|
PT874830E
(pt)
*
|
1995-12-08 |
2003-06-30 |
Agouron Pharma |
Inibidor de metaloproteinases composicao farmaceutica contendo este inibidor e a utilizacao farmaceutica e metodo util para a sua preparacao
|
|
US6500948B1
(en)
|
1995-12-08 |
2002-12-31 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
|
|
RU2221781C2
(ru)
*
|
1996-07-22 |
2004-01-20 |
Монсанто Компани |
Тиолсульфоновые соединения в качестве ингибитора матриксной металлопротеазы и способы лечения
|
|
US6747027B1
(en)
|
1996-07-22 |
2004-06-08 |
Pharmacia Corporation |
Thiol sulfonamide metalloprotease inhibitors
|
|
SK25099A3
(en)
|
1996-08-28 |
2000-02-14 |
Procter & Gamble |
Substituted cyclic amine metalloprotease inhibitors
|
|
US6872742B2
(en)
|
1996-08-28 |
2005-03-29 |
The Procter & Gamble Company |
Substituted cyclic amine metalloprotease inhibitors
|
|
BR9712792A
(pt)
*
|
1996-08-28 |
1999-12-14 |
Procter & Gamble |
Inibidores de metaloprotease bidentada.
|
|
CA2264045A1
(en)
*
|
1996-08-28 |
1998-03-05 |
Randall Stryker Matthews |
Heterocyclic metalloprotease inhibitors
|
|
AU734834B2
(en)
*
|
1996-08-28 |
2001-06-21 |
Procter & Gamble Company, The |
Heterocyclic metalloprotease inhibitors
|
|
ATE227274T1
(de)
*
|
1996-08-28 |
2002-11-15 |
Procter & Gamble |
1,3-diheterozyklische metalloprotease inhibitoren
|
|
DE69718038D1
(de)
*
|
1996-10-16 |
2003-01-30 |
American Cyanamid Co |
Herstellung und verwendung von ortho-sulfonamido-heteroarylhydroxamsäuren als matrix-metalloproteinase und tace inhibitoren
|
|
US5929097A
(en)
*
|
1996-10-16 |
1999-07-27 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
US6228869B1
(en)
|
1996-10-16 |
2001-05-08 |
American Cyanamid Company |
Ortho-sulfonamido bicyclic hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US6548524B2
(en)
|
1996-10-16 |
2003-04-15 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US5977408A
(en)
*
|
1996-10-16 |
1999-11-02 |
American Cyanamid Company |
Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors
|
|
US5962481A
(en)
*
|
1996-10-16 |
1999-10-05 |
American Cyanamid Company |
Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors
|
|
US6174915B1
(en)
|
1997-03-25 |
2001-01-16 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
US6008243A
(en)
*
|
1996-10-24 |
1999-12-28 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
|
|
US6333324B1
(en)
|
1996-12-17 |
2001-12-25 |
Fujisawa Pharmaceutical Co., Ltd. |
Piperazine compounds as inhibitors of MMP or TNF
|
|
WO1998039316A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
N-hydroxy 4-sulfonyl butanamide compounds
|
|
ES2234103T3
(es)
*
|
1997-03-04 |
2005-06-16 |
Pharmacia Corporation |
Compuestos de acido tioarilsulfonamidohidroxamico.
|
|
US6696449B2
(en)
|
1997-03-04 |
2004-02-24 |
Pharmacia Corporation |
Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
|
|
WO1998039315A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
|
|
US7115632B1
(en)
|
1999-05-12 |
2006-10-03 |
G. D. Searle & Co. |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
|
|
US6794511B2
(en)
|
1997-03-04 |
2004-09-21 |
G. D. Searle |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
|
|
US6087359A
(en)
*
|
1997-03-04 |
2000-07-11 |
Getman; Daniel P. |
Thioaryl sulfonamide hydroxamic acid compounds
|
|
KR20000075954A
(ko)
|
1997-03-04 |
2000-12-26 |
죤 에이치. 뷰센 |
N-히드록시 4-술포닐 부탄아미드 화합물
|
|
WO1998039326A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds
|
|
US5985900A
(en)
*
|
1997-04-01 |
1999-11-16 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
KR20010005940A
(ko)
*
|
1997-04-01 |
2001-01-15 |
아구론 파마슈티컬스, 인크. |
메탈로프로테이나제 억제제를 포함하는 약제학적 조성물 및 이의 약제학적 용도
|
|
AU7294098A
(en)
*
|
1997-05-09 |
1998-11-27 |
Agouron Pharmaceuticals, Inc. |
Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
|
|
JP2004137284A
(ja)
*
|
1997-06-17 |
2004-05-13 |
Kaken Pharmaceut Co Ltd |
2−スルファモイル安息香酸誘導体
|
|
BR9810841A
(pt)
|
1997-07-31 |
2001-07-10 |
Procter & Gamble |
Inibidores de metaloprotease alicìclicos
|
|
US6403632B1
(en)
*
|
2000-03-01 |
2002-06-11 |
Bristol Myers Squibb Pharma Co |
Lactam metalloprotease inhibitors
|
|
JPH11199512A
(ja)
*
|
1997-10-24 |
1999-07-27 |
Pfizer Prod Inc |
変形性関節症および他のmmp媒介疾患の治療のためのmmp−13選択的阻害剤の使用
|
|
CA2306460A1
(en)
|
1997-11-14 |
1999-05-27 |
G.D. Searle & Co. |
Aromatic sulfone hydroxamic acid metalloprotease inhibitor
|
|
US6750228B1
(en)
|
1997-11-14 |
2004-06-15 |
Pharmacia Corporation |
Aromatic sulfone hydroxamic acid metalloprotease inhibitor
|
|
US20010039287A1
(en)
|
1997-11-14 |
2001-11-08 |
Thomas E Barta |
Aromatic sulfone hydroxamic acid metalloprotease inhibitor
|
|
BR9907746A
(pt)
*
|
1998-01-27 |
2000-10-17 |
American Cyanamid Co |
ácidos 2,3,4,5-tetraidro-1h[1,4]-benzodiazepina-3-hidroxâmic os como inibidores de matriz de metaloproteinase
|
|
US6071903A
(en)
*
|
1998-01-27 |
2000-06-06 |
American Cyanamid Company |
2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids
|
|
US6410580B1
(en)
|
1998-02-04 |
2002-06-25 |
Novartis Ag |
Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
|
|
EP1918278A1
(en)
|
1998-02-04 |
2008-05-07 |
Novartis AG |
Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases
|
|
US6329418B1
(en)
*
|
1998-04-14 |
2001-12-11 |
The Procter & Gamble Company |
Substituted pyrrolidine hydroxamate metalloprotease inhibitors
|
|
WO1999058531A1
(en)
*
|
1998-05-14 |
1999-11-18 |
Du Pont Pharmaceuticals Company |
Novel substituted aryl hydroxamic acids as metalloproteinase inhibitors
|
|
WO1999065867A1
(en)
|
1998-06-17 |
1999-12-23 |
Du Pont Pharmaceuticals Company |
Cyclic hydroxamic acids as metalloproteinase inhibitors
|
|
ES2310636T3
(es)
|
1998-06-18 |
2009-01-16 |
F. Hoffmann-La Roche Ag |
Proceso para sulfuros de arilalquilo.
|
|
FR2780402B1
(fr)
*
|
1998-06-30 |
2001-04-27 |
Adir |
Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
CA2340182A1
(en)
*
|
1998-08-12 |
2000-02-24 |
Pfizer Products Inc. |
Tace inhibitors
|
|
UA59453C2
(uk)
*
|
1998-08-12 |
2003-09-15 |
Пфайзер Продактс Інк. |
Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ
|
|
US6509337B1
(en)
*
|
1998-09-17 |
2003-01-21 |
Pfizer Inc. |
Arylsulfonyl Hydroxamic Acid derivatives as MMP and TNF inhibitors
|
|
US6307049B1
(en)
|
1998-09-30 |
2001-10-23 |
The Procter & Gamble Co. |
Heterocyclic 2-substituted ketoamides
|
|
US6300341B1
(en)
|
1998-09-30 |
2001-10-09 |
The Procter & Gamble Co. |
2-substituted heterocyclic sulfonamides
|
|
AU6060199A
(en)
*
|
1998-09-30 |
2000-04-17 |
Procter & Gamble Company, The |
Method of treating hair loss using sulfonamides
|
|
US6288261B1
(en)
*
|
1998-12-18 |
2001-09-11 |
Abbott Laboratories |
Inhibitors of matrix metalloproteinases
|
|
US6858598B1
(en)
*
|
1998-12-23 |
2005-02-22 |
G. D. Searle & Co. |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
|
|
JP2002533404A
(ja)
*
|
1998-12-23 |
2002-10-08 |
ジー・ディー・サール・アンド・カンパニー |
新生物形成の治療における組合わせ療法としてインテグリン拮抗剤及び放射線治療を使用する方法
|
|
BR0007784A
(pt)
|
1999-01-27 |
2002-02-05 |
American Cyanamid Co |
Composto, método para inibir mudanças patológicas mediadas pela enzima que converte o tnf-alfa (tace) em um mamìfero, composição farmacêutica, e, processo para preparar um composto
|
|
US6762178B2
(en)
|
1999-01-27 |
2004-07-13 |
Wyeth Holdings Corporation |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
US6225311B1
(en)
|
1999-01-27 |
2001-05-01 |
American Cyanamid Company |
Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors
|
|
US6313123B1
(en)
|
1999-01-27 |
2001-11-06 |
American Cyanamid Company |
Acetylenic sulfonamide thiol tace inhibitors
|
|
US6277885B1
(en)
|
1999-01-27 |
2001-08-21 |
American Cyanamid Company |
Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
US6200996B1
(en)
|
1999-01-27 |
2001-03-13 |
American Cyanamid Company |
Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors
|
|
US6544984B1
(en)
|
1999-01-27 |
2003-04-08 |
American Cyanamid Company |
2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
|
|
US6753337B2
(en)
|
1999-01-27 |
2004-06-22 |
Wyeth Holdings Corporation |
Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
|
|
US6946473B2
(en)
|
1999-01-27 |
2005-09-20 |
Wyeth Holdings Corporation |
Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
|
|
US6340691B1
(en)
|
1999-01-27 |
2002-01-22 |
American Cyanamid Company |
Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase and tace inhibitors
|
|
US6326516B1
(en)
|
1999-01-27 |
2001-12-04 |
American Cyanamid Company |
Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
|
|
AR022423A1
(es)
*
|
1999-01-27 |
2002-09-04 |
American Cyanamid Co |
Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
|
|
US6800646B1
(en)
|
1999-02-08 |
2004-10-05 |
Pharmacia Corporation |
Sulfamato hydroxamic acid metalloprotease inhibitor
|
|
KR20010102000A
(ko)
|
1999-02-08 |
2001-11-15 |
윌리암스 로저 에이 |
술파마토 히드록삼산 메탈로프로테아제 억제제
|
|
MXPA01008855A
(es)
|
1999-03-03 |
2002-07-02 |
Procter & Gamble |
Inhibidores de metaloproteasa que contienen alquenilo y alquinilo.
|
|
HK1044935A1
(zh)
|
1999-03-03 |
2002-11-08 |
The Procter & Gamble Company |
双异取代的金属蛋白酶抑制剂
|
|
AUPP982399A0
(en)
*
|
1999-04-19 |
1999-05-13 |
Fujisawa Pharmaceutical Co., Ltd. |
Mmp inhibitor
|
|
US6583299B1
(en)
|
1999-05-20 |
2003-06-24 |
G.D. Searle & Co. |
α-amino-β-sulfonyl hydroxamic acid compounds
|
|
US6869951B1
(en)
|
1999-07-16 |
2005-03-22 |
Pharmacia Corporation |
Method of changing conformation of a matrix metalloproteinase
|
|
AR033651A1
(es)
|
1999-10-01 |
2004-01-07 |
Hoffmann La Roche |
Derivados de pirimidina-2,4,6-triona, composiciones farmaceuticas que contienen dichos compuestos y el empleo de los mismos para la manufactura de un medicamento
|
|
CZ20023033A3
(cs)
|
2000-03-17 |
2003-01-15 |
Bristol-Myers Squibb Pharma Company |
Deriváty cyklických beta-aminokyselin jako inhibitory matrixových metaloproteáz a TNF-alfa
|
|
WO2001070734A2
(en)
|
2000-03-17 |
2001-09-27 |
Bristol-Myers Squibb Pharma Company |
Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha
|
|
EP1138680A1
(en)
*
|
2000-03-29 |
2001-10-04 |
Pfizer Products Inc. |
Gem substituted sulfonyl hydroxamic acids as MMP inhibitors
|
|
CA2372352A1
(en)
*
|
2000-04-07 |
2001-10-18 |
Hyun-Gyu Park |
Sulfonamide derivative as a matrix metalloproteinase inhibitor
|
|
US6683093B2
(en)
|
2000-05-12 |
2004-01-27 |
Pharmacia Corporation |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors
|
|
US6927216B2
(en)
|
2000-10-03 |
2005-08-09 |
Bristol-Myers Squibb Pharma Company |
Cyclic sulfonyl compounds as inhibitors of metalloproteases
|
|
EP1355901A2
(en)
|
2001-01-11 |
2003-10-29 |
Bristol-Myers Squibb Pharma Company |
1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a)
|
|
CA2434044A1
(en)
|
2001-01-11 |
2002-07-18 |
Bristol-Myers Squibb Pharma Company |
1,2-disubstituted cyclic inhibitors of matrix metallorproteases and tnf-alpha
|
|
FR2819252A1
(fr)
*
|
2001-01-11 |
2002-07-12 |
Servier Lab |
Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
MXPA01013326A
(es)
|
2001-02-14 |
2002-08-26 |
Warner Lambert Co |
Bifenil sulfonamidas utiles como inhibisdores de metaloproteinasa de matriz.
|
|
EP1373199A4
(en)
|
2001-03-15 |
2004-04-07 |
Bristol Myers Squibb Pharma Co |
SPIROCYCLIC BETA-AMINOACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND THE CONVERSION ENZYME OF TNF-ALPHA (TAGE)
|
|
US6716845B2
(en)
|
2001-03-30 |
2004-04-06 |
Hoffmann-La Roche Inc. |
Barbituric acid derivatives
|
|
YU85403A
(sh)
|
2001-05-11 |
2006-03-03 |
Pharmacia Corporation |
Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora
|
|
EP1404325A2
(en)
*
|
2001-05-29 |
2004-04-07 |
Guilford Pharmaceuticals Inc. |
Method for treating nerve injury caused by surgery
|
|
US6683078B2
(en)
|
2001-07-19 |
2004-01-27 |
Pharmacia Corporation |
Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
|
|
AUPR726201A0
(en)
*
|
2001-08-24 |
2001-09-20 |
Fujisawa Pharmaceutical Co., Ltd. |
New use of a cyclic compound
|
|
JP2003081937A
(ja)
*
|
2001-09-07 |
2003-03-19 |
Bayer Ag |
ベンゼンスルホンアミド誘導体
|
|
CN1610661A
(zh)
|
2001-11-01 |
2005-04-27 |
惠氏控股公司 |
用作基质金属蛋白酶和tace的抑制剂的丙二烯芳基磺酰胺异羟肟酸
|
|
AU2002356979A1
(en)
*
|
2001-11-30 |
2003-06-17 |
Bristol-Myers Squibb Company |
Method of producing n-((2s)-sulfanyl-4-(1,5,5-trimethylhydantoinyl)butanoyl)-l-leucyl-l-tert-leucine n-methylamide and intermediate thereof
|
|
PE20030701A1
(es)
|
2001-12-20 |
2003-08-21 |
Schering Corp |
Compuestos para el tratamiento de trastornos inflamatorios
|
|
MXPA04010555A
(es)
|
2002-04-25 |
2005-02-17 |
Pharmacia Corp |
Acidos piperidinil- y piperazinil-sulfonilmetil hidroxamicos y su uso como inhibidores de proteasa.
|
|
WO2003104224A1
(en)
|
2002-06-10 |
2003-12-18 |
Pfizer Inc. |
Metabolites of prinomastat and their sythesis
|
|
EP2428509A1
(en)
|
2002-06-12 |
2012-03-14 |
Symphony Evolution, Inc. |
Human adam-10 inhibitors
|
|
JP2006502980A
(ja)
*
|
2002-06-25 |
2006-01-26 |
ファルマシア・コーポレーション |
アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用
|
|
WO2005021489A2
(en)
|
2002-12-23 |
2005-03-10 |
Wyeth Holdings Corporation |
Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
|
|
AU2004212335A1
(en)
*
|
2003-02-14 |
2004-08-26 |
Merck Serono Sa |
Piperazine-2-carboxamide derivatives
|
|
CA2516328A1
(en)
*
|
2003-02-18 |
2004-09-02 |
Pfizer Inc. |
Inhibitors of hepatitis c virus, compositions and treatments using the same
|
|
ATE413178T1
(de)
|
2003-03-24 |
2008-11-15 |
Actimis Pharmaceuticals Inc |
2-phenoxy- und 2-phenylsulfanyl-benzenesulfonamid derivate mit ccr3 antagonistischer aktivität zur behandlung von asthma und anderen entzündlichen oder immunologischen erkrankungen
|
|
GT200500139A
(es)
|
2004-06-08 |
2005-07-25 |
|
Metodo para la preparacion de acidos hidroxamicos
|
|
DK2041181T3
(da)
*
|
2006-06-08 |
2011-08-29 |
Helmholtz Zentrum Muenchen |
Specifikke proteaseinhibitorer og deres anvendelse i cancerterapi
|
|
US8426415B2
(en)
|
2007-10-16 |
2013-04-23 |
Symphony Evolution, Inc. |
Human ADAM-10 inhibitors
|
|
EP2147684A1
(en)
*
|
2008-07-22 |
2010-01-27 |
Bracco Imaging S.p.A |
Diagnostic Agents Selective Against Metalloproteases
|
|
WO2011081884A1
(en)
|
2009-12-14 |
2011-07-07 |
Massachusetts Institute Of Technology |
Systems and methods related to optical nanosensors including photoluminescent nanostructures
|
|
IT1401253B1
(it)
|
2010-04-23 |
2013-07-18 |
Uni Degli Studi Carlo Bo Urbino |
Uso del sulodexide per la riduzione delle metalloproteinasi di matrice.
|
|
WO2013050476A1
(en)
*
|
2011-10-04 |
2013-04-11 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
New apoptosis inducing compounds
|
|
WO2020070239A1
(en)
|
2018-10-04 |
2020-04-09 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Egfr inhibitors for treating keratodermas
|
|
JP7484901B2
(ja)
*
|
2019-04-26 |
2024-05-16 |
日産化学株式会社 |
アリールスルホン酸エステル化合物の製造方法
|
|
WO2020252439A1
(en)
*
|
2019-06-14 |
2020-12-17 |
Loyola University Of Chicago |
Carborane hydroxamic acid matrix metalloproteinase agents for boron neutron capture therapy
|