IL96838A - Diastirio-selective process for the preparation of phosphinate esters - Google Patents

Diastirio-selective process for the preparation of phosphinate esters

Info

Publication number
IL96838A
IL96838A IL9683890A IL9683890A IL96838A IL 96838 A IL96838 A IL 96838A IL 9683890 A IL9683890 A IL 9683890A IL 9683890 A IL9683890 A IL 9683890A IL 96838 A IL96838 A IL 96838A
Authority
IL
Israel
Prior art keywords
lower alkyl
reaction
hydrogen
diastereomeric pair
formula
Prior art date
Application number
IL9683890A
Other languages
English (en)
Hebrew (he)
Other versions
IL96838A0 (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IL96838A0 publication Critical patent/IL96838A0/xx
Publication of IL96838A publication Critical patent/IL96838A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32—Esters thereof
    • C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3264—Esters with hydroxyalkyl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL9683890A 1990-01-19 1990-12-31 Diastirio-selective process for the preparation of phosphinate esters IL96838A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/467,451 US5008399A (en) 1990-01-19 1990-01-19 Diastereoselective preparation of phosphinate esters

Publications (2)

Publication Number Publication Date
IL96838A0 IL96838A0 (en) 1991-09-16
IL96838A true IL96838A (en) 1995-11-27

Family

ID=23855753

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9683890A IL96838A (en) 1990-01-19 1990-12-31 Diastirio-selective process for the preparation of phosphinate esters

Country Status (19)

Country Link
US (1) US5008399A (ko)
EP (1) EP0437799B1 (ko)
JP (1) JP2846484B2 (ko)
KR (2) KR0179368B1 (ko)
CN (1) CN1026791C (ko)
AT (1) ATE118779T1 (ko)
AU (1) AU623562B2 (ko)
CA (1) CA2032900C (ko)
DE (1) DE69017183T2 (ko)
DK (1) DK0437799T3 (ko)
ES (1) ES2068321T3 (ko)
FI (1) FI101539B (ko)
HU (1) HU208142B (ko)
IE (1) IE67354B1 (ko)
IL (1) IL96838A (ko)
NO (1) NO179915C (ko)
PT (1) PT96519B (ko)
RU (1) RU2044740C1 (ko)
ZA (1) ZA9196B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304619D0 (en) * 1993-03-06 1993-04-21 Ciba Geigy Ag Esters
US6555139B2 (en) 1999-06-28 2003-04-29 Wockhardt Europe Limited Preparation of micron-size pharmaceutical particles by microfluidization
US7078532B2 (en) * 2001-04-30 2006-07-18 Lupin Laboratories Limited Process for manufacture of fosinopril sodium
CN100488969C (zh) * 2005-10-27 2009-05-20 上海医药工业研究院 光学活性的取代氧膦基乙酸盐及其用途
CN100497335C (zh) * 2005-10-27 2009-06-10 上海医药工业研究院 取代氧膦基乙酸的光学拆分方法
IT1394407B1 (it) * 2009-05-25 2012-06-15 Dipharma Francis Srl Procedimento per la preparazione di fosinopril e suoi intermedi
IT1406151B1 (it) 2010-12-06 2014-02-14 Dipharma Francis Srl Procedimento per la preparazione di fosinopril e suoi intermedi

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4873356A (en) * 1987-09-30 1989-10-10 E. R. Squibb & Sons, Inc. Method for preparing phosphinic acids used in preparing ace inhibitors and intermediates produced thereby

Also Published As

Publication number Publication date
FI101539B1 (fi) 1998-07-15
IE910047A1 (en) 1991-07-31
CN1026791C (zh) 1994-11-30
AU6831990A (en) 1991-07-25
KR0179368B1 (ko) 1999-05-15
HUT56573A (en) 1991-09-30
CN1053431A (zh) 1991-07-31
FI910231A0 (fi) 1991-01-16
ZA9196B (en) 1991-10-30
JP2846484B2 (ja) 1999-01-13
ATE118779T1 (de) 1995-03-15
IE67354B1 (en) 1996-03-20
DE69017183T2 (de) 1995-06-14
PT96519B (pt) 1998-06-30
RU2044740C1 (ru) 1995-09-27
FI101539B (fi) 1998-07-15
EP0437799B1 (en) 1995-02-22
US5008399A (en) 1991-04-16
AU623562B2 (en) 1992-05-14
KR910014389A (ko) 1991-08-31
HU910179D0 (en) 1991-08-28
NO179915B (no) 1996-09-30
IL96838A0 (en) 1991-09-16
DE69017183D1 (de) 1995-03-30
NO179915C (no) 1997-01-08
PT96519A (pt) 1991-10-15
NO910214D0 (no) 1991-01-18
NO910214L (no) 1991-07-22
EP0437799A1 (en) 1991-07-24
FI910231A (fi) 1991-07-20
DK0437799T3 (da) 1995-03-27
CA2032900A1 (en) 1991-07-20
KR0179470B1 (ko) 1999-05-15
CA2032900C (en) 2000-06-06
ES2068321T3 (es) 1995-04-16
HU208142B (en) 1993-08-30
JPH04235191A (ja) 1992-08-24

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