IN2014CN00408A - - Google Patents
Info
- Publication number
- IN2014CN00408A IN2014CN00408A IN408CHN2014A IN2014CN00408A IN 2014CN00408 A IN2014CN00408 A IN 2014CN00408A IN 408CHN2014 A IN408CHN2014 A IN 408CHN2014A IN 2014CN00408 A IN2014CN00408 A IN 2014CN00408A
- Authority
- IN
- India
- Prior art keywords
- formula
- relates
- pyridine ring
- present
- membered fused
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A—HUMAN NECESSITIES
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161509397P | 2011-07-19 | 2011-07-19 | |
EP11174578 | 2011-07-19 | ||
PCT/EP2012/063552 WO2013010868A1 (fr) | 2011-07-19 | 2012-07-11 | 4-imidazopyridazin-1-yl-benzamides et 4-imidazotriazin-1-yl-benzamides en tant qu'inhibiteurs de btk |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014CN00408A true IN2014CN00408A (fr) | 2015-04-03 |
Family
ID=47557677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN408CHN2014 IN2014CN00408A (fr) | 2011-07-19 | 2012-07-11 |
Country Status (36)
Country | Link |
---|---|
US (7) | US9290504B2 (fr) |
EP (4) | EP4249076A3 (fr) |
JP (6) | JP5826931B2 (fr) |
KR (2) | KR101802689B1 (fr) |
CN (2) | CN106243113B (fr) |
AU (4) | AU2012285987C1 (fr) |
BR (1) | BR112014001255B1 (fr) |
CA (1) | CA2841886C (fr) |
CL (1) | CL2014000130A1 (fr) |
CO (1) | CO6940411A2 (fr) |
CR (1) | CR20140030A (fr) |
CY (1) | CY1125613T1 (fr) |
DK (2) | DK3689878T3 (fr) |
DO (1) | DOP2014000008A (fr) |
EA (2) | EA037644B1 (fr) |
EC (1) | ECSP14013217A (fr) |
ES (3) | ES2904707T3 (fr) |
GT (1) | GT201400009A (fr) |
HR (2) | HRP20212021T1 (fr) |
HU (3) | HUE041987T2 (fr) |
IL (3) | IL230511B (fr) |
IN (1) | IN2014CN00408A (fr) |
LT (1) | LT2734522T (fr) |
MA (1) | MA35348B1 (fr) |
MX (1) | MX342983B (fr) |
MY (1) | MY192354A (fr) |
PE (1) | PE20141681A1 (fr) |
PH (1) | PH12017500166B1 (fr) |
PL (2) | PL3689878T3 (fr) |
PT (1) | PT3689878T (fr) |
RS (2) | RS62760B1 (fr) |
SG (1) | SG10201605913VA (fr) |
SI (2) | SI3689878T1 (fr) |
TN (1) | TN2014000027A1 (fr) |
UA (1) | UA115312C2 (fr) |
WO (1) | WO2013010868A1 (fr) |
Families Citing this family (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120101113A1 (en) * | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
KR101580714B1 (ko) | 2010-06-03 | 2016-01-04 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 인산화효소(btk)의 억제제의 용도 |
PL2710005T3 (pl) | 2011-05-17 | 2017-07-31 | Principia Biopharma Inc. | Inhibitory kinazy tyrozynowej |
US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
JP2014520863A (ja) | 2011-07-13 | 2014-08-25 | ファーマサイクリックス,インク. | Bruton型チロシンキナーゼの阻害剤 |
HUE041987T2 (hu) | 2011-07-19 | 2019-06-28 | Merck Sharp & Dohme | 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók |
EP2548877A1 (fr) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK |
CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
RS58956B1 (sr) | 2012-09-10 | 2019-08-30 | Principia Biopharma Inc | Jedinjenja pirazolopirimidina kao inhibitori kinaze |
JP2015532287A (ja) | 2012-09-26 | 2015-11-09 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ire1の調節 |
KR20150067298A (ko) * | 2012-10-04 | 2015-06-17 | 유니버시티 오브 유타 리서치 파운데이션 | 티로신 수용체 키나아제 btk 억제제로서의 치환된 n-(3-(피리미딘-4-일)페닐)아크릴아미드 유사체 |
WO2014113942A1 (fr) | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
WO2014114185A1 (fr) | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
BR112015029969A2 (pt) | 2013-05-30 | 2017-07-25 | Infinity Pharmaceuticals Inc | tratamento de câncer usando moduladores de isoformas quinase pi3 |
HUE042111T2 (hu) | 2013-07-31 | 2019-06-28 | Merck Patent Gmbh | Piridinek, pirimidinek és pirazinok mint BTK inhibitorok, továbbá ezek alkalmazása |
WO2015057992A1 (fr) * | 2013-10-16 | 2015-04-23 | Izumi Raquel | Inhibiteurs btk pour la mobilisation hématopoïétique |
BR112016012794A2 (pt) | 2013-12-05 | 2017-08-08 | Acerta Pharma Bv | Combinação terapêutica de um inibidor de pi3k e um inibidor de btk |
WO2015095099A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
WO2015095102A1 (fr) | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
US10272083B2 (en) | 2014-01-21 | 2019-04-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor |
WO2015110923A2 (fr) * | 2014-01-21 | 2015-07-30 | Acerta Pharma B.V. | Méthodes de traitement de la leucémie lymphoïde chronique et du lymphome à petits lymphocytes en utilisant un inhibiteur de btk |
ES2841248T3 (es) | 2014-02-21 | 2021-07-07 | Principia Biopharma Inc | Sales y forma sólida de un inhibidor de BTK |
WO2015185998A2 (fr) | 2014-04-11 | 2015-12-10 | Acerta Pharma B.V. | Procédés de blocage de la voie de signalisation des cxcr-4/sdf-1 à l'aide d'inhibiteurs de kinase x de moelle osseuse |
US9937171B2 (en) | 2014-04-11 | 2018-04-10 | Acerta Pharma B.V. | Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
US9949971B2 (en) | 2014-06-17 | 2018-04-24 | Acerta Pharma B.V. | Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor and/or a JAK-2 inhibitor |
WO2016019233A1 (fr) * | 2014-08-01 | 2016-02-04 | Pharmacyclics Llc | Inhibiteurs de la tyrosine kinase de bruton |
WO2016020901A1 (fr) | 2014-08-07 | 2016-02-11 | Acerta Pharma B.V. | Procédés de traitement de cancers, maladies immunitaires et auto-immunes, et maladies inflammatoires basés sur l'occupation de btk et le taux de resynthèse de btk |
TW201609099A (zh) * | 2014-08-11 | 2016-03-16 | 艾森塔製藥公司 | 使用布魯頓(Bruton)氏酪胺酸激酶(BTK)抑制劑以治療慢性淋巴球性白血病和小淋巴球性白血病之方法 |
HUE056329T2 (hu) | 2014-08-11 | 2022-02-28 | Acerta Pharma Bv | BTK-inhibitor és BCL-2-inhibitor terápiás kombinációi |
TW201618774A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | 使用btk抑制劑透過調變腫瘤微環境來治療實體腫瘤及其他疾病之方法 |
WO2016024231A1 (fr) | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Combinaisons thérapeutiques d'un inhibiteur de btk, d'un inhibiteur de pi3k, d'un inhibiteur de jak-2, d'un inhibiteur de pd-1 et/ou d'un inhibiteur de pd-l1 |
WO2016024232A1 (fr) | 2014-08-11 | 2016-02-18 | Acerta Pharma B.V. | Combinaisons thérapeutiques d'un inhibiteur de la btk, d'un inhibiteur de la pi3k, d'un inhibiteur de la jak-2 et/ou d'un inhibiteur de la cdk 4/6 |
CN106660997B (zh) | 2014-08-18 | 2019-05-21 | 卫材R&D管理有限公司 | 单环吡啶衍生物的盐及其晶体 |
EP3191098A4 (fr) * | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Combinaisons et régimes posologiques pour traiter des tumeurs rb-positives |
WO2016055982A1 (fr) * | 2014-10-10 | 2016-04-14 | Acerta Pharma B.V. | Composés quinoléine et quinazoline |
WO2016087994A1 (fr) | 2014-12-05 | 2016-06-09 | Acerta Pharma B.V. | Inhibiteurs de btk pour le traitement de tumeurs solides par modulation du micro-environnement tumoral |
PT3233103T (pt) * | 2014-12-18 | 2021-01-18 | Principia Biopharma Inc | Tratamento de pênfigo |
WO2016106629A1 (fr) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
WO2016106625A1 (fr) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
WO2016106626A1 (fr) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Analogues de l'imidazopyrazine avec substitutions sur carbone tertiaire 3 en tant qu'inhibiteurs de btk |
WO2016106624A1 (fr) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Inhibiteurs de la btk comprenant une imidazopyrazine d'alcool tertiaire |
WO2016106627A1 (fr) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
WO2016106623A1 (fr) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Composés benzamides et imidazopyrazines utilisés comme inhibiteurs de la btk |
WO2016128912A1 (fr) * | 2015-02-12 | 2016-08-18 | Acerta Pharma B.V. | Combinaisons thérapeutiques d'un inhibiteur de btk, d'un inhibiteur de pi3k, d'un inhibiteur de jak-2, d'un inhibiteur de pd-1, et/ou d'un inhibiteur de pd-l1 |
WO2016161571A1 (fr) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | Inhibiteurs de la btk de type indazole et azaindazole |
WO2016192074A1 (fr) * | 2015-06-04 | 2016-12-08 | Merck Sharp & Dohme Corp. | Inhibiteurs de la btk |
MA42242A (fr) | 2015-06-24 | 2018-05-02 | Principia Biopharma Inc | Inhibiteurs de la tyrosine kinase |
HRP20211511T1 (hr) | 2015-07-02 | 2021-12-24 | Acerta Pharma B.V. | Čvrsti oblici i formulacije (s)-4-(8-amino-3-(1-(but-2-inoil)pirolidin-2-il)imidazo[1,5-a]pirazin-1-il)-n-(piridin-2-il)benzamida |
WO2017033113A1 (fr) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Associations thérapeutiques d'un inhibiteur de mek et d'un inhibiteur de btk |
MA44909A (fr) * | 2015-09-15 | 2018-07-25 | Acerta Pharma Bv | Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk |
WO2017046746A1 (fr) | 2015-09-15 | 2017-03-23 | Acerta Pharma B.V. | Associations thérapeuthiques d'un inhibiteur de la btk et d'une molécule de liaison à gitr, d'un agoniste de 4-1bb, ou d'un agoniste d'ox40 |
WO2017077507A1 (fr) | 2015-11-06 | 2017-05-11 | Acerta Pharma B.V. | Inhibiteurs de type imidazopyrazine de tyrosine kinase de bruton |
ES2839408T3 (es) | 2016-01-13 | 2021-07-05 | Acerta Pharma Bv | Combinaciones terapéuticas de un antifolato y un inhibidor de BTK |
KR102515813B1 (ko) | 2016-06-29 | 2023-03-30 | 프린시피아 바이오파마, 인코퍼레이티드 | 2-[3-[4-아미노-3-(2-플루오로-4-페녹시-페닐)피라졸로[3,4-d]피리미딘-1-일]피페리딘-1-카르보닐]-4-메틸-4-[4-(옥세탄-3-일)피페라진-1-일]펜트-2-엔니트릴의 변형 방출 제제 |
WO2018001331A1 (fr) * | 2016-06-30 | 2018-01-04 | 杭州华东医药集团新药研究院有限公司 | Dérivé d'imidazopyridinamine phényle et son utilisation |
WO2018002958A1 (fr) * | 2016-06-30 | 2018-01-04 | Sun Pharma Advanced Research Company Limited | Nouveaux composés contenant de l'hydrazide utilisés comme inhibiteurs de btk |
EP3492471B1 (fr) * | 2016-08-17 | 2020-12-02 | Shenzhen TargetRx, Inc. | Composé bicyclique fusionné pour inhiber l'activité de la tyrosine kinase |
WO2018064797A1 (fr) * | 2016-10-05 | 2018-04-12 | 杭州领业医药科技有限公司 | Forme cristalline d'acp-196, procédé de préparation et composition pharmaceutique associés |
CN107056786B (zh) * | 2016-10-14 | 2019-05-07 | 苏州明锐医药科技有限公司 | 阿卡替尼的制备方法 |
CN108101905A (zh) * | 2016-11-24 | 2018-06-01 | 中国科学院上海药物研究所 | 嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途 |
CA3046578A1 (fr) * | 2016-12-21 | 2018-06-28 | Acerta Pharma B.V. | Inhibiteurs de type imidazopyrazine de tyrosine kinase de bruton |
WO2018115965A1 (fr) | 2016-12-23 | 2018-06-28 | Acerta Pharma Bv | Formes solides de composés d'imidazopyrazine |
CN106588937B (zh) * | 2017-01-16 | 2018-09-21 | 东莞市真兴贝特医药技术有限公司 | 咪唑并吡嗪类化合物及其制备方法和应用 |
WO2018134786A1 (fr) | 2017-01-19 | 2018-07-26 | Acerta Pharma B.V. | Compositions et procédés pour l'évaluation de l'occupation d'une cible de médicament pour la tyrosine kinase de bruton |
CN106831787B (zh) | 2017-01-20 | 2018-10-23 | 成都倍特药业有限公司 | 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用 |
WO2018148961A1 (fr) * | 2017-02-20 | 2018-08-23 | 杭州领业医药科技有限公司 | Forme cristalline du sel acp-196, procédé de préparation, composition pharmaceutique et utilisation associés |
EP3585789A1 (fr) | 2017-02-24 | 2020-01-01 | Gilead Sciences, Inc. | Inhibiteurs de tyrosine kinase de bruton |
WO2018156895A1 (fr) | 2017-02-24 | 2018-08-30 | Gilead Sciences, Inc. | Inhibiteurs de la tyrosine kinase de bruton |
US11554118B2 (en) * | 2017-03-22 | 2023-01-17 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
JOP20190233A1 (ar) | 2017-04-14 | 2019-10-02 | Biogen Ma Inc | نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون |
CA3058682A1 (fr) | 2017-04-20 | 2018-10-25 | Apotex Inc. | Procedes de preparation d'acalabrutinib, et ses intermediaires |
US10717740B2 (en) | 2017-06-13 | 2020-07-21 | Dr. Reddy's Laboratories Limited. | Solid forms of acalabrutinib and process for preparation thereof |
CN107522701B (zh) * | 2017-09-01 | 2019-11-08 | 苏州富士莱医药股份有限公司 | 一种治疗慢性淋巴细胞白血病的BTK抑制剂Acalabrutinib的合成方法 |
CN107602564B (zh) * | 2017-09-20 | 2019-08-30 | 南京亘泰医药技术有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
BR112020005039A2 (pt) | 2017-09-25 | 2020-09-15 | Astrazeneca Ab | combinação de um inibidor de btk e um inibidor de cdk9 para tratar câncer |
US11161851B2 (en) | 2017-11-06 | 2021-11-02 | Suzhou Pengxu Pharmatech Co. Ltd. | Processes to produce acalabrutinib |
CN109836416B (zh) * | 2017-11-27 | 2023-02-03 | 苏州鹏旭医药科技有限公司 | 一种化合物的制备方法 |
EP3736273A4 (fr) * | 2018-01-05 | 2021-02-24 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | Nouvelle forme cristalline d'acalabrutinib, son procédé de préparation et son utilisation |
CN108250186B (zh) * | 2018-02-07 | 2020-01-14 | 杭州科巢生物科技有限公司 | Acalabrutinib及其中间体的合成方法 |
CN110256438B (zh) * | 2018-03-12 | 2020-07-17 | 新发药业有限公司 | 一种阿可替尼的制备方法 |
MX2020008610A (es) | 2018-03-28 | 2020-09-21 | Eisai R&D Man Co Ltd | Agente terapeutico para carcinoma hepatocelular. |
JP7331843B2 (ja) | 2018-04-27 | 2023-08-23 | 小野薬品工業株式会社 | Btk阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および/または治療剤 |
TW202014184A (zh) | 2018-04-30 | 2020-04-16 | 瑞典商阿斯特捷利康公司 | 用於治療癌症之組合 |
WO2019239374A1 (fr) | 2018-06-13 | 2019-12-19 | Acerta Pharma B.V. | Inhibiteurs imidazopyrazines de kinase de lymphocytes t inductible par l'interleukine-2 |
EP3810270A1 (fr) | 2018-06-19 | 2021-04-28 | Regeneron Pharmaceuticals, Inc. | Anticorps anti-facteur xii/xiia et leurs utilisations |
EP3587421A1 (fr) | 2018-06-29 | 2020-01-01 | Sandoz AG | Formes cristallines de (s)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo [1,5-alpha]pyrazin-1-yl-n-(pyridin-2-yl)benzamide |
US20220127270A1 (en) * | 2018-08-29 | 2022-04-28 | Acerta Pharma B.V. | PROCESSES FOR THE PREPARATION OF 4-{8-AMINO-3-[(2S)-1-(BUT-2-YNOYL)-PYRROLIDIN-2-YL]IMIDAZO[1,5-a]-PYRAZIN-1-YL}N-(PYRIDIN-2-YL)-BENZAMIDE |
WO2020053795A2 (fr) | 2018-09-13 | 2020-03-19 | Fresenius Kabi Oncology Ltd. | Procédé de préparation d'acalabrutinib et de ses intermédiaires |
EP3830091A1 (fr) | 2018-09-25 | 2021-06-09 | Cipla Limited | Nouveaux polymorphes d'acalabrutinib, un inhibiteur de la tyrosine kinase de bruton |
CN109020977B (zh) * | 2018-10-26 | 2020-11-13 | 安庆奇创药业有限公司 | 一种Acalabrutinib的制备方法 |
EP3897631A4 (fr) | 2018-12-20 | 2022-11-23 | C4 Therapeutics, Inc. | Dégradation ciblée de protéines |
EP3903828A4 (fr) | 2018-12-21 | 2022-10-05 | Daiichi Sankyo Company, Limited | Combinaison d'un conjugué anticorps-médicament et d'un inhibiteur de kinase |
CN111377929A (zh) * | 2018-12-28 | 2020-07-07 | 南京艾德凯腾生物医药有限责任公司 | 一种可用于治疗白血病阿卡替尼(Acalabrutinib)制备的方法 |
CN111377928A (zh) * | 2018-12-28 | 2020-07-07 | 南京艾德凯腾生物医药有限责任公司 | 一种制备Acalabrutinib的方法 |
EP3930712A4 (fr) * | 2019-02-27 | 2022-09-28 | Optikira LLC | Composés d'imidazolopyrazine pour inhibition d'ire1 |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
WO2020198429A1 (fr) * | 2019-03-27 | 2020-10-01 | Assia Chemical Industries Ltd | Formes à l'état solide d'acalabrutinib |
WO2020225831A1 (fr) * | 2019-05-09 | 2020-11-12 | Msn Laboratories Private Limited, R&D Center | Procédé amélioré pour la préparation de 4-{8-amino-3-[(2s)-1-(but-2-ynoyl)pyrrolidin-2-yl] imidazo[1,5-a]pyrazin-1-yl)}-n-(pyridine-2-yl)benzamide |
WO2021038540A1 (fr) | 2019-08-31 | 2021-03-04 | Sun Pharma Advanced Research Company Limited | Acides cycloalkylidènecarboxyliques et dérivés en tant qu'inhibiteurs de la btk |
CN110563733A (zh) * | 2019-09-12 | 2019-12-13 | 安帝康(无锡)生物科技有限公司 | 作为选择性btk抑制剂的咪唑并吡嗪类化合物 |
AU2020381240C1 (en) | 2019-11-04 | 2024-02-15 | Astrazeneca Ab | Therapeutic combinations of acalabrutinib and capivasertib to treat B-cell malignancies |
EP4054579A1 (fr) | 2019-11-08 | 2022-09-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Méthodes pour le traitement de cancers qui ont acquis une résistance aux inhibiteurs de kinase |
WO2021148581A1 (fr) | 2020-01-22 | 2021-07-29 | Onxeo | Nouvelle molécule dbait et son utilisation |
CA3186141A1 (fr) | 2020-06-19 | 2021-12-23 | Acerta Pharma B.V. | Formes posologiques de maleate d'acalabrutinib |
CN112386597B (zh) * | 2020-10-15 | 2022-03-15 | 天津济坤医药科技有限公司 | 泽布替尼在制备治疗肺纤维化疾病药物中的应用 |
CN113264938B (zh) * | 2021-07-21 | 2021-11-02 | 北京鑫开元医药科技有限公司 | 一种咪唑并[1,5-a]吡嗪-8-胺类化合物、制备方法、药物组合物和应用 |
WO2023014817A1 (fr) | 2021-08-03 | 2023-02-09 | Syros Pharmaceuticals, Inc. | Compositions et méthodes pour traiter des lymphomes avec un inhibiteur de cdk7 en combinaison avec un inhibiteur de btk |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9913887A (pt) | 1998-09-18 | 2001-10-23 | Basf Ag | Composto, e, métodos de inibir a atividade de proteìna quinase, de tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase e de diminuir a fertilidade em um paciente |
US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
EP1268481B1 (fr) | 1999-09-17 | 2007-12-12 | Abbott GmbH & Co. KG | Inhibiteurs de kinase utilises comme agents therapeutiques |
US6998391B2 (en) | 2002-02-07 | 2006-02-14 | Supergen.Inc. | Method for treating diseases associated with abnormal kinase activity |
WO2005014599A1 (fr) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines et methodes d'inhibition de la tyrosine kinase de bruton par de tels composes |
AU2004282219C1 (en) | 2003-10-15 | 2009-12-17 | Osi Pharmaceuticals, Inc. | Imidazo [1, 5 - a] pyrazine tyrosine kinase inhibitors |
JP4832426B2 (ja) | 2004-04-02 | 2011-12-07 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | 6,6−二環置換されたヘテロ二環式タンパク質キナーゼ阻害剤 |
BRPI0618622A2 (pt) | 2005-11-17 | 2011-09-06 | Osi Pharm Inc | composto, composição, e, uso de um composto |
PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
AR057960A1 (es) | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
US7651687B2 (en) | 2006-03-13 | 2010-01-26 | Osi Pharmaceuticals, Inc. | Combined treatment with an EGFR kinase inhibitor and an agent that sensitizes tumor cells to the effects of EGFR kinase inhibitors |
DK2081435T3 (en) | 2006-09-22 | 2016-08-15 | Pharmacyclics Llc | INHIBITORS OF BRUTON'S TYROSINKINASE |
SG10202107066WA (en) * | 2007-03-28 | 2021-07-29 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
US20120101113A1 (en) | 2007-03-28 | 2012-04-26 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
JP2011506455A (ja) | 2007-12-13 | 2011-03-03 | ノバルティス アーゲー | 癌を処置するための治療薬の組み合わせ剤 |
JP5637982B2 (ja) * | 2008-04-09 | 2014-12-10 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 脂肪酸アミド加水分解酵素の阻害剤 |
US9095592B2 (en) | 2008-11-07 | 2015-08-04 | The Research Foundation For The State University Of New York | Bruton's tyrosine kinase as anti-cancer drug target |
WO2010126960A1 (fr) | 2009-04-29 | 2010-11-04 | Locus Pharmaceuticals, Inc. | Composés de pyrrolotriazine |
MX2012009208A (es) * | 2010-02-08 | 2012-09-07 | Msd Oss Bv | Compuestos de 8-metil-1-fenil-imidazol[1, 5-a]pirazina. |
UY33288A (es) | 2010-03-25 | 2011-10-31 | Glaxosmithkline Llc | Derivados de indolina inhibidores de la proteina quinasa r del reticulo endoplasmatico |
MX2012013622A (es) | 2010-05-31 | 2013-02-01 | Ono Pharmaceutical Co | Derivado de purinona. |
KR101580714B1 (ko) | 2010-06-03 | 2016-01-04 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 인산화효소(btk)의 억제제의 용도 |
US20120053189A1 (en) | 2010-06-28 | 2012-03-01 | Pharmacyclics, Inc. | Btk inhibitors for the treatment of immune mediated conditions |
CN103717602B (zh) | 2011-05-17 | 2016-11-09 | 加利福尼亚大学董事会 | 激酶抑制剂 |
AU2012275275A1 (en) | 2011-06-28 | 2014-01-23 | Pharmacyclics Llc | Methods and compositions for inhibition of bone resorption |
JP2014520863A (ja) | 2011-07-13 | 2014-08-25 | ファーマサイクリックス,インク. | Bruton型チロシンキナーゼの阻害剤 |
HUE041987T2 (hu) * | 2011-07-19 | 2019-06-28 | Merck Sharp & Dohme | 4-Imidazopiridazin-1-il-benzamidok és 4-imidazotriazin-1-il-benzamidok mint BTK-gátlók |
CA2841887A1 (fr) | 2011-07-19 | 2013-01-24 | Merck Sharp & Dohme B.V. | 4-imidazopyridazin-1-yl-benzamides et 4-imidazotriazin-1-yl-benzamides inhibiteurs de btk |
EP2548877A1 (fr) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | Dérivés de 4-(pyridine condensée à 5 chaînons)benzamide comme inhibiteurs de BTK |
CN110801454A (zh) | 2011-10-19 | 2020-02-18 | 药品循环有限责任公司 | 布鲁顿酪氨酸激酶(btk)抑制剂的用途 |
US20140212425A1 (en) | 2011-12-05 | 2014-07-31 | Immunomedics, Inc. | Therapeutic use of anti-cd22 antibodies for inducing trogocytosis |
US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
WO2014114185A1 (fr) | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Inhibiteurs de btk |
CN105073115A (zh) | 2013-03-14 | 2015-11-18 | 药品循环有限责任公司 | 布鲁顿氏酪氨酸激酶抑制剂和cyp3a4抑制剂的组合 |
WO2014143807A2 (fr) | 2013-03-15 | 2014-09-18 | Stromatt Scott | Anticorps anti-cd37 et polythérapie par antagoniste de la voie bcr pour le traitement de malignités b et de troubles des lymphocytes b |
JP6575952B2 (ja) | 2013-04-08 | 2019-09-18 | ファーマサイクリックス エルエルシー | イブルチニブ併用療法 |
WO2015018522A1 (fr) | 2013-08-06 | 2015-02-12 | Oncoethix Sa | Inhibiteur de bromodomaine bet présentant une synergie avec plusieurs agents anti-cancéreux dans des modèles cliniques de lymphome diffus de cellule b de grande taille (dlbcl) |
-
2012
- 2012-07-11 HU HUE12733505A patent/HUE041987T2/hu unknown
- 2012-07-11 IN IN408CHN2014 patent/IN2014CN00408A/en unknown
- 2012-07-11 SI SI201231956T patent/SI3689878T1/sl unknown
- 2012-07-11 PT PT192157832T patent/PT3689878T/pt unknown
- 2012-07-11 SI SI201231495T patent/SI2734522T1/sl unknown
- 2012-07-11 HU HUE19215783A patent/HUE056249T2/hu unknown
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