IT1283770B1 - Trombopoietina. - Google Patents

Trombopoietina.

Info

Publication number
IT1283770B1
IT1283770B1 IT95TO000002A ITTO950002A IT1283770B1 IT 1283770 B1 IT1283770 B1 IT 1283770B1 IT 95TO000002 A IT95TO000002 A IT 95TO000002A IT TO950002 A ITTO950002 A IT TO950002A IT 1283770 B1 IT1283770 B1 IT 1283770B1
Authority
IT
Italy
Prior art keywords
thrombopoietin
Prior art date
Application number
IT95TO000002A
Other languages
English (en)
Italian (it)
Inventor
Dan L Eaton
Sauvage Frederic J De
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/196,689 external-priority patent/US8357513B1/en
Priority claimed from US08/249,376 external-priority patent/US8192955B1/en
Priority claimed from US08/348,657 external-priority patent/US6660256B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ITTO950002A0 publication Critical patent/ITTO950002A0/it
Publication of ITTO950002A1 publication Critical patent/ITTO950002A1/it
Application granted granted Critical
Publication of IT1283770B1 publication Critical patent/IT1283770B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
IT95TO000002A 1994-01-03 1995-01-02 Trombopoietina. IT1283770B1 (it)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17655394A 1994-01-03 1994-01-03
US18560794A 1994-01-21 1994-01-21
US08/196,689 US8357513B1 (en) 1994-01-03 1994-02-15 Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A 1994-04-04 1994-04-04
US08/249,376 US8192955B1 (en) 1994-01-03 1994-05-25 Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A 1994-12-02 1994-12-02
US08/348,657 US6660256B1 (en) 1994-01-03 1994-12-02 Porcine mpl ligand

Publications (3)

Publication Number Publication Date
ITTO950002A0 ITTO950002A0 (it) 1995-01-02
ITTO950002A1 ITTO950002A1 (it) 1995-07-03
IT1283770B1 true IT1283770B1 (it) 1998-04-30

Family

ID=27569151

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95TO000002A IT1283770B1 (it) 1994-01-03 1995-01-02 Trombopoietina.

Country Status (28)

Country Link
EP (1) EP0738323A1 (sl)
JP (2) JPH09508262A (sl)
CN (1) CN1134539C (sl)
AU (1) AU704266B2 (sl)
BG (1) BG63639B1 (sl)
CA (1) CA2178482C (sl)
CZ (1) CZ296130B6 (sl)
DK (1) DK149194A (sl)
ES (1) ES2114786B1 (sl)
FI (1) FI121573B (sl)
FR (1) FR2714670B1 (sl)
GB (1) GB2285446B (sl)
HR (1) HRP941020A2 (sl)
HU (1) HUT75657A (sl)
IE (1) IE72517B1 (sl)
IL (1) IL112184A (sl)
IT (1) IT1283770B1 (sl)
LU (1) LU88573A1 (sl)
LV (1) LV11632B (sl)
NL (1) NL9500010A (sl)
NO (1) NO326903B1 (sl)
NZ (1) NZ278726A (sl)
PT (1) PT101627B (sl)
RO (1) RO117110B1 (sl)
SG (1) SG47030A1 (sl)
SI (1) SI9420079A (sl)
SK (1) SK282265B6 (sl)
WO (1) WO1995018858A1 (sl)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968502A (en) 1991-11-05 1999-10-19 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6270989B1 (en) * 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5766581A (en) * 1994-03-31 1998-06-16 Amgen Inc. Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) * 1994-12-30 1999-11-16 Zymogenetics, Inc. Purified thrombopoietin and method of making it
TW387940B (en) * 1995-01-17 2000-04-21 Kirin Brewery Anti-tpo monodonal antibody
AU4658596A (en) 1995-02-03 1996-08-21 G.D. Searle & Co. Novel c-mpl ligands
US5696250A (en) 1995-02-15 1997-12-09 Amgen Inc. DNA encoding megakaryocyte growth and development factor analogs
WO1996025498A2 (en) * 1995-02-15 1996-08-22 Amgen Inc. Mpl ligand analogs
US5989538A (en) * 1995-02-15 1999-11-23 Amgen Inc. Mpl ligand analogs
TW434020B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
TW434021B (en) * 1995-03-15 2001-05-16 Kirin Brewery Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
ZA964382B (en) * 1995-06-06 1997-12-01 Genentech Inc Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) * 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
US6251864B1 (en) 1995-06-07 2001-06-26 Glaxo Group Limited Peptides and compounds that bind to a receptor
DK0885242T3 (da) * 1995-06-07 2008-07-14 Glaxo Group Ltd Peptider og forbindelser, der binder til en trombopoietinreceptor
TW497972B (en) * 1995-06-08 2002-08-11 Kirin Brewery Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) * 1996-01-24 2000-02-29 Biophage, Inc. Methods of generating novel peptides
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US7091311B2 (en) 1996-06-07 2006-08-15 Smithkline Beecham Corporation Peptides and compounds that bind to a receptor
WO1998006849A1 (en) * 1996-08-13 1998-02-19 Zymogenetics, Inc. Expression vectors, cells, and methods for preparing thrombopoietin polypeptides
JP4562815B2 (ja) * 1997-05-21 2010-10-13 ジェネンテック， インコーポレイテッド トロンボポエチンの新規な投与
US5980893A (en) * 1997-07-17 1999-11-09 Beth Israel Deaconess Medical Center, Inc. Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20000006549A (ko) * 1998-06-30 2000-01-25 윤재승 생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en) 1998-06-30 2003-12-11 Daewoong Pharmaceutical Co., Ltd. Novel human thrombopoietin mutein
CN1810832B (zh) 1998-10-23 2012-12-12 麒麟-安姆根有限公司 与MPl受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
CY2010012I2 (el) * 2000-05-25 2020-05-29 Novartis Ag Μιμητικα θρομβοποιητινης
UY26317A1 (es) * 2000-08-30 2000-10-31 Alfonso Cayota Carlos Pritsch Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en) 2001-10-11 2008-02-19 Amgen Inc. Peptides and related compounds having thrombopoietic activity
US20050177884A1 (en) 2001-11-15 2005-08-11 Kirin Beer Kabushiki Kaisha Chimeric nonhuman animal
KR100467750B1 (ko) * 2001-11-29 2005-01-24 씨제이 주식회사 생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
CA2499625A1 (en) 2002-09-18 2004-04-01 Ortho-Mcneil Pharmaceutical, Inc. Methods of increasing platelet and hematopoietic stem cell production
MXPA06002292A (es) 2003-08-28 2006-09-04 Johnson & Johnson Peptidos y compuestos que se unen a un receptor.
US7723295B2 (en) 2003-08-28 2010-05-25 Ortho-Mcneil Pharmaceutical, Inc. Peptides and compounds that bind to a receptor
WO2005116231A1 (en) 2004-05-18 2005-12-08 Intrexon Corporation Methods for dynamic vector assembly of dna cloning vector plasmids
MX2007000216A (es) 2004-07-08 2007-03-15 Amgen Inc Peptidos terapeuticos.
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
US9012605B2 (en) 2006-01-23 2015-04-21 Amgen Inc. Crystalline polypeptides
WO2007098547A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
US7981425B2 (en) 2006-06-19 2011-07-19 Amgen Inc. Thrombopoietic compounds
AU2007278748B2 (en) 2006-07-24 2013-08-15 The University Of Queensland Method of producing a population of cells
MX2009012609A (es) 2007-05-22 2009-12-07 Amgen Inc Composiciones y metodos para producir proteinas de fusion bioactivas.
US20110294733A1 (en) 2009-01-20 2011-12-01 Hanall Biopharma Co., Ltd. Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
WO2014089478A1 (en) * 2012-12-07 2014-06-12 University Of Tennessee Research Foundation Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
EP2934555B1 (en) 2012-12-21 2021-09-22 Astellas Institute for Regenerative Medicine Methods for production of platelets from pluripotent stem cells
CN103555760B (zh) * 2013-10-18 2015-05-20 江苏康禾生物制药有限公司 一种重组人血小板生成素的制备方法及其制剂
GB201700621D0 (en) 2017-01-13 2017-03-01 Guest Ryan Dominic Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
JP2022552940A (ja) * 2019-09-20 2022-12-21 ラクティゲン セラピューティクス 血小板減少症を治療するための核酸分子及びその応用
EP4077641A1 (en) 2019-12-20 2022-10-26 Instil Bio (Uk) Limited Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260417A (en) 1989-04-03 1993-11-09 Genetics Institute, Inc. Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
PT616645E (pt) * 1991-12-06 2002-02-28 Genentech Inc Celulas transformadas para prohormona convertase
IL139335A (en) 1994-01-03 2005-08-31 Genentech Inc Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

Also Published As

Publication number Publication date
ITTO950002A0 (it) 1995-01-02
SK282265B6 (sk) 2001-12-03
JPH09508262A (ja) 1997-08-26
HU9601805D0 (en) 1996-08-28
FI962723A (fi) 1996-09-03
CZ192296A3 (en) 1997-05-14
JPH10113186A (ja) 1998-05-06
ES2114786A1 (es) 1998-06-01
NO962783D0 (no) 1996-07-02
BG63639B1 (bg) 2002-07-31
IE950002A1 (en) 1995-07-12
AU1514695A (en) 1995-08-01
FI121573B (fi) 2011-01-14
GB9425831D0 (en) 1995-02-22
CN1134539C (zh) 2004-01-14
WO1995018858A1 (en) 1995-07-13
IL112184A0 (en) 1995-03-15
FR2714670B1 (fr) 1997-01-10
PT101627B (pt) 1996-11-29
SI9420079A (en) 1997-02-28
DK149194A (da) 1995-07-04
IL112184A (en) 2004-07-25
LV11632B (en) 1997-04-20
BG100693A (en) 1998-01-30
LV11632A (lv) 1996-12-20
HRP941020A2 (en) 1997-04-30
IE72517B1 (en) 1997-04-23
GB2285446A (en) 1995-07-12
ITTO950002A1 (it) 1995-07-03
EP0738323A1 (en) 1996-10-23
NL9500010A (nl) 1995-08-01
GB2285446B (en) 1999-07-28
CA2178482A1 (en) 1995-07-13
SG47030A1 (en) 1998-03-20
FI962723A0 (fi) 1996-07-02
CN1141061A (zh) 1997-01-22
SK87596A3 (en) 1997-11-05
LU88573A1 (de) 1995-06-01
FR2714670A1 (fr) 1995-07-07
CA2178482C (en) 2012-01-03
CZ296130B6 (cs) 2006-01-11
HUT75657A (en) 1997-05-28
RO117110B1 (ro) 2001-10-30
NO962783L (no) 1996-09-03
NZ278726A (en) 1998-06-26
NO326903B1 (no) 2009-03-16
AU704266B2 (en) 1999-04-15
PT101627A (pt) 1995-11-30
ES2114786B1 (es) 1999-01-01

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