PT92991A - Processo para a preparacao de derivados haparinicos - Google Patents

Processo para a preparacao de derivados haparinicos

Info

Publication number
PT92991A
PT92991A PT92991A PT9299190A PT92991A PT 92991 A PT92991 A PT 92991A PT 92991 A PT92991 A PT 92991A PT 9299190 A PT9299190 A PT 9299190A PT 92991 A PT92991 A PT 92991A
Authority
PT
Portugal
Prior art keywords
comprised
derivatives
heparins
heparinic derivatives
heparinic
Prior art date
Application number
PT92991A
Other languages
English (en)
Other versions
PT92991B (pt
Inventor
Silvano Piani
Gianfranco Tamagnone
Raul Roberto Alpino
Maria Rita Milani
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of PT92991A publication Critical patent/PT92991A/pt
Publication of PT92991B publication Critical patent/PT92991B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Medical Uses (AREA)
PT92991A 1989-01-30 1990-01-29 Processo para a preparacao de derivados haparinicos PT92991B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8903328A IT1234826B (it) 1989-01-30 1989-01-30 Derivati eparinici e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
PT92991A true PT92991A (pt) 1990-07-31
PT92991B PT92991B (pt) 1995-12-29

Family

ID=11105069

Family Applications (1)

Application Number Title Priority Date Filing Date
PT92991A PT92991B (pt) 1989-01-30 1990-01-29 Processo para a preparacao de derivados haparinicos

Country Status (18)

Country Link
US (1) US5104860A (pt)
EP (1) EP0380943B1 (pt)
JP (1) JPH0678369B2 (pt)
KR (1) KR0161667B1 (pt)
AT (1) ATE111107T1 (pt)
AU (1) AU610034B2 (pt)
CA (1) CA2007616C (pt)
DE (1) DE69012154T2 (pt)
DK (1) DK0380943T3 (pt)
ES (1) ES2058609T3 (pt)
FI (1) FI96425C (pt)
IE (1) IE66563B1 (pt)
IL (1) IL92912A (pt)
IT (1) IT1234826B (pt)
NO (1) NO301719B1 (pt)
NZ (1) NZ232115A (pt)
PT (1) PT92991B (pt)
ZA (1) ZA90263B (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5250519A (en) * 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US5668118A (en) * 1992-07-24 1997-09-16 Cavalier Pharmaceuticals Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
IL129877A (en) * 1996-11-27 2004-08-31 Aventis Pharm Prod Inc A pharmaceutical preparation containing a component having an Xa antagonist activity and an antifouling agent
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
ES2324701T3 (es) 2000-09-12 2009-08-13 Massachusetts Institute Of Technology Metodos y productos relacionados con heparina de peso molecular bajo.
AU2007200688B2 (en) * 2000-09-12 2010-02-04 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
AU2003225724A1 (en) * 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1582531A1 (en) 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
EP1792621B1 (en) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Orally administrable heparin derivatives
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
ES2817779T3 (es) * 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
KR101794877B1 (ko) * 2010-09-14 2017-11-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 고순도 헤파린 및 그 제조방법
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
HUE053247T2 (hu) 2012-05-09 2021-06-28 Cantex Pharmaceuticals Inc Mieloszuppresszió kezelése
US10052346B2 (en) 2015-02-17 2018-08-21 Cantex Pharmaceuticals, Inc. Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids
EP3997238A1 (en) 2019-07-09 2022-05-18 Optimvia, LLC Methods for synthesizing anticoagulant polysaccharides
EP4182452A1 (en) 2020-07-14 2023-05-24 Optimvia, LLC Methods for synthesizing non-anticoagulant heparan sulfate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5318520B2 (pt) * 1972-07-05 1978-06-15
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
EP0066908B1 (en) * 1981-05-21 1985-08-28 Akzo N.V. New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
JPH02240102A (ja) 1990-09-25
NZ232115A (en) 1991-05-28
FI900446A0 (fi) 1990-01-29
IE66563B1 (en) 1996-01-24
KR900011789A (ko) 1990-08-02
NO900392L (no) 1990-07-31
NO301719B1 (no) 1997-12-01
IT1234826B (it) 1992-05-29
ATE111107T1 (de) 1994-09-15
NO900392D0 (no) 1990-01-29
ZA90263B (en) 1990-10-31
JPH0678369B2 (ja) 1994-10-05
IL92912A0 (en) 1990-09-17
EP0380943A1 (en) 1990-08-08
KR0161667B1 (ko) 1998-11-16
FI96425C (fi) 1996-06-25
AU4885890A (en) 1990-10-25
EP0380943B1 (en) 1994-09-07
DE69012154D1 (de) 1994-10-13
IL92912A (en) 1994-06-24
DK0380943T3 (da) 1994-12-19
DE69012154T2 (de) 1995-02-23
AU610034B2 (en) 1991-05-09
PT92991B (pt) 1995-12-29
ES2058609T3 (es) 1994-11-01
IE900316L (en) 1990-07-30
CA2007616A1 (en) 1990-07-30
FI96425B (fi) 1996-03-15
CA2007616C (en) 1996-05-14
US5104860A (en) 1992-04-14
IT8903328A0 (it) 1989-01-30

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Legal Events

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FG3A Patent granted, date of granting

Effective date: 19950929

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040331