IL91474A - History of Azaspiro, their preparation and pharmaceutical preparations containing them - Google Patents

History of Azaspiro, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL91474A
IL91474A IL9147489A IL9147489A IL91474A IL 91474 A IL91474 A IL 91474A IL 9147489 A IL9147489 A IL 9147489A IL 9147489 A IL9147489 A IL 9147489A IL 91474 A IL91474 A IL 91474A
Authority
IL
Israel
Prior art keywords
group
carbon atoms
carboxylic acid
compound
dihydro
Prior art date
Application number
IL9147489A
Other languages
English (en)
Hebrew (he)
Other versions
IL91474A0 (en
Original Assignee
Daiichi Pharmaceitical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceitical Co Ltd filed Critical Daiichi Pharmaceitical Co Ltd
Publication of IL91474A0 publication Critical patent/IL91474A0/xx
Publication of IL91474A publication Critical patent/IL91474A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Luminescent Compositions (AREA)
  • Dental Preparations (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IL9147489A 1988-08-31 1989-08-30 History of Azaspiro, their preparation and pharmaceutical preparations containing them IL91474A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP21763888 1988-08-31
JP23131888 1988-09-14
JP29698588 1988-11-24
JP15631689 1989-06-19

Publications (2)

Publication Number Publication Date
IL91474A0 IL91474A0 (en) 1990-04-29
IL91474A true IL91474A (en) 1994-05-30

Family

ID=27473404

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9147489A IL91474A (en) 1988-08-31 1989-08-30 History of Azaspiro, their preparation and pharmaceutical preparations containing them

Country Status (20)

Country Link
US (1) US5508428A (de)
EP (2) EP0529688B1 (de)
KR (2) KR0148688B1 (de)
CN (1) CN1036193C (de)
AT (1) ATE160141T1 (de)
AU (1) AU619891B2 (de)
CA (1) CA1336090C (de)
DE (2) DE68910441T2 (de)
DK (1) DK174689B1 (de)
ES (2) ES2111029T3 (de)
FI (1) FI92703C (de)
HK (1) HK1003000A1 (de)
IE (2) IE63492B1 (de)
IL (1) IL91474A (de)
IN (1) IN170262B (de)
MY (1) MY104652A (de)
NO (1) NO177638C (de)
NZ (1) NZ230484A (de)
PH (1) PH31278A (de)
PT (1) PT91602B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
US5407943A (en) * 1991-06-19 1995-04-18 Pfizer Inc. Azaspiro quinolone antibacterial agents
EP0541086A1 (de) * 1991-11-08 1993-05-12 Kaken Pharmaceutical Co., Ltd. Antibakterielle 6-Fluoro-Chinolone mit einer Oximegruppe an dem Substituent in Position 7
EP0550016A1 (de) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Chinoloncarbonsäure-Derivate und Verfahren zu ihrer Herstellung
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
DE69509442T2 (de) * 1994-06-16 1999-09-02 Lg Chemical Ltd. Chinolincarbonsäurederivate mit 7-(4-Amino-methyl-3-oxim)-pyrrolidin-Substituenten und Verfahren zu ihrer Herstellung
AU5778996A (en) * 1995-05-26 1996-12-11 Daiichi Pharmaceutical Co., Ltd. Processes for preparing cyclic compounds
SG43383A1 (en) * 1995-07-13 1997-10-17 Smithkline Beecham Corp N n-diethyl-8,8-dipropyl-2-azaspiro[4.5]decane-2- propanamine dimaleate
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
DE69802692D1 (de) 1997-06-26 2002-01-10 Dong Wha Pharm Ind Co Ltd Derivate der chinoloncarbonsäure
DE19751948A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
CA2398988C (en) * 2000-02-09 2010-06-22 Makoto Takemura Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
JP5052729B2 (ja) 2000-08-08 2012-10-17 第一三共株式会社 双環化合物の製造方法およびその中間体
JP4108311B2 (ja) * 2001-10-02 2008-06-25 ダイセル化学工業株式会社 １−アシル−１−シクロプロパンカルボン酸エステル誘導体の製造法
JP2003171354A (ja) 2001-12-06 2003-06-20 Daicel Chem Ind Ltd 光学活性アミン化合物又はその塩の製造方法
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
US20090176996A1 (en) * 2008-01-07 2009-07-09 Ahmed Abdel-Magid Process for the preparation of sulfamide derivatives
MX345780B (es) 2011-03-15 2017-02-15 Trius Therapeutics Inc Inhibidores triciclicos de girasa.
WO2012150221A2 (de) 2011-05-04 2012-11-08 Bayer Cropscience Ag Neue halogenierte benzylalkoholester der cyclopropancarbonsäure als schädlingsbekämpfungsmittel
WO2012150208A1 (de) 2011-05-04 2012-11-08 Bayer Cropscience Ag Verwendung von substituierten benzylalkoholestern der cyclopropancarbonsäure zur bekämpfung von insektizid-resistenten insekten
CN103073481A (zh) * 2013-02-06 2013-05-01 上海药明康德新药开发有限公司 一种4-氮杂螺[2.4]庚烷盐酸盐的制备方法
CN110944999A (zh) * 2017-08-01 2020-03-31 勃林格殷格翰国际有限公司 中间体化合物和方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2814622A (en) * 1955-07-18 1957-11-26 Upjohn Co Organic compounds
GB984119A (en) * 1960-06-20 1965-02-24 Aspro Nicholas Ltd Substituted piperidines and methods for their preparation
US3418324A (en) * 1961-03-13 1968-12-24 Geschickter Fund Med Res Heterocyclic secondary amines
BE648317A (de) * 1963-05-27
DE1961474A1 (de) * 1968-12-19 1970-07-02 Leuna Werke Veb Verfahren zur Herstellung von am Stickstoff unsubstituierten Oxaziridinen
US3859292A (en) * 1972-08-15 1975-01-07 Scm Corp N-haloacyl (2-spirocycloaliphatic) oxazolidines
US4011233A (en) * 1973-06-28 1977-03-08 Givaudan Corporation 2-methyl-2-(4-methyl-3-pentene-1-yl) thiazolidine
SE7713314L (sv) * 1976-12-17 1978-06-18 Rohm & Haas Artropodrepellenter
DD152706A5 (de) * 1980-08-21 1981-12-09 Stauffer Chemical Co Unkrautvertilgungsmittelzusammensetzung
US4777175A (en) * 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
DE3721745A1 (de) * 1986-07-04 1988-01-14 Lentia Gmbh Bicyclisch substituierte chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
ZA877471B (en) * 1986-10-08 1988-04-05 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
WO1989000158A1 (en) * 1987-07-02 1989-01-12 Pfizer Inc. Bridged-diazabicycloalkyl quinolone carboxylic acids and esters
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤

Also Published As

Publication number Publication date
EP0357047A1 (de) 1990-03-07
PT91602A (pt) 1990-03-08
EP0529688B1 (de) 1997-11-12
DE68928447D1 (de) 1997-12-18
IE892785L (en) 1990-02-28
FI92703B (fi) 1994-09-15
FI894045A0 (fi) 1989-08-29
CN1036193C (zh) 1997-10-22
PT91602B (pt) 1995-05-31
NO893453L (no) 1990-03-01
DK426289A (da) 1990-03-01
ES2111029T3 (es) 1998-03-01
IE63492B1 (en) 1995-05-03
DE68928447T2 (de) 1998-06-18
IE930570L (en) 1990-02-28
NO177638B (no) 1995-07-17
AU619891B2 (en) 1992-02-06
KR900003152A (ko) 1990-03-23
IL91474A0 (en) 1990-04-29
US5508428A (en) 1996-04-16
PH31278A (en) 1998-07-06
EP0529688A3 (de) 1993-03-10
DE68910441T2 (de) 1994-03-03
FI92703C (fi) 1994-12-27
HK1003000A1 (en) 1998-09-30
ATE160141T1 (de) 1997-11-15
EP0529688A2 (de) 1993-03-03
DK174689B1 (da) 2003-09-15
IE82128B1 (en) 2002-02-20
DE68910441D1 (de) 1993-12-09
MY104652A (en) 1994-05-31
IN170262B (de) 1992-03-07
AU4100689A (en) 1990-03-08
DK426289D0 (da) 1989-08-30
CN1100095A (zh) 1995-03-15
EP0357047B1 (de) 1993-11-03
CA1336090C (en) 1995-06-27
FI894045A (fi) 1990-03-01
KR0148719B1 (en) 1998-08-17
NO893453D0 (no) 1989-08-29
NO177638C (no) 1995-10-25
ES2061845T3 (es) 1994-12-16
KR0148688B1 (ko) 1998-08-17
NZ230484A (en) 1991-06-25

Similar Documents

Publication Publication Date Title
EP0357047B1 (de) Spiro-Verbindungen
USRE41149E1 (en) Optically active pyridonecarboxylic acid derivatives
AU671386B2 (en) Quinolone carboxylic acid derivatives and pharmaceutical formulations containing them
US5286723A (en) Spiro compound
CS246065B2 (en) Method of new 7-substituted cyclic aminonaphthyridine-,quinoline-and benzoxazinecarboxylic acids production
JPH06239857A (ja) 二環性環状アミン誘導体
US6586604B2 (en) Tricyclic amine derivatives
JP2807277B2 (ja) スピロ化合物
US5399553A (en) Tricyclic compound or salts thereof, method for producing the same and anti-microbial agent containing the same
JP3026162B2 (ja) スピロ化合物
BG62965B1 (bg) Производни на хинолон-и нафтиридонкарбонови киселини
JPH03188080A (ja) ピリドンカルボン酸誘導体
RU2094432C1 (ru) Спиросоединение или его соли, способ его получения и фармацевтическая композиция на его основе, обладающая противомикробной активностью
FI101536B (fi) Menetelmä terapeuttisesti käyttökelpoisten spirosubstituentin sisältäv ien kinoliini- tai naftyridiinikarboksyylihappojohdannaisten valmistam iseksi
HU211328A9 (hu) Spirovegyületek Az átmeneti oltalom az 1-34. igénypontokra vonatkozik.
SI8911674A (sl) Spiro spojina
AU668286B2 (en) Diazabicyclo(4.3.0)nonane and (3.3.0)octane heterocycles
JPH06192262A (ja) ７−（アミノメチル−オキサ−７−アザ−ビシクロ［３．３．０］オクト−７−イル）キノロンカルボン酸および７−（アミノメチル−オキサ−７−アザ−ビシクロ［３．３．０］オクト−７−イル）ナフチリドンカルボン酸誘導体
NZ239485A (en) Diazabicyclo(3.3.0)octane and (4.3.0)nonane compounds and trans-3-(ethyl or methyl) amino-4-methylthio-pyrrolidine
IE19970856A1 (en) 7-(1-Pyrrolidinyl)-3-quinolone and naphthyridone carboxylic acid derivatives, method for their preparation and for substituted mono- and bicyclic pyrrolidine intermediates, and their antibacterial and feed additive compositions

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired