US5206344A
(en)
*
|
1985-06-26 |
1993-04-27 |
Cetus Oncology Corporation |
Interleukin-2 muteins and polymer conjugation thereof
|
CA1283046C
(en)
*
|
1986-05-29 |
1991-04-16 |
Nandini Katre |
Tumor necrosis factor formulation
|
US4745180A
(en)
*
|
1986-06-27 |
1988-05-17 |
Cetus Corporation |
Solubilization of proteins for pharmaceutical compositions using heparin fragments
|
US5004605A
(en)
*
|
1987-12-10 |
1991-04-02 |
Cetus Corporation |
Low pH pharmaceutical compositions of recombinant β-interferon
|
US4847325A
(en)
*
|
1988-01-20 |
1989-07-11 |
Cetus Corporation |
Conjugation of polymer to colony stimulating factor-1
|
IE62463B1
(en)
*
|
1988-07-07 |
1995-02-08 |
Res Dev Foundation |
Immunoconjugates for cancer diagnosis and therapy
|
US5091176A
(en)
*
|
1988-11-02 |
1992-02-25 |
W. R. Grace & Co.-Conn. |
Polymer-modified peptide drugs having enhanced biological and pharmacological activities
|
US6166183A
(en)
*
|
1992-11-30 |
2000-12-26 |
Kirin-Amgen, Inc. |
Chemically-modified G-CSF
|
EP0401384B1
(en)
*
|
1988-12-22 |
1996-03-13 |
Kirin-Amgen, Inc. |
Chemically modified granulocyte colony stimulating factor
|
US4902502A
(en)
*
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
US5166322A
(en)
*
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
WO1990015628A1
(en)
*
|
1989-06-14 |
1990-12-27 |
Cetus Corporation |
Polymer/antibiotic conjugate
|
JPH04506662A
(ja)
*
|
1989-07-14 |
1992-11-19 |
アメリカン・サイアナミド・カンパニー |
接合体ワクチンのためのサイトカイニンおよびホルモンのキヤリヤー
|
IL95031A
(en)
|
1989-07-18 |
2007-03-08 |
Amgen Inc |
Method for the production of a human recombinant tumor necrosis factor inhibitor
|
JP2662311B2
(ja)
*
|
1989-08-07 |
1997-10-08 |
デビオファルム ソシエテ アノニム |
生物学的に活性な新規薬剤・ポリマー誘導体およびその製造方法
|
US5393735A
(en)
*
|
1990-08-09 |
1995-02-28 |
Rohm And Haas Company |
Herbicidal glutarimides
|
US5552391A
(en)
*
|
1990-01-16 |
1996-09-03 |
La Jolla Pharmaceutical Company |
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
|
JPH04218000A
(ja)
*
|
1990-02-13 |
1992-08-07 |
Kirin Amgen Inc |
修飾ポリペプチド
|
FR2658519B1
(fr)
*
|
1990-02-19 |
1995-07-07 |
Serbio |
Substrats peptidiques pour identification du facteur xa.
|
FR2658521B1
(fr)
*
|
1990-02-19 |
1994-01-21 |
Serbioo |
Bipeptides symetriques comportant un reste polyalkyleneglycol, procede de preparation et utilisation dans le dosage des proteases.
|
US6552170B1
(en)
|
1990-04-06 |
2003-04-22 |
Amgen Inc. |
PEGylation reagents and compounds formed therewith
|
US5312903A
(en)
*
|
1990-06-01 |
1994-05-17 |
E. I. Du Pont De Nemours And Company |
Lysine-glycosylated recombinant interleukin-2
|
IE912365A1
(en)
*
|
1990-07-23 |
1992-01-29 |
Zeneca Ltd |
Continuous release pharmaceutical compositions
|
US5229366A
(en)
*
|
1990-10-23 |
1993-07-20 |
Fuji Photo Film Co., Ltd. |
Peptide-containing polyethylene glycol derivatives and application thereof
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
US5382657A
(en)
*
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
KR100361933B1
(ko)
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
DK0642798T3
(da)
*
|
1993-09-08 |
2007-09-10 |
Jolla Pharma |
Kemisk definerede, ikke polymere valensplatformmolekyler og konjugater deraf
|
US5880131A
(en)
*
|
1993-10-20 |
1999-03-09 |
Enzon, Inc. |
High molecular weight polymer-based prodrugs
|
US5446090A
(en)
*
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
US5629384A
(en)
*
|
1994-05-17 |
1997-05-13 |
Consiglio Nazionale Delle Ricerche |
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
|
US20030053982A1
(en)
|
1994-09-26 |
2003-03-20 |
Kinstler Olaf B. |
N-terminally chemically modified protein compositions and methods
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
EP0824541B1
(en)
*
|
1995-05-04 |
2009-12-16 |
Gilead Sciences, Inc. |
Nucleic acid ligand complexes
|
US8071737B2
(en)
|
1995-05-04 |
2011-12-06 |
Glead Sciences, Inc. |
Nucleic acid ligand complexes
|
US5874409A
(en)
|
1995-06-07 |
1999-02-23 |
La Jolla Pharmaceutical Company |
APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
|
CN1200036A
(zh)
*
|
1995-09-14 |
1998-11-25 |
Lxr生物技术有限公司 |
含有磷脂混合物并具有抗细胞程序死亡活性的组合物
|
TW517067B
(en)
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
TW555765B
(en)
|
1996-07-09 |
2003-10-01 |
Amgen Inc |
Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
|
DE69836222T2
(de)
*
|
1997-01-15 |
2007-11-15 |
Phoenix Pharmacologics, Inc. |
Modifizierter tumor-nekrosefaktor
|
EP0973384A4
(en)
|
1997-02-13 |
2004-10-13 |
Sky High Llc |
ORGAN PRESERVATION SOLUTION
|
UA66857C2
(uk)
*
|
1998-04-28 |
2004-06-15 |
Апплайд Резеч Сістемз Арс Холдінг Н.В. |
КОН'ЮГАТ ПОЛІОЛ-<font face="Symbol">b</font>-ІНТЕРФЕРОН, СПОСІБ ОДЕРЖАННЯ КОН'ЮГАТУ ПОЛІОЛ-<font face="Symbol">b</font>-ІНТЕРФЕРОН ТА СПОСІБ ЛІКУВАННЯ ІНФЕКЦІЙНИХ ХВОРОБ, ПУХЛИН І АУТОІМУННИХ І ЗАПАЛЬНИХ ЗАХВОРЮВАНЬ
|
US6858210B1
(en)
|
1998-06-09 |
2005-02-22 |
La Jolla Pharmaceutical Co. |
Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same
|
PT1588716E
(pt)
|
1998-08-06 |
2011-05-25 |
Mountain View Pharmaceuticals |
Conjugados de peg-urato oxidase e sua utiliza??o
|
US6783965B1
(en)
*
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
EA004789B9
(ru)
*
|
1998-10-16 |
2017-05-31 |
Байоджен, Инк. |
Полимерные конъюгаты бета-1а-интерферона и их использование
|
WO2000023472A2
(en)
*
|
1998-10-16 |
2000-04-27 |
Biogen, Inc. |
Interferon-beta fusion proteins and uses
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
US6399578B1
(en)
|
1998-12-09 |
2002-06-04 |
La Jolla Pharmaceutical Company |
Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same
|
US6458953B1
(en)
|
1998-12-09 |
2002-10-01 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising carbamate linkages
|
US7431921B2
(en)
|
1999-08-27 |
2008-10-07 |
Maxygen Aps |
Interferon beta-like molecules
|
EP1328295A2
(en)
*
|
1999-08-27 |
2003-07-23 |
Maxygen Aps |
New interferon beta-like molecules
|
US7144574B2
(en)
|
1999-08-27 |
2006-12-05 |
Maxygen Aps |
Interferon β variants and conjugates
|
US6531122B1
(en)
|
1999-08-27 |
2003-03-11 |
Maxygen Aps |
Interferon-β variants and conjugates
|
TR200101086A3
(OSRAM)
*
|
1999-10-15 |
2001-08-21 |
|
|
US7230081B1
(en)
|
1999-11-12 |
2007-06-12 |
Maxygen Holdings, Ltd. |
Interferon gamma conjugates
|
IL149267A0
(en)
|
1999-11-12 |
2002-11-10 |
Maxygen Holdings Ltd |
Interferon gamma conjugates
|
DE60139110D1
(de)
|
2000-01-10 |
2009-08-13 |
Maxygen Holdings Ltd |
G-csf konjugate
|
DE60138364D1
(de)
|
2000-02-11 |
2009-05-28 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
HK1054684A1
(zh)
|
2000-06-08 |
2003-12-12 |
La Jolla Pharmaceutical |
包含高分子量聚环氧乙烷的多价平台分子
|
ZA200305980B
(en)
|
2001-02-12 |
2007-01-31 |
Res Dev Foundation |
Modified proteins, designer toxins, and methods of making thereof
|
CA2469846A1
(en)
|
2001-02-27 |
2002-09-26 |
Maxygen Aps |
New interferon beta-like molecules
|
US6958388B2
(en)
|
2001-04-06 |
2005-10-25 |
Maxygen, Aps |
Interferon gamma polypeptide variants
|
US7038015B2
(en)
|
2001-04-06 |
2006-05-02 |
Maxygen Holdings, Ltd. |
Interferon gamma polypeptide variants
|
JP4142569B2
(ja)
*
|
2001-06-22 |
2008-09-03 |
協和醗酵工業株式会社 |
軟膏剤
|
JP2004535202A
(ja)
|
2001-07-17 |
2004-11-25 |
リサーチ ディベロップメント ファンデーション |
アポトーシス促進性蛋白質を含む治療剤
|
JP2005507870A
(ja)
|
2001-08-13 |
2005-03-24 |
ユニバーシティ・オブ・サザン・カリフォルニア |
低毒性のインターロイキン−2突然変異体
|
US7297511B2
(en)
|
2001-10-10 |
2007-11-20 |
Neose Technologies, Inc. |
Interferon alpha: remodeling and glycoconjugation of interferon alpha
|
US7399613B2
(en)
|
2001-10-10 |
2008-07-15 |
Neose Technologies, Inc. |
Sialic acid nucleotide sugars
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7795210B2
(en)
|
2001-10-10 |
2010-09-14 |
Novo Nordisk A/S |
Protein remodeling methods and proteins/peptides produced by the methods
|
HK1080090B
(zh)
|
2001-10-10 |
2012-12-14 |
诺和诺德公司 |
肽的重构和糖缀合的方法
|
US7265084B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
US7265085B2
(en)
|
2001-10-10 |
2007-09-04 |
Neose Technologies, Inc. |
Glycoconjugation methods and proteins/peptides produced by the methods
|
US7179617B2
(en)
|
2001-10-10 |
2007-02-20 |
Neose Technologies, Inc. |
Factor IX: remolding and glycoconjugation of Factor IX
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
US7439043B2
(en)
|
2001-10-10 |
2008-10-21 |
Neose Technologies, Inc. |
Galactosyl nucleotide sugars
|
US7696163B2
(en)
|
2001-10-10 |
2010-04-13 |
Novo Nordisk A/S |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
US7226903B2
(en)
|
2001-10-10 |
2007-06-05 |
Neose Technologies, Inc. |
Interferon beta: remodeling and glycoconjugation of interferon beta
|
US7125843B2
(en)
|
2001-10-19 |
2006-10-24 |
Neose Technologies, Inc. |
Glycoconjugates including more than one peptide
|
US7473680B2
(en)
|
2001-11-28 |
2009-01-06 |
Neose Technologies, Inc. |
Remodeling and glycoconjugation of peptides
|
CA2473526C
(en)
|
2002-01-18 |
2013-10-22 |
Biogen Idec Ma Inc. |
Polyalkylene polymer compounds and uses thereof
|
JP4634145B2
(ja)
|
2002-06-21 |
2011-02-16 |
ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト |
ペジル化されたvii因子糖形体
|
EP1539814A2
(en)
|
2002-07-03 |
2005-06-15 |
Maxygen Holdings Ltd. c/o Close Brothers (Cayman) Limited |
Full-length interferon gamma polypeptide variants
|
TWI406672B
(zh)
*
|
2002-12-26 |
2013-09-01 |
Mountain View Pharmaceuticals |
生物效力增進的β干擾素聚合物共軛體
|
US7803777B2
(en)
|
2003-03-14 |
2010-09-28 |
Biogenerix Ag |
Branched water-soluble polymers and their conjugates
|
US7691603B2
(en)
|
2003-04-09 |
2010-04-06 |
Novo Nordisk A/S |
Intracellular formation of peptide conjugates
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
JP4674702B2
(ja)
|
2003-04-09 |
2011-04-20 |
バイオジェネリクス エージー |
グリコペギレ−ション法およびその方法により生成されたタンパク質/ペプチド
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
PT2251353E
(pt)
*
|
2003-08-07 |
2013-05-07 |
Zymogenetics Inc |
Preparações homogéneas de il-28 e il-29
|
WO2005019260A1
(ja)
*
|
2003-08-25 |
2005-03-03 |
Toray Industries, Inc. |
インターフェロンβ複合体
|
DE602004029173D1
(de)
|
2003-10-10 |
2010-10-28 |
Novo Nordisk As |
Il-21-derivate
|
EP2633866A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
KR20060120141A
(ko)
|
2003-11-24 |
2006-11-24 |
네오스 테크놀로지스, 인크. |
글리코페질화 에리트로포이에틴
|
KR20060130182A
(ko)
|
2004-02-02 |
2006-12-18 |
암브룩스, 인코포레이티드 |
변형된 인간 인터페론 폴리펩티드 및 이의 용도
|
DE602005019038D1
(de)
|
2004-05-04 |
2010-03-11 |
Novo Nordisk Healthcare Ag |
O-verknüpfte glykoformen von faktor vii und verfahren zu deren herstellung
|
JP2008503217A
(ja)
|
2004-06-18 |
2008-02-07 |
アンブレツクス・インコーポレイテツド |
新規抗原結合ポリペプチド及びそれらの使用
|
EP1771066A2
(en)
|
2004-07-13 |
2007-04-11 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
|
WO2006091231A2
(en)
|
2004-07-21 |
2006-08-31 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
WO2006031811A2
(en)
|
2004-09-10 |
2006-03-23 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
JP5948627B2
(ja)
|
2004-10-29 |
2016-07-20 |
レイショファーム ゲーエムベーハー |
線維芽細胞成長因子(fgf)のリモデリングと糖質ペグ化
|
MX2007007580A
(es)
|
2004-12-22 |
2007-12-11 |
Ambrx Inc |
Hormona del crecimiento humana modificada.
|
WO2006074467A2
(en)
|
2005-01-10 |
2006-07-13 |
Neose Technologies, Inc. |
Glycopegylated granulocyte colony stimulating factor
|
US20070154992A1
(en)
|
2005-04-08 |
2007-07-05 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
KR20080009111A
(ko)
|
2005-04-11 |
2008-01-24 |
새비언트 파마수티컬즈 인크. |
유레이트 옥시다아제의 변이형 및 이의 용도
|
EP1891231A4
(en)
|
2005-05-25 |
2011-06-22 |
Novo Nordisk As |
GLYCOPEGYLATED FACTOR IX
|
EP1893632B1
(en)
|
2005-06-17 |
2015-08-12 |
Novo Nordisk Health Care AG |
Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
DK2339014T3
(en)
|
2005-11-16 |
2015-07-20 |
Ambrx Inc |
Methods and compositions comprising non-natural amino acids
|
RU2304586C1
(ru)
*
|
2006-03-27 |
2007-08-20 |
Михаил Николаевич Смирнов |
Препарат интерлейкина-2 и способ его получения
|
RU2322452C2
(ru)
*
|
2006-03-27 |
2008-04-20 |
Михаил Николаевич Смирнов |
Иммуномодулирующая композиция
|
CN104593348A
(zh)
|
2006-05-24 |
2015-05-06 |
诺沃—诺迪斯克保健股份有限公司 |
具有延长的体内半寿期的因子ix类似物
|
EP2049144B8
(en)
|
2006-07-21 |
2015-02-18 |
ratiopharm GmbH |
Glycosylation of peptides via o-linked glycosylation sequences
|
CA2663083A1
(en)
|
2006-09-08 |
2008-03-13 |
Ambrx, Inc. |
Modified human plasma polypeptide or fc scaffolds and their uses
|
MX2009002820A
(es)
*
|
2006-09-15 |
2009-06-04 |
Creabilis Therapeutics Spa |
Conjugados polimericos de box-a de hmgb1 y variantes de box-a de hmgb1.
|
EP2054521A4
(en)
|
2006-10-03 |
2012-12-19 |
Novo Nordisk As |
PROCESS FOR CLEANING POLYPEPTIDE CONJUGATES
|
DK2068909T3
(da)
|
2007-03-30 |
2012-08-06 |
Ambrx Inc |
Modificerede FGF-21-polypeptider og anvendelse heraf
|
HRP20130382T1
(hr)
|
2007-04-03 |
2013-05-31 |
Biogenerix Ag |
Postupci lijeäśenja pomoä†u glikopegiliranog g-csf
|
JP5876649B2
(ja)
|
2007-06-12 |
2016-03-02 |
ラツィオファルム ゲーエムベーハーratiopharm GmbH |
ヌクレオチド糖の改良製造法
|
RS53404B
(en)
|
2007-08-27 |
2014-10-31 |
Ratiopharm Gmbh |
LIQUID FORMULATION OF G-CSF CONJUGATES
|
MX338336B
(es)
|
2007-11-20 |
2016-04-07 |
Ambrx Inc |
Polipeptidos de insulina modificados y sus usos.
|
US8497303B2
(en)
*
|
2008-01-18 |
2013-07-30 |
Dow Global Technologies Llc |
Method to enhance aqueous solubility of poorly soluble actives
|
AU2009206748B2
(en)
|
2008-01-22 |
2014-03-20 |
Araim Pharmaceuticals, Inc. |
Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
|
NZ602170A
(en)
|
2008-02-08 |
2014-03-28 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
EP2257311B1
(en)
|
2008-02-27 |
2014-04-16 |
Novo Nordisk A/S |
Conjugated factor viii molecules
|
JP5592355B2
(ja)
|
2008-05-13 |
2014-09-17 |
アドヴァンスト リキッド ロジック インコーポレイテッド |
液滴アクチュエータ装置、システム、および方法
|
PL3225248T3
(pl)
|
2008-07-23 |
2023-11-27 |
Ambrx, Inc. |
Zmodyfikowane polipeptydy bydlęcego G-CSF i ich zastosowania
|
CA2737026C
(en)
|
2008-09-26 |
2019-12-24 |
Ambrx, Inc. |
Modified animal erythropoietin polypeptides and their uses
|
AU2009296267B2
(en)
|
2008-09-26 |
2013-10-31 |
Ambrx, Inc. |
Non-natural amino acid replication-dependent microorganisms and vaccines
|
CN102803954A
(zh)
|
2009-06-25 |
2012-11-28 |
萨文特制药公司 |
通过监测peg化尿酸酶治疗期间的血清尿酸预测输液反应风险和抗体介导的响应丧失的方法和试剂盒
|
EP2516454A4
(en)
|
2009-12-21 |
2013-05-22 |
Ambrx Inc |
MODIFIED BOVINE SOMATOTROPIN POLYPEPTIDES AND ITS USES
|
BR112012015597A2
(pt)
|
2009-12-21 |
2017-01-31 |
Ambrx Inc |
peptídeos de somatotropina suínos modificados e seus usos
|
US9815876B2
(en)
|
2010-03-05 |
2017-11-14 |
Omeros Corporation |
Chimeric inhibitor molecules of complement activation
|
WO2011143274A1
(en)
|
2010-05-10 |
2011-11-17 |
Perseid Therapeutics |
Polypeptide inhibitors of vla4
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
NZ607069A
(en)
|
2010-08-17 |
2014-10-31 |
Ambrx Inc |
Modified relaxin polypeptides and their uses
|
AR083006A1
(es)
|
2010-09-23 |
2013-01-23 |
Lilly Co Eli |
Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
|
EA037083B1
(ru)
|
2010-11-12 |
2021-02-03 |
Нектар Терапьютикс |
Иммуномодулирующий конъюгат, включающий il-2 и водорастворимые полимеры
|
PL3489255T3
(pl)
|
2011-02-10 |
2021-11-22 |
Roche Glycart Ag |
Zmutowane polipeptydy interleukiny-2
|
JP2014522641A
(ja)
|
2011-07-01 |
2014-09-08 |
バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
リラキシン融合ポリペプチドおよびその使用
|
KR20140130705A
(ko)
|
2012-02-29 |
2014-11-11 |
도레이 카부시키가이샤 |
체강액 저류 억제제
|
IL235129B
(en)
|
2012-04-16 |
2022-06-01 |
Cantab Biopharmaceuticals Patents Ltd |
Optimised subcutaneous therapeutic agents
|
US9844582B2
(en)
|
2012-05-22 |
2017-12-19 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
|
HUE043552T2
(hu)
|
2012-06-08 |
2019-09-30 |
Sutro Biopharma Inc |
Antitestek, amelyek tartalmaznak helyspecifikus nem természetes aminosav maradékokat, eljárások elõállításukra és eljárások használatukra
|
DK2863955T3
(en)
|
2012-06-26 |
2017-01-23 |
Sutro Biopharma Inc |
MODIFIED FC PROTEINS, INCLUDING LOCATION-SPECIFIC NON-NATURAL AMINO ACID RESIDUES, CONJUGATES THEREOF, METHODS OF PRODUCING ITS AND PROCEDURES FOR USE THEREOF
|
CN104981254B
(zh)
|
2012-08-31 |
2018-05-22 |
苏特罗生物制药公司 |
含有叠氮基的经修饰的氨基酸
|
WO2014201378A1
(en)
*
|
2013-06-13 |
2014-12-18 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il -2 and adoptive cell therapy
|
US9764039B2
(en)
|
2013-07-10 |
2017-09-19 |
Sutro Biopharma, Inc. |
Antibodies comprising multiple site-specific non-natural amino acid residues, methods of their preparation and methods of their use
|
US9840493B2
(en)
|
2013-10-11 |
2017-12-12 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
WO2016065326A2
(en)
|
2014-10-24 |
2016-04-28 |
Bristol-Myers Squibb Company |
Modified fgf-21 polypeptides and uses thereof
|
MA47290A
(fr)
|
2015-10-08 |
2019-11-27 |
Nektar Therapeutics |
Combinaison d'un agoniste sélectif de l'il-2rbeta et d'un agoniste de l'il-15 à action prolongée
|
US10864253B2
(en)
|
2016-04-29 |
2020-12-15 |
Araim Pharmaceuticals, Inc. |
Tissue protective peptides for preventing and treating diseases and disorders associated with tissue damage
|
AU2018219283B2
(en)
|
2017-02-08 |
2022-05-19 |
Bristol-Myers Squibb Company |
Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
|
CN110382525B
(zh)
|
2017-04-03 |
2023-10-20 |
豪夫迈·罗氏有限公司 |
免疫缀合物
|
KR102461885B1
(ko)
|
2017-04-03 |
2022-11-03 |
에프. 호프만-라 로슈 아게 |
항-pd-1 항체와 돌연변이 il-2 또는 il-15의 면역접합체
|
AU2018394189B2
(en)
*
|
2017-12-27 |
2023-12-21 |
Kyowa Kirin Co., Ltd. |
IL-2 variant
|
US12049485B2
(en)
|
2018-09-11 |
2024-07-30 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and their uses
|
WO2020082057A1
(en)
|
2018-10-19 |
2020-04-23 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
EP3964266A4
(en)
|
2019-01-28 |
2022-12-28 |
Toray Industries, Inc. |
POLYETHYLENE GLYCOL MODIFIED FORM OF HEPATOCYTE GROWTH FACTOR OR ACTIVE FRAGMENT THEREOF
|
US20220220176A1
(en)
|
2019-01-28 |
2022-07-14 |
Toray Industries, Inc. |
Polyethylene glycol-modified form of hepatocyte growth factor or active fragment thereof
|
AU2020223031B2
(en)
|
2019-02-12 |
2024-08-29 |
Ambrx, Inc. |
Compositions containing, methods and uses of antibody-TLR agonist conjugates
|
JP2022538139A
(ja)
|
2019-07-02 |
2022-08-31 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
変異体インターロイキン-2及び抗cd8抗体を含む免疫複合体
|
US11648296B2
(en)
*
|
2019-12-13 |
2023-05-16 |
Synthekine, Inc. |
IL-2 orthologs and methods of use
|
CN115243726B
(zh)
|
2020-03-11 |
2025-07-15 |
北京泰德制药股份有限公司 |
白介素-2多肽偶联物及其使用方法
|
CR20220512A
(es)
|
2020-04-15 |
2022-11-07 |
Hoffmann La Roche |
Inmunoconjugados
|
US20230181712A1
(en)
|
2020-05-11 |
2023-06-15 |
Hoffmann-La Roche Inc. |
Combination therapy with modified pbmcs and an immunoconjugate
|
US20230302150A1
(en)
|
2020-08-20 |
2023-09-28 |
Ambrx, Inc. |
Antibody-tlr agonist conjugates, methods and uses thereof
|
AU2021393752A1
(en)
|
2020-12-04 |
2023-05-18 |
F. Hoffmann-La Roche Ag |
Ph-dependent mutant interleukin-2 polypeptides
|
WO2022148853A1
(en)
|
2021-01-11 |
2022-07-14 |
F. Hoffmann-La Roche Ag |
Immunoconjugates
|
JP2024512775A
(ja)
|
2021-04-03 |
2024-03-19 |
アンブルックス,インコーポレイテッド |
抗her2抗体薬物コンジュゲート及びその使用
|
WO2023052541A1
(en)
|
2021-09-30 |
2023-04-06 |
Imcheck Therapeutics |
Combination of an anti-btn3a activating antibody and an il-2 agonist for use in therapy
|
WO2023062050A1
(en)
|
2021-10-14 |
2023-04-20 |
F. Hoffmann-La Roche Ag |
New interleukin-7 immunoconjugates
|
CN118139648A
(zh)
|
2021-10-14 |
2024-06-04 |
豪夫迈·罗氏有限公司 |
用于治疗癌症的替代的PD1-IL7v免疫缀合物
|
AR131636A1
(es)
|
2023-01-20 |
2025-04-16 |
Hoffmann La Roche |
Polipéptidos de dominio fc - variante de il2 recombinantes y politerapia con polipéptidos de unión al antígeno anclados a la membrana
|
US12269875B2
(en)
|
2023-08-03 |
2025-04-08 |
Jeff R. Peterson |
Gout flare prevention methods using IL-1BETA blockers
|
US20250249093A1
(en)
|
2024-02-01 |
2025-08-07 |
Astrazeneca Ab |
Cytokine engagers and uses thereof
|