RU2193030C2 - Азотсодержащие гетероциклические соединения, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества - Google Patents

Азотсодержащие гетероциклические соединения, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества Download PDF

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RU2193030C2
RU2193030C2 RU99115746/04A RU99115746A RU2193030C2 RU 2193030 C2 RU2193030 C2 RU 2193030C2 RU 99115746/04 A RU99115746/04 A RU 99115746/04A RU 99115746 A RU99115746 A RU 99115746A RU 2193030 C2 RU2193030 C2 RU 2193030C2
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compound
formula
mmol
mixture
nmr
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RU99115746/04A
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Russian (ru)
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RU99115746A (ru
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Бенджамин Пелкман
Эдвард Робертс
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АСТРА ФАРМА Инк.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
RU99115746/04A 1996-12-20 1997-12-09 Азотсодержащие гетероциклические соединения, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества RU2193030C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604786-5 1996-12-20
SE9604786A SE9604786D0 (sv) 1996-12-20 1996-12-20 New compounds

Publications (2)

Publication Number Publication Date
RU99115746A RU99115746A (ru) 2001-05-27
RU2193030C2 true RU2193030C2 (ru) 2002-11-20

Family

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Family Applications (1)

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RU99115746/04A RU2193030C2 (ru) 1996-12-20 1997-12-09 Азотсодержащие гетероциклические соединения, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества

Country Status (31)

Country Link
US (3) US6153626A (https=)
EP (2) EP1428821A1 (https=)
JP (1) JP2001507021A (https=)
KR (1) KR20000069600A (https=)
CN (2) CN1154635C (https=)
AR (1) AR010378A1 (https=)
AT (1) ATE266638T1 (https=)
AU (1) AU738002B2 (https=)
BR (1) BR9713785A (https=)
CA (1) CA2274117A1 (https=)
CZ (1) CZ220099A3 (https=)
DE (1) DE69729115T2 (https=)
DK (1) DK0946510T3 (https=)
EE (1) EE03966B1 (https=)
ES (1) ES2219783T3 (https=)
HU (1) HUP0000613A3 (https=)
ID (1) ID21662A (https=)
IL (1) IL130536A0 (https=)
IS (1) IS5078A (https=)
MY (1) MY132705A (https=)
NO (1) NO313632B1 (https=)
NZ (1) NZ336028A (https=)
PL (1) PL188945B1 (https=)
PT (1) PT946510E (https=)
RU (1) RU2193030C2 (https=)
SE (1) SE9604786D0 (https=)
SK (1) SK283300B6 (https=)
TR (1) TR199901411T2 (https=)
UA (1) UA54481C2 (https=)
WO (1) WO1998028270A1 (https=)
ZA (1) ZA9711049B (https=)

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US6436959B1 (en) 1998-12-23 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. 4-[aryl(piperidin-4-yl)]aminobenzamides
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SE0101771D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab Novel compounds
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EA006507B1 (ru) 2001-10-15 2005-12-29 Янссен Фармацевтика Н.В. Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов
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SE0203303D0 (sv) 2002-11-07 2002-11-07 Astrazeneca Ab Novel Compounds
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KR101234421B1 (ko) 2004-08-02 2013-02-18 아스트라제네카 아베 디아릴메틸 피페라진 유도체, 이의 제조 방법 및 용도
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US4680296A (en) * 1984-10-16 1987-07-14 Synthelabo Piperidine derivatives and pharmaceutical compositions containing them
RU2039043C1 (ru) * 1989-12-21 1995-07-09 Актиеболагет Астра Производное n-замещенного 1-гексил-4-фенил-4-пиперидинкарбоксамида или его фармацевтически приемлемая соль и способ его получения

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EP1049676B1 (en) * 1997-12-24 2005-10-12 Ortho-Mcneil Pharmaceutical, Inc. 4- aryl(piperidin-4-yl)] aminobenzamides which bind to the delta-opioid receptor
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US4460586A (en) * 1981-01-16 1984-07-17 Sandoz Ltd. 2-Cyano-4-(2-hydroxy-3-substituted-aminopropoxy) indoles
US4680296A (en) * 1984-10-16 1987-07-14 Synthelabo Piperidine derivatives and pharmaceutical compositions containing them
RU2039043C1 (ru) * 1989-12-21 1995-07-09 Актиеболагет Астра Производное n-замещенного 1-гексил-4-фенил-4-пиперидинкарбоксамида или его фармацевтически приемлемая соль и способ его получения

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2332401C2 (ru) * 2003-01-16 2008-08-27 Акадиа Фармасьютикалз Инк. Селективные обратные агонисты серотонин 2а/2с рецептора, применяемые в качестве лекарственных средств при нейродегенеративных заболеваниях

Also Published As

Publication number Publication date
WO1998028270A1 (en) 1998-07-02
IS5078A (is) 1999-06-11
HUP0000613A2 (hu) 2000-09-28
EP0946510B1 (en) 2004-05-12
IL130536A0 (en) 2000-06-01
EE9900261A (et) 2000-02-15
AU738002B2 (en) 2001-09-06
HK1022910A1 (en) 2000-08-25
SK283300B6 (sk) 2003-05-02
EE03966B1 (et) 2003-02-17
EP1428821A8 (en) 2005-01-26
MY132705A (en) 2007-10-31
TR199901411T2 (xx) 1999-09-21
JP2001507021A (ja) 2001-05-29
CN1241178A (zh) 2000-01-12
SE9604786D0 (sv) 1996-12-20
US6399635B1 (en) 2002-06-04
AU5351398A (en) 1998-07-17
CN1539824A (zh) 2004-10-27
ZA9711049B (en) 1998-06-22
PL334370A1 (en) 2000-02-28
ATE266638T1 (de) 2004-05-15
NO993023L (no) 1999-08-12
EP0946510A1 (en) 1999-10-06
PT946510E (pt) 2004-08-31
CZ220099A3 (cs) 1999-11-17
KR20000069600A (ko) 2000-11-25
EP1428821A1 (en) 2004-06-16
UA54481C2 (uk) 2003-03-17
US20030055045A1 (en) 2003-03-20
CA2274117A1 (en) 1998-07-02
CN1154635C (zh) 2004-06-23
HUP0000613A3 (en) 2002-10-28
DE69729115D1 (de) 2004-06-17
NO313632B1 (no) 2002-11-04
US6153626A (en) 2000-11-28
NZ336028A (en) 2001-03-30
PL188945B1 (pl) 2005-05-31
DK0946510T3 (da) 2004-08-09
AR010378A1 (es) 2000-06-07
ID21662A (id) 1999-07-08
ES2219783T3 (es) 2004-12-01
DE69729115T2 (de) 2005-04-28
NO993023D0 (no) 1999-06-18
US6710179B2 (en) 2004-03-23
HK1023996A1 (en) 2000-09-29
SK76399A3 (en) 2000-01-18
BR9713785A (pt) 2000-02-08

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