DK0560730T3 - Aminosyrederivater med antithrombotisk virkning - Google Patents

Aminosyrederivater med antithrombotisk virkning

Info

Publication number
DK0560730T3
DK0560730T3 DK93810172.2T DK93810172T DK0560730T3 DK 0560730 T3 DK0560730 T3 DK 0560730T3 DK 93810172 T DK93810172 T DK 93810172T DK 0560730 T3 DK0560730 T3 DK 0560730T3
Authority
DK
Denmark
Prior art keywords
amino acid
acid derivatives
antithrombotic effect
antithrombotic
effect
Prior art date
Application number
DK93810172.2T
Other languages
English (en)
Inventor
Georg Kottirsch
Rainer Metternich
Original Assignee
Sandoz Ltd
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd, Sandoz Ag filed Critical Sandoz Ltd
Application granted granted Critical
Publication of DK0560730T3 publication Critical patent/DK0560730T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/70Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK93810172.2T 1992-03-10 1993-03-08 Aminosyrederivater med antithrombotisk virkning DK0560730T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4207544 1992-03-10

Publications (1)

Publication Number Publication Date
DK0560730T3 true DK0560730T3 (da) 1996-10-28

Family

ID=6453662

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93810172.2T DK0560730T3 (da) 1992-03-10 1993-03-08 Aminosyrederivater med antithrombotisk virkning

Country Status (26)

Country Link
US (1) US5561112A (da)
EP (1) EP0560730B1 (da)
JP (1) JP2860222B2 (da)
KR (1) KR930019690A (da)
CN (1) CN1076200A (da)
AT (1) ATE142618T1 (da)
AU (1) AU659281B2 (da)
CA (1) CA2091292A1 (da)
CZ (1) CZ36193A3 (da)
DE (1) DE69304573T2 (da)
DK (1) DK0560730T3 (da)
ES (1) ES2090934T3 (da)
FI (1) FI931023A (da)
GR (1) GR3021030T3 (da)
HU (2) HUT63609A (da)
IL (1) IL104972A (da)
MX (1) MX9301298A (da)
MY (1) MY109060A (da)
NO (1) NO300778B1 (da)
NZ (1) NZ247084A (da)
PH (1) PH30893A (da)
RU (1) RU2106356C1 (da)
SG (1) SG47059A1 (da)
SK (1) SK17093A3 (da)
TW (1) TW256828B (da)
ZA (1) ZA931724B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563141A (en) * 1993-03-29 1996-10-08 Zeneca Limited Heterocyclic compounds
EP0825184B1 (en) * 1993-03-29 2001-06-20 AstraZeneca AB Heterocyclic derivatives as platelet aggregation inhibitors
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
US5811398A (en) * 1995-04-11 1998-09-22 G. D. Searle & Co. Platelet aggregation inhibitors containing C-terminal aminergic side chain amino acid residues
DK0892780T3 (da) * 1996-02-22 2003-03-03 Bristol Myers Squibb Pharma Co m-Amidinophenylanaloger som faktor Xa-inhibitorer
US5942544A (en) * 1996-02-22 1999-08-24 Dupont Pharmaceuticals Company α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
JP2005526023A (ja) * 2002-01-28 2005-09-02 ノバルティス アクチエンゲゼルシャフト β−ホモリジンコンジュゲートおよび輸送エンハンサーとしてのそれらの使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
IL104972A (en) 1998-04-05
AU659281B2 (en) 1995-05-11
JP2860222B2 (ja) 1999-02-24
US5561112A (en) 1996-10-01
EP0560730A2 (en) 1993-09-15
MY109060A (en) 1996-11-30
CA2091292A1 (en) 1993-09-11
EP0560730A3 (en) 1993-12-01
AU3406993A (en) 1993-09-16
IL104972A0 (en) 1993-07-08
KR930019690A (ko) 1993-10-18
CZ36193A3 (en) 1994-01-19
HU9300501D0 (en) 1993-05-28
RU2106356C1 (ru) 1998-03-10
NO930830L (no) 1993-09-13
ES2090934T3 (es) 1996-10-16
NZ247084A (en) 1995-09-26
GR3021030T3 (en) 1996-12-31
TW256828B (da) 1995-09-11
HU210878A9 (en) 1995-09-28
CN1076200A (zh) 1993-09-15
NO300778B1 (no) 1997-07-21
MX9301298A (es) 1993-10-01
NO930830D0 (no) 1993-03-08
SG47059A1 (en) 1998-03-20
JPH0665175A (ja) 1994-03-08
ATE142618T1 (de) 1996-09-15
DE69304573T2 (de) 1997-03-20
ZA931724B (en) 1994-09-10
SK17093A3 (en) 1993-10-06
HUT63609A (en) 1993-09-28
FI931023A0 (fi) 1993-03-08
PH30893A (en) 1997-12-23
DE69304573D1 (de) 1996-10-17
EP0560730B1 (en) 1996-09-11
FI931023A (fi) 1993-09-11

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