JP2001521020A5 - - Google Patents
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- Publication number
- JP2001521020A5 JP2001521020A5 JP2000517936A JP2000517936A JP2001521020A5 JP 2001521020 A5 JP2001521020 A5 JP 2001521020A5 JP 2000517936 A JP2000517936 A JP 2000517936A JP 2000517936 A JP2000517936 A JP 2000517936A JP 2001521020 A5 JP2001521020 A5 JP 2001521020A5
- Authority
- JP
- Japan
- Prior art keywords
- acetic acid
- aminomethyl
- cyclopentyl
- methyl
- cyclobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6364497P | 1997-10-27 | 1997-10-27 | |
| US60/063,644 | 1997-10-27 | ||
| US9768598P | 1998-08-24 | 1998-08-24 | |
| US60/097,685 | 1998-08-24 | ||
| PCT/US1998/019876 WO1999021824A1 (en) | 1997-10-27 | 1998-09-23 | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005319009A Division JP4263717B2 (ja) | 1997-10-27 | 2005-11-02 | 医薬として有用な環状アミノ酸およびその誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001521020A JP2001521020A (ja) | 2001-11-06 |
| JP2001521020A5 true JP2001521020A5 (https=) | 2006-01-05 |
| JP3756761B2 JP3756761B2 (ja) | 2006-03-15 |
Family
ID=26743626
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000517936A Expired - Fee Related JP3756761B2 (ja) | 1997-10-27 | 1998-09-23 | 医薬として有用な環状アミノ酸およびその誘導体 |
| JP2005319009A Expired - Fee Related JP4263717B2 (ja) | 1997-10-27 | 2005-11-02 | 医薬として有用な環状アミノ酸およびその誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005319009A Expired - Fee Related JP4263717B2 (ja) | 1997-10-27 | 2005-11-02 | 医薬として有用な環状アミノ酸およびその誘導体 |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US6635673B1 (https=) |
| EP (1) | EP1032555B1 (https=) |
| JP (2) | JP3756761B2 (https=) |
| KR (1) | KR100589066B1 (https=) |
| CN (2) | CN1303059C (https=) |
| AR (1) | AR013726A1 (https=) |
| AT (1) | ATE323067T1 (https=) |
| AU (1) | AU755800B2 (https=) |
| BR (1) | BR9813284B1 (https=) |
| CA (1) | CA2303244C (https=) |
| CO (1) | CO5280097A1 (https=) |
| CU (1) | CU23048A3 (https=) |
| CY (1) | CY1105062T1 (https=) |
| DE (1) | DE69834204T2 (https=) |
| DK (1) | DK1032555T3 (https=) |
| ES (1) | ES2260850T3 (https=) |
| GE (1) | GEP20094817B (https=) |
| HU (1) | HUP0004310A3 (https=) |
| IL (1) | IL134732A (https=) |
| IS (1) | IS2489B (https=) |
| NO (1) | NO327671B1 (https=) |
| NZ (1) | NZ503651A (https=) |
| PE (1) | PE122799A1 (https=) |
| PL (2) | PL199794B1 (https=) |
| PT (1) | PT1032555E (https=) |
| SI (1) | SI1032555T1 (https=) |
| TR (1) | TR200001170T2 (https=) |
| UY (1) | UY25223A1 (https=) |
| WO (1) | WO1999021824A1 (https=) |
| ZA (1) | ZA989740B (https=) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU225502B1 (en) * | 1998-12-29 | 2007-01-29 | Richter Gedeon Vegyeszet | Process for producing 1-(amino-metyl)-cyclohexene-acetic-acid and intermediates |
| ES2228524T3 (es) * | 1999-05-26 | 2005-04-16 | Warner-Lambert Company Llc | Aminoacidos policiclicos fundidos utilizados como agentes farmaceuticos. |
| EP1840117A1 (en) * | 1999-06-10 | 2007-10-03 | Warner-Lambert Company LLC | Mono- and disubstituted 3-propyl gamma-aminobutyric acids |
| US6642398B2 (en) | 1999-06-10 | 2003-11-04 | Warner-Lambert Company | Mono-and disubstituted 3-propyl gamma-aminobutyric acids |
| ES2317839T3 (es) * | 1999-06-10 | 2009-05-01 | Warner-Lambert Company Llc | Acidos 3-propil gamma-aminobutiricos monosustituidos. |
| US7164034B2 (en) | 1999-06-10 | 2007-01-16 | Pfizer Inc. | Alpha2delta ligands for fibromyalgia and other disorders |
| HN2000000224A (es) | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| US6864390B2 (en) | 1999-12-08 | 2005-03-08 | Warner-Lambert Company | Method for the stereoselective synthesis of cyclic amino acids |
| CN1607201A (zh) * | 1999-12-08 | 2005-04-20 | 沃尼尔·朗伯公司 | 立体选择性地合成环状氨基酸的方法 |
| GB2362646A (en) * | 2000-05-26 | 2001-11-28 | Warner Lambert Co | Cyclic amino acid derivatives useful as pharmaceutical agents |
| IL152770A0 (en) * | 2000-06-26 | 2003-06-24 | Warner Lambert Co | Gabapentin analogues for sleep disorders |
| GB2364049A (en) * | 2000-06-28 | 2002-01-16 | Warner Lambert Co | Cyclic ketones and their use in the synthesis of amino acids |
| EP1361847A2 (en) | 2000-10-06 | 2003-11-19 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| WO2002028881A1 (en) | 2000-10-06 | 2002-04-11 | Xenoport, Inc. | Bile-acid derived compounds for providing sustained systemic concentrations of drugs after oral administration |
| EP1226820A1 (en) | 2001-01-26 | 2002-07-31 | Warner-Lambert Company | Use of bicyclic amino acids for preventing and treating visceral pain and gastrointestinal disorders |
| GB2374595A (en) * | 2001-04-19 | 2002-10-23 | Warner Lambert Co | Fused bicyclic or tricyclic amino acids |
| SK12822003A3 (sk) * | 2001-04-19 | 2004-04-06 | Warner - Lambert Company Llc | Fúzne bicyklické alebo tricyklické aminokyseliny |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US7420002B2 (en) | 2001-06-11 | 2008-09-02 | Xenoport | Amino acid conjugates providing for sustained systemic concentrations of GABA analogues |
| ATE540678T1 (de) | 2001-06-11 | 2012-01-15 | Xenoport Inc | Prodrugs aus gaba-analoga, zusammensetzungen und ihre verwendungen |
| WO2003077902A1 (en) | 2002-02-19 | 2003-09-25 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| AU2003222033A1 (en) | 2002-03-20 | 2003-10-08 | Xenoport | Cyclic 1-(acyloxy)-alkyl prodrugs of gaba analogs, compositions and uses thereof |
| WO2003099338A2 (en) | 2002-05-17 | 2003-12-04 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| US7018818B2 (en) | 2002-10-04 | 2006-03-28 | Pfizer Inc. | Intermediates in the preparation of therapeutic fused bicyclic amino acids |
| GB0223072D0 (en) * | 2002-10-04 | 2002-11-13 | Pfizer Ltd | Cyclic nitromethyl acetic acid derivatives |
| US7025745B2 (en) * | 2002-10-07 | 2006-04-11 | Advanced Cardiovascular Systems, Inc. | Method of making a catheter balloon using a tapered mandrel |
| WO2004052360A1 (en) | 2002-12-11 | 2004-06-24 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
| BR0317253A (pt) | 2002-12-13 | 2005-11-01 | Warner Lambert Co | Derivados pregabalina para o tratamento da fibromialgia e outras patologias |
| WO2004054560A1 (en) | 2002-12-13 | 2004-07-01 | Warner-Lambert Company Llc | Alpha-2-delta ligand to treat lower urinary tract symptoms |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| PL377286A1 (pl) * | 2002-12-13 | 2006-01-23 | Warner-Lambert Company Llc | Analogi gabapentyny do włókniako-mięśniakowych i innych pokrewnych zaburzeń |
| WO2005002585A1 (en) * | 2003-07-02 | 2005-01-13 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor |
| KR20060119971A (ko) | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Gaba 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
| NZ545494A (en) | 2003-09-12 | 2009-10-30 | Pfizer | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| AU2004274002B2 (en) | 2003-09-17 | 2011-04-28 | Arbor Pharmaceuticals, Llc | Treating or preventing restless legs syndrome using prodrugs of GABA analogs |
| PT1677767E (pt) | 2003-10-14 | 2011-10-13 | Xenoport Inc | Forma cristalina de análogo de ácido gama-aminobutírico |
| US20050176680A1 (en) | 2003-12-11 | 2005-08-11 | Sepracor, Inc. | Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| UA82292C2 (uk) * | 2004-04-14 | 2008-03-25 | Пфайзер Продактс Инк. | Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти) |
| CA2584338C (en) | 2004-11-04 | 2013-08-06 | Xenoport, Inc. | Gabapentin prodrug sustained release oral dosage forms |
| WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
| WO2007010387A2 (en) * | 2005-07-18 | 2007-01-25 | Pharmacia & Upjohn Company Llc | Stereoselective synthesis of 3,4-disubstituted cyclopentanones and related compounds |
| EP1820502A1 (en) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
| CN101420947A (zh) * | 2006-03-06 | 2009-04-29 | 辉瑞产品公司 | 用于非恢复性睡眠的α-2-δ配体 |
| AR061728A1 (es) * | 2006-06-30 | 2008-09-17 | Pfizer Prod Inc | Composicion para tratamiento usando compuestos selectivos alfa-2-delta-1 |
| CA2673545A1 (en) | 2006-12-22 | 2008-07-03 | Recordati Ireland Limited | Combination therapy of lower urinary tract disorders with .alpha.2.delta. ligands and nsaids |
| WO2008155619A2 (en) * | 2007-06-21 | 2008-12-24 | Pfizer Inc. | Preparation of optically-active cyclic amino acids |
| BRPI0818193B8 (pt) | 2007-09-28 | 2021-05-25 | Daiichi Sankyo Co Ltd | composto, composição farmacêutica, e, uso de um composto |
| US7868043B2 (en) | 2008-01-25 | 2011-01-11 | Xenoport, Inc. | Mesophasic forms of (3S)-aminomethyl-5-methyl-hexanoic acid prodrugs and methods of use |
| CA2706575C (en) | 2008-01-25 | 2015-07-14 | Xenoport, Inc. | Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs |
| EP2250148B1 (en) | 2008-01-25 | 2016-08-17 | XenoPort, Inc. | Crystalline form of calcium-salts of (3s)-aminomethyl-5-methyl-hexanoic acids and methods of use |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| CN105330603A (zh) | 2008-10-08 | 2016-02-17 | 凯飞药业公司 | Gaba偶联物及其使用方法 |
| JP5557292B2 (ja) | 2009-03-26 | 2014-07-23 | 第一三共株式会社 | 二環性γ−アミノ酸誘導体の製造方法 |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
| EP2353591A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for potentiating the analgesic effect of opioids and opiates in post-operative pain and attenuating the dependency thereof |
| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
| EP2524694A1 (en) | 2011-05-19 | 2012-11-21 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in diabetes type-2 associated pain |
| ES2659162T3 (es) | 2011-06-08 | 2018-03-14 | Daiichi Sankyo Company, Limited | Procedimiento de producción de compuesto bicíclico a través de una sal de iminio |
| HUE035366T2 (en) | 2011-06-08 | 2018-05-02 | Daiichi Sankyo Co Ltd | A method for the preparation of a bicyclic compound by Claisen rearrangement |
| KR101944575B1 (ko) | 2011-12-15 | 2019-04-17 | 다이이찌 산쿄 가부시키가이샤 | 부제 촉매를 사용하는 2고리형 화합물의 광학 분할 방법 |
| EP2837689B1 (en) | 2012-04-10 | 2017-02-15 | Daiichi Sankyo Company, Limited | Optical resolution method for bicyclic compound using enzyme |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| CA2903000C (en) | 2013-01-28 | 2021-10-12 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor |
| TWI635071B (zh) | 2013-07-08 | 2018-09-11 | 第一三共股份有限公司 | 光學活性二環γ-胺基酸衍生物及其製造方法 |
| TW201607538A (zh) | 2013-12-17 | 2016-03-01 | 以斯提夫博士實驗室股份有限公司 | 血清素-去甲腎上腺素再攝取抑制劑(SNRIS)和σ受體配體組合物 |
| WO2015091505A1 (en) | 2013-12-17 | 2015-06-25 | Laboratorios Del Dr. Esteve, S.A. | Gabapentinoids and sigma receptor ligands combinations |
| CN112424158A (zh) | 2018-05-14 | 2021-02-26 | 昌郁医药公司 | 萘普生和普瑞巴林的1-(酰氧基)-烷基氨基甲酸酯药物缀合物的结晶形式 |
| TWI808217B (zh) | 2018-07-12 | 2023-07-11 | 大陸商四川海思科製藥有限公司 | 稠合三環γ-胺基酸衍生物之組合物及其製備方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4087544A (en) | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE2611690A1 (de) | 1976-03-19 | 1977-09-22 | Goedecke Ag | Cyclische sulfonyloxyimide |
| CA1085420A (en) | 1977-03-24 | 1980-09-09 | Johannes Hartenstein | 1-aminomethyl-1-cycloalkane-acetic acid |
| US5132451A (en) | 1989-08-25 | 1992-07-21 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
| DE3928184A1 (de) | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte |
| US5319135A (en) | 1989-08-25 | 1994-06-07 | Warner-Lambert Company | Process for cyclic amino acid anticonvulsant compounds |
| US5084479A (en) | 1990-01-02 | 1992-01-28 | Warner-Lambert Company | Novel methods for treating neurodegenerative diseases |
| EP0458751A1 (en) | 1990-05-25 | 1991-11-27 | Warner-Lambert Company | Delivery system for cyclic amino acids with improved taste, texture and compressibility |
| US5025035A (en) | 1990-10-12 | 1991-06-18 | Warner-Lambert Company | Method of treating depression |
| DE69116499T2 (de) | 1990-10-20 | 1996-08-22 | Takasago Perfumery Co Ltd | Verfahren zur Herstellung von Alpha-Hydroxyketonen |
| JP3333510B2 (ja) | 1991-10-02 | 2002-10-15 | スミスクライン・ビーチャム・コーポレイション | 抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体 |
| US5631291A (en) | 1992-05-29 | 1997-05-20 | Bayer Aktiengesellschaft | Cyclopentane- and -pentene-β-amino acids |
| DE4400749A1 (de) | 1994-01-13 | 1995-07-20 | Bayer Ag | Neues hochenantioselektives Verfahren zur Herstellung von enantiomerenreinen Cyclopentan- und -penten-beta-Aminosäuren |
| RU2168982C2 (ru) | 1994-07-27 | 2001-06-20 | Варнер-Ламберт Компани | Способ лечения состояния страха или лечения и/или предупреждения состояния паники, очищенный белок, способный связывать габапентин, и фармацевтическая композиция, обладающая успокоительным, противопаническим и противосудорожным действием |
| US5510381A (en) | 1995-05-15 | 1996-04-23 | Warner-Lambert Company | Method of treatment of mania and bipolar disorder |
| HU224720B1 (en) * | 1996-03-14 | 2006-01-30 | Warner Lambert Co | Novel substituted cyclic amino acid derivatives use as pharmaceutical agents |
| HRP980342A2 (en) | 1997-06-25 | 1999-02-28 | Warner Lambert Co | Anti-inflammatory method |
| US9858641B2 (en) * | 2014-12-15 | 2018-01-02 | International Business Machines Corporation | Representing a system using viewpoints |
| US9419648B1 (en) * | 2015-09-18 | 2016-08-16 | Intel Corporation | Supporting data compression using match scoring |
-
1998
- 1998-09-23 AT AT98950649T patent/ATE323067T1/de active
- 1998-09-23 ES ES98950649T patent/ES2260850T3/es not_active Expired - Lifetime
- 1998-09-23 TR TR2000/01170T patent/TR200001170T2/xx unknown
- 1998-09-23 HU HU0004310A patent/HUP0004310A3/hu unknown
- 1998-09-23 PT PT98950649T patent/PT1032555E/pt unknown
- 1998-09-23 JP JP2000517936A patent/JP3756761B2/ja not_active Expired - Fee Related
- 1998-09-23 CN CNB2003101209321A patent/CN1303059C/zh not_active Expired - Fee Related
- 1998-09-23 NZ NZ503651A patent/NZ503651A/xx not_active IP Right Cessation
- 1998-09-23 DK DK98950649T patent/DK1032555T3/da active
- 1998-09-23 KR KR1020007004472A patent/KR100589066B1/ko not_active Expired - Fee Related
- 1998-09-23 SI SI9830831T patent/SI1032555T1/sl unknown
- 1998-09-23 US US09/485,382 patent/US6635673B1/en not_active Expired - Fee Related
- 1998-09-23 CN CNB98810346XA patent/CN1138755C/zh not_active Expired - Fee Related
- 1998-09-23 CA CA002303244A patent/CA2303244C/en not_active Expired - Fee Related
- 1998-09-23 IL IL13473298A patent/IL134732A/en not_active IP Right Cessation
- 1998-09-23 DE DE69834204T patent/DE69834204T2/de not_active Expired - Lifetime
- 1998-09-23 AU AU96638/98A patent/AU755800B2/en not_active Ceased
- 1998-09-23 PL PL380277A patent/PL199794B1/pl not_active IP Right Cessation
- 1998-09-23 WO PCT/US1998/019876 patent/WO1999021824A1/en not_active Ceased
- 1998-09-23 BR BRPI9813284-9A patent/BR9813284B1/pt not_active IP Right Cessation
- 1998-09-23 GE GEAP199811187A patent/GEP20094817B/en unknown
- 1998-09-23 CU CU20000089A patent/CU23048A3/es not_active IP Right Cessation
- 1998-09-23 EP EP98950649A patent/EP1032555B1/en not_active Expired - Lifetime
- 1998-09-23 PL PL340285A patent/PL199500B1/pl not_active IP Right Cessation
- 1998-10-26 ZA ZA989740A patent/ZA989740B/xx unknown
- 1998-10-26 AR ARP980105348A patent/AR013726A1/es active IP Right Grant
- 1998-10-26 CO CO98062354A patent/CO5280097A1/es not_active Application Discontinuation
- 1998-10-26 UY UY25223A patent/UY25223A1/es not_active IP Right Cessation
- 1998-10-27 PE PE1998001007A patent/PE122799A1/es not_active Application Discontinuation
-
2000
- 2000-03-03 IS IS5395A patent/IS2489B/is unknown
- 2000-04-26 NO NO20002118A patent/NO327671B1/no not_active IP Right Cessation
-
2003
- 2003-05-30 US US10/448,834 patent/US6921835B2/en not_active Expired - Fee Related
-
2005
- 2005-03-11 US US11/078,961 patent/US7122678B2/en not_active Expired - Fee Related
- 2005-11-02 JP JP2005319009A patent/JP4263717B2/ja not_active Expired - Fee Related
-
2006
- 2006-07-03 CY CY20061100906T patent/CY1105062T1/el unknown
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