ES2068407T3 - Tratamiento de apneas durante el sueño con derivados de azapirona. - Google Patents

Tratamiento de apneas durante el sueño con derivados de azapirona.

Info

Publication number
ES2068407T3
ES2068407T3 ES91101889T ES91101889T ES2068407T3 ES 2068407 T3 ES2068407 T3 ES 2068407T3 ES 91101889 T ES91101889 T ES 91101889T ES 91101889 T ES91101889 T ES 91101889T ES 2068407 T3 ES2068407 T3 ES 2068407T3
Authority
ES
Spain
Prior art keywords
derivatives
treatment
azapirona
during sleep
chem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91101889T
Other languages
English (en)
Inventor
Jeffrey L Schwimmer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2068407T3 publication Critical patent/ES2068407T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

DERIVADOS DE LA AZAPIRONA DE LAS FORMULAS (I) Y (II) SON UTILES EN EL TRATAMIENTO DE LAS APNEAS DEL SUEÑO. Z ES UN MIEMBRO SELECCIONADO ENTRE EL GRUPO ESTANDO R ELEVADO 3 Y R ELEVADO 4 SELECCIONADAS INDEPENDIENTEMENTE ENTRE ALQUIL C SUB 1-4 E HIDROGENO. A PUEDE SER -CH SUB 2 -, -O-, -CH SUB 2 CH SUB 2 -CH=CH-. LA LINEA PUNTEADA Y LA LINEA CONTINUA REPRESENTAN CADA UNA UN SIMPLE O UN DOBLE ENLACE QUIMICO.
ES91101889T 1990-02-12 1991-02-11 Tratamiento de apneas durante el sueño con derivados de azapirona. Expired - Lifetime ES2068407T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47882090A 1990-02-12 1990-02-12

Publications (1)

Publication Number Publication Date
ES2068407T3 true ES2068407T3 (es) 1995-04-16

Family

ID=23901492

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91101889T Expired - Lifetime ES2068407T3 (es) 1990-02-12 1991-02-11 Tratamiento de apneas durante el sueño con derivados de azapirona.

Country Status (12)

Country Link
EP (1) EP0442424B1 (es)
JP (1) JP3227578B2 (es)
KR (1) KR910015301A (es)
AT (1) ATE115858T1 (es)
CA (1) CA2036039A1 (es)
CY (1) CY1990A (es)
DE (1) DE69106008T2 (es)
DK (1) DK0442424T3 (es)
ES (1) ES2068407T3 (es)
HK (1) HK19797A (es)
HU (1) HUT56497A (es)
IL (1) IL97053A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620993A (en) * 1995-06-07 1997-04-15 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US5661163A (en) * 1995-06-07 1997-08-26 Merck & Co., Inc. Alpha-1a adrenergic receptor antagonists
US6331536B1 (en) 1998-02-27 2001-12-18 The Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
US7160898B2 (en) 2001-12-14 2007-01-09 Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
DE19953625A1 (de) * 1999-11-08 2001-05-17 Richter Diethelm Wolfgang Verwendung von 5HT-1A Serotonin Rezeptor Agonisten zur Behandlung von genetischen oder funktionellen Atemrhythmusstörungen
KR20070087678A (ko) 2004-12-20 2007-08-28 컬리지움 파마슈티칼, 인코포레이티드 수면 장애용 약제 조성물

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612312A (en) * 1984-07-30 1986-09-16 Merrell Dow Pharmaceuticals Inc. Glutarimide antianxiety and antihypertensive agents

Also Published As

Publication number Publication date
DK0442424T3 (da) 1995-02-20
DE69106008T2 (de) 1995-05-04
IL97053A0 (en) 1992-03-29
KR910015301A (ko) 1991-09-30
HU910437D0 (en) 1991-08-28
DE69106008D1 (de) 1995-02-02
ATE115858T1 (de) 1995-01-15
HK19797A (en) 1997-02-20
JP3227578B2 (ja) 2001-11-12
EP0442424B1 (en) 1994-12-21
JPH0517358A (ja) 1993-01-26
CA2036039A1 (en) 1991-08-13
EP0442424A1 (en) 1991-08-21
CY1990A (en) 1997-09-05
HUT56497A (en) 1991-09-30
IL97053A (en) 1995-10-31

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