IT1256566B - Procedimento e apparecchiatura per controllare la concentrazione della sorgente di carbonio in una coltura aerobica di un microorganismo - Google Patents

Procedimento e apparecchiatura per controllare la concentrazione della sorgente di carbonio in una coltura aerobica di un microorganismo

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Publication number
IT1256566B
IT1256566B ITMI913198A ITMI913198A IT1256566B IT 1256566 B IT1256566 B IT 1256566B IT MI913198 A ITMI913198 A IT MI913198A IT MI913198 A ITMI913198 A IT MI913198A IT 1256566 B IT1256566 B IT 1256566B
Authority
IT
Italy
Prior art keywords
culture
carbon source
microorganism
concentration
feeding
Prior art date
Application number
ITMI913198A
Other languages
English (en)
Inventor
Takashi Nakamura
Tatsuya Nakayama
Yosuke Koyama
Keishi Shimazaki
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12699291A external-priority patent/JP3074781B2/ja
Priority claimed from JP27793891A external-priority patent/JP2932791B2/ja
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of ITMI913198A0 publication Critical patent/ITMI913198A0/it
Publication of ITMI913198A1 publication Critical patent/ITMI913198A1/it
Application granted granted Critical
Publication of IT1256566B publication Critical patent/IT1256566B/it

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Computer Hardware Design (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La presente invenzione riguarda un metodo per controllare la concentrazione della sorgente di carbonio nella coltura erobica di un microrganismo. La sorgente di carbonio di substrato rimane ad un livello basso nel recipiente di coltura durante l'alimentazione della coltura in colture aerobiche ad alimentazione discontinua, continua oppure continua con riciclo di cellule. Ciò viene realizzato controllando l'aumento del pH oppure del contenuto in ossigeno disciolto nel mezzo di coltura e aggiungendo la soluzione di alimentazione a intervalli in un recipiente di coltura in corrispondenza di una portata di alimentazione calcolata impiegando un dispositivo di controllo dell'alimentazione controllato da un computer. La presente invenzione riguarda inoltre un procedimento per produrre L-lisina mediante fermentazione il quale procedimento ha vantaggi rispetto ai metodi precedenti, questi vantaggi essendo una migliorata produttività, maggiori concentrazioni di prodotti accumulato e rese aumentate di L-lisina.
ITMI913198A 1990-11-30 1991-11-29 Procedimento e apparecchiatura per controllare la concentrazione della sorgente di carbonio in una coltura aerobica di un microorganismo IT1256566B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33968790 1990-11-30
JP12699291A JP3074781B2 (ja) 1991-03-12 1991-03-12 発酵法によるｌ−リジンの製造法
JP27793891A JP2932791B2 (ja) 1990-11-30 1991-10-24 微生物好気培養における炭素源濃度の制御方法及び装置

Publications (3)

Publication Number Publication Date
ITMI913198A0 ITMI913198A0 (it) 1991-11-29
ITMI913198A1 ITMI913198A1 (it) 1993-05-29
IT1256566B true IT1256566B (it) 1995-12-11

Family

ID=27315443

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI913198A IT1256566B (it) 1990-11-30 1991-11-29 Procedimento e apparecchiatura per controllare la concentrazione della sorgente di carbonio in una coltura aerobica di un microorganismo

Country Status (6)

Country Link
US (2) US5912113A (it)
BE (1) BE1008008A3 (it)
BR (1) BR9105208A (it)
FR (2) FR2669935B1 (it)
IT (1) IT1256566B (it)
MY (1) MY121534A (it)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4130868C2 (de) * 1991-09-17 1994-10-13 Degussa Tierfuttermittelsupplement auf der Basis einer Aminosäure und Verfahren zu dessen Herstellung
US5342763A (en) * 1992-11-23 1994-08-30 Genentech, Inc. Method for producing polypeptide via bacterial fermentation
JP3812019B2 (ja) * 1996-11-21 2006-08-23 味の素株式会社 連続発酵によるｌ−グルタミン酸の製造法
EP0952212A1 (de) * 1998-04-20 1999-10-27 Rohner AG Verfahren zur aeroben Kultivierung von Mikroorganismen
US6284453B1 (en) * 1999-09-29 2001-09-04 Steven Anthony Siano Method for controlling fermentation growth and metabolism
AR026743A1 (es) * 1999-12-09 2003-02-26 Pharmacia Ab Produccion de peptidos
SE9904502D0 (sv) * 1999-12-09 1999-12-09 Pharmacia & Upjohn Ab Production of peptides
JP4362959B2 (ja) * 2000-08-24 2009-11-11 味の素株式会社 塩基性アミノ酸の製造方法
WO2002064729A2 (en) * 2001-02-14 2002-08-22 Gadi Steiner Methods of controlling microorganism fermentation
US6955892B2 (en) * 2002-11-12 2005-10-18 Akzo Nobel N.V. Feeding processes for fermentation
US20040115304A1 (en) * 2002-12-16 2004-06-17 Frank Dubner Feesdstuffs additives containing L-lysine with improved abrasion resistance, and process for their production
EP1649033A1 (en) * 2003-08-01 2006-04-26 Degussa AG Process for the preparation of l-threonine
EP1649031A1 (en) * 2003-08-01 2006-04-26 Degussa AG Process for the preparation of l-threonine
WO2005014841A1 (en) * 2003-08-01 2005-02-17 Degussa Ag Process for the preparation of l-threonine
DE102004029639A1 (de) * 2003-08-12 2005-03-24 Degussa Ag Verfahren zur Herstellung von L-Threonin
WO2005021774A1 (en) * 2003-08-29 2005-03-10 Degussa Ag Process for the preparation of l-lysine
WO2005021772A1 (en) * 2003-08-29 2005-03-10 Degussa Ag Process for the preparation of l-lysine
WO2005021773A1 (en) * 2003-08-29 2005-03-10 Degussa Ag Process for the preparation of l-lysine
WO2005021771A2 (en) * 2003-08-29 2005-03-10 Degussa Ag Process for the production of l-lysine
KR100677952B1 (ko) 2004-08-13 2007-02-05 한국생명공학연구원 재조합 단백질 생산을 위한 재조합 숙주 세포의 배양방법
CN101111602B (zh) * 2004-10-07 2012-07-04 味之素株式会社 生产碱性物质的方法
JP2009153382A (ja) 2006-03-30 2009-07-16 Ajinomoto Co Inc メタノール資化性細菌を用いたカルボン酸の製造法
MX284139B (es) 2006-05-26 2011-02-18 Amyris Biotechnologies Inc Produccion de isoprenoides.
EP2041262A4 (en) * 2006-07-14 2012-07-18 Abb Research Ltd METHOD FOR ONLINE LINE OPTIMIZATION OF A FED BATCH FERMENTATION UNIT FOR MAXIMIZING PRODUCT LIFE
JP2010017082A (ja) 2006-10-10 2010-01-28 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010110216A (ja) 2007-02-20 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸または核酸の製造方法
JP2010110217A (ja) 2007-02-22 2010-05-20 Ajinomoto Co Inc Ｌ−アミノ酸生産菌及びｌ−アミノ酸の製造法
CN101939412B (zh) 2007-09-04 2016-01-20 味之素株式会社 生产氨基酸的微生物以及氨基酸的生产方法
DE102008002210A1 (de) * 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur fermentativen Herstellung von Erythropoietin
JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2382320B1 (en) 2009-01-23 2018-04-18 Ajinomoto Co., Inc. Process for producing l-amino acids employing bacteria of the enterobacteriacea family in a culture medium with controlled glycerol concentration
US8679782B2 (en) 2009-06-15 2014-03-25 Massachusetts Institute Of Technology Production of triacylglycerides, fatty acids, and their derivatives
JP2013074795A (ja) 2010-02-08 2013-04-25 Ajinomoto Co Inc 変異型ｒｐｓＡ遺伝子及びＬ−アミノ酸の製造法
US8889400B2 (en) 2010-05-20 2014-11-18 Pond Biofuels Inc. Diluting exhaust gas being supplied to bioreactor
US8969067B2 (en) 2010-05-20 2015-03-03 Pond Biofuels Inc. Process for growing biomass by modulating supply of gas to reaction zone
US20120156669A1 (en) 2010-05-20 2012-06-21 Pond Biofuels Inc. Biomass Production
US8940520B2 (en) 2010-05-20 2015-01-27 Pond Biofuels Inc. Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply
US11512278B2 (en) 2010-05-20 2022-11-29 Pond Technologies Inc. Biomass production
JP2014036576A (ja) 2010-12-10 2014-02-27 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
DE102010063033B4 (de) * 2010-12-14 2013-10-24 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Verfahren zur Inbetriebnahme eines Messgeräts
US20120276633A1 (en) 2011-04-27 2012-11-01 Pond Biofuels Inc. Supplying treated exhaust gases for effecting growth of phototrophic biomass
US9534261B2 (en) 2012-10-24 2017-01-03 Pond Biofuels Inc. Recovering off-gas from photobioreactor
US20160046900A1 (en) 2013-03-29 2016-02-18 Roquette Freres Microalgal biomass protein enrichment method
FR3008991B1 (fr) * 2013-07-26 2016-11-04 Roquette Freres Procede de fermentation de chlorelles en mode discontinu alimente par apports sequentiels et automatises en glucose
JP2016527912A (ja) 2013-08-23 2016-09-15 ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ 酸素アベイラビリティを制御することによる「オフノート」なしの脂質に富む微細藻類バイオマスからの粉末の工業的製造方法
BR112016008830B1 (pt) 2013-10-23 2023-02-23 Ajinomoto Co., Inc Método para produzir uma substância alvo
CA3010666A1 (fr) 2016-02-08 2017-08-17 Corbion Biotech, Inc. Procede d'enrichissement en proteines de la biomasse de microalgues
JP2019062742A (ja) 2016-02-24 2019-04-25 味の素株式会社 Ｌ−アミノ酸の製造法
EP3415622A1 (en) 2017-06-14 2018-12-19 Evonik Degussa GmbH Method for production of fine chemicals using a corynebacterium secreting modified alpha-1,6-glucosidases
EP3456833A1 (en) 2017-09-18 2019-03-20 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3467099A1 (en) 2017-10-05 2019-04-10 Evonik Degussa GmbH Method for the fermentative production of l-amino acids
EP3498853A1 (en) 2017-12-14 2019-06-19 Evonik Degussa GmbH Method for the fermentative production of l-lysine
EP3594355A1 (en) 2018-07-12 2020-01-15 Evonik Operations GmbH Method for the fermentative production of l-lysine
EP3599282B1 (en) 2018-07-24 2021-03-17 Evonik Operations GmbH Method for the fermentative production of l-lysine
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
CN111099740B (zh) * 2018-10-26 2022-06-07 中国石油化工股份有限公司 一种化能自养微生物培养过程的补料控制方法
EP3660158A1 (en) 2018-11-29 2020-06-03 Evonik Operations GmbH Method for the fermentative production of l-lysine
CN111349573B (zh) * 2018-12-24 2022-11-18 中粮生物科技股份有限公司 一种酵母菌的高密度发酵方法
CN112746030B (zh) * 2019-10-30 2023-02-03 中国石油化工股份有限公司 一种硝化细菌的培养方法
WO2023041425A1 (en) 2021-09-20 2023-03-23 Evonik Operations Gmbh Method for the fermentative production of l-lysine using c. glutamicum strains expressing modified gluconate repressor proteins gntr1 and gntr2
EP4497818A1 (en) 2023-07-25 2025-01-29 Evonik Operations GmbH Method for the fermentative production of l-lysine using c. glutamicum strains expressing heterologous nicotinamide nucleotide transhydrogenase pntab

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE220852C (it) *
US3002894A (en) * 1958-11-14 1961-10-03 Vogelbusch Gmbh Method and device for controlling the growth of microbial cultures
US3010881A (en) * 1959-12-14 1961-11-28 Vogelbusch Gmbh Method and apparatus for controlling the growth of microbial cultures
JPS4744183B1 (it) * 1969-10-27 1972-11-08
FR2092686A1 (en) * 1970-06-08 1972-01-28 Inst Biosinteza Automatic control device - for biosynthesis processes by microorganisms
US3941662A (en) * 1971-06-09 1976-03-02 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Apparatus for culturing cells
US3926738A (en) * 1972-05-10 1975-12-16 Wilson John D Method and apparatus for control of biochemical processes
US3857757A (en) * 1972-11-30 1974-12-31 Gen Electric Means for the oxygen/temperature control of aerobic fermentations
DE2308087A1 (de) * 1973-02-19 1974-08-22 Kellner Maximilian Dipl Braur Fermentationsverfahren
US4073692A (en) * 1975-04-21 1978-02-14 Ciaccio Leonard L Method and apparatus for automated measurement of energy oxygen
JPS521091A (en) * 1975-12-01 1977-01-06 Ajinomoto Co Inc Process for preparing amino acids
DE2657209A1 (de) * 1976-12-17 1978-06-22 Bender & Hobein Gmbh Biokulturverfahren und vorrichtung zu seiner ausuebung
RO72660A2 (ro) * 1977-12-30 1982-09-09 Intreprinderea De Antibiotice,Ro Procedeu de obtinere a l-lizinei
US4411991A (en) * 1980-10-07 1983-10-25 Kanegafuchi Chemical Industry Company, Limited Process for fermentative production of amino acids
DD268834A3 (de) * 1983-06-03 1989-06-14 Ve Forschungszentrum Biotechno Verfahren zur fermentativen herstellung von l-lysin
US4680267A (en) * 1985-03-01 1987-07-14 New Brunswick Scientific Company, Inc. Fermentor control system
DD254214A1 (de) * 1985-07-02 1988-02-17 Jenapharm Veb Verfahren zur ermittlung des prozesszustandes bei fermentationsprozessen nach dem fed-batch prinzip unter substratlimitation
US5316905A (en) * 1986-09-29 1994-05-31 Suzuki Shokan Co., Ltd. Culture medium supplying method and culture system
DD287271A5 (de) * 1989-08-22 1991-02-21 Akademie Der Wissenschaften Der Ddr,De Verfahren fuer die kontinuierliche fermentation
BE1004508A3 (nl) * 1991-02-01 1992-12-01 Organic Waste Systems Nv Werkwijze en inrichting voor het bepalen van de aerobe biologische afbreekbaarheid.

Also Published As

Publication number Publication date
FR2676234A1 (fr) 1992-11-13
FR2676234B1 (fr) 1996-12-20
ITMI913198A0 (it) 1991-11-29
BR9105208A (pt) 1992-07-21
FR2669935B1 (fr) 1996-08-02
BE1008008A3 (fr) 1995-12-12
FR2669935A1 (fr) 1992-06-05
US5912113A (en) 1999-06-15
ITMI913198A1 (it) 1993-05-29
MY121534A (en) 2006-02-28
US6025169A (en) 2000-02-15

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