DE69012154D1 - Heparinderivate und Verfahren zu ihrer Herstellung. - Google Patents

Heparinderivate und Verfahren zu ihrer Herstellung.

Info

Publication number
DE69012154D1
DE69012154D1 DE69012154T DE69012154T DE69012154D1 DE 69012154 D1 DE69012154 D1 DE 69012154D1 DE 69012154 T DE69012154 T DE 69012154T DE 69012154 T DE69012154 T DE 69012154T DE 69012154 D1 DE69012154 D1 DE 69012154D1
Authority
DE
Germany
Prior art keywords
comprised
heparins
derivatives
heparinic derivatives
heparinic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69012154T
Other languages
English (en)
Other versions
DE69012154T2 (de
Inventor
Silvano Piani
Gianfranco Tamagnone
Raul Roberto Alpino
Maria Rita Milani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Wasserman SpA
Original Assignee
Alfa Wasserman SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wasserman SpA filed Critical Alfa Wasserman SpA
Publication of DE69012154D1 publication Critical patent/DE69012154D1/de
Application granted granted Critical
Publication of DE69012154T2 publication Critical patent/DE69012154T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Medical Uses (AREA)
DE69012154T 1989-01-30 1990-01-12 Heparinderivate und Verfahren zu ihrer Herstellung. Expired - Fee Related DE69012154T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8903328A IT1234826B (it) 1989-01-30 1989-01-30 Derivati eparinici e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
DE69012154D1 true DE69012154D1 (de) 1994-10-13
DE69012154T2 DE69012154T2 (de) 1995-02-23

Family

ID=11105069

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69012154T Expired - Fee Related DE69012154T2 (de) 1989-01-30 1990-01-12 Heparinderivate und Verfahren zu ihrer Herstellung.

Country Status (18)

Country Link
US (1) US5104860A (de)
EP (1) EP0380943B1 (de)
JP (1) JPH0678369B2 (de)
KR (1) KR0161667B1 (de)
AT (1) ATE111107T1 (de)
AU (1) AU610034B2 (de)
CA (1) CA2007616C (de)
DE (1) DE69012154T2 (de)
DK (1) DK0380943T3 (de)
ES (1) ES2058609T3 (de)
FI (1) FI96425C (de)
IE (1) IE66563B1 (de)
IL (1) IL92912A (de)
IT (1) IT1234826B (de)
NO (1) NO301719B1 (de)
NZ (1) NZ232115A (de)
PT (1) PT92991B (de)
ZA (1) ZA90263B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5250519A (en) * 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US5668118A (en) * 1992-07-24 1997-09-16 Cavalier Pharmaceuticals Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
IL129877A (en) * 1996-11-27 2004-08-31 Aventis Pharm Prod Inc A pharmaceutical preparation containing a component having an Xa antagonist activity and an antifouling agent
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
ES2324701T3 (es) 2000-09-12 2009-08-13 Massachusetts Institute Of Technology Metodos y productos relacionados con heparina de peso molecular bajo.
AU2007200688B2 (en) * 2000-09-12 2010-02-04 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
AU2003225724A1 (en) * 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
EP1792621B1 (de) 2005-11-30 2012-04-04 Istituto di Ricerche Chimiche e Biochimiche "G. Ronzoni" Oral verabreichbare Heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
ES2817779T3 (es) * 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
KR101794877B1 (ko) * 2010-09-14 2017-11-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 고순도 헤파린 및 그 제조방법
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
HUE053247T2 (hu) 2012-05-09 2021-06-28 Cantex Pharmaceuticals Inc Mieloszuppresszió kezelése
US10052346B2 (en) 2015-02-17 2018-08-21 Cantex Pharmaceuticals, Inc. Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids
EP3997238A1 (de) 2019-07-09 2022-05-18 Optimvia, LLC Verfahren zur synthese von antikoagulierenden polysacchariden
EP4182452A1 (de) 2020-07-14 2023-05-24 Optimvia, LLC Verfahren zur synthese von nicht-antikoagulierendem heparansulfat

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5318520B2 (de) * 1972-07-05 1978-06-15
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
EP0066908B1 (de) * 1981-05-21 1985-08-28 Akzo N.V. Antithrombotikum auf Basis von Polysacchariden, Verfahren zur dessen Herstellung und medizinale Zusammensetzungen
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
JPH02240102A (ja) 1990-09-25
NZ232115A (en) 1991-05-28
FI900446A0 (fi) 1990-01-29
IE66563B1 (en) 1996-01-24
KR900011789A (ko) 1990-08-02
PT92991A (pt) 1990-07-31
NO900392L (no) 1990-07-31
NO301719B1 (no) 1997-12-01
IT1234826B (it) 1992-05-29
ATE111107T1 (de) 1994-09-15
NO900392D0 (no) 1990-01-29
ZA90263B (en) 1990-10-31
JPH0678369B2 (ja) 1994-10-05
IL92912A0 (en) 1990-09-17
EP0380943A1 (de) 1990-08-08
KR0161667B1 (ko) 1998-11-16
FI96425C (fi) 1996-06-25
AU4885890A (en) 1990-10-25
EP0380943B1 (de) 1994-09-07
IL92912A (en) 1994-06-24
DK0380943T3 (da) 1994-12-19
DE69012154T2 (de) 1995-02-23
AU610034B2 (en) 1991-05-09
PT92991B (pt) 1995-12-29
ES2058609T3 (es) 1994-11-01
IE900316L (en) 1990-07-30
CA2007616A1 (en) 1990-07-30
FI96425B (fi) 1996-03-15
CA2007616C (en) 1996-05-14
US5104860A (en) 1992-04-14
IT8903328A0 (it) 1989-01-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee