IL92912A - Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation - Google Patents

Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation

Info

Publication number
IL92912A
IL92912A IL9291289A IL9291289A IL92912A IL 92912 A IL92912 A IL 92912A IL 9291289 A IL9291289 A IL 9291289A IL 9291289 A IL9291289 A IL 9291289A IL 92912 A IL92912 A IL 92912A
Authority
IL
Israel
Prior art keywords
reaction mixture
heparin
sodium
aqueous solution
sulfate
Prior art date
Application number
IL9291289A
Other languages
English (en)
Hebrew (he)
Other versions
IL92912A0 (en
Original Assignee
Alfa Wassermann Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Wassermann Spa filed Critical Alfa Wassermann Spa
Publication of IL92912A0 publication Critical patent/IL92912A0/xx
Publication of IL92912A publication Critical patent/IL92912A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
IL9291289A 1989-01-30 1989-12-28 Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation IL92912A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8903328A IT1234826B (it) 1989-01-30 1989-01-30 Derivati eparinici e procedimento per la loro preparazione

Publications (2)

Publication Number Publication Date
IL92912A0 IL92912A0 (en) 1990-09-17
IL92912A true IL92912A (en) 1994-06-24

Family

ID=11105069

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9291289A IL92912A (en) 1989-01-30 1989-12-28 Pararene derivatives with anti-stone activity, showing a typical signal in 3,101 parts per million in the spectrum of RMN-31C and a process for their preparation

Country Status (18)

Country Link
US (1) US5104860A (de)
EP (1) EP0380943B1 (de)
JP (1) JPH0678369B2 (de)
KR (1) KR0161667B1 (de)
AT (1) ATE111107T1 (de)
AU (1) AU610034B2 (de)
CA (1) CA2007616C (de)
DE (1) DE69012154T2 (de)
DK (1) DK0380943T3 (de)
ES (1) ES2058609T3 (de)
FI (1) FI96425C (de)
IE (1) IE66563B1 (de)
IL (1) IL92912A (de)
IT (1) IT1234826B (de)
NO (1) NO301719B1 (de)
NZ (1) NZ232115A (de)
PT (1) PT92991B (de)
ZA (1) ZA90263B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
US5250519A (en) * 1991-03-29 1993-10-05 Glycomed Incorporated Non-anticoagulant heparin derivatives
IT1254216B (it) * 1992-02-25 1995-09-14 Opocrin Spa Derivati polisaccaridici di eparina, eparan solfato, loro frazioni e frammenti, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT1260136B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3
IT1260137B (it) * 1992-04-17 1996-03-28 Alfa Wassermann Spa Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato
US5668118A (en) * 1992-07-24 1997-09-16 Cavalier Pharmaceuticals Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5296471A (en) * 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5336620A (en) * 1993-01-27 1994-08-09 American Home Products Corporation Process for the production of an anticoagulant composition
IT1264102B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonico sostituito con radicali
IT1264101B1 (it) * 1993-03-29 1996-09-10 Alfa Wassermann Spa Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2
US20020055710A1 (en) * 1998-04-30 2002-05-09 Ronald J. Tuch Medical device for delivering a therapeutic agent and method of preparation
BR9713141A (pt) * 1996-11-27 2000-02-08 Rhone Poulenc Rorer Pharma Composição farmcêutica processo e kit para o tratamento ou a prevenção de um quadro fisiológico asociado com um distúrbio isquêmico relacionado com trombose e um paciente, uso de quantidades farmaceuticamente efetivas de um composto com atividade anti-xa e de um composto antagonista de agregação de plaquetas, produto contendo estes compostos, e, uso destes compostos.
US6203536B1 (en) 1997-06-17 2001-03-20 Medtronic, Inc. Medical device for delivering a therapeutic substance and method therefor
US6106454A (en) * 1997-06-17 2000-08-22 Medtronic, Inc. Medical device for delivering localized radiation
US6013099A (en) 1998-04-29 2000-01-11 Medtronic, Inc. Medical device for delivering a water-insoluble therapeutic salt or substance
US7259152B2 (en) 2000-06-07 2007-08-21 Alfa Wasserman, Inc. Methods and compositions using sulodexide for the treatment of diabetic nephropathy
AU2007200688B2 (en) * 2000-09-12 2010-02-04 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
US7083937B2 (en) * 2000-09-12 2006-08-01 Massachusetts Institute Of Technology Methods and products related to the analysis of polysaccarides
JP4828795B2 (ja) 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2526122B1 (de) * 2010-01-19 2020-06-10 Momenta Pharmaceuticals, Inc. Beurteilung von heparinzubereitungen
JPWO2012036152A1 (ja) * 2010-09-14 2014-02-03 国立大学法人 宮崎大学 高純度ヘパリンおよびその製造方法
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
SG10201603059YA (en) 2012-05-09 2016-05-30 Cantex Pharmaceuticals Inc Treatment Of Myelosuppression
WO2016133910A1 (en) 2015-02-17 2016-08-25 Cantex Pharmaceuticals, Inc. Treatment of cancers and hematopoietic stem cell disorders privileged by cxcl12-cxcr4 interaction
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
WO2021007429A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5318520B2 (de) * 1972-07-05 1978-06-15
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
DE3265781D1 (en) * 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
DE3422518A1 (de) * 1984-06-16 1985-12-19 B. Braun Melsungen Ag, 3508 Melsungen Heparin-derivate, verfahren zu ihrer herstellung, diese enthaltende arzneimittel und ihre verwendung bei der behandlung von fettstoffwechselstoerungen
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
IT1234508B (it) * 1988-06-10 1992-05-19 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione
IT1234826B (it) * 1989-01-30 1992-05-29 Alfa Wassermann Spa Derivati eparinici e procedimento per la loro preparazione

Also Published As

Publication number Publication date
FI96425C (fi) 1996-06-25
NO900392L (no) 1990-07-31
PT92991B (pt) 1995-12-29
IE900316L (en) 1990-07-30
PT92991A (pt) 1990-07-31
DE69012154T2 (de) 1995-02-23
IT8903328A0 (it) 1989-01-30
ATE111107T1 (de) 1994-09-15
FI900446A0 (fi) 1990-01-29
JPH02240102A (ja) 1990-09-25
IE66563B1 (en) 1996-01-24
ES2058609T3 (es) 1994-11-01
KR900011789A (ko) 1990-08-02
AU4885890A (en) 1990-10-25
ZA90263B (en) 1990-10-31
EP0380943B1 (de) 1994-09-07
CA2007616A1 (en) 1990-07-30
NO301719B1 (no) 1997-12-01
KR0161667B1 (ko) 1998-11-16
NO900392D0 (no) 1990-01-29
FI96425B (fi) 1996-03-15
EP0380943A1 (de) 1990-08-08
DE69012154D1 (de) 1994-10-13
US5104860A (en) 1992-04-14
NZ232115A (en) 1991-05-28
AU610034B2 (en) 1991-05-09
CA2007616C (en) 1996-05-14
DK0380943T3 (da) 1994-12-19
IT1234826B (it) 1992-05-29
IL92912A0 (en) 1990-09-17
JPH0678369B2 (ja) 1994-10-05

Similar Documents

Publication Publication Date Title
EP0380943B1 (de) Heparinderivate und Verfahren zu ihrer Herstellung
US5010063A (en) Heparin derivatives and process for their preparation
US5013724A (en) Process for the sulfation of glycosaminoglycans, the sulfated glycosaminoglycans and their biological applications
US4981955A (en) Depolymerization method of heparin
US4933326A (en) Oligosaccharides obtained by heparin depolymerization having antiatherosclerotic activity
EP0014184B2 (de) Fragmentiertes Heparin mit selektiver anti-koagulierender Wirksamkeit und Verfahren zu dessen Herstellung
KR910006809B1 (ko) 천연 헤파란 설페이트 및 더머탄 설페이트의 제조방법
JPH0323528B2 (de)
JPH03243601A (ja) 血液凝固の制御能をもつムコ多糖組成物およびその製造方法
WO1992002232A1 (en) Heparin fragment showing complement inhibition activity
JP2012526174A (ja) 新規なアシル化十糖類および抗血栓剤としてのこの使用
JP2714718B2 (ja) 新規硫酸化多糖及びその薬学的に許容される塩、その製造方法並びにそれを有効成分とする医薬
EP0600934A1 (de) Dermatansulfatoligosaccharide, Verfahren zu ihrer Herstellung und diese enthaltende phamazeutische Zusammensetzungen.
KR0184260B1 (ko) 항트롬보 활성을 지닌 황산화 글리코스아미노글리큐로난
JP2005533878A (ja) 非常に大きい硫酸化度を持つｋ５多糖体のエピマー化誘導体
US5470965A (en) Complexable heterogenous oligosaccharides and alpha-hydosanes having therapeutical activity, process for their preparation and related pharmaceutical compositions
WO1994029352A1 (en) Polysaccharides having high antithrombotic and anticoagulant activity
KR101104107B1 (ko) 헤파린으로부터 유도된 다당류의 혼합물, 이의 제조방법 및이를 함유하는 약제학적 조성물

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed