IN2015DN01609A - - Google Patents

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Publication number
IN2015DN01609A
IN2015DN01609A IN1609DEN2015A IN2015DN01609A IN 2015DN01609 A IN2015DN01609 A IN 2015DN01609A IN 1609DEN2015 A IN1609DEN2015 A IN 1609DEN2015A IN 2015DN01609 A IN2015DN01609 A IN 2015DN01609A
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IN
India
Prior art keywords
presented
methods
amplicons
approaches
quantifying
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English (en)
Inventor
Imran R Malik
Xiomara L Madero
Erika F Garcia
Sheel M Shah
Axel Scherer
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of IN2015DN01609A publication Critical patent/IN2015DN01609A/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Algebra (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Mathematical Physics (AREA)
  • Pure & Applied Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Time-Division Multiplex Systems (AREA)
IN1609DEN2015 2012-08-03 2013-08-02 IN2015DN01609A (enrdf_load_stackoverflow)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261679547P 2012-08-03 2012-08-03
PCT/US2013/053512 WO2014022827A1 (en) 2012-08-03 2013-08-02 Multiplexing and quantification in pcr with reduced hardware and requirements

Publications (1)

Publication Number Publication Date
IN2015DN01609A true IN2015DN01609A (enrdf_load_stackoverflow) 2015-07-03

Family

ID=50025861

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1609DEN2015 IN2015DN01609A (enrdf_load_stackoverflow) 2012-08-03 2013-08-02

Country Status (5)

Country Link
US (3) US9791372B2 (enrdf_load_stackoverflow)
EP (2) EP3901243A1 (enrdf_load_stackoverflow)
CN (2) CN108753932B (enrdf_load_stackoverflow)
IN (1) IN2015DN01609A (enrdf_load_stackoverflow)
WO (1) WO2014022827A1 (enrdf_load_stackoverflow)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4361608A3 (en) 2012-02-03 2024-07-24 California Institute of Technology Signal encoding and decoding in multiplexed biochemical assays
IN2015DN01609A (enrdf_load_stackoverflow) * 2012-08-03 2015-07-03 California Inst Of Techn
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
DE102014105129B3 (de) * 2014-04-10 2015-07-02 Kist Europe-Korea Institute of Science and Technologie Europe Forschungsgesellschaft mbh Verfahren und Master-Mix für die quantitative Echtzeit-PCR für Multiplex-Ziel-Nukleinsäuremoleküle
CN103884679B (zh) * 2014-04-18 2016-01-20 山西大学 结合卡尔曼滤波器的腔衰荡光谱技术气体浓度监测方法
KR102084405B1 (ko) 2014-12-09 2020-03-04 주식회사 씨젠 타겟 핵산 서열에 대한 시그널의 구별
EP3130679B1 (de) * 2015-08-13 2018-02-28 Cladiac GmbH Verfahren und testsystem zum nachweis und/oder quantifizieren einer ziel-nukleinsäure in einer probe
EP3472354A4 (en) * 2016-06-17 2020-01-01 California Institute of Technology NUCLEIC ACID REACTIONS AND RELATED METHODS AND COMPOSITIONS
US11915795B2 (en) * 2016-12-23 2024-02-27 The Regents Of The University Of California Method and device for digital high resolution melt
US20190112636A1 (en) * 2017-10-16 2019-04-18 ChromaCode, Inc. Methods and compositions for nucleic acid detection
CN108841939B (zh) * 2018-06-21 2020-09-22 北京致雨生物科技有限公司 多重数字pcr浓度测量方法及微滴式数字pcr系统
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
JP7221491B2 (ja) * 2018-09-18 2023-02-14 株式会社ミズホメディー 複数の標的核酸を検出するキットを用いる検出方法
KR102789582B1 (ko) 2019-07-16 2025-03-31 멜리오랩스 인코포레이티드 단일-세포 기반 디지털 고해상도 용융을 위한 방법 및 장치

Family Cites Families (152)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3785591T2 (de) 1986-01-10 1993-09-02 Amoco Corp Kompetitiver homogener test.
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US6127155A (en) 1986-08-22 2000-10-03 Roche Molecular Systems, Inc. Stabilized thermostable nucleic acid polymerase compositions containing non-ionic polymeric detergents
US5079351A (en) 1986-11-26 1992-01-07 Cetus Corporation Oligonucleotides and kits for detection of htlvi and htlvii viruses by hybridization
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
US5994056A (en) 1991-05-02 1999-11-30 Roche Molecular Systems, Inc. Homogeneous methods for nucleic acid amplification and detection
EP0519338B1 (en) 1991-06-20 1996-08-28 F. Hoffmann-La Roche Ag Improved methods for nucleic acid amplification
DE69333650T2 (de) 1992-02-19 2006-01-12 The Public Health Research Institute Of The City Of New York, Inc. Neue anordnungn von oligonukleotiden und ihr nutzen zum sortieren, isolieren, sequenzieren und manipulieren von nukleinsäuren
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5948360A (en) 1994-07-11 1999-09-07 Tekmar Company Autosampler with robot arm
CN1100258C (zh) 1995-02-02 2003-01-29 中外制药株式会社 以调节化学发光为手段分析被分析物的方法
JPH11511238A (ja) 1995-04-25 1999-09-28 イロリ 遠隔プログラム可能なメモリ付きマトリックス及びその使用
DE69610304T2 (de) 1995-05-05 2001-04-05 Perkin-Elmer Corp., Foster City Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
US5882856A (en) 1995-06-07 1999-03-16 Genzyme Corporation Universal primer sequence for multiplex DNA amplification
US5773258A (en) 1995-08-25 1998-06-30 Roche Molecular Systems, Inc. Nucleic acid amplification using a reversibly inactivated thermostable enzyme
US20050112637A1 (en) 1995-09-08 2005-05-26 Chatterjee Deb K. Mutant DNA polymerases and uses thereof
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
US6007994A (en) 1995-12-22 1999-12-28 Yale University Multiparametric fluorescence in situ hybridization
US6156504A (en) 1996-03-15 2000-12-05 The Penn State Research Foundation Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays
CA2250118C (en) 1996-03-26 2009-09-29 Michael S. Kopreski Method enabling use of extracellular rna extracted from plasma or serum to detect, monitor or evaluate cancer
DK0912766T4 (da) 1996-06-04 2012-04-02 Univ Utah Res Found Overvågning af hybridisering under PCR
US5834203A (en) * 1997-08-25 1998-11-10 Applied Spectral Imaging Method for classification of pixels into groups according to their spectra using a plurality of wide band filters and hardwire therefore
CA2306501C (en) 1997-10-14 2011-03-29 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
US6235480B1 (en) 1998-03-13 2001-05-22 Promega Corporation Detection of nucleic acid hybrids
AU3555599A (en) 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
US7060431B2 (en) 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
CA2333253C (en) 1998-07-02 2010-09-07 Gen-Probe Incorporated Molecular torches
US6642062B2 (en) 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
EP1171636A2 (en) 1999-04-22 2002-01-16 Albert Einstein College Of Medicine Of Yeshiva University Assay of gene expression patterns by multi-fluor fish
ATE368125T1 (de) 1999-07-23 2007-08-15 Forensic Science Service Ltd Verfahren zur erkennung von einzel-nukleotid- polymorphismen
CA2387306C (en) 1999-10-22 2010-04-27 The Public Health Research Institute Of The City Of New York, Inc. Assays for short sequence variants
WO2001059144A1 (en) * 2000-02-10 2001-08-16 The Penn State Research Foundation Method of analyzing single nucleotide polymorphisms using melting curve and restriction endonuclease digestion
US20040053230A1 (en) 2001-03-07 2004-03-18 Schaffer Michael Edward Real time quantitative pcr with intercalating dye for single and multiplex target dna
EP1715063B1 (en) 2000-03-29 2011-01-26 LGC Limited Hybridisation beacon and method of rapid sequence detection and discrimination
US6734420B2 (en) 2000-04-06 2004-05-11 Quantum Dot Corporation Differentiable spectral bar code methods and systems
CA2314398A1 (en) 2000-08-10 2002-02-10 Edward Shipwash Microarrays and microsystems for amino acid analysis and protein sequencing
US20020142345A1 (en) 2000-12-22 2002-10-03 Nelsen Anita J. Methods for encoding and decoding complex mixtures in arrayed assays
CA2445960A1 (en) 2001-02-21 2002-12-19 Amnis Corporation Method and apparatus for labeling and analyzing cellular components
AU2002247248B2 (en) 2001-03-02 2007-07-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education PCR method
AU2002322457A1 (en) 2001-06-28 2003-03-03 Illumina, Inc. Multiplex decoding of array sensors with microspheres
JP2005508493A (ja) 2001-06-28 2005-03-31 アドヴァンスト リサーチ アンド テクノロジー インスティテュート、インコーポレイティッド 多色量子ドット標識ビーズおよびそのコンジュゲートの製造方法
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
EP1288308A1 (en) 2001-08-28 2003-03-05 Roche Diagnostics GmbH A method for the determination of multiple analytes
US6852491B2 (en) 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
US20030134320A1 (en) 2002-01-15 2003-07-17 Myriad Genetics, Incorporated Method system and computer program product for quality assurance in detecting biochemical markers
EP1426448A1 (en) 2002-12-03 2004-06-09 bioMérieux BV Method for lowering the effects of sequence variations in a diagnostic hybridization assay, probe for use in the assay and assay
US8137616B2 (en) 2003-04-04 2012-03-20 Roche Molecular Systems, Inc. System for multi color real time PCR
US7385043B1 (en) 2003-04-30 2008-06-10 The Public Health Research Institute Of The City Of New York, Inc. Homogeneous multiplex screening assays and kits
US20050053950A1 (en) * 2003-09-08 2005-03-10 Enrique Zudaire Ubani Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons
US20050064435A1 (en) 2003-09-24 2005-03-24 Xing Su Programmable molecular barcodes
TWI232934B (en) 2003-11-19 2005-05-21 Ind Tech Res Inst A biochip containing splitable reaction confinement and method for producing same and application thereof
WO2005051967A2 (en) 2003-11-19 2005-06-09 Allelogic Biosciences Corp. Oligonucleotides labeled with a plurality of fluorophores
US7601821B2 (en) 2004-03-24 2009-10-13 Applied Biosystems, Llc Encoding and decoding reactions for determining target molecules
CA2560945C (en) 2004-04-01 2013-06-18 Bio-Rad Laboratories, Inc. Quantitative amplification with a labeled probe and 3' to 5' exonuclease activity
JP4951505B2 (ja) 2004-05-07 2012-06-13 セファイド 生物学的因子の複合検出
US7575864B2 (en) 2004-05-27 2009-08-18 E.I. Du Pont De Nemours And Company Method for the direct detection of diagnostic RNA
DE102004043870B4 (de) 2004-09-10 2009-11-19 Eppendorf Ag Verfahren zur Erweiterung des dynamischen Erfassungsbereich bei Mikroarrays
WO2006032487A2 (en) 2004-09-24 2006-03-30 Universität Bern Molecular beacons
ES2359322T3 (es) * 2004-10-18 2011-05-20 Brandeis University Procedimiento para la amplificación de ácidos nucleicos.
AU2005299590B2 (en) 2004-10-27 2010-09-16 Cepheid Closed-system multi-stage nucleic acid amplification reactions
US20060246475A1 (en) 2005-01-21 2006-11-02 Third Wave Technologies Compositions and methods for increased dynamic range detection of nucleic acids
US7709249B2 (en) * 2005-04-01 2010-05-04 3M Innovative Properties Company Multiplex fluorescence detection device having fiber bundle coupling multiple optical modules to a common detector
US7507575B2 (en) 2005-04-01 2009-03-24 3M Innovative Properties Company Multiplex fluorescence detection device having removable optical modules
CA2579918A1 (en) 2005-06-16 2006-12-28 Biotools Biotechnological & Medical Laboratories, S.A. Nucleic acid detection method involving the direct generation of a measurable signal
US7919242B2 (en) 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
EP1937834B1 (en) 2005-09-01 2014-06-11 AusDiagnostics Pty Ltd. Methods for the amplification, quantitation and identification of nucleic acids
US7553955B2 (en) 2005-09-01 2009-06-30 The Trustees Of The University Of Pennsylvania Molecular beacons, methods and kits for detecting DNA damage response
CN1936019B (zh) 2005-10-18 2013-01-30 厦门大学 用于多重实时核酸扩增检测的探针编码方法
EP1963500B1 (en) 2005-12-23 2013-02-13 Nanostring Technologies, Inc. Compositions comprising oriented, immobilized macromolecules and methods for their preparation
ATE525482T1 (de) 2005-12-23 2011-10-15 Nanostring Technologies Inc Nanoreporter und verfahren zu deren herstellung und verwendung
US9133506B2 (en) 2006-01-10 2015-09-15 Applied Spectral Imaging Ltd. Methods and systems for analyzing biological samples
US8455184B2 (en) 2006-04-18 2013-06-04 The United States Of America As Represented By The Secretary Of The Air Force Differential multiplexing with pattern recognition
US20090062129A1 (en) 2006-04-19 2009-03-05 Agencourt Personal Genomics, Inc. Reagents, methods, and libraries for gel-free bead-based sequencing
JP5081232B2 (ja) 2006-05-22 2012-11-28 ナノストリング テクノロジーズ， インコーポレイテッド ナノレポーターを分析するためのシステムおよび方法
CA2653454A1 (en) 2006-05-23 2007-11-29 Molecular Detection, Inc. Ambient temperature stable kits for molecular diagnostics
EP2041318A2 (en) 2006-06-26 2009-04-01 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
WO2008036614A1 (en) 2006-09-18 2008-03-27 California Institute Of Technology Apparatus for detecting target molecules and related methods
US20100062436A1 (en) 2006-10-31 2010-03-11 Noxxon Pharma Ag Methods for Detection of a Single- or Double-Stranded Nucleic Acid Molecule
US9201063B2 (en) 2006-11-16 2015-12-01 General Electric Company Sequential analysis of biological samples
WO2008067567A2 (en) 2006-11-30 2008-06-05 Gen-Probe Incorporated Quantitative method employing adjustment of pre-defined master calibration curves
CN101657548B (zh) * 2006-12-13 2012-10-10 卢米耐克斯公司 用于实时pcr多重分析的系统和方法
CA2580589C (en) 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
WO2008109636A1 (en) 2007-03-05 2008-09-12 University Of Utah Research Foundation Methods and compositions related to nucleic acid detection
WO2008118998A2 (en) 2007-03-27 2008-10-02 Primera Biosystems Inc. Method for multiplex detection and quantitation of nucleic acids
EP2155899A2 (en) 2007-04-10 2010-02-24 Nanostring Technologies, Inc. Methods and computer systems for identifying target-specific sequences for use in nanoreporters
EP2167537A2 (en) 2007-07-03 2010-03-31 Dako Denmark A/S Compiled methods for analysing and sorting samples
CN101821609A (zh) * 2007-08-29 2010-09-01 艾本德股份有限公司 用于多个样品的辐射度测量的设备和方法
EP2195453A4 (en) 2007-09-20 2011-02-02 Molecular Plant Breeding Nominees Ltd METHOD FOR AMPLIFYING NUCLEIC ACID
WO2009081967A1 (ja) 2007-12-26 2009-07-02 Arkray, Inc. 標的核酸配列の増幅方法およびそれに用いるプローブ
EP2116614A1 (en) 2008-05-06 2009-11-11 Qiagen GmbH Simultaneous detection of multiple nucleic acid sequences in a reaction
GB0812862D0 (en) 2008-07-14 2008-08-20 Lumora Ltd Nucleic acid amplification
WO2010013017A1 (en) 2008-07-31 2010-02-04 Oxitec Limited Multiplex amplification and detection
AU2009279457A1 (en) * 2008-08-08 2010-02-11 Smiths Detection Inc. Detection algorithm for PCR assay
AU2009281836B2 (en) 2008-08-14 2015-02-19 Bruker Spatial Biology, Inc. Stable nanoreporters
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9921154B2 (en) 2011-03-18 2018-03-20 Bio-Rad Laboratories, Inc. Multiplexed digital assays
CN102224257A (zh) * 2008-11-21 2011-10-19 皇家飞利浦电子股份有限公司 使用双链核酸特异性染料在固体表面上的实时多重pcr检测
US8614061B2 (en) 2008-12-01 2013-12-24 Qiagen, Gmbh Combination of fluorescent dyes for the detection of nucleic acids
CA2747026A1 (en) 2008-12-17 2010-07-08 Life Technologies Corporation Methods, compositions, and kits for detecting allelic variants
CA2748265C (en) * 2008-12-22 2018-04-03 University Of Utah Research Foundation Monochrome multiplex quantitative pcr
US8361738B2 (en) 2009-03-06 2013-01-29 California Institute Of Technology Methods for quantitative target detection and related devices and systems
US8039215B2 (en) * 2009-03-10 2011-10-18 Roche Molecular Systems, Inc. Multiplex quantitative nucleic acid amplification and melting assay
CN101570782B (zh) 2009-03-20 2012-01-11 曹际娟 乳制品中8种致病菌检测试剂盒及其检测方法
FI20095514A0 (fi) * 2009-05-07 2009-05-07 Expression Analytics Oy Menetelmä, laitteisto ja tietokoneohjelmatuote PCR-tuotteiden kvantifioimiseksi
US20120040349A1 (en) 2009-05-12 2012-02-16 Piia Von Lode Method for detecting nucleic acids
CN102449167B (zh) 2009-05-26 2014-12-17 厦门大学 一种检测核酸序列变异的方法
WO2010135916A1 (zh) 2009-05-26 2010-12-02 厦门大学 一种单管检测多个单核苷酸变异或单核苷酸多态性的方法
EP2280080A1 (en) 2009-07-31 2011-02-02 Qiagen GmbH Method of normalized quantification of nucleic acids using anchor oligonucleotides and adapter oligonucleotides
EP3375891B1 (en) 2009-09-10 2020-02-19 DiaSorin S.p.A. Methods and devices for compensation of spectral crosstalk in multiplex nucleic acid amplification
KR101590175B1 (ko) 2009-09-24 2016-01-29 주식회사 씨젠 반복적 엑소핵산 절단 반응에 의한 타겟 핵산서열의 검출
US8962251B2 (en) 2009-10-08 2015-02-24 Medical Service Consultation International, Llc Methods and compositions for identifying sulfur and iron modifying bacteria
AU2010306862B2 (en) 2009-10-13 2015-08-27 Bruker Spatial Biology, Inc. Protein detection via nanoreporters
US9752187B2 (en) 2009-12-11 2017-09-05 Nucleix Categorization of DNA samples
EP2516681B1 (en) 2010-02-11 2017-10-18 Nanostring Technologies, Inc Compositions and methods for the detection of preferably small rnas by bridge hybridisation and ligation
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
CA2789425C (en) 2010-02-12 2020-04-28 Raindance Technologies, Inc. Digital analyte analysis with polymerase error correction
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US20110229888A1 (en) 2010-03-16 2011-09-22 Hengen Paul N Compositions and Methods for the Detection of Genomic Features
EP2572001A2 (en) 2010-05-19 2013-03-27 QIAGEN Gaithersburg, Inc. Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids
CN102269759B (zh) * 2010-06-07 2014-05-07 常州楚天生物科技有限公司 一种基于免疫pcr和dna熔解曲线分析的多重检测方法
EP2588629B1 (en) 2010-06-30 2017-05-17 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US8877464B2 (en) 2010-07-29 2014-11-04 Roche Molecular Systems, Inc. Qualitative and quantitative detection of microbial nucleic acids
GB201017978D0 (en) * 2010-10-25 2010-12-08 Oxitec Ltd Multiplex amplification and detection
US10024796B2 (en) 2010-10-29 2018-07-17 President And Fellows Of Harvard College Nucleic acid nanostructure barcode probes
EP3410080B1 (en) 2011-01-20 2022-07-13 University of Washington through its Center for Commercialization Methods and systems for performing digital measurements
US20150140554A1 (en) 2011-02-03 2015-05-21 Richard O. Snyder Detection Methods for Target DNA
EP2686449B1 (en) 2011-03-18 2020-11-18 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
WO2012129115A2 (en) 2011-03-18 2012-09-27 University Of South Florida Materials and methods for profiling micrornas
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US20130017971A1 (en) 2011-06-24 2013-01-17 Nanostring Technologies, Inc. Multivariate Diagnostic Assays and Methods for Using Same
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8858623B2 (en) 2011-11-04 2014-10-14 Valtech Cardio, Ltd. Implant having multiple rotational assemblies
CN102559868B (zh) * 2011-11-28 2014-11-05 厦门大学 一种单管定性并定量检测多个目标核酸序列的方法
EP4108782B1 (en) 2011-12-22 2023-06-07 President and Fellows of Harvard College Compositions and methods for analyte detection
EP4361608A3 (en) 2012-02-03 2024-07-24 California Institute of Technology Signal encoding and decoding in multiplexed biochemical assays
CN108624654A (zh) 2012-06-27 2018-10-09 新泽西鲁特格斯州立大学 通过使用流式细胞术的rna测量快速检测t细胞活化
IN2015DN01609A (enrdf_load_stackoverflow) 2012-08-03 2015-07-03 California Inst Of Techn
GB201218909D0 (en) 2012-10-22 2012-12-05 Univ Singapore Assay for the parallel detection of biological material based on PCR
CA2897474A1 (en) 2013-01-24 2014-07-31 California Institute Of Technology Chromophore-based characterization and detection methods
CN105339505B (zh) 2013-03-12 2021-08-10 生命技术公司 基于通用报告体的基因分型方法和材料
EP2873740A1 (en) 2013-11-19 2015-05-20 Oncodiag Methods for the surveillance, diagnosis and screening of bladder cancer
US9670530B2 (en) 2014-01-30 2017-06-06 Illumina, Inc. Haplotype resolved genome sequencing
WO2015147370A1 (en) 2014-03-28 2015-10-01 Seegene, Inc. Detection of target nucleic acid sequences using different detection temperatures
US10801067B2 (en) 2014-05-09 2020-10-13 Eurofins Lifecodexx Gmbh Detection of DNA that originates from a specific cell-type and related methods
JP2019513345A (ja) 2016-02-10 2019-05-30 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 核酸の検知
WO2017173035A1 (en) 2016-04-01 2017-10-05 Chromacode Inc. Competitive probes for engineering signal generation
EP3472354A4 (en) 2016-06-17 2020-01-01 California Institute of Technology NUCLEIC ACID REACTIONS AND RELATED METHODS AND COMPOSITIONS
US11435338B2 (en) 2016-10-24 2022-09-06 Ontera Inc. Fractional abundance of polynucleotide sequences in a sample
EP4039829B1 (en) 2017-06-28 2024-03-20 ChromaCode, Inc. Multiplexed fluorometric measurements with droplet pcr systems
US20190112636A1 (en) 2017-10-16 2019-04-18 ChromaCode, Inc. Methods and compositions for nucleic acid detection
CN112041460A (zh) 2018-02-28 2020-12-04 克罗玛科德公司 用于胎儿核酸分析的分子靶标

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US20240201090A1 (en) 2024-06-20
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