IL92912A - Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation - Google Patents

Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation

Info

Publication number
IL92912A
IL92912A IL9291289A IL9291289A IL92912A IL 92912 A IL92912 A IL 92912A IL 9291289 A IL9291289 A IL 9291289A IL 9291289 A IL9291289 A IL 9291289A IL 92912 A IL92912 A IL 92912A
Authority
IL
Israel
Prior art keywords
reaction mixture
heparin
sodium
aqueous solution
sulfate
Prior art date
Application number
IL9291289A
Other languages
English (en)
Hebrew (he)
Other versions
IL92912A0 (en
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of IL92912A0 publication Critical patent/IL92912A0/xx
Publication of IL92912A publication Critical patent/IL92912A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Medical Uses (AREA)
IL9291289A 1989-01-30 1989-12-28 Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation IL92912A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8903328A IT1234826B (it) 1989-01-30 1989-01-30 Derivati eparinici e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
IL92912A0 IL92912A0 (en) 1990-09-17
IL92912A true IL92912A (en) 1994-06-24

Family

ID=11105069

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9291289A IL92912A (en) 1989-01-30 1989-12-28 Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation

Country Status (18)

Country Link
US (1) US5104860A (ja)
EP (1) EP0380943B1 (ja)
JP (1) JPH0678369B2 (ja)
KR (1) KR0161667B1 (ja)
AT (1) ATE111107T1 (ja)
AU (1) AU610034B2 (ja)
CA (1) CA2007616C (ja)
DE (1) DE69012154T2 (ja)
DK (1) DK0380943T3 (ja)
ES (1) ES2058609T3 (ja)
FI (1) FI96425C (ja)
IE (1) IE66563B1 (ja)
IL (1) IL92912A (ja)
IT (1) IT1234826B (ja)
NO (1) NO301719B1 (ja)
NZ (1) NZ232115A (ja)
PT (1) PT92991B (ja)
ZA (1) ZA90263B (ja)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5250519A (en) * 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
US5668118A (en) * 1992-07-24 1997-09-16 Cavalier Pharmaceuticals Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
US20020055710A1 (en) 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
KR100512671B1 (ko) * 1996-11-27 2005-09-07 아벤티스 파마슈티칼스 인크. 항 Ｘａ 활성을 지닌 화합물 및 혈소판 응집 길항제 화합물을포함하는 약제학적 조성물
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6203536B1 (en) * 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
AU2007200688B2 (en) * 2000-09-12 2010-02-04 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
JP4911865B2 (ja) * 2000-09-12 2012-04-04 マサチューセッツ インスティテュート オブ テクノロジー 低分子量ヘパリンに関連する方法および生成物
EP2284535A1 (en) 2002-03-11 2011-02-16 Momenta Pharmaceuticals, Inc. Low molecular weight heparins
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
US8435795B2 (en) * 2010-01-19 2013-05-07 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN103209997B (zh) * 2010-09-14 2016-03-16 国立大学法人宫崎大学 高纯度肝素及其制备方法
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN108498532B (zh) 2012-05-09 2021-07-23 坎泰克斯制药股份有限公司 骨髓抑制的治疗
WO2016133910A1 (en) 2015-02-17 2016-08-25 Cantex Pharmaceuticals, Inc. Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A4 (en) 2020-07-14 2024-07-31 Optimvia Llc METHOD FOR THE SYNTHESIS OF NON-ANTICOAGULATING HEPARAN SULFATE

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5318520B2 (ja) * 1972-07-05 1978-06-15
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
DE3265781D1 (en) * 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
EP0380943A1 (en) 1990-08-08
DK0380943T3 (da) 1994-12-19
IT1234826B (it) 1992-05-29
ZA90263B (en) 1990-10-31
DE69012154T2 (de) 1995-02-23
PT92991B (pt) 1995-12-29
FI96425C (fi) 1996-06-25
CA2007616A1 (en) 1990-07-30
NO900392D0 (no) 1990-01-29
JPH0678369B2 (ja) 1994-10-05
KR0161667B1 (ko) 1998-11-16
KR900011789A (ko) 1990-08-02
IL92912A0 (en) 1990-09-17
ES2058609T3 (es) 1994-11-01
US5104860A (en) 1992-04-14
AU610034B2 (en) 1991-05-09
DE69012154D1 (de) 1994-10-13
IE900316L (en) 1990-07-30
FI96425B (fi) 1996-03-15
AU4885890A (en) 1990-10-25
CA2007616C (en) 1996-05-14
PT92991A (pt) 1990-07-31
NO900392L (no) 1990-07-31
NO301719B1 (no) 1997-12-01
NZ232115A (en) 1991-05-28
IT8903328A0 (it) 1989-01-30
FI900446A0 (fi) 1990-01-29
EP0380943B1 (en) 1994-09-07
JPH02240102A (ja) 1990-09-25
ATE111107T1 (de) 1994-09-15
IE66563B1 (en) 1996-01-24

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