IN2014CN04676A - - Google Patents

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Publication number
IN2014CN04676A
IN2014CN04676A IN4676CHN2014A IN2014CN04676A IN 2014CN04676 A IN2014CN04676 A IN 2014CN04676A IN 4676CHN2014 A IN4676CHN2014 A IN 4676CHN2014A IN 2014CN04676 A IN2014CN04676 A IN 2014CN04676A
Authority
IN
India
Prior art keywords
general formula
compounds
prodrugs
solvates
inhibitors
Prior art date
Application number
Other languages
English (en)
Inventor
Steve Courtney
Chris Yarnold
Stuart Flanagan
Gareth Brace
John Barker
Osamu Ichihara
Elise Gadouleau
Anthony Richardson
Takashi Kondo
Akira Imagawa
Shingo Nakatani
Ryo Suzuki
Sho Kouyama
Original Assignee
Ono Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1122139.7A external-priority patent/GB2497806A/en
Priority claimed from GB201217290A external-priority patent/GB201217290D0/en
Application filed by Ono Pharmaceutical Co filed Critical Ono Pharmaceutical Co
Publication of IN2014CN04676A publication Critical patent/IN2014CN04676A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IN4676CHN2014 2011-12-21 2012-12-20 IN2014CN04676A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1122139.7A GB2497806A (en) 2011-12-21 2011-12-21 Pyridinone and pyrimidinone derivatives as factor XIa inhibitors
GB201217290A GB201217290D0 (en) 2012-09-27 2012-09-27 Compounds
PCT/GB2012/053217 WO2013093484A1 (fr) 2011-12-21 2012-12-20 Dérivés de pyridinone et de pyrimidinone comme inhibiteurs du facteur xia

Publications (1)

Publication Number Publication Date
IN2014CN04676A true IN2014CN04676A (fr) 2015-09-18

Family

ID=47553259

Family Applications (1)

Application Number Title Priority Date Filing Date
IN4676CHN2014 IN2014CN04676A (fr) 2011-12-21 2012-12-20

Country Status (23)

Country Link
US (2) US9732085B2 (fr)
EP (2) EP2794597B1 (fr)
JP (2) JP6137193B2 (fr)
KR (1) KR102011534B1 (fr)
CN (1) CN104136431B (fr)
AU (1) AU2012356374B2 (fr)
BR (1) BR112014015669B1 (fr)
CA (1) CA2859604C (fr)
DK (1) DK2794597T3 (fr)
ES (2) ES2765891T3 (fr)
HK (1) HK1198386A1 (fr)
HU (1) HUE036010T2 (fr)
IL (1) IL233154A (fr)
IN (1) IN2014CN04676A (fr)
MX (1) MX351471B (fr)
NO (1) NO2794597T3 (fr)
PH (1) PH12014501365A1 (fr)
PL (1) PL2794597T3 (fr)
PT (1) PT2794597T (fr)
RU (1) RU2630677C2 (fr)
SG (1) SG11201403402VA (fr)
TW (1) TWI613199B (fr)
WO (1) WO2013093484A1 (fr)

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RS55975B1 (sr) 2012-08-03 2017-09-29 Bristol Myers Squibb Co Dihidropiridon p1 kao inhibitori xia faktora
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WO2014059202A1 (fr) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Composés de tétrahydroisoquinoléine substitués par guanidine comme inhibiteurs du facteur xia
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WO2014160592A2 (fr) 2013-03-27 2014-10-02 Merck Sharp & Dohme Corp. Inhibiteurs du facteur xia
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WO2015123091A1 (fr) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Inhibiteurs du facteur xia
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EP3134408B1 (fr) 2014-04-22 2020-08-12 Merck Sharp & Dohme Corp. Inhibiteurs du facteur xia
WO2016011940A1 (fr) * 2014-07-25 2016-01-28 江苏恒瑞医药股份有限公司 Dérivé d'indole-amide, son procédé de préparation et son application en médecine
WO2016015593A1 (fr) 2014-07-28 2016-02-04 Merck Sharp & Dohme Corp. Inhibiteurs du facteur xia
ES2714283T3 (es) 2014-09-04 2019-05-28 Bristol Myers Squibb Co Macrociclos de diamida que son inhibidores de FXIa
CN104311537B (zh) * 2014-09-19 2016-08-24 广东东阳光药业有限公司 含有嘧啶酮乙酰基取代基吡唑类化合物及其组合物及用途
WO2016046164A1 (fr) * 2014-09-24 2016-03-31 Bayer Pharma Aktiengesellschaft Dérivés d'oxopyridine substitués
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US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
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MX351471B (es) 2017-10-17
ES2655669T3 (es) 2018-02-21
US10717738B2 (en) 2020-07-21
CA2859604C (fr) 2019-12-17
MX2014007269A (es) 2014-07-22
BR112014015669A2 (pt) 2017-06-13
DK2794597T3 (en) 2018-01-15
EP2794597B1 (fr) 2017-11-15
EP3290413B9 (fr) 2020-04-29
CA2859604A1 (fr) 2013-06-27
PH12014501365B1 (en) 2014-09-22
KR102011534B1 (ko) 2019-08-16
TW201339157A (zh) 2013-10-01
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HK1198386A1 (en) 2015-04-17
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AU2012356374B2 (en) 2017-06-22
CN104136431A (zh) 2014-11-05
PH12014501365A1 (en) 2014-09-22
JP2017160239A (ja) 2017-09-14
EP3290413B1 (fr) 2019-11-13
RU2014129797A (ru) 2016-02-10
AU2012356374A8 (en) 2014-08-07
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EP2794597A1 (fr) 2014-10-29
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