IN2014CN03073A - - Google Patents

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Publication number
IN2014CN03073A
IN2014CN03073A IN3073CHN2014A IN2014CN03073A IN 2014CN03073 A IN2014CN03073 A IN 2014CN03073A IN 3073CHN2014 A IN3073CHN2014 A IN 3073CHN2014A IN 2014CN03073 A IN2014CN03073 A IN 2014CN03073A
Authority
IN
India
Prior art keywords
compounds
treating
useful
formula
pharmaceutically acceptable
Prior art date
Application number
Other languages
English (en)
Inventor
Pengcheng Patrick Shao
Feng Ye
Petr Vachal
Deyou Sha
Revathi Reddy Katipally
Jian Liu
Wanying Sun
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of IN2014CN03073A publication Critical patent/IN2014CN03073A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IN3073CHN2014 2011-10-28 2012-10-25 IN2014CN03073A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552592P 2011-10-28 2011-10-28
PCT/US2012/061842 WO2013063217A1 (en) 2011-10-28 2012-10-25 Fused bicyclic oxazolidinone cetp inhibitor

Publications (1)

Publication Number Publication Date
IN2014CN03073A true IN2014CN03073A (zh) 2015-07-31

Family

ID=47143312

Family Applications (1)

Application Number Title Priority Date Filing Date
IN3073CHN2014 IN2014CN03073A (zh) 2011-10-28 2012-10-25

Country Status (41)

Country Link
US (2) US8871738B2 (zh)
EP (1) EP2771345B1 (zh)
JP (1) JP5658427B2 (zh)
KR (1) KR101686308B1 (zh)
CN (1) CN103958524B (zh)
AR (1) AR088565A1 (zh)
AU (1) AU2012328759B2 (zh)
BR (1) BR112014010204A2 (zh)
CA (1) CA2852743C (zh)
CL (1) CL2014001090A1 (zh)
CO (1) CO6940419A2 (zh)
CR (1) CR20140256A (zh)
CY (1) CY1118464T1 (zh)
DK (1) DK2771345T3 (zh)
DO (1) DOP2014000086A (zh)
EA (1) EA026123B1 (zh)
EC (1) ECSP14002458A (zh)
ES (1) ES2604953T3 (zh)
GE (1) GEP20166434B (zh)
HK (1) HK1195558A1 (zh)
HR (1) HRP20161541T1 (zh)
HU (1) HUE030568T2 (zh)
IL (1) IL232130A (zh)
IN (1) IN2014CN03073A (zh)
JO (1) JO3210B1 (zh)
LT (1) LT2771345T (zh)
MA (1) MA35643B1 (zh)
ME (1) ME02557B (zh)
MX (1) MX345222B (zh)
NI (1) NI201400034A (zh)
PE (1) PE20141230A1 (zh)
PL (1) PL2771345T3 (zh)
PT (1) PT2771345T (zh)
RS (1) RS55420B1 (zh)
SG (1) SG11201401884PA (zh)
SI (1) SI2771345T1 (zh)
TN (1) TN2014000158A1 (zh)
TW (1) TWI601731B (zh)
UA (1) UA114612C2 (zh)
WO (1) WO2013063217A1 (zh)
ZA (2) ZA201403091B (zh)

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US9221834B2 (en) 2010-10-29 2015-12-29 Merck Sharp & Dohme Corp. Cyclic amine substituted oxazolidinone CETP inhibitor
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
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WO2014099836A1 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Spirocyclic cetp inhibitors
WO2014099834A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. Therapeutic thiazolidinone compounds
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EP3027619B1 (en) * 2013-07-30 2019-01-02 Merck Sharp & Dohme Corp. Bicyclic ureas and thiadiazolidine-1,1-dioxides as cetp inhibitors
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BR112016022062B1 (pt) 2014-03-26 2023-04-11 Astex Therapeutics Limited Combinação, composição farmacêutica, uso de uma combinação ou de uma composição farmacêutica, e, produto farmacêutico
HUE053654T2 (hu) 2014-03-26 2021-07-28 Astex Therapeutics Ltd FGFR- és CMET-inhibitorok kombinációi a rák kezelésére
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US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
WO2016201310A1 (en) * 2015-06-12 2016-12-15 Rhodia Operations Hybrid nanoparticles containing dendrons, methods of producing such hybrid nanoparticles, and uses thereof
EP3322420B1 (en) * 2015-07-13 2021-12-29 Merck Sharp & Dohme Corp. Bicyclic heterocycles as inhibitors of cholesterol ester transfer protein
HRP20220012T1 (hr) 2015-09-23 2022-04-01 Janssen Pharmaceutica Nv Bi-heteroaril supstituirani 1,4-benzodiazepini i njihova upotreba za liječenje raka
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CN106432053A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 一种尼拉帕布中间体4‑(3s‑哌啶‑3‑基)溴苯的制备方法
CN106432058A (zh) * 2016-09-17 2017-02-22 青岛云天生物技术有限公司 一种Niraparib中间体4‑（3S‑哌啶‑3‑基）苯胺的制备方法
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Also Published As

Publication number Publication date
CO6940419A2 (es) 2014-05-09
ES2604953T3 (es) 2017-03-10
CR20140256A (es) 2014-07-15
EP2771345B1 (en) 2016-09-21
US9346825B2 (en) 2016-05-24
MX2014005074A (es) 2014-08-01
CN103958524A (zh) 2014-07-30
IL232130A0 (en) 2014-05-28
US20140378493A1 (en) 2014-12-25
AR088565A1 (es) 2014-06-18
HUE030568T2 (en) 2017-05-29
RS55420B1 (sr) 2017-04-28
JP2014532652A (ja) 2014-12-08
SG11201401884PA (en) 2014-09-26
SI2771345T1 (sl) 2016-12-30
GEP20166434B (en) 2016-02-10
CN103958524B (zh) 2016-04-06
CY1118464T1 (el) 2017-07-12
ECSP14002458A (es) 2015-11-30
CL2014001090A1 (es) 2014-08-01
UA114612C2 (uk) 2017-07-10
CA2852743A1 (en) 2013-05-02
JO3210B1 (ar) 2018-03-08
EP2771345A1 (en) 2014-09-03
JP5658427B2 (ja) 2015-01-28
ME02557B (me) 2017-02-20
PL2771345T3 (pl) 2017-04-28
TW201321388A (zh) 2013-06-01
TN2014000158A1 (en) 2015-09-30
MX345222B (es) 2017-01-20
US8871738B2 (en) 2014-10-28
HK1195558A1 (zh) 2014-11-14
CA2852743C (en) 2016-08-02
NI201400034A (es) 2014-10-10
NZ625435A (en) 2015-12-24
ZA201406833B (en) 2016-02-24
KR20140094571A (ko) 2014-07-30
BR112014010204A2 (pt) 2017-05-09
PE20141230A1 (es) 2014-09-28
EA026123B1 (ru) 2017-03-31
LT2771345T (lt) 2016-11-25
MA35643B1 (fr) 2014-11-01
AU2012328759B2 (en) 2015-09-10
HRP20161541T1 (hr) 2016-12-30
EA201490889A1 (ru) 2015-05-29
DK2771345T3 (en) 2017-01-09
IL232130A (en) 2017-07-31
AU2012328759A1 (en) 2014-05-01
PT2771345T (pt) 2016-11-30
ZA201403091B (en) 2015-04-29
TWI601731B (zh) 2017-10-11
US20130109649A1 (en) 2013-05-02
KR101686308B1 (ko) 2016-12-13
WO2013063217A1 (en) 2013-05-02
DOP2014000086A (es) 2014-07-15

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