JP2001512964A - 分化した胎仔および成体ドナー細胞による核移植 - Google Patents
分化した胎仔および成体ドナー細胞による核移植Info
- Publication number
- JP2001512964A JP2001512964A JP53095898A JP53095898A JP2001512964A JP 2001512964 A JP2001512964 A JP 2001512964A JP 53095898 A JP53095898 A JP 53095898A JP 53095898 A JP53095898 A JP 53095898A JP 2001512964 A JP2001512964 A JP 2001512964A
- Authority
- JP
- Japan
- Prior art keywords
- cell
- cells
- disease
- differentiated
- cicm
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8771—Bovine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/873—Techniques for producing new embryos, e.g. nuclear transfer, manipulation of totipotent cells or production of chimeric embryos
- C12N15/877—Techniques for producing new mammalian cloned embryos
- C12N15/8778—Swine embryos
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/101—Bovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/106—Primate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/02—Cells from transgenic animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2517/00—Cells related to new breeds of animals
- C12N2517/04—Cells produced using nuclear transfer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Physics & Mathematics (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Reproductive Health (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/781,752 | 1997-01-10 | ||
| US08/781,752 US5945577A (en) | 1997-01-10 | 1997-01-10 | Cloning using donor nuclei from proliferating somatic cells |
| PCT/US1998/000002 WO1998030683A2 (en) | 1997-01-10 | 1998-01-05 | Nuclear transfer with differentiated fetal and adult donor cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007084406A Division JP2007167078A (ja) | 1997-01-10 | 2007-03-28 | 分化した胎仔および成体ドナー細胞による核移植 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001512964A true JP2001512964A (ja) | 2001-08-28 |
| JP2001512964A5 JP2001512964A5 (https=) | 2006-01-05 |
Family
ID=25123802
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP53095898A Ceased JP2001512964A (ja) | 1997-01-10 | 1998-01-05 | 分化した胎仔および成体ドナー細胞による核移植 |
| JP2007084406A Pending JP2007167078A (ja) | 1997-01-10 | 2007-03-28 | 分化した胎仔および成体ドナー細胞による核移植 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007084406A Pending JP2007167078A (ja) | 1997-01-10 | 2007-03-28 | 分化した胎仔および成体ドナー細胞による核移植 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US5945577A (https=) |
| EP (2) | EP1015572B1 (https=) |
| JP (2) | JP2001512964A (https=) |
| CN (1) | CN1248288B (https=) |
| AT (1) | ATE356203T1 (https=) |
| AU (1) | AU742363C (https=) |
| BR (1) | BR9806872A (https=) |
| CA (1) | CA2277192C (https=) |
| DE (1) | DE69837270T2 (https=) |
| ES (1) | ES2284197T3 (https=) |
| IL (2) | IL130829A0 (https=) |
| NZ (1) | NZ336612A (https=) |
| WO (1) | WO1998030683A2 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000512159A (ja) * | 1998-01-16 | 2000-09-19 | アグロバイオジェン ゲーエムベーハー | 胎仔線維芽細胞による効率的な核移入 |
| JP2002500864A (ja) * | 1998-01-21 | 2002-01-15 | ユニバーシティ・オブ・ハワイ | 成体の体細胞核を再構成した被核除去卵母細胞からの動物の満期の成長 |
| JP2006522609A (ja) * | 2003-04-09 | 2006-10-05 | マギー−ウイメンズ・ヘルス・コーポレイション | 動物の体細胞核移植と関係する紡錘体欠損を修正するための方法 |
| JPWO2016140353A1 (ja) * | 2015-03-04 | 2018-01-25 | 株式会社医療実験用大動物供給事業準備会社 | 安定した表現型を示す疾患モデルブタおよびその作製方法 |
Families Citing this family (216)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9517779D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| GB9517780D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US5945577A (en) * | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
| US6215041B1 (en) * | 1997-01-10 | 2001-04-10 | University Of Mmassachusetts | Cloning using donor nuclei from a non-quiesecent somatic cells |
| US20090092588A1 (en) * | 1997-01-10 | 2009-04-09 | University Of Massachusetts As Represented By Its Amherst Campus | Cloned ungulate embryos and animals, use of cells, tissues and organs thereof for transplantation therapies including parkinson's disease |
| US6235969B1 (en) | 1997-01-10 | 2001-05-22 | University Of Massachusetts | Cloning pigs using donor nuclei from non-quiescent differentiated cells |
| US6011197A (en) | 1997-03-06 | 2000-01-04 | Infigen, Inc. | Method of cloning bovines using reprogrammed non-embryonic bovine cells |
| AU745334B2 (en) * | 1997-03-06 | 2002-03-21 | Advanced Cell Technology, Inc. | Method of cloning animals |
| IL133786A0 (en) | 1997-07-03 | 2001-04-30 | Univ Massachusetts | Cloning using donor nuclei from non-serum starved, differentiated cells |
| AU8587598A (en) * | 1997-07-26 | 1999-02-16 | Wisconsin Alumni Research Foundation | Trans-species nuclear transfer |
| WO1999046982A1 (en) * | 1998-03-16 | 1999-09-23 | Relag Pty Ltd | Porcine nuclear transfer |
| AUPP294898A0 (en) * | 1998-04-15 | 1998-05-07 | Monash University | Method of nuclear transfer |
| GB9808325D0 (en) * | 1998-04-20 | 1998-06-17 | Ltr Ciz Di Associazione Italia | Source of nuclei for nuclear transfer |
| GB9811859D0 (en) * | 1998-06-02 | 1998-07-29 | Biotech & Biolog Scien Res | Biological manipulation |
| CA2340242A1 (en) * | 1998-08-11 | 2000-02-24 | Teruhiko Wakayama | Method of performing transgenesis |
| JP2002523084A (ja) * | 1998-09-01 | 2002-07-30 | ウイスコンシン アラムニ リサーチ ファンデーション | 適合性組織適合遺伝子を有する霊長類の胚幹細胞 |
| ATE357514T1 (de) * | 1998-11-02 | 2007-04-15 | Tufts College | Verfahren zur klonierung von tieren |
| US6781030B1 (en) | 1998-11-02 | 2004-08-24 | Trustee Of Tufts College, Ballou Hall | Methods for cloning mammals using telophase oocytes |
| US20030177513A1 (en) * | 1998-11-02 | 2003-09-18 | Yann Echelard | Transgenic and cloned mammals |
| US6580017B1 (en) * | 1998-11-02 | 2003-06-17 | Genzyme Transgenics Corporation | Methods of reconstructed goat embryo transfer |
| US6700037B2 (en) | 1998-11-24 | 2004-03-02 | Infigen, Inc. | Method of cloning porcine animals |
| US7531715B1 (en) | 1999-01-13 | 2009-05-12 | Ppl Therapeutics (Scotland) | Double nuclear transfer method and results thereof |
| NZ514620A (en) | 1999-03-04 | 2004-04-30 | Ppl Therapeutics Scotland Ltd | Genetic modification of somatic cells and uses thereof |
| US20020012660A1 (en) * | 1999-03-04 | 2002-01-31 | Alan Colman | Method of preparing a somatic cells for nuclear transfer |
| EP1198169B1 (en) * | 1999-05-06 | 2008-05-07 | Stem Cell Sciences (Australia) Pty Ltd | A process of cell reprogramming through production of a heterokaryon |
| CN1304445A (zh) * | 1999-06-30 | 2001-07-18 | 黄禹锡 | 一种通过用种间核转移技术生产克隆虎的方法 |
| WO2007019398A1 (en) | 2005-08-03 | 2007-02-15 | Advanced Cell Technology, Inc. | Improved methods of reprogramming animal somatic cells |
| CN1304444A (zh) * | 1999-06-30 | 2001-07-18 | 黄禹锡 | 一种通过用种间核转移技术生产人类克隆胚胎的方法 |
| RU2205536C2 (ru) * | 1999-06-30 | 2003-06-10 | Воо-Сук ХВАНГ | Способ получения клонированной коровы |
| CN1377424A (zh) * | 1999-09-07 | 2002-10-30 | 先进细胞技术公司 | 由衰老体细胞克隆的动物中的端粒恢复和细胞寿命延长 |
| US20050255596A1 (en) * | 1999-09-07 | 2005-11-17 | West Michael D | Methods of repairing tandemly repeated DNA sequences and extending cell life-span nuclear transfer |
| US20040180430A1 (en) * | 1999-09-07 | 2004-09-16 | West Michael D. | Methods of restoring telomere length and extending cell lifespan using nuclear transfer |
| CN1377225A (zh) * | 1999-09-13 | 2002-10-30 | 马萨诸塞大学 | 使用来自分化细胞的供体细胞或细胞核克隆猪以及多能猪的生成 |
| EP2275559A3 (en) | 1999-09-28 | 2011-03-23 | Shire Human Genetic Therapies, Inc. | Optimized messenger RNA |
| WO2002064799A2 (en) | 1999-09-28 | 2002-08-22 | Transkaryotic Therapies, Inc. | Optimized messenger rna |
| WO2001029206A1 (en) * | 1999-10-15 | 2001-04-26 | Advanced Cell Technology, Inc. | Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells |
| MXPA02004233A (es) | 1999-10-28 | 2004-02-17 | Univ Massachusetts | Produccion ginogenetica o androgenetica de celulas pluripotentes y lineas celulares, y uso de las mismas para producir celulas diferenciadas y tejidos. |
| EP1242591A1 (en) * | 1999-10-29 | 2002-09-25 | Nexia Biotechnologies, Inc. | Production of transgenic animals using nuclear transfer and oocytes recovered by lopu |
| WO2001032015A1 (en) * | 1999-11-02 | 2001-05-10 | University Of Massachusetts, As Represented By Its Amherst Campus | Use of haploid genomes for genetic diagnosis, modification and multiplication |
| WO2001035735A1 (en) * | 1999-11-19 | 2001-05-25 | Hematech, Llc | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7820878B2 (en) * | 1999-11-19 | 2010-10-26 | Kyowa Hakko Kirin Co., Ltd. | Production of ungulates, preferably bovines that produce human immunoglobulins |
| US7414170B2 (en) * | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| US7074983B2 (en) | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| KR100417566B1 (ko) * | 1999-11-19 | 2004-02-05 | 한국생명공학연구원 | 체세포 핵치환 복제수정란의 대량생산방법 |
| EP1244352A4 (en) | 2000-01-04 | 2003-04-23 | Univ Connecticut | OVOCYTE VITRIFICATION TECHNIQUE |
| AU2766401A (en) * | 2000-01-04 | 2001-07-16 | University Of Connecticut, The | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
| US20060174358A1 (en) * | 2001-01-04 | 2006-08-03 | Xiangzhong Yang | Method for cloning animals with targetted genetic alterations by transfer of long-term cultured male or female somatic cell nuclei, comprising artificially-induced genetic alterations, to enucleated recipient cells |
| US6635802B1 (en) * | 2000-01-10 | 2003-10-21 | The Texas A&M University System | Nuclear transfer using cells cultured in serum starvation media containing apoptosis inhibitors |
| GB0001401D0 (en) * | 2000-01-22 | 2000-03-08 | Univ Edinburgh | Methods for amplifying genetic material and use thereof |
| CA2403344C (en) * | 2000-03-15 | 2013-05-21 | The University Of Georgia Research Foundation, Inc. | Effective nuclear reprogramming in mammals |
| WO2001083731A1 (en) * | 2000-05-04 | 2001-11-08 | Biotime, Inc. | Methods and compositions for producing donor cells |
| AU2001261968A1 (en) * | 2000-05-25 | 2001-12-03 | Oregon Health Sciences University | Pt32 sperm protein, sperm c-yes, oocyte cytoplasmic c-yes, and uses thereof |
| US8030537B1 (en) | 2000-07-27 | 2011-10-04 | Apogene Gmbh & Co. Kg | Somatic cloning gene transfer for the production of recombinant proteins, cells and organs |
| US20030032180A1 (en) * | 2000-07-29 | 2003-02-13 | Strelchenko Larissa V. | Reconstituted cell lines prepared by nuclear transfer between differentiated cells |
| US20030172394A1 (en) * | 2001-08-01 | 2003-09-11 | Holzer George L | Selection and cloning methods |
| EA013564B1 (ru) | 2000-08-03 | 2010-06-30 | Терапеутик Хьюман Поликлоналз Инк. | Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция |
| US20040029825A1 (en) * | 2001-10-03 | 2004-02-12 | Davies Christopher J | Methods of minimizing immunological rejection of a nuclear transfer fetus |
| FR2814642B1 (fr) | 2000-10-03 | 2005-07-01 | Ass Pour Le Dev De La Rech En | Souris transgenique pour la recombinaison ciblee mediee par la cre-er modifiee |
| AU2001297880B2 (en) * | 2000-11-30 | 2007-05-31 | Stemron Inc. | Isolated homozygous stem cells differentiated cells derived therefrom and materials and methods for making and using same |
| US20030027331A1 (en) * | 2000-11-30 | 2003-02-06 | Yan Wen Liang | Isolated homozygous stem cells, differentiated cells derived therefrom, and materials and methods for making and using same |
| MXPA03005624A (es) * | 2000-12-22 | 2004-12-03 | Vaurox Llc | Metodos para clonar mamiferos usando cromatina reprogramada del donador o celulas donadoras. |
| WO2004029226A2 (en) * | 2002-04-30 | 2004-04-08 | Nucleotech, Llc | Methods for altering cell fate to generate t-cells specific for an antigen of interest |
| US20020142397A1 (en) * | 2000-12-22 | 2002-10-03 | Philippe Collas | Methods for altering cell fate |
| US7491534B2 (en) * | 2000-12-22 | 2009-02-17 | Kirin Holdings Kabushiki Kaisha | Methods for altering cell fate to generate T-cells specific for an antigen of interest |
| EP1217071B1 (en) | 2000-12-22 | 2010-04-28 | Institut National De La Recherche Agronomique | Position-independent and tissue specific expression of a transgene in milk of transgenic animals |
| KR20030088023A (ko) | 2001-01-02 | 2003-11-15 | 스템론 인크. | 미리 선별된 면역형 및(또는) 유전자형을 갖는 동형접합성간세포 군집의 제조 방법, 그로부터 유래된 이식에 적합한세포, 및 이들을 사용하는 재료 및 방법 |
| AUPR247901A0 (en) * | 2001-01-10 | 2001-02-01 | Garelag Pty Ltd | Activation of nuclear transfer embryos |
| US20050177883A1 (en) | 2001-01-30 | 2005-08-11 | Rebholtz Paul C. | Systems of transferring embryos and managing recipients |
| WO2002062131A2 (en) * | 2001-02-02 | 2002-08-15 | Infigen, Inc. | Method of cloning transgenic mammalian animals using pseudonuclei |
| JP2004524843A (ja) | 2001-02-23 | 2004-08-19 | イーラン ファーマスーティカルズ、インコーポレイテッド | Bace−1のトランスジェニックノックアウト |
| JP2002262716A (ja) * | 2001-03-07 | 2002-09-17 | National Agricultural Research Organization | 株化細胞を用いて家畜個体を作出する方法 |
| WO2002073187A1 (en) * | 2001-03-09 | 2002-09-19 | Advanced Cell Technology, Inc. | Method for generating replacement cells and/or tissues |
| WO2002073188A1 (en) * | 2001-03-13 | 2002-09-19 | Advanced Cell Technology, Inc. | Method for generating replacement cells and/or tissues |
| WO2002078449A2 (en) * | 2001-04-02 | 2002-10-10 | Advanced Cell Technology, Inc. | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
| AUPR446701A0 (en) | 2001-04-18 | 2001-05-17 | Gene Stream Pty Ltd | Transgenic mammals for pharmacological and toxicological studies |
| US20030092174A1 (en) * | 2001-05-14 | 2003-05-15 | Monika Liljedahl | Tissues or organs for use in xenotransplantation |
| US20030153044A1 (en) * | 2001-05-14 | 2003-08-14 | Monika Liljedahl | Tissues or organs for use in xenotransplantation |
| EP1405068A4 (en) * | 2001-06-14 | 2007-09-26 | Infigen Inc | PROCESS FOR CLONING MAMMALS USING REMODELING FACTORS |
| US20030101469A1 (en) * | 2001-07-09 | 2003-05-29 | Kenneth Bondioli | Cloned non-human mammals from contact inhibited donor cells |
| US20060083722A1 (en) * | 2001-07-18 | 2006-04-20 | Advanced Cell Technology, Inc | Methods and compositions for cell therapy |
| US20030017587A1 (en) * | 2001-07-18 | 2003-01-23 | Rader William C. | Embryonic stem cells, clinical applications and methods for expanding in vitro |
| WO2003011016A2 (en) * | 2001-07-31 | 2003-02-13 | Stell | Genetically modified cows having reduced susceptibility to mad cow disease |
| JP4381139B2 (ja) * | 2001-08-13 | 2009-12-09 | エンブレクス,インコーポレイテッド | 鳥類の卵の処理方法 |
| US20030211603A1 (en) * | 2001-08-14 | 2003-11-13 | Earp David J. | Reprogramming cells for enhanced differentiation capacity using pluripotent stem cells |
| EP1421181A1 (en) * | 2001-08-23 | 2004-05-26 | Reliance Life Sciences Pvt., Ltd. | ISOLATION OF INNER CELL MASS FOR THE ESTABLISHMENT OF HUMAN EMBRYONIC STEM CELL (hESC) LINES |
| MXPA04001725A (es) * | 2001-08-24 | 2005-04-11 | Advanced Cell Tech Inc | ANáLISIS DE SELECCION PARA IDENTIFICAR AGENTES INDUCTORES DE DIFERENCIACION Y PRODUCCION DE CELULAS DIFERENCIADAS PARA TERAPIA CELULAR. |
| CN1284851C (zh) * | 2001-11-06 | 2006-11-15 | 上海第二医科大学 | 体细胞起源的胚胎干细胞及其分化细胞 |
| AU2002361601A1 (en) * | 2001-11-06 | 2003-05-19 | Mark C. Fishman | Stem and progenitor cell capture for tissue regeneration |
| MXPA04005010A (es) * | 2001-11-26 | 2005-04-08 | Advanced Cell Tech Inc | METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS. |
| US7018819B2 (en) * | 2001-11-30 | 2006-03-28 | Cellectricon Ab | Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof |
| US20030113910A1 (en) * | 2001-12-18 | 2003-06-19 | Mike Levanduski | Pluripotent stem cells derived without the use of embryos or fetal tissue |
| US20040133931A1 (en) * | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| EP1463802A1 (en) * | 2002-01-11 | 2004-10-06 | GTC Biotherapeutics, Inc. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| US20030217374A1 (en) * | 2002-01-15 | 2003-11-20 | Advanced Cell Technology | Cloning B and T lymphocytes |
| US20030134422A1 (en) * | 2002-01-16 | 2003-07-17 | Sayre Chauncey Bigelow | Stem cell maturation for all tissue lines |
| US20050090004A1 (en) * | 2003-01-16 | 2005-04-28 | Sayre Chauncey B. | Stem cell maturation for all tissue lines |
| US20050170506A1 (en) * | 2002-01-16 | 2005-08-04 | Primegen Biotech Llc | Therapeutic reprogramming, hybrid stem cells and maturation |
| WO2003087341A2 (en) * | 2002-01-23 | 2003-10-23 | The University Of Utah Research Foundation | Targeted chromosomal mutagenesis using zinc finger nucleases |
| US6991066B2 (en) * | 2002-02-01 | 2006-01-31 | International Business Machines Corporation | Customized self-checkout system |
| US20030180268A1 (en) * | 2002-02-05 | 2003-09-25 | Anthony Atala | Tissue engineered construct for supplementing or replacing a damaged organ |
| US20030229909A1 (en) * | 2002-02-13 | 2003-12-11 | The Texas A&M University System | Cloning cats by nuclear transplantation |
| WO2003072708A2 (en) * | 2002-02-21 | 2003-09-04 | Advanced Cell Technology, Inc. | Pluripotent cells comprising allogenic nucleus and mitochondria |
| US20030161818A1 (en) * | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| WO2003080809A2 (en) | 2002-03-21 | 2003-10-02 | Sangamo Biosciences, Inc. | Methods and compositions for using zinc finger endonucleases to enhance homologous recombination |
| JP2005528095A (ja) * | 2002-04-01 | 2005-09-22 | ジーティーシー バイオセラピューティックス インコーポレイテッド | 哺乳類種における核移植に使用するための細胞株を選択する方法 |
| US20030217378A1 (en) * | 2002-04-05 | 2003-11-20 | The University Of Georgia Research Foundation, Inc | Cloning using rapidly matured oocytes |
| AU2003232003B2 (en) * | 2002-04-18 | 2006-05-11 | Idaho Research Foundation | Activation of equine oocytes |
| JP2005523031A (ja) * | 2002-04-24 | 2005-08-04 | ユニバーシテイ・オブ・ジヨージア・リサーチ・フアウンデイシヨン | 冷却死骸からのクローン化された仔の生産 |
| US20040091936A1 (en) * | 2002-05-24 | 2004-05-13 | Michael West | Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
| EP2679671B1 (en) | 2002-05-24 | 2019-12-11 | Advanced Cell Technology, Inc. | A bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
| US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
| AU2003257155A1 (en) * | 2002-08-02 | 2004-02-23 | The General Hospital Corporation | Methods for the production of cells and mammals with desired genetic modifications |
| EP2806025B1 (en) * | 2002-09-05 | 2019-04-03 | California Institute of Technology | Use of zinc finger nucleases to stimulate gene targeting |
| US20050034175A1 (en) * | 2002-09-09 | 2005-02-10 | Latif Zuhair A. | Immune cloning and uses thereof |
| US20040219563A1 (en) * | 2002-10-16 | 2004-11-04 | Michael West | Method using gene trapped stem cells for making pathways of stem cell differentiation and making and isolating differentiated cells |
| US20040077077A1 (en) * | 2002-10-18 | 2004-04-22 | Xiangzhong Yang | Novel methods for the production of cloned mammals, mammals cloned according to the methods, and methods of use of same |
| KR100479638B1 (ko) * | 2002-10-21 | 2005-03-31 | 주식회사 마크로젠 | 전기자극 및 막항원 표시자를 이용한 핵이식용 공여체 준비방법 및 이를 이용한 복제동물의 생산방법 |
| US7429690B2 (en) * | 2002-11-08 | 2008-09-30 | Kirin Holdings Kabushiki Kaisha | Transgenic bovines having reduced prion protein production |
| US7627373B2 (en) | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
| CN1683524A (zh) * | 2003-04-08 | 2005-10-19 | 东南大学 | 用体细胞核移植技术制备移核胚胎干细胞的方法 |
| US20060037086A1 (en) * | 2003-04-09 | 2006-02-16 | Schatten Gerald P | Methods for correcting mitotic spindle defects and optimizing preimplantation embryonic developmental rates associated with somatic cell nuclear transfer in animals |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US11311574B2 (en) | 2003-08-08 | 2022-04-26 | Sangamo Therapeutics, Inc. | Methods and compositions for targeted cleavage and recombination |
| US20120196370A1 (en) | 2010-12-03 | 2012-08-02 | Fyodor Urnov | Methods and compositions for targeted genomic deletion |
| US7888121B2 (en) * | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| CA2537273A1 (en) * | 2003-09-05 | 2005-03-17 | Gtc Biotherapeutics, Inc. | Method for the production of fusion proteins in transgenic mammal milk |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US20050186608A1 (en) * | 2004-02-19 | 2005-08-25 | Olsen Byron V. | Method for the production of transgenic proteins useful in the treatment of obesity and diabetes |
| US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
| US20050197496A1 (en) * | 2004-03-04 | 2005-09-08 | Gtc Biotherapeutics, Inc. | Methods of protein fractionation using high performance tangential flow filtration |
| AU2005237494B2 (en) * | 2004-04-22 | 2010-06-10 | Kyowa Hakko Kirin Co., Ltd | Transgenic animals and uses thereof |
| US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
| US7828711B2 (en) * | 2004-08-16 | 2010-11-09 | Cardiac Pacemakers, Inc. | Method and apparatus for modulating cellular growth and regeneration using ventricular assist device |
| JP2006081542A (ja) * | 2004-08-18 | 2006-03-30 | Institute Of Physical & Chemical Research | クローン哺乳動物の作成方法 |
| EP1778835A1 (en) * | 2004-08-20 | 2007-05-02 | Ingenium Pharmaceuticals AG | Methods for the production of improved live stocks and disease models for therapeutic research |
| US20060121004A1 (en) * | 2004-12-07 | 2006-06-08 | Yann Echelard | Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin |
| US20060123500A1 (en) * | 2004-12-07 | 2006-06-08 | Gtc Biotherapeutics, Inc. | Methods of prescreening cells for nuclear transfer procedures |
| US20060130159A1 (en) * | 2004-12-09 | 2006-06-15 | Nick Masiello | Method of purifying recombinant MSP 1-42 derived from Plasmodium falciparum |
| US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
| US8060219B2 (en) | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
| KR100733012B1 (ko) | 2005-07-26 | 2007-06-28 | 재단법인서울대학교산학협력재단 | 복제된 개과 동물 및 이의 생산 방법 |
| EP3138403A1 (en) | 2005-08-09 | 2017-03-08 | Revivicor, Inc. | Transgenic ungulates expressing ctla4-ig and uses thereof |
| US7732202B2 (en) | 2005-10-21 | 2010-06-08 | International Stem Cell Corporation | Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells |
| KR20140133958A (ko) | 2005-10-21 | 2014-11-20 | 엘에프비 유에스에이, 인크. | 항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및 사용 방법 |
| US7531632B2 (en) * | 2006-02-16 | 2009-05-12 | Gtc Biotherapeutics, Inc. | Clarification of transgenic milk using depth filtration |
| EP2484308A1 (en) * | 2006-07-24 | 2012-08-08 | International Stem Cell Corporation | Synthetic cornea from retinal stem cells |
| PE20081216A1 (es) | 2006-09-01 | 2008-09-04 | Therapeutic Human Polyclonals Inc | Expresion mejorada de la inmunoglobulina humana o humanizada en animales transgenicos no humanos |
| WO2008085891A1 (en) * | 2007-01-05 | 2008-07-17 | Worcester Polytechnic Institute | Oocyte spindle-associated factors improve somatic cell cloning |
| KR100829426B1 (ko) * | 2007-01-17 | 2008-05-15 | 재단법인서울대학교산학협력재단 | 복제개의 생산 방법 |
| US8796021B2 (en) | 2007-02-23 | 2014-08-05 | Advanced Cell Technology, Inc. | Blastomere culture to produce mammalian embryonic stem cells |
| US20080222745A1 (en) * | 2007-03-07 | 2008-09-11 | Utah State University | Colcemid-Treatment of Oocytes to enhance Nuclear Transfer Cloning |
| US20080299091A1 (en) | 2007-04-06 | 2008-12-04 | International Stem Cell Corporation | Patient-specific stem cell lines derived from human parthenogenetic blastocysts |
| KR100868245B1 (ko) * | 2007-05-29 | 2008-11-11 | 강원대학교산학협력단 | 데메콜친 처리에 의한 효율적인 복제 동물의 생산방법 |
| CN101668847A (zh) * | 2007-11-19 | 2010-03-10 | 财团法人首尔大学校产学协力财团 | 用于体细胞核移植的犬科出生率的提高方法 |
| EP2232985A4 (en) | 2008-01-04 | 2011-02-16 | Seoul Nat Univ Ind Foundation | PROCESS FOR PREPARING CLONED TRANSGENIC CANIDAE |
| US8557773B2 (en) | 2008-05-02 | 2013-10-15 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Treatment of bleeding with low half-life fibrinogen |
| EP2267153A1 (en) | 2009-05-26 | 2010-12-29 | Université Claude Bernard Lyon 1 | Identification of netrin-1 receptor unc5c gene mutation in solid cancers |
| DK2498796T3 (en) | 2009-11-09 | 2018-03-05 | Aal Scient Inc | HEART DISEASE TREATMENT |
| WO2012020077A1 (en) | 2010-08-11 | 2012-02-16 | Inserm (Institut Mational De La Santé Et De La Recherche Médicale) | Methods of growing an embryo to a blastocyst stage of development |
| EP3721880B1 (en) | 2010-09-01 | 2022-02-02 | Thomas Jefferson University | Composition and method for muscle repair and regeneration |
| JP2013545439A (ja) | 2010-09-17 | 2013-12-26 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 多能性幹細胞の有用性および安全性の特徴決定を行うための機能的ゲノミクスアッセイ |
| ES2680636T3 (es) | 2011-02-14 | 2018-09-10 | Revivicor Inc. | Cerdos genéticamente modificados para xenotrasplante de xenoinjertos vascularizados y derivados de los mismos |
| PT2709445T (pt) | 2011-05-16 | 2018-11-27 | Univ Missouri | Animais resistentes ao vírus da síntese reprodutiva e respiratória porcino |
| US10865383B2 (en) | 2011-07-12 | 2020-12-15 | Lineage Cell Therapeutics, Inc. | Methods and formulations for orthopedic cell therapy |
| CN104168913A (zh) | 2011-08-10 | 2014-11-26 | 法国化学与生物科技实验室 | 高半乳糖基化抗体 |
| EP2599859A1 (en) | 2011-11-30 | 2013-06-05 | IMBA-Institut für Molekulare Biotechnologie GmbH | Haploid cells |
| ES2773863T3 (es) | 2011-12-01 | 2020-07-15 | New York Stem Cell Found Inc | Sistema automatizado para la producción de células madre pluripotentes inducidas o células diferenciadas |
| US9828583B2 (en) | 2012-01-13 | 2017-11-28 | The General Hospital Corporation | Isolated human lung progenitor cells and uses thereof |
| HRP20191677T1 (hr) | 2012-04-30 | 2019-12-13 | Univ Health Network | POSTUPCI I SASTAVI ZA GENERIRANJE PANKREASNIH PROGENITORA I FUNKCIONALNIH BETA STANICA IZ hPSC |
| WO2014052458A1 (en) | 2012-09-25 | 2014-04-03 | Yale University | Differentiation of human ips cells to human alveolar type ii via definitive endoderm |
| EP3594230A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| WO2014125377A2 (en) | 2013-02-13 | 2014-08-21 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Highly galactosylated anti-her2 antibodies and uses thereof |
| CN105358577A (zh) | 2013-02-13 | 2016-02-24 | 法国化学与生物科技实验室 | 具有经修饰的糖基化的西妥昔单抗及其用途 |
| US10034921B2 (en) | 2013-02-13 | 2018-07-31 | Laboratoire Français Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| WO2014161075A1 (en) | 2013-04-05 | 2014-10-09 | University Health Network | Methods and compositions for generating chondrocyte lineage cells and/or cartilage like tissue |
| US11085067B2 (en) | 2013-06-10 | 2021-08-10 | President And Fellows Of Harvard College | Early developmental genomic assay for characterizing pluripotent stem cell utility and safety |
| CN120796168A (zh) | 2013-06-11 | 2025-10-17 | 哈佛学院校长同事会 | SC-β细胞以及用于产生其的组合物和方法 |
| WO2014201254A1 (en) | 2013-06-12 | 2014-12-18 | University Of Washington Through Its Center For Commercialization | Methods for maturing cardiomyocytes and uses thereof |
| US11028367B2 (en) | 2013-08-16 | 2021-06-08 | Yale University | Epithelial cell differentiation of human mesenchymal stromal cells |
| WO2015035506A1 (en) | 2013-09-13 | 2015-03-19 | University Health Network | Methods and compositions for generating epicardium cells |
| WO2015069736A1 (en) | 2013-11-08 | 2015-05-14 | The Mclean Hospital Corporation | METHODS FOR EFFICIENT GENERATION OF GABAergic INTERNEURONS FROM PLURIPOTENT STEM CELLS |
| US20160331528A1 (en) | 2014-01-23 | 2016-11-17 | President And Fellows Of Harvard College | Engineered polymeric valves, tubular structures, and sheets and uses thereof |
| KR20170040132A (ko) | 2014-06-02 | 2017-04-12 | 라보라토이레 프란카이즈 듀 프락티온네먼트 에트 데스 바이오테크놀로지스 | Fc 단편의 제조 |
| MA40589A (fr) | 2014-08-22 | 2017-06-28 | Procella Therapeutics Ab | Utilisation de jagged 1/frizzled 4 à titre de marqueurs de surface cellulaire pour isoler des cellules progénitrices ventriculaires cardiaques humaines |
| US10596200B2 (en) | 2014-08-22 | 2020-03-24 | Procella Therapeutics Ab | Use of LIFR or FGFR3 as a cell surface marker for isolating human cardiac ventricular progenitor cells |
| EP3194581A4 (en) | 2014-09-15 | 2018-04-25 | Children's Medical Center Corporation | Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation |
| CN104488853B (zh) * | 2015-01-12 | 2016-08-24 | 中国农业大学 | 一种牛胚胎玻璃化冷冻甩管解冻和直接移植方法 |
| HK1248270A1 (zh) | 2015-02-17 | 2018-10-12 | 大学健康网路 | 制备和使用窦房结样起搏器心肌细胞和心室样心肌细胞的方法 |
| WO2016178089A1 (en) | 2015-05-04 | 2016-11-10 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Transgenic production of fc fusion proteins |
| WO2016178087A1 (en) | 2015-05-04 | 2016-11-10 | Biosourcing Sa | Transgenic production of chorionic gonadotropin |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| RS65691B1 (sr) | 2015-08-06 | 2024-07-31 | Univ Missouri | Svinja i ćelije rezistentne na virus reproduktivnog i respiratornog sindroma svinja (prrsv) koje imaju modifikovane cd163 gene |
| DK3417073T3 (da) | 2016-02-19 | 2023-10-30 | Procella Therapeutics Ab | Genetiske markører til transplantation af humane, hjerteventrikulære progenitorceller |
| US11534466B2 (en) | 2016-03-09 | 2022-12-27 | Aal Scientifics, Inc. | Pancreatic stem cells and uses thereof |
| WO2017202814A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of neuropathological disorders characterized by a loss of cortical neurons |
| WO2018085516A2 (en) | 2016-11-02 | 2018-05-11 | Aal Scientifics, Inc. | Non-mesenchymal human lung stem cells and methods of their use for treating respiratory diseases |
| US10508263B2 (en) | 2016-11-29 | 2019-12-17 | Procella Therapeutics Ab | Methods for isolating human cardiac ventricular progenitor cells |
| WO2019038587A1 (en) | 2017-08-23 | 2019-02-28 | Procella Therapeutics Ab | USE OF NEUROPILIN-1 (NRP1) AS A CELL SURFACE MARKER FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS |
| JP7271539B2 (ja) | 2017-11-14 | 2023-05-11 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | リンホトキシンアルファ遺伝子について遺伝的に改変された調節性t細胞及びその使用 |
| WO2019116096A1 (en) | 2017-12-15 | 2019-06-20 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Production of fc fragments |
| US11160260B2 (en) | 2018-04-17 | 2021-11-02 | The Curators Of The University Of Missouri | Methods for protecting porcine fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV) |
| CA3101021A1 (en) | 2018-05-31 | 2019-12-05 | University Health Network | Methods and compositions comprising tankyrase inhibitors for generating insulin producing cells |
| EP3847244B1 (en) | 2018-09-07 | 2025-07-30 | Hebecell Corporation | Methods and compositions for retinal neuron generation in carrier-free 3d sphere suspension culture |
| WO2020053661A1 (en) | 2018-09-13 | 2020-03-19 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Methods of purifying antibodies from the milk of transgenic non-human mammals comprising the use of chitosan |
| WO2020229546A1 (en) | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Regulatory t cells targeted by lymphotoxin alpha blocking agent and uses thereof |
| JP2022552270A (ja) | 2019-10-09 | 2022-12-15 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 変異cxcr4を発現するように改変された又は部分的に欠失されたt細胞及びその使用 |
| US20220211018A1 (en) | 2020-11-20 | 2022-07-07 | Revivicor, Inc. | Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation |
| CA3232376A1 (en) | 2021-09-20 | 2023-03-23 | Maria KOKKINAKI | Multitransgenic pigs comprising ten genetic modifications for xenotransplantation |
| CA3245841A1 (en) | 2022-03-16 | 2023-09-21 | The Children's Medical Center Corporation | ARTICULAR CHONDROCYTE COMPOSITIONS DERIVED FROM HUMAN PARTHENOGENETIC STEM CELLS, SYSTEMS AND METHODS OF USING THESE |
| JP2025512066A (ja) | 2022-04-15 | 2025-04-16 | スマートセラ ソリューションズ エービー | エキソソームを介したmRNA剤の送達のための組成物及び方法 |
| US20230380446A1 (en) | 2022-05-26 | 2023-11-30 | Tender Food, Inc. | Plant-based shredded meat products, and methods of producing the same |
| EP4586822A1 (en) | 2022-09-16 | 2025-07-23 | Tender Food, Inc. | Plant and animal cell blended meat products and methods of producing the same |
| JP2026504725A (ja) | 2022-12-16 | 2026-02-09 | テンダー フード,インコーポレイテッド | 植物ベースの家禽製品及びその製造方法 |
| WO2025217332A1 (en) | 2024-04-10 | 2025-10-16 | Tender Food, Inc. | Apparatus for production of food-grade fibers and methods of operating the same |
| WO2026083330A1 (en) | 2024-10-17 | 2026-04-23 | Roslin Cell Therapies Limited | Compositions and methods for reprogramming of cells |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026884A1 (en) * | 1993-05-14 | 1994-11-24 | Biotechnology Research And Development Corporation | Embryonic stem cells for making chimeric and transgenic ungulates |
| JP2000506722A (ja) * | 1995-08-31 | 2000-06-06 | ロスリン インスティテュート(エジンバラ) | 核転移用の静止状態の細胞集団 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4994384A (en) * | 1986-12-31 | 1991-02-19 | W. R. Grace & Co.-Conn. | Multiplying bovine embryos |
| US5057420A (en) * | 1987-06-05 | 1991-10-15 | Granada Biosciences, Inc. | Bovine nuclear transplantation |
| AU1439295A (en) * | 1993-12-17 | 1995-07-03 | Abs Global, Inc. | Ungulate preblastocyst derived embryonic stem cells and use thereof to produce cloned transgenic and chimeric ungulates |
| WO1995017500A1 (en) * | 1993-12-23 | 1995-06-29 | Abs Global, Inc. | Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals |
| AUPM621394A0 (en) * | 1994-06-10 | 1994-07-07 | Mitchell, John | Cathode connection for aluminium smelter pot |
| AU699869B2 (en) * | 1994-06-15 | 1998-12-17 | Meiji Dairies Corporation | EG Cells of Ungulates |
| GB9417831D0 (en) * | 1994-09-05 | 1994-10-26 | Biotech & Biolog Scien Res | Biological manipulation |
| DE19532098A1 (de) * | 1995-08-30 | 1997-03-06 | Stuemed Gmbh | Vorrichtung für endoskopische Operationen, insbesondere spreizbares Stütz-Epi-Hypopharyngo-Laryngoskop nach Feyh-Kastenbauer |
| GB9517779D0 (en) * | 1995-08-31 | 1995-11-01 | Roslin Inst Edinburgh | Biological manipulation |
| US5905042A (en) * | 1996-04-01 | 1999-05-18 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Cultured inner cell mass cell lines derived from bovine or porcine embryos |
| US5945577A (en) * | 1997-01-10 | 1999-08-31 | University Of Massachusetts As Represented By Its Amherst Campus | Cloning using donor nuclei from proliferating somatic cells |
-
1997
- 1997-01-10 US US08/781,752 patent/US5945577A/en not_active Expired - Fee Related
- 1997-09-22 US US08/935,052 patent/US6235970B1/en not_active Expired - Fee Related
-
1998
- 1998-01-05 AT AT98903349T patent/ATE356203T1/de not_active IP Right Cessation
- 1998-01-05 EP EP98903349A patent/EP1015572B1/en not_active Expired - Lifetime
- 1998-01-05 ES ES98903349T patent/ES2284197T3/es not_active Expired - Lifetime
- 1998-01-05 CA CA2277192A patent/CA2277192C/en not_active Expired - Lifetime
- 1998-01-05 NZ NZ336612A patent/NZ336612A/xx unknown
- 1998-01-05 JP JP53095898A patent/JP2001512964A/ja not_active Ceased
- 1998-01-05 WO PCT/US1998/000002 patent/WO1998030683A2/en not_active Ceased
- 1998-01-05 DE DE69837270T patent/DE69837270T2/de not_active Expired - Lifetime
- 1998-01-05 CN CN988027941A patent/CN1248288B/zh not_active Expired - Lifetime
- 1998-01-05 AU AU60145/98A patent/AU742363C/en not_active Ceased
- 1998-01-05 EP EP07004337A patent/EP1808484A1/en not_active Withdrawn
- 1998-01-05 BR BR9806872-5A patent/BR9806872A/pt not_active Application Discontinuation
- 1998-01-05 IL IL13082998A patent/IL130829A0/xx active IP Right Grant
-
1999
- 1999-07-07 IL IL130829A patent/IL130829A/en not_active IP Right Cessation
-
2001
- 2001-04-10 US US09/828,876 patent/US20020010949A1/en not_active Abandoned
-
2004
- 2004-09-02 US US10/932,921 patent/US20050108785A1/en not_active Abandoned
-
2007
- 2007-03-28 JP JP2007084406A patent/JP2007167078A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026884A1 (en) * | 1993-05-14 | 1994-11-24 | Biotechnology Research And Development Corporation | Embryonic stem cells for making chimeric and transgenic ungulates |
| JP2000506722A (ja) * | 1995-08-31 | 2000-06-06 | ロスリン インスティテュート(エジンバラ) | 核転移用の静止状態の細胞集団 |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000512159A (ja) * | 1998-01-16 | 2000-09-19 | アグロバイオジェン ゲーエムベーハー | 胎仔線維芽細胞による効率的な核移入 |
| JP2002500864A (ja) * | 1998-01-21 | 2002-01-15 | ユニバーシティ・オブ・ハワイ | 成体の体細胞核を再構成した被核除去卵母細胞からの動物の満期の成長 |
| JP2006522609A (ja) * | 2003-04-09 | 2006-10-05 | マギー−ウイメンズ・ヘルス・コーポレイション | 動物の体細胞核移植と関係する紡錘体欠損を修正するための方法 |
| JPWO2016140353A1 (ja) * | 2015-03-04 | 2018-01-25 | 株式会社医療実験用大動物供給事業準備会社 | 安定した表現型を示す疾患モデルブタおよびその作製方法 |
| JP2021176317A (ja) * | 2015-03-04 | 2021-11-11 | 株式会社ポル・メド・テック | 安定した表現型を示す疾患モデルブタおよびその作製方法 |
| US11246299B2 (en) | 2015-03-04 | 2022-02-15 | Pormedtec Co., Ltd. | Disease model pig exhibiting stable phenotype, and production method thereof |
| JP7699330B2 (ja) | 2015-03-04 | 2025-06-27 | 株式会社ポル・メド・テック | 安定した表現型を示す疾患モデルブタおよびその作製方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1248288A (zh) | 2000-03-22 |
| EP1015572A2 (en) | 2000-07-05 |
| ES2284197T3 (es) | 2007-11-01 |
| JP2007167078A (ja) | 2007-07-05 |
| ATE356203T1 (de) | 2007-03-15 |
| EP1808484A1 (en) | 2007-07-18 |
| WO1998030683A2 (en) | 1998-07-16 |
| DE69837270T2 (de) | 2008-01-24 |
| US20050108785A1 (en) | 2005-05-19 |
| US20020010949A1 (en) | 2002-01-24 |
| CA2277192C (en) | 2011-03-15 |
| US6235970B1 (en) | 2001-05-22 |
| CA2277192A1 (en) | 1998-07-16 |
| NZ336612A (en) | 2002-09-27 |
| EP1015572B1 (en) | 2007-03-07 |
| AU742363C (en) | 2007-06-28 |
| IL130829A0 (en) | 2001-01-28 |
| AU6014598A (en) | 1998-08-03 |
| CN1248288B (zh) | 2011-11-09 |
| US5945577A (en) | 1999-08-31 |
| DE69837270D1 (de) | 2007-04-19 |
| AU742363B2 (en) | 2002-01-03 |
| IL130829A (en) | 2008-11-26 |
| WO1998030683A3 (en) | 1998-09-17 |
| BR9806872A (pt) | 2000-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1248288B (zh) | 用分化胎儿和成年供体细胞进行的核转移 | |
| AU740709B2 (en) | Embryonic or stem-like cell lines produced by cross species nuclear transplanta tion | |
| US6215041B1 (en) | Cloning using donor nuclei from a non-quiesecent somatic cells | |
| US20020035737A1 (en) | Cloning pigs using donor nuclei from differentiated cells | |
| JP2001509361A (ja) | 分化した無血清飢餓細胞からの供与核を用いるクローニング | |
| US20010012513A1 (en) | Embryonic or stem-like cell lines produced by cross species nuclear transplantation | |
| JP2002505100A (ja) | 種間核移植によって作製された胚性または幹細胞様細胞株 | |
| JP2003509031A (ja) | ドナー細胞又は分化細胞からの核を使用する豚のクローニング並びに多能性豚の産生 | |
| US20020194637A1 (en) | Embryonic or stem-like cell lines produced by cross species nuclear transplantation | |
| MXPA00000201A (en) | Cloning using donor nuclei from non-serum starved, differentiated cells | |
| AU2006202185A1 (en) | Cloning using donor nuclei from non-serum starved, differentiated cells | |
| AU2006236032A1 (en) | Nuclear transfer with differentiated fetal and adult donor cells | |
| AU2011202964A1 (en) | Nuclear transfer with differentiated fetal and adult donor cells | |
| MXPA99001706A (es) | Lineas celulares embrionicas o similares a las desoporte producidas por transplante nuclear de especies cruzadas | |
| MXPA99006464A (en) | Nuclear transfer with differentiated fetal and adult donor cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20050105 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20050105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20050303 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080610 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20080910 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20081020 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20081010 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20081121 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20081110 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20081222 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20081209 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20091110 |
|
| A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20100301 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20100406 |