JP2000506847A - ４―アミノ―ピリミジン誘導体、これらの化合物を含む医薬品、それらの使用及び製造法 - Google Patents

４―アミノ―ピリミジン誘導体、これらの化合物を含む医薬品、それらの使用及び製造法

Info

Publication number
JP2000506847A
JP2000506847A JP9531444A JP53144497A JP2000506847A JP 2000506847 A JP2000506847 A JP 2000506847A JP 9531444 A JP9531444 A JP 9531444A JP 53144497 A JP53144497 A JP 53144497A JP 2000506847 A JP2000506847 A JP 2000506847A
Authority
JP
Japan
Prior art keywords
group
amino
piperidinyl
alkyl
pyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9531444A
Other languages
English (en)
Japanese (ja)
Inventor
フランク ヒンメルスバッハ
ゲオルク ダーマン
リューデン トーマス フォン
トーマス メッツ
Original Assignee
ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1996108631 external-priority patent/DE19608631A1/de
Application filed by ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング filed Critical ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング
Publication of JP2000506847A publication Critical patent/JP2000506847A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP9531444A 1996-03-06 1997-03-03 ４―アミノ―ピリミジン誘導体、これらの化合物を含む医薬品、それらの使用及び製造法 Pending JP2000506847A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19608631.0 1996-03-06
DE1996108631 DE19608631A1 (de) 1996-03-06 1996-03-06 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arnzeimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19629652.8 1996-07-23
DE19629652A DE19629652A1 (de) 1996-03-06 1996-07-23 4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1997/001057 WO1997032881A1 (de) 1996-03-06 1997-03-03 4-amino-pyrimidin-derivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
JP2000506847A true JP2000506847A (ja) 2000-06-06

Family

ID=26023531

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9531444A Pending JP2000506847A (ja) 1996-03-06 1997-03-03 ４―アミノ―ピリミジン誘導体、これらの化合物を含む医薬品、それらの使用及び製造法

Country Status (19)

Country Link
EP (1) EP0885226A1 (de)
JP (1) JP2000506847A (de)
KR (1) KR19990087550A (de)
CN (1) CN1212695A (de)
AU (1) AU710274B2 (de)
BG (1) BG102708A (de)
BR (1) BR9708312A (de)
CA (1) CA2243994A1 (de)
CZ (1) CZ281798A3 (de)
DE (1) DE19629652A1 (de)
EE (1) EE9800277A (de)
HU (1) HUP9901820A3 (de)
IL (1) IL125404A0 (de)
NO (1) NO984084L (de)
NZ (1) NZ331546A (de)
PL (1) PL328771A1 (de)
SK (1) SK120598A3 (de)
TR (1) TR199801749T2 (de)
WO (1) WO1997032881A1 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530212A (ja) * 2005-02-16 2008-08-07 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有するピペラジン−ピペリジン
JP2012510481A (ja) * 2008-12-01 2012-05-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌に対するオータキシン阻害剤としての２，５−ジアミノ−置換ピリド［４，３−ｄ］ピリミジン

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DE69709319T2 (de) 1996-03-05 2002-08-14 Astrazeneca Ab 4-anilinochinazolin derivate
EP1396489A1 (de) * 1999-01-27 2004-03-10 Pfizer Products Inc. Heteroaromatische Bicyclen als anti-Krebs Mittel
UA71945C2 (en) * 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
US7173038B1 (en) 1999-11-05 2007-02-06 Astrazeneca Ab Quinazoline derivatives as VEGF inhibitors
CA2530023A1 (en) 2003-06-24 2004-12-29 Neurosearch A/S Novel 8-aza-bicyclo[3.2.1]octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MX2011004824A (es) 2008-11-07 2012-01-12 Triact Therapeutics Inc Uso de derivados de butano catecólico en terapia contra el cáncer.
JP2012518657A (ja) 2009-02-25 2012-08-16 オーエスアイ・ファーマシューティカルズ，エルエルシー 併用抗癌治療
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
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WO2010099363A1 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
EP2408479A1 (de) 2009-03-18 2012-01-25 OSI Pharmaceuticals, LLC Kombinationskrebstherapie mit verabreichung eines egfr-hemmers und eines igf-1r-hemmers
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EP2468883A1 (de) 2010-12-22 2012-06-27 Pangaea Biotech S.L. Molekulare Biomarker zur Vorhersage der Reaktion auf Tyrosinkinaseinhibitoren bei Lungenkrebs
US9134297B2 (en) 2011-01-11 2015-09-15 Icahn School Of Medicine At Mount Sinai Method and compositions for treating cancer and related methods
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WO2012129145A1 (en) 2011-03-18 2012-09-27 OSI Pharmaceuticals, LLC Nscle combination therapy
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MX2020012261A (es) 2018-06-12 2021-03-31 Amgen Inc Inhibidores de kras g12c que comprenden un anillo de piperazina y uso de estos en el tratamiento del cancer.
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JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
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JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
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IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
DE4431867A1 (de) * 1994-09-07 1996-03-14 Thomae Gmbh Dr K Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530212A (ja) * 2005-02-16 2008-08-07 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有するピペラジン−ピペリジン
JP2012510481A (ja) * 2008-12-01 2012-05-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌に対するオータキシン阻害剤としての２，５−ジアミノ−置換ピリド［４，３−ｄ］ピリミジン

Also Published As

Publication number Publication date
CA2243994A1 (en) 1997-09-12
IL125404A0 (en) 1999-03-12
EP0885226A1 (de) 1998-12-23
KR19990087550A (ko) 1999-12-27
AU710274B2 (en) 1999-09-16
NO984084D0 (no) 1998-09-04
BR9708312A (pt) 1999-08-03
DE19629652A1 (de) 1998-01-29
SK120598A3 (en) 1999-06-11
HUP9901820A2 (hu) 1999-09-28
BG102708A (en) 1999-09-30
PL328771A1 (en) 1999-02-15
NO984084L (no) 1998-09-04
CN1212695A (zh) 1999-03-31
EE9800277A (et) 1999-02-15
CZ281798A3 (cs) 1999-02-17
NZ331546A (en) 2000-03-27
TR199801749T2 (xx) 1998-12-21
AU1925197A (en) 1997-09-22
HUP9901820A3 (en) 2001-10-29
WO1997032881A1 (de) 1997-09-12

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