DE68910441T2 - Spiro-Verbindungen. - Google Patents

Spiro-Verbindungen.

Info

Publication number
DE68910441T2
DE68910441T2 DE89116022T DE68910441T DE68910441T2 DE 68910441 T2 DE68910441 T2 DE 68910441T2 DE 89116022 T DE89116022 T DE 89116022T DE 68910441 T DE68910441 T DE 68910441T DE 68910441 T2 DE68910441 T2 DE 68910441T2
Authority
DE
Germany
Prior art keywords
integer equal
spiro
connections
inclusive
spiro connections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89116022T
Other languages
English (en)
Other versions
DE68910441D1 (de
Inventor
Isao Hayakawa
Shohgo Atarashi
Masazumi Imamura
Youichi Kimura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE68910441D1 publication Critical patent/DE68910441D1/de
Publication of DE68910441T2 publication Critical patent/DE68910441T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/54—Spiro-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
DE89116022T 1988-08-31 1989-08-30 Spiro-Verbindungen. Expired - Lifetime DE68910441T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP21763888 1988-08-31
JP23131888 1988-09-14
JP29698588 1988-11-24
JP15631689 1989-06-19

Publications (2)

Publication Number Publication Date
DE68910441D1 DE68910441D1 (de) 1993-12-09
DE68910441T2 true DE68910441T2 (de) 1994-03-03

Family

ID=27473404

Family Applications (2)

Application Number Title Priority Date Filing Date
DE89116022T Expired - Lifetime DE68910441T2 (de) 1988-08-31 1989-08-30 Spiro-Verbindungen.
DE68928447T Expired - Lifetime DE68928447T2 (de) 1988-08-31 1989-08-30 Azaspiro(n,m)alkane und Diazaspiro(n,m)alkane

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE68928447T Expired - Lifetime DE68928447T2 (de) 1988-08-31 1989-08-30 Azaspiro(n,m)alkane und Diazaspiro(n,m)alkane

Country Status (20)

Country Link
US (1) US5508428A (de)
EP (2) EP0357047B1 (de)
KR (2) KR0148688B1 (de)
CN (1) CN1036193C (de)
AT (1) ATE160141T1 (de)
AU (1) AU619891B2 (de)
CA (1) CA1336090C (de)
DE (2) DE68910441T2 (de)
DK (1) DK174689B1 (de)
ES (2) ES2061845T3 (de)
FI (1) FI92703C (de)
HK (1) HK1003000A1 (de)
IE (2) IE82128B1 (de)
IL (1) IL91474A (de)
IN (1) IN170262B (de)
MY (1) MY104652A (de)
NO (1) NO177638C (de)
NZ (1) NZ230484A (de)
PH (1) PH31278A (de)
PT (1) PT91602B (de)

Families Citing this family (28)

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MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
DK0641339T3 (da) * 1991-06-19 1999-12-20 Pfizer Antibakterielle midler med azaspiroquinolon
US5276041A (en) * 1991-11-08 1994-01-04 Kaken Pharmaceutical Co., Ltd. Oxime derivatives
KR960011370B1 (ko) * 1991-12-31 1996-08-22 재단법인 한국화학연구소 스피로알킬아민 유도체와 그의 제조방법
EP0550016A1 (de) * 1991-12-31 1993-07-07 Korea Research Institute Of Chemical Technology Chinoloncarbonsäure-Derivate und Verfahren zu ihrer Herstellung
US5527910A (en) * 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
DK0688772T3 (da) * 1994-06-16 1999-11-01 Lg Chemical Ltd Quinolincarboxylsyrederivater med 7-(4-aminomethyl-3-oxim)-pyrrolidinsubstituenter og fremgangsmåde til deres fremstilling
EP1148047A3 (de) 1995-05-26 2004-10-06 Daiichi Pharmaceutical Co., Ltd. Verfahren zur Herstellung von zyklischen Verbindungen
NZ286951A (en) * 1995-07-13 1998-02-26 Anormed Inc Substituted Under N-n-diethyl-8,8-dipropyl-2-azaspiro[4,5]decane-2-propanamine dimaleate
TW519542B (en) * 1996-09-27 2003-02-01 Daiichi Seiyaku Co Bicyclic amine derivative
MA24500A1 (fr) * 1997-03-21 1998-10-01 Lg Life Sciences Ltd Derive du sel d'acide carboxylique de naphthyridine .
US20020032216A1 (en) 1997-03-21 2002-03-14 Lg Chemical Ltd. Salt of naphthyridine carboxylic acid derivative
WO1999000393A1 (en) * 1997-06-26 1999-01-07 Dong Wha Pharmaceutical Industrial Co., Ltd. Quinolone carboxylic acid derivatives
DE19751948A1 (de) 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
WO2001058876A1 (fr) * 2000-02-09 2001-08-16 Daiichi Pharmaceutical Co., Ltd. Agents antibacteriens acidoresistants renfermant des acides pyridonecarboxyliques comme principe actif
KR100895421B1 (ko) * 2000-08-08 2009-05-07 다이이찌 세이야꾸 가부시기가이샤 쌍환 화합물의 제조방법 및 이의 중간체
JP4108311B2 (ja) * 2001-10-02 2008-06-25 ダイセル化学工業株式会社 １−アシル−１−シクロプロパンカルボン酸エステル誘導体の製造法
JP2003171354A (ja) 2001-12-06 2003-06-20 Daicel Chem Ind Ltd 光学活性アミン化合物又はその塩の製造方法
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
US7563805B2 (en) 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
US7977346B2 (en) 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
EP2249828A1 (de) * 2008-01-07 2010-11-17 Janssen Pharmaceutica, N.V. Herstellung von sulfamid-derivaten
TWI527818B (zh) 2011-03-15 2016-04-01 特留斯治療學有限公司 三環旋轉酶抑制劑
WO2012150221A2 (de) 2011-05-04 2012-11-08 Bayer Cropscience Ag Neue halogenierte benzylalkoholester der cyclopropancarbonsäure als schädlingsbekämpfungsmittel
WO2012150208A1 (de) 2011-05-04 2012-11-08 Bayer Cropscience Ag Verwendung von substituierten benzylalkoholestern der cyclopropancarbonsäure zur bekämpfung von insektizid-resistenten insekten
CN103073481A (zh) * 2013-02-06 2013-05-01 上海药明康德新药开发有限公司 一种4-氮杂螺[2.4]庚烷盐酸盐的制备方法
JP7166331B2 (ja) * 2017-08-01 2022-11-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 中間体化合物及び方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2814622A (en) * 1955-07-18 1957-11-26 Upjohn Co Organic compounds
GB984119A (en) * 1960-06-20 1965-02-24 Aspro Nicholas Ltd Substituted piperidines and methods for their preparation
US3418324A (en) * 1961-03-13 1968-12-24 Geschickter Fund Med Res Heterocyclic secondary amines
NL124128C (de) * 1963-05-27
DE1961474A1 (de) * 1968-12-19 1970-07-02 Leuna Werke Veb Verfahren zur Herstellung von am Stickstoff unsubstituierten Oxaziridinen
US3859292A (en) * 1972-08-15 1975-01-07 Scm Corp N-haloacyl (2-spirocycloaliphatic) oxazolidines
US4011233A (en) * 1973-06-28 1977-03-08 Givaudan Corporation 2-methyl-2-(4-methyl-3-pentene-1-yl) thiazolidine
SE7713314L (sv) * 1976-12-17 1978-06-18 Rohm & Haas Artropodrepellenter
DD152706A5 (de) * 1980-08-21 1981-12-09 Stauffer Chemical Co Unkrautvertilgungsmittelzusammensetzung
US4777175A (en) * 1982-09-09 1988-10-11 Warner-Lambert Company Antibacterial agents
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
US4430335A (en) * 1983-02-09 1984-02-07 Hoechst-Roussel Pharmaceuticals Inc. Substituted 1-azaspiro[4,5]decanes and their analgesic compositions
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
DE3721745A1 (de) * 1986-07-04 1988-01-14 Lentia Gmbh Bicyclisch substituierte chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
ZA877471B (en) * 1986-10-08 1988-04-05 Bristol-Myers Company 1-tertiary-alkyl-substituted naphthyridine-and quinoline-carboxylic acid antibacterial agents
WO1989000158A1 (en) * 1987-07-02 1989-01-12 Pfizer Inc. Bridged-diazabicycloalkyl quinolone carboxylic acids and esters
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
MY105136A (en) * 1988-04-27 1994-08-30 Daiichi Seiyaku Co Optically active pyridonecarboxylic acid derivatives.
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤

Also Published As

Publication number Publication date
ES2111029T3 (es) 1998-03-01
IL91474A0 (en) 1990-04-29
NO893453L (no) 1990-03-01
EP0529688A2 (de) 1993-03-03
PH31278A (en) 1998-07-06
CN1100095A (zh) 1995-03-15
CN1036193C (zh) 1997-10-22
DK426289A (da) 1990-03-01
IE82128B1 (en) 2002-02-20
KR0148688B1 (ko) 1998-08-17
HK1003000A1 (en) 1998-09-30
FI894045A0 (fi) 1989-08-29
IE892785L (en) 1990-02-28
FI894045A (fi) 1990-03-01
EP0529688B1 (de) 1997-11-12
EP0357047A1 (de) 1990-03-07
NZ230484A (en) 1991-06-25
IE930570L (en) 1990-02-28
EP0529688A3 (de) 1993-03-10
MY104652A (en) 1994-05-31
FI92703C (fi) 1994-12-27
IN170262B (de) 1992-03-07
DE68928447T2 (de) 1998-06-18
PT91602A (pt) 1990-03-08
DE68928447D1 (de) 1997-12-18
US5508428A (en) 1996-04-16
DK426289D0 (da) 1989-08-30
PT91602B (pt) 1995-05-31
ES2061845T3 (es) 1994-12-16
IE63492B1 (en) 1995-05-03
NO893453D0 (no) 1989-08-29
KR900003152A (ko) 1990-03-23
IL91474A (en) 1994-05-30
NO177638B (no) 1995-07-17
AU619891B2 (en) 1992-02-06
ATE160141T1 (de) 1997-11-15
KR0148719B1 (en) 1998-08-17
DK174689B1 (da) 2003-09-15
FI92703B (fi) 1994-09-15
AU4100689A (en) 1990-03-08
CA1336090C (en) 1995-06-27
EP0357047B1 (de) 1993-11-03
NO177638C (no) 1995-10-25
DE68910441D1 (de) 1993-12-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition