JP2001522241A - 診断方法および試薬 - Google Patents
診断方法および試薬Info
- Publication number
- JP2001522241A JP2001522241A JP54254598A JP54254598A JP2001522241A JP 2001522241 A JP2001522241 A JP 2001522241A JP 54254598 A JP54254598 A JP 54254598A JP 54254598 A JP54254598 A JP 54254598A JP 2001522241 A JP2001522241 A JP 2001522241A
- Authority
- JP
- Japan
- Prior art keywords
- disease
- sequence
- protein
- rna
- mutation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Psychology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4316397P | 1997-04-10 | 1997-04-10 | |
US60/043,163 | 1997-04-10 | ||
PCT/IB1998/000705 WO1998045322A2 (fr) | 1997-04-10 | 1998-04-02 | Reactifs pour diagnostics et procede correspondant |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2001522241A true JP2001522241A (ja) | 2001-11-13 |
Family
ID=21925819
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP54254598A Pending JP2001522241A (ja) | 1997-04-10 | 1998-04-02 | 診断方法および試薬 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0971952A2 (fr) |
JP (1) | JP2001522241A (fr) |
AU (1) | AU7071598A (fr) |
CA (1) | CA2287084A1 (fr) |
WO (1) | WO1998045322A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026353A1 (fr) * | 2003-09-16 | 2005-03-24 | Sumitomo Chemical Company, Limited | Procede pour evaluer le degre de cancerisation |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO314086B1 (no) | 1998-05-08 | 2003-01-27 | Gemvax As | Peptider og farmasöytiske sammensetninger inneholdende disse, nukleinsyresekvenser som koder for slike peptider, plasmider og virusvektoreromfattende slike DNA-sekvenser samt anvendelse av disse for fremstilling avfarmasöytiske preparater til |
AU2715601A (en) * | 1999-12-03 | 2001-06-12 | Koninklijke Nederlandse Akademie Van Wetenschappen | Clearance of aberrant protein in correlation with disease |
US7358063B2 (en) * | 2001-07-19 | 2008-04-15 | Sysmex Corporation | Method of detecting PS2V |
WO2004001421A2 (fr) * | 2002-06-21 | 2003-12-31 | Innogenetics N.V. | Procede de diagnostic et diagnostic differentiel des maladies neurologiques |
JP4813364B2 (ja) | 2003-11-25 | 2011-11-09 | アメリカ合衆国 | 突然変異型抗cd22抗体および免疫複合体 |
FR2869909B1 (fr) * | 2004-05-04 | 2007-12-21 | Univ Angers | Peptide capable d'inhiber la polymerisation de la tubuline et son utilisation pour inhiber la proliferation cellulaire |
EP1916259A1 (fr) | 2006-10-26 | 2008-04-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Fragment SCFV anti-gycoprotéine VI pour le traitement de la thrombose |
ES2618292T3 (es) | 2008-01-31 | 2017-06-21 | Inserm - Institut National De La Sante Et De La Recherche Medicale | Anticuerpos contra CD39 humano y uso de los mismos para inhibir la actividad de las células T reguladoras |
WO2010040766A1 (fr) | 2008-10-07 | 2010-04-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps neutralisants et fragments de ceux-ci orientés contre un variant 1 de facteur de plaquette 4 (pf4v1) |
EP2408818A1 (fr) | 2009-03-17 | 2012-01-25 | Université de la Méditerranée | Anticorps anti-btla et leurs utilisations |
ES2615881T3 (es) | 2009-05-07 | 2017-06-08 | Stallergenes | Uso de inmunoglobulinas igg1 y/o de ligandos del receptor cd32 para el tratamiento de enfermedades y manifestaciones inflamatorias por vía mucosa. |
JP2009203240A (ja) * | 2009-06-15 | 2009-09-10 | National Institute Of Advanced Industrial & Technology | リポソームおよびそれからなる細胞への物質導入担体 |
CN102655882B (zh) | 2009-09-11 | 2014-11-19 | 美国政府健康及人类服务部 | 具有降低的免疫原性的改进的假单胞菌外毒素a |
WO2011080322A1 (fr) | 2009-12-30 | 2011-07-07 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Méthode de pronostic de l'issue d'une hémophilie acquise et de traitement de l'hémophilie |
WO2012010696A1 (fr) | 2010-07-23 | 2012-01-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthodes de gestion du cancer ciblant co-029 |
EP2412724A1 (fr) | 2010-07-29 | 2012-02-01 | Centre National de la Recherche Scientifique (C.N.R.S) | Régulation de l'activité 4 glypican pour moduler le sort de cellules souches et leurs utilisations |
WO2012080769A1 (fr) | 2010-12-15 | 2012-06-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps anti-cd277 et leurs utilisations |
DK2654789T3 (en) | 2010-12-22 | 2018-09-03 | Orega Biotech | ANTIBODIES AGAINST HUMAN CD39 AND USE THEREOF |
WO2012101125A1 (fr) | 2011-01-24 | 2012-08-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps spécifiques dirigés contre le cxcl4 humain et leurs utilisations |
EP2681239B8 (fr) | 2011-02-28 | 2015-09-09 | F. Hoffmann-La Roche AG | Protéines de liaison à un antigène |
BR112013025045B1 (pt) | 2011-03-31 | 2020-10-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | anticorpos direcionados contra icos e usos dos mesmos |
BR112013028537A2 (pt) | 2011-05-06 | 2017-01-17 | Us Gov Health & Human Serv | imunotoxina recombinante que visa a mesotelina |
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US9346859B2 (en) | 2011-06-09 | 2016-05-24 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Pseudomonas exotoxin A with less immunogenic T cell and/or B cell epitopes |
EP2723376B1 (fr) | 2011-06-22 | 2018-12-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps anti-axl et leurs utilisations |
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WO2013000922A1 (fr) * | 2011-06-27 | 2013-01-03 | Universite Pierre Et Marie Curie (Paris 6) | Peptides antagonistes de ccr2 |
EP2543678A1 (fr) | 2011-07-08 | 2013-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps pour la prévention et le traitement de la thrombose |
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EP2543679A1 (fr) | 2011-07-08 | 2013-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anticorps pour la prévention et le traitement de la thrombose |
EP3301110A1 (fr) | 2011-09-16 | 2018-04-04 | The USA, as represented by The Secretary, Department of Health and Human Services | Exotoxine a de pseudomonas des épitopes de cellules b moins immunogènes |
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AU2013204200B2 (en) * | 2012-10-11 | 2016-10-20 | Brandeis University | Treatment of amyotrophic lateral sclerosis |
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JP6441232B2 (ja) | 2012-12-27 | 2018-12-19 | サノフイSanofi | 抗lamp1抗体および抗体薬物コンジュゲート、ならびにその使用 |
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AU2014329437B2 (en) | 2013-10-06 | 2018-10-18 | F. Hoffmann-La Roche Ag | Modified Pseudomonas exotoxin A |
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BR112018067525A2 (pt) | 2016-02-26 | 2019-02-05 | Centre Nat Rech Scient | anticorpos tendo especificidade para o btla e seus usos |
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JP7523358B2 (ja) * | 2018-06-13 | 2024-07-26 | アジェンデ・キミケ・リウニテ・アンジェリニ・フランチェスコ・ア・チ・エレ・ア・エフェ・ソシエタ・ペル・アチオニ | ムスカリン受容体m3に対して阻害活性を有するペプチド |
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TW202206110A (zh) | 2020-04-24 | 2022-02-16 | 法商賽諾菲公司 | 包含抗ceacam5抗體接合物、三氟胸苷和替吡嘧啶的抗腫瘤組合 |
KR20230005203A (ko) | 2020-04-24 | 2023-01-09 | 사노피 | 항-ceacam5 항체 접합체 및 folfox를 함유하는 항종양 조합 |
MX2022013402A (es) | 2020-04-24 | 2022-11-14 | Sanofi Sa | Combinaciones antitumorales que contienen productos conjugados de anticuerpos anti-ceacam5 y folfiri. |
CN115551553A (zh) | 2020-05-12 | 2022-12-30 | Inserm(法国国家健康医学研究院) | 治疗皮肤t细胞淋巴瘤和tfh起源淋巴瘤的新方法 |
WO2022048883A1 (fr) | 2020-09-04 | 2022-03-10 | Merck Patent Gmbh | Anticorps anti-ceacam5, conjugués et leurs utilisations |
EP4281187A1 (fr) | 2021-01-20 | 2023-11-29 | Bioentre LLC | Protéines de liaison à ctla4 et méthodes de traitement du cancer |
CA3226537A1 (fr) | 2021-07-29 | 2023-02-02 | Ana HENNINO | Proteine anti-.beta.ig-h3 humaine humanisee et ses utilisations |
WO2023079057A1 (fr) | 2021-11-05 | 2023-05-11 | Sanofi | Combinaisons antitumorales contenant des conjugués anticorps-médicament anti-ceacam5 et des anticorps anti-vegfr-2 |
WO2023150181A1 (fr) | 2022-02-01 | 2023-08-10 | President And Fellows Of Harvard College | Méthodes et compositions pour le traitement du cancer |
TW202346354A (zh) | 2022-03-09 | 2023-12-01 | 德商馬克專利公司 | 抗ceacam5抗體及其結合物及用途 |
WO2023172968A1 (fr) | 2022-03-09 | 2023-09-14 | Merck Patent Gmbh | Anticorps anti-gd2, immunoconjugués et leurs utilisations thérapeutiques |
WO2023240287A1 (fr) | 2022-06-10 | 2023-12-14 | Bioentre Llc | Combinaisons de protéines de liaison à ctla4 et procédés de traitement du cancer |
WO2024052503A1 (fr) | 2022-09-08 | 2024-03-14 | Institut National de la Santé et de la Recherche Médicale | Anticorps présentant une spécificité pour ltbp2 et leurs utilisations |
WO2024056668A1 (fr) | 2022-09-12 | 2024-03-21 | Institut National de la Santé et de la Recherche Médicale | Nouveaux anticorps anti-itgb8 et leurs utilisations |
WO2024180192A1 (fr) | 2023-03-01 | 2024-09-06 | Sanofi | Utilisation d'immunoconjugués anti-ceacam5 pour le traitement de cancers neuroendocriniens exprimant ceacam5 |
EP4427763A1 (fr) | 2023-03-06 | 2024-09-11 | Sanofi | Combinaisons antitumorales contenant des conjugués anticorps anti-ceacam5-médicament, anticorps anti-vegfr-2 et anticorps anti-pd1/pd-l1 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8718779D0 (en) * | 1987-08-07 | 1987-09-16 | Grosveld F G | Dna sequence & expression vector |
US5015570A (en) * | 1988-05-13 | 1991-05-14 | Molecular Therapeutics, Inc. | Molecular diagnosis of Alzheimer Disease |
EP0451700A1 (fr) * | 1990-04-10 | 1991-10-16 | Miles Inc. | Minigènes APP recombinants pour l'expression dans des souris transgéniques comme modèles de la maladie d'Alzheimer |
US5455169A (en) * | 1992-06-04 | 1995-10-03 | Alzheimer's Institute Of America, Inc. | Nucleic acids for diagnosing and modeling Alzheimer's disease |
EP0654077A4 (fr) * | 1992-07-17 | 1996-03-13 | Ribozyme Pharm Inc | Procede et reactif pour le traitement de maladies chez les animaux. |
US5854392A (en) * | 1992-08-31 | 1998-12-29 | Bristol-Myers Squibb Company | β APP-C100 receptor |
US5449604A (en) * | 1992-10-21 | 1995-09-12 | University Of Washington | Chromosome 14 and familial Alzheimers disease genetic markers and assays |
GB9410922D0 (en) * | 1994-06-01 | 1994-07-20 | Townsend Alain R M | Vaccines |
US5958684A (en) * | 1995-10-02 | 1999-09-28 | Van Leeuwen; Frederik Willem | Diagnosis of neurodegenerative disease |
-
1998
- 1998-04-02 JP JP54254598A patent/JP2001522241A/ja active Pending
- 1998-04-02 EP EP98917502A patent/EP0971952A2/fr not_active Withdrawn
- 1998-04-02 CA CA002287084A patent/CA2287084A1/fr not_active Abandoned
- 1998-04-02 AU AU70715/98A patent/AU7071598A/en not_active Abandoned
- 1998-04-02 WO PCT/IB1998/000705 patent/WO1998045322A2/fr not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026353A1 (fr) * | 2003-09-16 | 2005-03-24 | Sumitomo Chemical Company, Limited | Procede pour evaluer le degre de cancerisation |
US8980559B2 (en) | 2003-09-16 | 2015-03-17 | Sumitomo Chemical Company, Limited | Method for assessing cancerous state |
Also Published As
Publication number | Publication date |
---|---|
WO1998045322A2 (fr) | 1998-10-15 |
EP0971952A2 (fr) | 2000-01-19 |
CA2287084A1 (fr) | 1998-10-15 |
AU7071598A (en) | 1998-10-30 |
WO1998045322A3 (fr) | 1999-04-15 |
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