IN2015DN03795A - - Google Patents

Info

Publication number
IN2015DN03795A
IN2015DN03795A IN3795DEN2015A IN2015DN03795A IN 2015DN03795 A IN2015DN03795 A IN 2015DN03795A IN 3795DEN2015 A IN3795DEN2015 A IN 3795DEN2015A IN 2015DN03795 A IN2015DN03795 A IN 2015DN03795A
Authority
IN
India
Prior art keywords
promoting
applications
function
kinase inhibitor
relates
Prior art date
Application number
Other languages
English (en)
Inventor
Stéphane Dalle
Jean Francois Tanti
Anne Wojtusciszyn
Elodie Varin
Original Assignee
Inserm Inst Nat De La Santé Et De La Rech Médicale
Univ Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inserm Inst Nat De La Santé Et De La Rech Médicale, Univ Montpellier filed Critical Inserm Inst Nat De La Santé Et De La Rech Médicale
Publication of IN2015DN03795A publication Critical patent/IN2015DN03795A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2278Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • C12N2501/72Transferases [EC 2.]
    • C12N2501/727Kinases (EC 2.7.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IN3795DEN2015 2012-10-24 2013-10-24 IN2015DN03795A (US07981874-20110719-C00313.png)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261717828P 2012-10-24 2012-10-24
EP12306321 2012-10-24
PCT/EP2013/072314 WO2014064215A1 (en) 2012-10-24 2013-10-24 TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL

Publications (1)

Publication Number Publication Date
IN2015DN03795A true IN2015DN03795A (US07981874-20110719-C00313.png) 2015-10-02

Family

ID=47115690

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3795DEN2015 IN2015DN03795A (US07981874-20110719-C00313.png) 2012-10-24 2013-10-24

Country Status (5)

Country Link
US (1) US20150297573A1 (US07981874-20110719-C00313.png)
EP (1) EP2911655A1 (US07981874-20110719-C00313.png)
CN (1) CN105142621A (US07981874-20110719-C00313.png)
IN (1) IN2015DN03795A (US07981874-20110719-C00313.png)
WO (1) WO2014064215A1 (US07981874-20110719-C00313.png)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017007689A1 (en) 2015-07-06 2017-01-12 Gilead Sciences, Inc. Cot modulators and methods of use thereof
SI3319955T1 (sl) 2015-07-06 2021-01-29 Gilead Sciences, Inc. 6-amino-kinolin-3-karbonitrili kot modulatorji COT
US10059695B2 (en) 2016-06-30 2018-08-28 Gilead Sciences, Inc. Cot modulators and methods of use thereof
CN106512014A (zh) * 2016-10-27 2017-03-22 武汉大学 肿瘤进展位点2在治疗脂肪肝和ⅱ型糖尿病中的功能和应用
JP2021503486A (ja) 2017-11-20 2021-02-12 アイカーン スクール オブ メディシン アット マウント サイナイ キナーゼ阻害剤化合物ならびに組成物および使用法
US11788064B2 (en) 2018-01-05 2023-10-17 Icahn School Of Medicine At Mount Sinai Method of increasing proliferation of pancreatic beta cells, treatment method, and composition
US11866427B2 (en) 2018-03-20 2024-01-09 Icahn School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use
CN108578683A (zh) * 2018-06-27 2018-09-28 中国人民解放军南京军区福州总医院 利拉鲁肽在银屑病治疗药物中以及在2型糖尿病合并银屑病治疗药物中的应用
CN113508111A (zh) * 2018-12-31 2021-10-15 西奈山伊坎医学院 激酶抑制剂化合物和组合物及使用方法
TW202235416A (zh) 2019-06-14 2022-09-16 美商基利科學股份有限公司 Cot 調節劑及其使用方法
KR20220032568A (ko) 2019-06-25 2022-03-15 길리애드 사이언시즈, 인코포레이티드 Flt3l-fc 융합 단백질 및 사용 방법
KR20220085796A (ko) 2019-10-18 2022-06-22 포티 세븐, 인코포레이티드 골수이형성 증후군 및 급성 골수성 백혈병을 치료하기 위한 조합 치료
CN110862968A (zh) * 2019-10-30 2020-03-06 中国农业科学院兰州兽医研究所 Map3k8基因敲除pk-15细胞系的构建方法及其应用
US20210147568A1 (en) 2019-10-31 2021-05-20 Forty Seven, Inc. Anti-cd47 based treatment of blood cancer
TWI778443B (zh) 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
EP4081305B1 (en) 2019-12-24 2024-09-18 Carna Biosciences, Inc. Diacylglycerol kinase modulating compounds
CN115087488A (zh) 2020-02-14 2022-09-20 震动疗法股份有限公司 与ccr8结合的抗体和融合蛋白及其用途
US11655237B2 (en) 2020-03-30 2023-05-23 Gilead Sciences, Inc. Solid forms of a Cot inhibitor compound
AU2021245924B2 (en) 2020-04-02 2024-02-29 Gilead Sciences, Inc. Process for preparing a Cot inhibitor compound
AU2021264550A1 (en) 2020-05-01 2022-11-17 Gilead Sciences, Inc. CD73 inhibiting 2,4-dioxopyrimidine compounds
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 CD47/SIRPα結合及NEDD8活化酶E1調節次單元之共抑制以用於治療癌症
WO2022245671A1 (en) 2021-05-18 2022-11-24 Gilead Sciences, Inc. Methods of using flt3l-fc fusion proteins
AU2022297367A1 (en) 2021-06-23 2023-12-07 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240025616A (ko) 2021-06-23 2024-02-27 길리애드 사이언시즈, 인코포레이티드 다이아실글리세롤 키나제 조절 화합물
EP4359415A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
EP4359411A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240091056A (ko) 2021-10-28 2024-06-21 길리애드 사이언시즈, 인코포레이티드 피리디진-3(2h)-온 유도체
CN118201941A (zh) 2021-10-29 2024-06-14 吉利德科学公司 Cd73化合物
AU2022417491A1 (en) 2021-12-22 2024-05-23 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
CA3239528A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7抑制劑
EP4245756A1 (en) 2022-03-17 2023-09-20 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
US20230355796A1 (en) 2022-03-24 2023-11-09 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
TW202345901A (zh) 2022-04-05 2023-12-01 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
WO2023205719A1 (en) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Kras g12d modulating compounds
US20240116928A1 (en) 2022-07-01 2024-04-11 Gilead Sciences, Inc. Cd73 compounds
US20240091351A1 (en) 2022-09-21 2024-03-21 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY
WO2024137852A1 (en) 2022-12-22 2024-06-27 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof

Family Cites Families (191)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514646A (en) 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
DE19616486C5 (de) 1996-04-25 2016-06-30 Royalty Pharma Collection Trust Verfahren zur Senkung des Blutglukosespiegels in Säugern
JP3149958B2 (ja) 1996-08-30 2001-03-26 ノボ ノルディスク アクティーゼルスカブ Glp―1誘導体
PT958296E (pt) 1996-12-31 2003-11-28 Reddys Lab Ltd Dr Compostos heterociclicos processo para a sua preparacao composicoes farmaceuticas contendo-os e sua utilizacao no tratamento da diabetes e doencas relacionadas
US6506559B1 (en) 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
CA2319195A1 (en) 1998-02-02 1999-08-05 Trustees Of Tufts College Method of regulating glucose metabolism, and reagents related thereto
AUPP249298A0 (en) 1998-03-20 1998-04-23 Ag-Gene Australia Limited Synthetic genes and genetic constructs comprising same I
US6566131B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of Smad6 expression
WO2000001191A1 (fr) 1998-06-30 2000-01-06 Matsushita Electric Industrial Co., Ltd. Systeme de commande de reseau et procede correspondant
US20030219427A1 (en) 1998-08-18 2003-11-27 Allen Hamish J. TPL-2/COT kinase and methods of use
US6410323B1 (en) 1999-08-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of human Rho family gene expression
US6107091A (en) 1998-12-03 2000-08-22 Isis Pharmaceuticals Inc. Antisense inhibition of G-alpha-16 expression
US5981732A (en) 1998-12-04 1999-11-09 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-13 expression
CZ295768B6 (cs) 1998-12-07 2005-10-12 Societe De Conseils De Recherches Et D'application Analogy GLP-1, mající beta-alanin na pozici 35, jejich použití a farmaceutické prostředky je obsahující
US6046321A (en) 1999-04-09 2000-04-04 Isis Pharmaceuticals Inc. Antisense modulation of G-alpha-i1 expression
EP1076066A1 (en) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
GB9927444D0 (en) 1999-11-19 2000-01-19 Cancer Res Campaign Tech Inhibiting gene expression
JP2003526367A (ja) 2000-03-16 2003-09-09 ジェネティカ インコーポレイテッド Rna干渉の方法とrna干渉組成物
US6365354B1 (en) 2000-07-31 2002-04-02 Isis Pharmaceuticals, Inc. Antisense modulation of lysophospholipase I expression
US6566135B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of caspase 6 expression
HUP0200849A2 (hu) 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
HUP0202001A2 (hu) 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
ATE390416T1 (de) 2002-10-18 2008-04-15 Merck & Co Inc Heterozyklische beta-aminoverbindungen als inhibitoren des dipeptidylpeptidase zur behandlung bzw. prevention von diabetes
UY28103A1 (es) 2002-12-03 2004-06-30 Boehringer Ingelheim Pharma Nuevas imidazo-piridinonas sustituidas, su preparación y su empleo como medicacmentos
DE10333935A1 (de) 2003-07-25 2005-02-24 Aventis Pharma Deutschland Gmbh Neue bicyclische Cyanoheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PE20050249A1 (es) 2003-07-25 2005-06-01 Aventis Pharma Gmbh Nuevas cianopirrolididas y procedimiento para su preparacion como medicamentos
BRPI0414539B8 (pt) 2003-09-19 2021-05-25 Novo Nordisk As composto, composição farmacêutica, e, uso de um composto
TW200519105A (en) 2003-10-20 2005-06-16 Lg Life Science Ltd Novel inhibitors of DPP-IV, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent
DE10359098A1 (de) 2003-12-17 2005-07-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue 2-(Piperazin-1-yl)- und 2-([1,4]Diazepan-1-yl)-imidazo[4,5-d]pyridazin-4-one, deren Herstellung und deren Verwendung als Arzneimittel
US20060074102A1 (en) 2004-05-14 2006-04-06 Kevin Cusack Kinase inhibitors as therapeutic agents
DE102004037554A1 (de) 2004-08-03 2006-03-16 Sanofi-Aventis Deutschland Gmbh Substituierte 8-Aminoalkylthio-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102004038269A1 (de) 2004-08-06 2006-03-16 Sanofi-Aventis Deutschland Gmbh Substituierte, bizyklische 8-Piperidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102004038270A1 (de) 2004-08-06 2006-03-16 Sanofi-Aventis Deutschland Gmbh Substituierte, bizyklische 8-Amino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102004038268A1 (de) 2004-08-06 2006-03-16 Sanofi-Aventis Deutschland Gmbh Substituierte, bizyklische 8-Pyrrolidino-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102004039507A1 (de) 2004-08-14 2006-03-02 Sanofi-Aventis Deutschland Gmbh Substituierte 8-Aminoalkoxi-xanthine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2582447C (en) 2004-10-01 2012-04-17 Merck & Co., Inc. Aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
JP2008515856A (ja) 2004-10-07 2008-05-15 ノボ ノルディスク アクティーゼルスカブ 遅延性glp−1化合物
US8030273B2 (en) 2004-10-07 2011-10-04 Novo Nordisk A/S Protracted exendin-4 compounds
JP2006160733A (ja) 2004-11-15 2006-06-22 Taisho Pharmaceut Co Ltd シアノフルオロピロリジン誘導体を有効成分として含有する医薬
EP1819674B1 (en) 2004-11-29 2011-10-05 Merck Sharp & Dohme Corp. Fused aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2006065826A2 (en) 2004-12-15 2006-06-22 Merck & Co., Inc. Process to chiral beta amino acid derivatives by asymmetric hydrogenation
CA2590912A1 (en) 2004-12-24 2006-06-29 Dainippon Sumitomo Pharma Co., Ltd. Bicyclic pyrrole derivatives
US7635699B2 (en) 2004-12-29 2009-12-22 Bristol-Myers Squibb Company Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
WO2006073167A1 (ja) 2005-01-07 2006-07-13 Ono Pharmaceutical Co., Ltd. ピロリジン誘導体
CN101107251A (zh) 2005-01-19 2008-01-16 默克公司 用于治疗或预防糖尿病的作为二肽基肽酶-ⅳ抑制剂的双环嘧啶类
WO2006085685A1 (ja) 2005-02-09 2006-08-17 Takeda Pharmaceutical Company Limited ピラゾール化合物
PE20061099A1 (es) 2005-02-25 2006-12-05 Takeda Pharmaceutical Compuestos de piridil acido acetico como inhibidores de peptidasa
DE102005012873B4 (de) 2005-03-19 2007-05-03 Sanofi-Aventis Deutschland Gmbh Aminocarbonyl substituierte 8-N-Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102005012874A1 (de) 2005-03-19 2006-09-21 Sanofi-Aventis Deutschland Gmbh Amid substituierte 8-N-Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
TWI357902B (en) 2005-04-01 2012-02-11 Lg Life Science Ltd Dipeptidyl peptidase-iv inhibiting compounds, meth
DE102005017605B4 (de) 2005-04-16 2007-03-15 Sanofi-Aventis Deutschland Gmbh Substituierte 2-Aminoalkylthio-benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2608311C (en) 2005-05-13 2012-11-27 Eli Lilly And Company Glp-1 pegylated compounds
AU2006247520A1 (en) 2005-05-18 2006-11-23 Wyeth 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same
JP2008540667A (ja) 2005-05-18 2008-11-20 ワイス Tpl2キナーゼの4,6−ジアミノ−[1,7]ナフチリジン−3−カルボニトリル阻害物質ならびにそれを製造および使用する方法
JP5069678B2 (ja) 2005-05-25 2012-11-07 メルク・シャープ・エンド・ドーム・コーポレイション 糖尿病の治療又は予防のためのジペプチジルペプチダーゼiv阻害剤としてのアミノシクロヘキサン
DE602006007012D1 (de) 2005-07-20 2009-07-09 Lilly Co Eli Pyridinderivate als dipeptedyl-peptidase-hemmer
EP1916234B1 (en) 2005-07-29 2014-11-12 Takeda Pharmaceutical Company Limited Cyclopropanecarboxylic acid compound
US8017624B2 (en) 2005-08-26 2011-09-13 Merck Sharp & Dohme Corp. Fused aminopiperidines as dipeptidyi peptidase-IV inhibitors for the treatment or prevention of diabetes
WO2007029086A2 (en) 2005-09-05 2007-03-15 Ranbaxy Laboratories Limited Derivatives of 3-azabicyclo[3.1.0]hexane as dipeptidyl peptidase-iv inhibitors
AU2006291234A1 (en) 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
EP2073810B1 (en) 2006-09-13 2011-08-31 Takeda Pharmaceutical Company Limited Use of 2-6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile for treating diabetes, cancer, autoimmune disorders and hiv infection
WO2007063928A1 (ja) 2005-11-30 2007-06-07 Toray Industries, Inc. 新規な非環状アミンカルボキシアミド誘導体及びその塩
US7943615B2 (en) 2005-12-14 2011-05-17 Merck Sharp & Dohme Corp. Fused aminopiperidines as dipeptidyl peptidase-4 inhibitors for the treatment or prevention of diabetes
AU2006339348B2 (en) 2005-12-19 2013-01-17 Trustees Of Tufts College Soft protease inhibitors and pro-soft forms thereof
ATE482947T1 (de) 2005-12-21 2010-10-15 Hoffmann La Roche Neues salz und polymorph des dpp-iv-hemmers
EP1966215A1 (en) 2005-12-23 2008-09-10 Novartis AG Condensed heterocyclic compounds useful as dpp-iv inhibitors
PT1969004E (pt) 2005-12-28 2011-11-25 Novo Nordisk As Composições que compreendem uma insulina acilada e zinco e método para criar tais composições
US20090156465A1 (en) 2005-12-30 2009-06-18 Sattigeri Jitendra A Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
US7750034B2 (en) 2006-01-25 2010-07-06 Merck Sharp & Dohme Corp. Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
EP1986652B1 (en) 2006-02-15 2013-03-20 Merck Sharp & Dohme Corp. Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
WO2007099385A1 (en) 2006-03-01 2007-09-07 Glenmark Pharmaceuticals S.A. Dipeptidyl peptidase iv inhibitor compounds and compositions
US20070270492A1 (en) 2006-03-06 2007-11-22 Avestha Gengraine Technologies Pvt. Ltd. Nananoic acid derivatives as dipeptidyl peptidase inhibitors
US20080051452A1 (en) 2006-03-06 2008-02-28 Avestha Gengraine Technologies Pvt. Ltd. Hexanoic acid derivatives as dipeptidyl peptidase inhibitors
JP2009530281A (ja) 2006-03-14 2009-08-27 アムジエン・インコーポレーテツド 代謝障害の治療に有用である二環式カルボン酸誘導体
JP5252435B2 (ja) 2006-03-15 2013-07-31 ノボ・ノルデイスク・エー/エス アミリン誘導体
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
TW200806669A (en) 2006-03-28 2008-02-01 Merck & Co Inc Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
MX2008012617A (es) 2006-03-31 2008-10-10 Novartis Ag Compuestos organicos.
JP2009532454A (ja) 2006-04-03 2009-09-10 マトリックス ラボラトリーズ リミテッド 新規ジペプチジルペプチダーゼiv阻害因子およびその調製方法、ならび該阻害因子を含む医薬組成物
CN101050194B (zh) 2006-04-05 2013-08-21 上海恒瑞医药有限公司 双环辛烷类衍生物、其制备方法及其在医药上的用途
BRPI0709961A2 (pt) 2006-04-11 2011-08-02 Novartis Ag compostos orgánicos
US7728146B2 (en) 2006-04-12 2010-06-01 Probiodrug Ag Enzyme inhibitors
RU2419452C2 (ru) 2006-04-13 2011-05-27 Ипсен Фарма С.А.С. ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ hGLP-1, ЭКСЕНДИНА-4 И ИХ АНАЛОГОВ
MX2008013304A (es) 2006-04-20 2008-10-27 Amgen Inc Compuestos de peptido 1 tipo glucagon.
TW200815377A (en) 2006-04-24 2008-04-01 Astellas Pharma Inc Oxadiazolidinedione compound
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
CA2810839A1 (en) 2006-05-04 2007-11-15 Boehringer Ingelheim International Gmbh A polymorphic form of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(r)-amino-piperidin-1-yl)-xanthine
BRPI0711416A2 (pt) 2006-05-11 2011-11-01 Sanofi Aventis ácidos carboxìlicos substituìdos com 4,5-difenil pirimidinila, processo para a produção e uso dos mesmos como medicamentos
DE102006021872B4 (de) 2006-05-11 2008-04-17 Sanofi-Aventis 4,5-Diphenyl-pyrimidinyl-oxy oder -mercapto substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102006021874B4 (de) 2006-05-11 2008-03-27 Sanofi-Aventis 4,5-Diphenyl-pyrimidinyl-amino substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102006021878A1 (de) 2006-05-11 2007-11-15 Sanofi-Aventis Phenylamino-benzoxazol substituierte Carbonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
EP2021327B1 (en) 2006-05-15 2012-04-04 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
AU2007254357B2 (en) 2006-05-16 2011-07-21 Merck Sharp & Dohme Corp. Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
JP2009190971A (ja) 2006-06-06 2009-08-27 Mitsubishi Tanabe Pharma Corp 2−シアノピロリジン誘導体
WO2007148185A2 (en) 2006-06-21 2007-12-27 Pfizer Products Inc. Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
PT2248812E (pt) 2006-06-27 2014-03-12 Takeda Pharmaceutical Compostos cíclicos fundidos como moduladores do receptor gpr40
JP2008031064A (ja) 2006-07-27 2008-02-14 Astellas Pharma Inc ジアシルピペラジン誘導体
JP2010500326A (ja) 2006-08-08 2010-01-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病の治療のためのdpp−iv阻害剤としてのピロロ[3,2−d]ピリミジン
WO2008022015A2 (en) 2006-08-11 2008-02-21 Trustees Of Tufts College Retro-inverso incretin analogues, and methods of use thereof
WO2008029217A2 (en) 2006-08-29 2008-03-13 Orchid Research Laboratories Limited Dipeptidyl peptidase iv inhibitors
CL2007002499A1 (es) 2006-08-30 2008-03-14 Phenomix Corp Sales citrato y tartrato de compuestos derivados de acido pirrolidinilaminoacetilpirrolidinboronico, inhibidores de dpp-iv; metodo de preparacion; forma solida; combinacion farmaceutica, util para el tratamiento de diabetes.
JP2008063256A (ja) 2006-09-06 2008-03-21 Astellas Pharma Inc β‐アミノ酸誘導体
WO2008028662A1 (en) 2006-09-07 2008-03-13 Santhera Pharmaceuticals (Schweiz) Ag N-[1-(3-amino-4-phenyl-butyryl)-4-hydroxy-pyrrolidin-2-ylmethyl}-propionamide and related compounds as dpp-iv inhibitors for the treatment of type 2 diabetes mellitus
AU2007293028B2 (en) 2006-09-07 2012-05-31 Amgen Inc. Heterocyclic GPR40 modulators
WO2008030618A1 (en) 2006-09-07 2008-03-13 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
NZ576023A (en) 2006-10-03 2012-06-29 Cadila Healthcare Ltd Antidiabetic compounds comprising a fragment of a glucagon peptide and derivatives thereof
WO2008040995A1 (en) 2006-10-07 2008-04-10 Peakdale Molecular Limited Indazoles for use as dpp-iv inhibitors
EP2079467B1 (en) 2006-10-31 2015-11-18 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2008054674A2 (en) 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
JP2010043001A (ja) 2006-11-09 2010-02-25 Sanwa Kagaku Kenkyusho Co Ltd Glp−1誘導体とその用途
CA2668662A1 (en) 2006-11-14 2008-05-22 Merck & Co., Inc. Tricyclic heteroaromatic compounds as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
US7750048B2 (en) 2006-11-15 2010-07-06 Janssen Pharmaceutica Nv GPR40 agonists
JP2010510317A (ja) 2006-11-20 2010-04-02 ブリストル−マイヤーズ スクイブ カンパニー ジペプチジルペプチダーゼivの阻害剤としての7,8−ジヒドロ−1,6−ナフチリジン−5(6h)−オンおよび関連二環式化合物、および方法
WO2008061355A1 (en) 2006-11-24 2008-05-29 Matregen Corp. Glp-1 depot systems, and methods of manufacture and uses thereof
JP5176964B2 (ja) 2006-11-29 2013-04-03 ユーハ味覚糖株式会社 ジペプチジルペプチダーゼiv阻害剤
TW200838526A (en) 2006-12-01 2008-10-01 Astellas Pharma Inc Carboxylic acid derivatives
US20130012485A1 (en) 2006-12-22 2013-01-10 Baeschlin Daniel Kaspar Organic compounds
JP2008156318A (ja) 2006-12-26 2008-07-10 Dainippon Sumitomo Pharma Co Ltd 1,3,4−オキサジアゾール−2−オン誘導体
US20090098130A1 (en) 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
JP2008169195A (ja) 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
KR100848491B1 (ko) 2007-01-16 2008-07-28 영진약품공업주식회사 베타아미노기를 갖는 2-싸이아졸리딘 유도체, 이의약학적으로 허용 가능한 염 및 이의 제조 방법
CN101230058A (zh) 2007-01-23 2008-07-30 上海恒瑞医药有限公司 双环氮杂烷类衍生物、其制备方法及其在医药上的用途
KR20080071476A (ko) 2007-01-30 2008-08-04 주식회사 엘지생명과학 신규한 디펩티딜 펩티데이즈 iv(dpp-iv) 저해제
JP2010120851A (ja) 2007-02-09 2010-06-03 Kyorin Pharmaceut Co Ltd 二量化シクロ誘導体
CA2677932A1 (en) 2007-02-15 2008-08-21 Indiana University Research And Technology Corporation Glucagon/glp-1 receptor co-agonists
EP1961742A1 (en) 2007-02-22 2008-08-27 Novartis AG compounds of formula (I) as serine protease inhibitors
US8618324B2 (en) 2007-03-13 2013-12-31 Board Of Regents, The University Of Texas System Composition and method for making oligo-benzamide compounds
EP1972349A1 (en) 2007-03-21 2008-09-24 Biocompatibles UK Limited GLP-1 fusion peptides conjugated to polymer(s), their production and use
US20100105629A1 (en) 2007-03-23 2010-04-29 Bachovchin William W N-Substituted Peptidomimetic Inhibitors of Dipeptidylpeptidase IV
WO2008116294A1 (en) 2007-03-23 2008-10-02 Matregen Corp. Exendin analogs
WO2008119005A1 (en) 2007-03-27 2008-10-02 Trustees Of Tufts College 3,4-dehydro-proline-containing inhibitors of dipeptidylpeptidase iv
EP1975176A1 (en) 2007-03-27 2008-10-01 Biocompatibles UK Limited Novel glp-1 fusion peptides, their production and use
US8133898B2 (en) 2007-03-30 2012-03-13 Takeda Pharmaceutical Company Limited Renin inhibitors
CN101274918A (zh) 2007-03-30 2008-10-01 中国科学院上海药物研究所 一类取代五元杂环化合物,其制备方法和医学用途
AU2008233548B2 (en) 2007-04-03 2011-12-01 Mitsubishi Tanabe Pharma Corporation Combined use of dipeptidyl peptidase IV inhibitor compound and sweetener
CN101279955B (zh) 2007-04-03 2012-11-28 北京摩力克科技有限公司 作为二肽肽激酶-iv抑制剂的n-取代硫吗啉衍生物及其医药用途
JP2010524932A (ja) 2007-04-16 2010-07-22 アムジエン・インコーポレーテツド 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸gpr40調節物質
CN102516184B (zh) 2007-04-19 2015-03-25 东亚St株式会社 包含β-氨基的DPP-IV抑制剂及其制备方法以及用于预防和治疗糖尿病或肥胖症的含有所述抑制剂的药物组合物
PE20090696A1 (es) 2007-04-20 2009-06-20 Bristol Myers Squibb Co Formas cristalinas de saxagliptina y procesos para preparar las mismas
US7829664B2 (en) 2007-06-01 2010-11-09 Boehringer Ingelheim International Gmbh Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof
US9353170B2 (en) 2007-06-08 2016-05-31 Sanofi-Aventis Deutschland Gmbh Long-acting transient polymer conjugates of exendin
DK2158214T3 (da) 2007-06-15 2011-12-05 Zealand Pharma As Glukagonanaloger
WO2009003681A1 (en) 2007-07-02 2009-01-08 Santhera Pharmaceuticals (Schweiz) Ag Dpp-iv inhibitors
WO2009014676A1 (en) 2007-07-23 2009-01-29 Merck & Co., Inc. Novel crystalline form of a dihydrochloride salt of a dipeptidyl peptidase-iv inhibitor
US8653059B2 (en) 2007-08-21 2014-02-18 Merck Sharp & Dohme Corp. Heterocyclic compounds as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
US20090105480A1 (en) 2007-08-30 2009-04-23 Ulrike Bromberger Process for the preparation of a dpp-iv inhibitor
CN101842386A (zh) 2007-09-05 2010-09-22 诺沃-诺迪斯克有限公司 截短的glp-1衍生物和它们的治疗用途
CN101868476B (zh) 2007-09-05 2015-02-25 诺沃-诺迪斯克有限公司 胰高血糖素样肽-1衍生物及其制药用途
JP5606314B2 (ja) 2007-09-05 2014-10-15 ノボ・ノルデイスク・エー/エス A−b−c−d−で誘導体化されたペプチドとその治療用途
WO2009035540A2 (en) 2007-09-07 2009-03-19 Ipsen Pharma S.A.S. Analogues of exendin-4 and exendin-3
EP2036923A1 (en) 2007-09-11 2009-03-18 Novo Nordisk A/S Improved derivates of amylin
WO2009038204A1 (ja) 2007-09-17 2009-03-26 Pharma Frontier Co., Ltd. 新規長鎖脂肪酸誘導体化合物及びそれら化合物を有効成分とするgタンパク質共役型レセプター作動剤
AU2008303975B2 (en) 2007-09-21 2013-05-16 Sanofi (Cyclopropyl-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
US8338450B2 (en) 2007-09-21 2012-12-25 Lupin Limited Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
JP5427784B2 (ja) 2007-09-21 2014-02-26 サノフイ (カルボキシルアルキレン−フェニル)−フェニル−オキサルアミド、その製造方法、及び薬剤としてのその使用
BRPI0818253A2 (pt) 2007-10-10 2015-04-07 Amgen Inc Moduladores de gpr40 bifenil substituídos
CN101417999A (zh) 2007-10-25 2009-04-29 上海恒瑞医药有限公司 哌嗪类衍生物,其制备方法及其在医药上的应用
CL2008003153A1 (es) 2007-10-26 2009-07-24 Japan Tobacco Inc Compuestos espiro condensados, agonistas de gpr40: composicion farmaceutica que comprende a uno de los compuestos; y el uso de los compuestos en la preparacion de medicamentos para el tratamiento de la diabetes, hiperglicemia, alteracion de tolerancia a la glucosa en ayuna, entre otras.
EP2215068B1 (en) 2007-10-29 2012-06-13 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
MX2010004298A (es) 2007-10-30 2010-05-03 Univ Indiana Res & Tech Corp Compuestos que exhiben actividad antagonista de glucagon y agonista de glp-1.
WO2009070314A2 (en) 2007-11-26 2009-06-04 Teva Pharmaceutical Industries Ltd. Crystalline form of sitagliptin
CN101918423B (zh) 2007-11-30 2013-05-15 诺瓦提斯公司 二肽基肽酶-iv抑制剂
ES2382579T3 (es) 2007-12-11 2012-06-11 Cadila Healthcare Limited Peptidomiméticos con actividad antagonista de glucagón y agonista de GLP-1
WO2009080024A1 (en) 2007-12-20 2009-07-02 Fertin Pharma A/S Compressed chewing gum comprising an incretin mimetic
WO2009080032A1 (en) 2007-12-20 2009-07-02 Fertin Pharma A/S Compressed chewing gum comprising a systemically active small peptide
AU2008341352B2 (en) 2007-12-21 2013-08-01 Lg Chem, Ltd. Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent
CN101468988A (zh) 2007-12-26 2009-07-01 上海恒瑞医药有限公司 哌嗪类衍生物,其制备方法及其在医药上的应用
TW200938200A (en) 2007-12-28 2009-09-16 Dainippon Sumitomo Pharma Co Methyl-substituted piperidine derivative
EP2231687A4 (en) 2008-01-10 2012-11-14 Sun Pharma Advanced Res Co Ltd NEW DERIVATIVES OF ACYL-CYANPYRROLIDINES
EP2250157B1 (en) 2008-01-24 2014-11-05 Panacea Biotec Limited Novel heterocyclic compounds
US20090238879A1 (en) 2008-01-24 2009-09-24 Northwestern University Delivery scaffolds and related methods of use
WO2009099172A1 (ja) 2008-02-07 2009-08-13 Takeda Pharmaceutical Company Limited 医薬
WO2009099171A1 (ja) 2008-02-07 2009-08-13 Takeda Pharmaceutical Company Limited 医薬
KR100864584B1 (ko) 2008-02-25 2008-10-24 성균관대학교산학협력단 비오틴으로 수식된 엑센딘 유도체, 이의 제조방법 및 이의용도
CN101970402B (zh) 2008-03-05 2013-12-18 财团法人国家卫生研究院 吡咯烷化合物
AU2009220163B2 (en) 2008-03-06 2011-10-06 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
CA2716664C (en) 2008-03-07 2016-10-11 Transtech Pharma, Inc. Oxadiazoanthracene compounds
AU2009222696A1 (en) 2008-03-10 2009-09-17 Dainippon Sumitomo Pharma Co., Ltd. Bicyclic pyrrole compound
US20090247532A1 (en) 2008-03-28 2009-10-01 Mae De Ltd. Crystalline polymorph of sitagliptin phosphate and its preparation
CN101565408A (zh) 2008-04-25 2009-10-28 国家新药筛选中心 一类受体信号转导增效剂,其制备方法和用途
US20110245173A1 (en) 2008-06-03 2011-10-06 Bachovchin William W Long-Acting GLP-1 Derivatives, and Methods of Treating Cardiac Dysfunction
US8450270B2 (en) 2008-06-17 2013-05-28 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
PE20100255A1 (es) 2008-06-17 2010-04-25 Univ Indiana Res & Tech Corp Co-agonistas del receptor de glucagon/glp-1
CA2727147A1 (en) 2008-06-17 2009-12-23 Otsuka Chemical Co., Ltd. Glycosylated glp-1 peptide
PT2586782E (pt) 2008-07-03 2015-02-03 Ratiopharm Gmbh Sais cristalinos de sitagliptina
JP2012503595A (ja) 2008-07-28 2012-02-09 シダンスク ユニバーシティ 代謝病の治療用の化合物
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament

Also Published As

Publication number Publication date
US20150297573A1 (en) 2015-10-22
CN105142621A (zh) 2015-12-09
EP2911655A1 (en) 2015-09-02
WO2014064215A1 (en) 2014-05-01

Similar Documents

Publication Publication Date Title
IN2015DN03795A (US07981874-20110719-C00313.png)
HK1209632A1 (en) Irak inhibitors and uses thereof -1 (irak)
EP2906684B8 (en) T cell modifying compounds and uses thereof
CA2900335C (en) Synthetic analogs of epipolythiodioxopiperazines and uses thereof
SI2920149T1 (sl) Spojine 3-aminocikloalkila kot zaviralci receptorja ROR-gama-t in uporaba teh spojin
HK1210732A1 (en) Irak inhibitors and uses thereof irak
HK1203477A1 (en) Substituted 3-haloallylamine inhibitors of ssao and uses thereof 3- ssao
MX355728B (es) Inhibidores de cinasas.
PL2532636T3 (pl) Inhibitor, mieszanina żywiczna zawierająca ten inhibitor i ich zastosowanie
PL2934404T3 (pl) Elastyczny laminat i sposób wytwarzania elastycznego laminatu
HK1209732A1 (en) Compound as wnt signaling inhibitor, composition, and use thereof wnt
MX2014012477A (es) Inhibidores pirrolopirazona de tanquirasa.
EP2847199A4 (en) PERMEABLE GLYCOSIDASE INHIBITORS AND USES THEREOF
IN2014DN06104A (US07981874-20110719-C00313.png)
HK1252801A1 (zh) 經修飾的紅細胞前體細胞及其用途
EP3088526A4 (en) Use of mirna-214 inhibitor in inhibiting regulatory t cells
MX2014015039A (es) Inhibidores de fbx03.
MX2015003711A (es) Metodos y composiciones para extender la vida útil en déposito de productos de plantas.
UA112760C2 (uk) Теобромін у комбінації з гвайфенезином для лікування кашлю
EP2971288A4 (en) COMPOSITIONS, METHODS, AND COMPUTER SYSTEMS ASSOCIATED WITH THE PRODUCTION AND ADMINISTRATION OF MODIFIED T CELLS
EP2938196A4 (en) ANOIKISRESISTENT PLAZENTASTAMM CELLS AND USES THEREOF
IN2015DN00962A (US07981874-20110719-C00313.png)
IN2014KN01772A (US07981874-20110719-C00313.png)
UA64156U (en) Social buisness-network
AU339394S (en) Protective case for tablet computer