IL60161A - N-hexahydroazocinylidene-n-phenylcarboximidamides,their production and pharmaceutical compositions containing them - Google Patents
N-hexahydroazocinylidene-n-phenylcarboximidamides,their production and pharmaceutical compositions containing themInfo
- Publication number
- IL60161A IL60161A IL60161A IL6016180A IL60161A IL 60161 A IL60161 A IL 60161A IL 60161 A IL60161 A IL 60161A IL 6016180 A IL6016180 A IL 6016180A IL 60161 A IL60161 A IL 60161A
- Authority
- IL
- Israel
- Prior art keywords
- phenylcarboximidamides
- hexahydroazocinylidene
- production
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000002357 guanidines Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/02—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH499379 | 1979-05-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL60161A0 IL60161A0 (en) | 1980-07-31 |
| IL60161A true IL60161A (en) | 1984-05-31 |
Family
ID=4286083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL60161A IL60161A (en) | 1979-05-29 | 1980-05-26 | N-hexahydroazocinylidene-n-phenylcarboximidamides,their production and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4626537A (cs) |
| EP (1) | EP0020303B1 (cs) |
| JP (1) | JPS55160764A (cs) |
| KR (2) | KR840002309B1 (cs) |
| AT (1) | ATE15189T1 (cs) |
| CS (2) | CS220327B2 (cs) |
| CY (1) | CY1442A (cs) |
| DD (1) | DD151163A5 (cs) |
| DE (1) | DE3071029D1 (cs) |
| DK (1) | DK156059B (cs) |
| ES (1) | ES491926A0 (cs) |
| FI (1) | FI75154C (cs) |
| GR (1) | GR68377B (cs) |
| HK (1) | HK80788A (cs) |
| HU (1) | HU183145B (cs) |
| IL (1) | IL60161A (cs) |
| NO (1) | NO153850C (cs) |
| PL (2) | PL126790B1 (cs) |
| PT (1) | PT71313A (cs) |
| SG (1) | SG33688G (cs) |
| SU (2) | SU1222191A3 (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8312665D0 (en) * | 1983-05-09 | 1983-06-15 | Ici Plc | 4,4'-alkylenedipiperidine derivatives |
| GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
| DK0690851T3 (da) * | 1993-03-23 | 1999-11-08 | Astra Ab | Guanidin-derivater, som er anvendelige til behandling |
| US6756389B2 (en) * | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
| WO2003099818A1 (en) * | 2002-05-23 | 2003-12-04 | Chiron Corporation | Substituted quinazolinone compounds |
| US7625909B2 (en) | 2003-05-23 | 2009-12-01 | Novartis Vaccines And Diagnostics, Inc. | Substituted quinazolinone compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH513156A (de) * | 1967-02-27 | 1971-09-30 | Hoffmann La Roche | Verfahren zur Herstellung von Pyrrolinverbindungen |
| DE2205744A1 (de) * | 1972-02-08 | 1973-08-09 | Thomae Gmbh Dr K | Neue durch einen guanidinylidenrest substituierte heterocyclen und verfahren zu ihrer herstellung |
| US3840524A (en) * | 1973-04-25 | 1974-10-08 | Richardson Merrell Inc | Alpha-cycloalkylbenzyl lactamimides |
| US4126612A (en) * | 1973-08-09 | 1978-11-21 | Eugene O. Retter | Substituted cycloalkyl lactamimides |
| US4211867A (en) * | 1976-03-19 | 1980-07-08 | Mcneil Laboratories, Incorporated | Nitrogen heterocyclic carboximidamide compounds |
| CS225804B2 (cs) * | 1976-03-19 | 1984-02-13 | Mcneilab Inc | Způsob výroby heterocyklických derivátů guanidinu |
| NZ183570A (en) * | 1976-03-19 | 1979-06-08 | Mcneilab Inc | Heterocyclic guanidine derivatives, having anti-secretory and hypogliycaemic activity |
-
1980
- 1980-05-12 JP JP6184880A patent/JPS55160764A/ja active Pending
- 1980-05-23 EP EP80810171A patent/EP0020303B1/de not_active Expired
- 1980-05-23 DE DE8080810171T patent/DE3071029D1/de not_active Expired
- 1980-05-23 AT AT80810171T patent/ATE15189T1/de active
- 1980-05-26 FI FI801690A patent/FI75154C/fi not_active IP Right Cessation
- 1980-05-26 IL IL60161A patent/IL60161A/xx unknown
- 1980-05-27 SU SU802928398A patent/SU1222191A3/ru active
- 1980-05-27 GR GR62058A patent/GR68377B/el unknown
- 1980-05-27 PL PL1980233449A patent/PL126790B1/pl unknown
- 1980-05-27 DD DD80221398A patent/DD151163A5/de unknown
- 1980-05-27 PL PL1980224523A patent/PL124028B1/pl unknown
- 1980-05-28 NO NO801585A patent/NO153850C/no unknown
- 1980-05-28 ES ES491926A patent/ES491926A0/es active Granted
- 1980-05-28 DK DK229480AA patent/DK156059B/da not_active Application Discontinuation
- 1980-05-28 PT PT71313A patent/PT71313A/pt unknown
- 1980-05-29 CS CS803792A patent/CS220327B2/cs unknown
- 1980-05-29 CS CS812654A patent/CS220336B2/cs unknown
- 1980-05-29 HU HU801356A patent/HU183145B/hu unknown
- 1980-05-29 KR KR1019800002130A patent/KR840002309B1/ko not_active Expired
-
1981
- 1981-08-24 SU SU813324653A patent/SU1227111A3/ru active
-
1984
- 1984-09-25 KR KR1019840005881A patent/KR840002310B1/ko not_active Expired
-
1986
- 1986-02-28 US US06/834,506 patent/US4626537A/en not_active Expired - Fee Related
-
1988
- 1988-05-27 SG SG336/88A patent/SG33688G/en unknown
- 1988-10-06 HK HK807/88A patent/HK80788A/xx unknown
-
1989
- 1989-03-10 CY CY1442A patent/CY1442A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK229480A (da) | 1980-11-30 |
| DK156059B (da) | 1989-06-19 |
| PT71313A (de) | 1980-06-01 |
| HK80788A (en) | 1988-10-14 |
| CS220327B2 (en) | 1983-03-25 |
| IL60161A0 (en) | 1980-07-31 |
| FI801690A7 (fi) | 1980-11-30 |
| US4626537A (en) | 1986-12-02 |
| KR830002716A (ko) | 1983-05-30 |
| DD151163A5 (de) | 1981-10-08 |
| SU1227111A3 (ru) | 1986-04-23 |
| GR68377B (cs) | 1981-12-28 |
| FI75154B (fi) | 1988-01-29 |
| PL124028B1 (en) | 1982-12-31 |
| JPS55160764A (en) | 1980-12-13 |
| DE3071029D1 (en) | 1985-10-03 |
| NO153850B (no) | 1986-02-24 |
| NO801585L (no) | 1980-12-01 |
| KR840002309B1 (ko) | 1984-12-17 |
| SU1222191A3 (ru) | 1986-03-30 |
| PL126790B1 (en) | 1983-08-31 |
| NO153850C (no) | 1986-06-04 |
| ES8103031A1 (es) | 1981-02-16 |
| ES491926A0 (es) | 1981-02-16 |
| CY1442A (en) | 1989-03-10 |
| CS220336B2 (en) | 1983-03-25 |
| ATE15189T1 (de) | 1985-09-15 |
| SG33688G (en) | 1989-01-27 |
| EP0020303B1 (de) | 1985-08-28 |
| FI75154C (fi) | 1988-05-09 |
| PL224523A1 (cs) | 1981-02-13 |
| EP0020303A1 (de) | 1980-12-10 |
| HU183145B (en) | 1984-04-28 |
| KR840002310B1 (ko) | 1984-12-17 |
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