044811C (zh) | 1994-01-19 | 1999-08-25 | 三共株式会社 | 吡咯并哒嗪衍生物 |
| SE9602286D0 (sv) | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
| SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
-
1997
- 1997-11-28 SE SE9704404A patent/SE9704404D0/xx unknown
-
1998
- 1998-11-16 TW TW087118942A patent/TW515798B/zh active
- 1998-11-16 ZA ZA9810468A patent/ZA9810468B/xx unknown
- 1998-11-16 AR ARP980105799A patent/AR016972A1/es unknown
- 1998-11-17 MY MYPI98005216A patent/MY121032A/en unknown
- 1998-11-18 SK SK674-2000A patent/SK283904B6/sk unknown
- 1998-11-18 DK DK98957270T patent/DK1042324T3/da active
- 1998-11-18 RU RU2000113729/04A patent/RU2241000C2/ru not_active IP Right Cessation
- 1998-11-18 CZ CZ20001947A patent/CZ292349B6/cs not_active IP Right Cessation
- 1998-11-18 EP EP98957270A patent/EP1042324B1/en not_active Expired - Lifetime
- 1998-11-18 ID IDW20000987A patent/ID24730A/id unknown
- 1998-11-18 CN CNB98813344XA patent/CN1142933C/zh not_active Expired - Fee Related
- 1998-11-18 JP JP2000523214A patent/JP2001525322A/ja active Pending
- 1998-11-18 TR TR2000/01530T patent/TR200001530T2/xx unknown
- 1998-11-18 NZ NZ504355A patent/NZ504355A/en unknown
- 1998-11-18 BR BR9814755-2A patent/BR9814755A/pt not_active Application Discontinuation
- 1998-11-18 UA UA2000052801A patent/UA70932C2/uk unknown
- 1998-11-18 HU HU0100601A patent/HUP0100601A3/hu unknown
- 1998-11-18 KR KR1020007005804A patent/KR20010032559A/ko not_active Ceased
- 1998-11-18 ES ES98957270T patent/ES2191356T3/es not_active Expired - Lifetime
- 1998-11-18 CA CA002311798A patent/CA2311798A1/en not_active Abandoned
- 1998-11-18 DE DE69811735T patent/DE69811735T2/de not_active Expired - Fee Related
- 1998-11-18 WO PCT/SE1998/002091 patent/WO1999028322A1/en not_active Ceased
- 1998-11-18 EE EEP200000315A patent/EE04060B1/xx not_active IP Right Cessation
- 1998-11-18 IL IL13614598A patent/IL136145A0/xx unknown
- 1998-11-18 US US09/194,823 patent/US6518270B1/en not_active Expired - Lifetime
- 1998-11-18 PL PL98340920A patent/PL340920A1/xx not_active Application Discontinuation
- 1998-11-18 AU AU13565/99A patent/AU752187C/en not_active Ceased
- 1998-11-18 PT PT98957270T patent/PT1042324E/pt unknown
- 1998-11-18 AT AT98957270T patent/ATE233263T1/de not_active IP Right Cessation
-
2000
- 2000-05-10 IS IS5486A patent/IS5486A/is unknown
- 2000-05-26 NO NO20002721A patent/NO315704B1/no unknown
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