JP2001507021A - 鎮痛作用を有する新規な化合物 - Google Patents

鎮痛作用を有する新規な化合物

Info

Publication number
JP2001507021A
JP2001507021A JP52867098A JP52867098A JP2001507021A JP 2001507021 A JP2001507021 A JP 2001507021A JP 52867098 A JP52867098 A JP 52867098A JP 52867098 A JP52867098 A JP 52867098A JP 2001507021 A JP2001507021 A JP 2001507021A
Authority
JP
Japan
Prior art keywords
formula
compound
independently
optionally
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP52867098A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001507021A5 (https=
Inventor
ペルクマン，ベンヤミン
ロバーツ，エドワード
Original Assignee
アストラ・フアーマ・インコーポレイテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アストラ・フアーマ・インコーポレイテツド filed Critical アストラ・フアーマ・インコーポレイテツド
Publication of JP2001507021A publication Critical patent/JP2001507021A/ja
Publication of JP2001507021A5 publication Critical patent/JP2001507021A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
JP52867098A 1996-12-20 1997-12-09 鎮痛作用を有する新規な化合物 Ceased JP2001507021A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9604786-5 1996-12-20
SE9604786A SE9604786D0 (sv) 1996-12-20 1996-12-20 New compounds
PCT/SE1997/002051 WO1998028270A1 (en) 1996-12-20 1997-12-09 Novel compounds with analgesic effect

Publications (2)

Publication Number Publication Date
JP2001507021A true JP2001507021A (ja) 2001-05-29
JP2001507021A5 JP2001507021A5 (https=) 2005-08-11

Family

ID=20405139

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52867098A Ceased JP2001507021A (ja) 1996-12-20 1997-12-09 鎮痛作用を有する新規な化合物

Country Status (31)

Country Link
US (3) US6153626A (https=)
EP (2) EP0946510B1 (https=)
JP (1) JP2001507021A (https=)
KR (1) KR20000069600A (https=)
CN (2) CN1539824A (https=)
AR (1) AR010378A1 (https=)
AT (1) ATE266638T1 (https=)
AU (1) AU738002B2 (https=)
BR (1) BR9713785A (https=)
CA (1) CA2274117A1 (https=)
CZ (1) CZ220099A3 (https=)
DE (1) DE69729115T2 (https=)
DK (1) DK0946510T3 (https=)
EE (1) EE03966B1 (https=)
ES (1) ES2219783T3 (https=)
HU (1) HUP0000613A3 (https=)
ID (1) ID21662A (https=)
IL (1) IL130536A0 (https=)
IS (1) IS5078A (https=)
MY (1) MY132705A (https=)
NO (1) NO313632B1 (https=)
NZ (1) NZ336028A (https=)
PL (1) PL188945B1 (https=)
PT (1) PT946510E (https=)
RU (1) RU2193030C2 (https=)
SE (1) SE9604786D0 (https=)
SK (1) SK283300B6 (https=)
TR (1) TR199901411T2 (https=)
UA (1) UA54481C2 (https=)
WO (1) WO1998028270A1 (https=)
ZA (1) ZA9711049B (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005525381A (ja) * 2002-03-13 2005-08-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのアミノ誘導体
JP2008137997A (ja) * 2006-11-10 2008-06-19 Otsuka Pharmaceut Co Ltd 医薬
JP2010095543A (ja) * 1998-03-10 2010-04-30 Research Triangle Inst 新規なオピエート化合物、その調製法及び使用法
JP4754068B2 (ja) * 1997-12-24 2011-08-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類

Families Citing this family (42)

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SE9504661D0 (sv) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
US6974825B1 (en) 1996-12-20 2005-12-13 Astrazeneca Canada Inc. Compounds with analgesic effect
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
AU2003220725B2 (en) * 1997-12-24 2006-06-01 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
SE9904675D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904674D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
SE9904673D0 (sv) * 1999-12-20 1999-12-20 Astra Pharma Inc Novel compounds
JP2003518119A (ja) * 1999-12-22 2003-06-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ４−［アリール（８−アザビシクロ［３．２．１］オクタン−３−イル）］アミノ安息香酸誘導体
WO2001060796A1 (fr) * 2000-02-18 2001-08-23 Meiji Seika Kaisha, Ltd. DERIVES DE PHENOXYALKYLAMINE UTILES EN TANT QU'AGONISTES DU RECEPTEUR OPIOIDE $g(d)
EP1263758A2 (en) 2000-03-03 2002-12-11 Ortho-McNeil Pharmaceutical, Inc. 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
US6790854B2 (en) 2000-03-24 2004-09-14 Meiji Seika Kaisha, Ltd. Diphenylalkylamine derivatives useful as opioid receptor agonists
SE0001209D0 (sv) 2000-04-04 2000-04-04 Astrazeneca Canada Inc Novel compounds
US6887876B2 (en) 2000-12-14 2005-05-03 Ortho-Mcneil Pharmaceutical, Inc. Benzamidine derivatives
IL155995A0 (en) * 2000-12-15 2003-12-23 Astrazeneca Ab New process for the preparation of diaryl-4-amino-piperidinyl compounds
SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101773D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
DK1395567T3 (da) 2001-05-18 2009-04-06 Astrazeneca Ab 4-(phenylpiperazinylmethyl)-benzamidderivater og deres anvendelse til behandling af smerte, angst eller mavetarmslidelser
SE0101770D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
SE0101769D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
BR0213327A (pt) 2001-10-15 2004-10-13 Janssen Pharmaceutica Nv Derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina substituìdos e sua aplicação como agonistas de delta opióides não-peptìdicos seletivos
EP2399903A1 (en) 2002-05-24 2011-12-28 Millennium Pharmaceuticals, Inc. Ccr9 inhibitors and methods of use thereof
SE0203300D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203302D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
US7741519B2 (en) 2007-04-23 2010-06-22 Chemocentryx, Inc. Bis-aryl sulfonamides
US6939885B2 (en) 2002-11-18 2005-09-06 Chemocentryx Aryl sulfonamides
US7227035B2 (en) 2002-11-18 2007-06-05 Chemocentryx Bis-aryl sulfonamides
US7420055B2 (en) 2002-11-18 2008-09-02 Chemocentryx, Inc. Aryl sulfonamides
DK2009000T3 (da) * 2003-01-16 2011-09-05 Acadia Pharm Inc Selektive serotonin 2A/2C-receptor invers-agonister som terapeutika for neurodegenerative sygdomme
US7589103B2 (en) * 2003-06-27 2009-09-15 Janssen Pharmaceutica N.V. Tricyclic-bridged piperidinylidene derivatives as 8-opioid modulators
EP1737853A1 (en) 2004-02-03 2007-01-03 Janssen Pharmaceutica N.V. 3-(diheteroarylmethylene)-8-azabicyclo¬3.2.1|octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo¬3.2.1|octane derivatives
DK1781631T3 (da) 2004-08-02 2012-05-14 Astrazeneca Ab Diarylmethylpiperazinderivater, præparater dermed og anvendelser deraf
EP1910353A1 (en) * 2004-08-05 2008-04-16 Janssen Pharmaceutica N.V. Tricyclic delta- opioid modulators
JP2008525483A (ja) * 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド調節剤
JP2008525481A (ja) * 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 三環式δ−オピオイド・モジュレーター
ATE432279T1 (de) * 2004-12-22 2009-06-15 Janssen Pharmaceutica Nv Tricyclische delta-opioid-modulatoren
KR20070104380A (ko) * 2005-01-06 2007-10-25 얀센 파마슈티카 엔.브이. 트리사이클릭 δ-오피오이드 조절제
TWI410406B (zh) * 2005-05-13 2013-10-01 Otsuka Pharma Co Ltd 吡咯烷化合物
ATE490251T1 (de) * 2005-06-16 2010-12-15 Janssen Pharmaceutica Nv Tricyclische opioidmodulatoren

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US4091096A (en) * 1976-03-19 1978-05-23 Eli Lilly And Company Dinitroanilines for the control of phytopathogens
EG12406A (en) * 1976-08-12 1979-03-31 Janssen Pharmaceutica Nv Process for preparing of novel n-aryl-n-(1-l-4-piperidinyl)-arylacetamides
SE441448B (sv) * 1977-05-23 1985-10-07 Pfizer Sett att framstella hexahydro-gamma-karbolinforeningar
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
EP0181793B1 (fr) * 1984-10-16 1988-07-27 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique
KR940003491B1 (ko) 1989-08-10 1994-04-23 리히터 게데온 베기에스제티 기아르 알.티 4,4-이중 치환된 피페리딘 유도체와 그 제조방법 및 상기 화합물을 함유하는 약제학적 조성물
YU150489A (sh) 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
SE8904298D0 (sv) * 1989-12-21 1989-12-21 Astra Ab New compounds
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
TW548271B (en) * 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (sv) 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
WO1999033806A1 (en) * 1997-12-24 1999-07-08 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
EP1512683B1 (en) 1998-03-10 2011-08-31 Research Triangle Institute Novel opiate compounds, methods of making and methods of use
US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4754068B2 (ja) * 1997-12-24 2011-08-24 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド δ−オピオイドレセプターに結合する４−［アリール（ピペリジン−４−イル）］アミノベンズアミド類
JP2010095543A (ja) * 1998-03-10 2010-04-30 Research Triangle Inst 新規なオピエート化合物、その調製法及び使用法
JP2005525381A (ja) * 2002-03-13 2005-08-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのアミノ誘導体
JP2008137997A (ja) * 2006-11-10 2008-06-19 Otsuka Pharmaceut Co Ltd 医薬

Also Published As

Publication number Publication date
HK1022910A1 (en) 2000-08-25
EP0946510A1 (en) 1999-10-06
NO993023L (no) 1999-08-12
ES2219783T3 (es) 2004-12-01
CN1539824A (zh) 2004-10-27
TR199901411T2 (xx) 1999-09-21
EP1428821A1 (en) 2004-06-16
EP1428821A8 (en) 2005-01-26
EE9900261A (et) 2000-02-15
BR9713785A (pt) 2000-02-08
ZA9711049B (en) 1998-06-22
AU738002B2 (en) 2001-09-06
AU5351398A (en) 1998-07-17
MY132705A (en) 2007-10-31
HUP0000613A3 (en) 2002-10-28
PT946510E (pt) 2004-08-31
HK1023996A1 (en) 2000-09-29
US20030055045A1 (en) 2003-03-20
DE69729115T2 (de) 2005-04-28
UA54481C2 (uk) 2003-03-17
SK283300B6 (sk) 2003-05-02
NO313632B1 (no) 2002-11-04
ATE266638T1 (de) 2004-05-15
DK0946510T3 (da) 2004-08-09
ID21662A (id) 1999-07-08
NZ336028A (en) 2001-03-30
IS5078A (is) 1999-06-11
CZ220099A3 (cs) 1999-11-17
EE03966B1 (et) 2003-02-17
SK76399A3 (en) 2000-01-18
EP0946510B1 (en) 2004-05-12
WO1998028270A1 (en) 1998-07-02
KR20000069600A (ko) 2000-11-25
IL130536A0 (en) 2000-06-01
PL188945B1 (pl) 2005-05-31
CA2274117A1 (en) 1998-07-02
AR010378A1 (es) 2000-06-07
US6399635B1 (en) 2002-06-04
PL334370A1 (en) 2000-02-28
US6153626A (en) 2000-11-28
CN1241178A (zh) 2000-01-12
HUP0000613A2 (hu) 2000-09-28
SE9604786D0 (sv) 1996-12-20
DE69729115D1 (de) 2004-06-17
RU2193030C2 (ru) 2002-11-20
US6710179B2 (en) 2004-03-23
NO993023D0 (no) 1999-06-18
CN1154635C (zh) 2004-06-23

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