DK0690851T3 - Guanidin-derivater, som er anvendelige til behandling - Google Patents
Guanidin-derivater, som er anvendelige til behandlingInfo
- Publication number
- DK0690851T3 DK0690851T3 DK94910453T DK94910453T DK0690851T3 DK 0690851 T3 DK0690851 T3 DK 0690851T3 DK 94910453 T DK94910453 T DK 94910453T DK 94910453 T DK94910453 T DK 94910453T DK 0690851 T3 DK0690851 T3 DK 0690851T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- derivatives useful
- guanidine derivatives
- condition
- disease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939305997A GB9305997D0 (en) | 1993-03-23 | 1993-03-23 | Pharmaceutically active compounds |
GB939306767A GB9306767D0 (en) | 1993-03-31 | 1993-03-31 | Pharmaceutically active compounds |
GB939307741A GB9307741D0 (en) | 1993-04-15 | 1993-04-15 | Pharmaceutically active compounds |
PCT/GB1994/000584 WO1994021621A1 (en) | 1993-03-23 | 1994-03-22 | Guanidine derivatives useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0690851T3 true DK0690851T3 (da) | 1999-11-08 |
Family
ID=27266630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94910453T DK0690851T3 (da) | 1993-03-23 | 1994-03-22 | Guanidin-derivater, som er anvendelige til behandling |
Country Status (9)
Country | Link |
---|---|
US (2) | US5885985A (da) |
EP (1) | EP0690851B1 (da) |
AT (1) | ATE180255T1 (da) |
AU (1) | AU6286294A (da) |
DE (1) | DE69418601T2 (da) |
DK (1) | DK0690851T3 (da) |
ES (1) | ES2132393T3 (da) |
GR (1) | GR3030867T3 (da) |
WO (1) | WO1994021621A1 (da) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5807885A (en) * | 1993-08-12 | 1998-09-15 | Astra Aktiebolag | Amidine derivatives with nitric oxide synthetase activities |
ATE182889T1 (de) * | 1994-05-07 | 1999-08-15 | Astra Ab | Bicyclische amidinderivate als no-synthetase inhibitoren |
US5665757A (en) * | 1994-07-13 | 1997-09-09 | Robert W. Dunn | Method for treating anxiety |
GB9418912D0 (en) * | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
AU2629795A (en) * | 1994-12-12 | 1996-07-03 | Chugai Seiyaku Kabushiki Kaisha | Aniline derivative having the effect of inhibiting nitrogen monoxide synthase |
WO1996021445A1 (en) * | 1995-01-13 | 1996-07-18 | The General Hospital Corporation | Methods of inhibiting neurodegenerative diseases |
CZ287969B6 (cs) * | 1995-08-10 | 2001-03-14 | Astra Pharmaceuticals Limited | Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití |
TW458978B (en) * | 1995-11-07 | 2001-10-11 | Astra Ab | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
US6140322A (en) * | 1995-11-07 | 2000-10-31 | Astra Aktiebolag | Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase |
US5908842A (en) * | 1995-12-08 | 1999-06-01 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
US6756389B2 (en) * | 1996-08-09 | 2004-06-29 | Cambridge Neuroscience, Inc. | Pharmaceutically active compounds and methods of use |
US5929085A (en) * | 1996-11-06 | 1999-07-27 | Astra Aktiebolag | Amidine and isothiourea derivatives, compositions containing them and their use as inhibitors of nitric oxide synthase |
US6160000A (en) * | 1996-12-23 | 2000-12-12 | Merck & Co., Inc. | Antidiabetic agents based on aryl and heteroarylacetic acids |
US6090839A (en) * | 1996-12-23 | 2000-07-18 | Merck & Co., Inc. | Antidiabetic agents |
FR2761066B1 (fr) * | 1997-03-24 | 2000-11-24 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
US6335445B1 (en) | 1997-03-24 | 2002-01-01 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
FR2783519B1 (fr) * | 1998-09-23 | 2003-01-24 | Sod Conseils Rech Applic | Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
FR2784678B1 (fr) * | 1998-09-23 | 2002-11-29 | Sod Conseils Rech Applic | Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
SE9904677D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
SE9904676D0 (sv) * | 1999-12-20 | 1999-12-20 | Astra Ab | Novel compounds |
US20040087798A1 (en) * | 2000-03-14 | 2004-05-06 | Akira Yamada | Novel amide compounds |
DZ3415A1 (fr) | 2000-08-31 | 2002-03-07 | Chiron Corp | Guanidinobenzamides comme mc4-r agonistes. |
EP1767525A1 (en) | 2001-04-09 | 2007-03-28 | Novartis Vaccines and Diagnostics, Inc. | Guanidino compounds as melanocortin-4 receptor (MC4-R) agonists |
BR0212787A (pt) * | 2001-09-24 | 2005-01-25 | Elan Pharm Inc | Composto ou sal farmaceuticamente aceitável do mesmo, métodos de tratamento ou prevenção de doenças e de preparação de um composto, uso de um composto ou sal, e, composição farmacêutica |
DE10162114A1 (de) * | 2001-12-12 | 2003-06-26 | Schering Ag | Neue Amidin-Derivate und deren Verwendung in Arzneimitteln |
US20050124652A1 (en) * | 2002-02-04 | 2005-06-09 | Rustum Boyce | Guanidino compounds |
US20030195187A1 (en) * | 2002-02-04 | 2003-10-16 | Chiron Corporation | Guanidino compounds |
US20030207814A1 (en) * | 2002-02-04 | 2003-11-06 | Chiron Corporation | Novel guanidinyl derivatives |
EP1487474A4 (en) * | 2002-02-25 | 2006-11-29 | Chiron Corp | INTRANASAL ADMINISTRATION OF MC4-R AGONISTS |
ATE478867T1 (de) * | 2002-05-23 | 2010-09-15 | Novartis Vaccines & Diagnostic | Substituierte quinazolinone verbindungen |
AU2004249120B2 (en) * | 2003-05-23 | 2008-07-24 | Glaxosmithkline | Guanidino-substituted quinazolinone compounds as MC4-R agonists |
MXPA06005736A (es) | 2003-11-19 | 2006-12-14 | Chiron Corp | Compuestos de quinazolinona con bioacumulacion reducida. |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1341245A (en) * | 1971-07-08 | 1973-12-19 | Vnii Chim Sredstv Zaschity | Substituted guanidines and fungicidal compositions comprising substituted guanidines |
US3976643A (en) * | 1973-07-13 | 1976-08-24 | William H. Rorer, Inc. | Guanidines |
NZ183570A (en) * | 1976-03-19 | 1979-06-08 | Mcneilab Inc | Heterocyclic guanidine derivatives, having anti-secretory and hypogliycaemic activity |
US4211867A (en) * | 1976-03-19 | 1980-07-08 | Mcneil Laboratories, Incorporated | Nitrogen heterocyclic carboximidamide compounds |
US4345083A (en) * | 1978-09-18 | 1982-08-17 | Mcneilab, Inc. | (1-Methyl-2-quinolinylidene) derivatives of guanidine |
CA1201119A (en) * | 1978-09-18 | 1986-02-25 | Mcneilab, Inc. | Diaza-cyclic derivatives of guanidine |
US4182865A (en) * | 1978-09-18 | 1980-01-08 | Mcneil Laboratories, Inc. | Diaza-cyclic derivatives of guanidine |
US4414211A (en) * | 1978-09-18 | 1983-11-08 | Mcneilab, Inc. | Heterocyclic derivatives of guanidine |
JPS55160764A (en) * | 1979-05-29 | 1980-12-13 | Ciba Geigy Ag | Guanidine* its manufacture and pharmaceutic medicine containing same |
GR71929B (da) * | 1979-11-13 | 1983-08-19 | Ici Ltd | |
IE62023B1 (en) * | 1989-01-02 | 1994-12-14 | Boots Co Plc | Therapeutic agents |
ES2181668T3 (es) * | 1990-03-02 | 2003-03-01 | Oregon State | Guanidinas tri- y tetra-substituidas y su uso como antagonistas de aminoacido excitador. |
IN172842B (da) * | 1990-05-17 | 1993-12-11 | Boots Pharmaceuticals Limited | |
US5268373A (en) * | 1992-07-28 | 1993-12-07 | Mcneilab, Inc. | Guanidine derivatives, compositions and use |
WO1995014465A2 (en) * | 1993-11-22 | 1995-06-01 | The Johns Hopkins University | Methods for amelioration of immunodeficiency virus induced neurodegeneration by covering nitric oxide or superoxide concentration |
-
1994
- 1994-03-22 ES ES94910453T patent/ES2132393T3/es not_active Expired - Lifetime
- 1994-03-22 WO PCT/GB1994/000584 patent/WO1994021621A1/en active IP Right Grant
- 1994-03-22 US US08/525,663 patent/US5885985A/en not_active Expired - Fee Related
- 1994-03-22 DK DK94910453T patent/DK0690851T3/da active
- 1994-03-22 AT AT94910453T patent/ATE180255T1/de not_active IP Right Cessation
- 1994-03-22 AU AU62862/94A patent/AU6286294A/en not_active Abandoned
- 1994-03-22 DE DE69418601T patent/DE69418601T2/de not_active Expired - Fee Related
- 1994-03-22 EP EP94910453A patent/EP0690851B1/en not_active Expired - Lifetime
-
1998
- 1998-11-16 US US09/193,333 patent/US5998399A/en not_active Expired - Fee Related
-
1999
- 1999-07-27 GR GR990401953T patent/GR3030867T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69418601T2 (de) | 1999-09-30 |
DE69418601D1 (de) | 1999-06-24 |
US5885985A (en) | 1999-03-23 |
ES2132393T3 (es) | 1999-08-16 |
US5998399A (en) | 1999-12-07 |
AU6286294A (en) | 1994-10-11 |
EP0690851B1 (en) | 1999-05-19 |
EP0690851A1 (en) | 1996-01-10 |
ATE180255T1 (de) | 1999-06-15 |
WO1994021621A1 (en) | 1994-09-29 |
GR3030867T3 (en) | 1999-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0690851T3 (da) | Guanidin-derivater, som er anvendelige til behandling | |
RU94036758A (ru) | Применение 2-фенил-3-ароилбензотиофенов для лечения пери-менопаузного синдрома | |
BR9813373A (pt) | Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, processos para efetuar imunossupressão e para tratar ou reduzir o risco de uma doença das vias aérias obstrutiva reversìvel em um paciente | |
MY137348A (en) | Highly selective norepinephrine reuptake inhibitors and methods of using the same | |
ATE410506T1 (de) | Behandlung der pompeschen krankheit | |
DK1014996T3 (da) | Præparater indeholdende saccharid til behandling af Alzheimers sygdom og andre amyloidoser | |
DK0682514T3 (da) | Anvendelse af lokalanæstetiske midler til fremstilling af et lægmiddel til behandling af bronchial astma | |
UA49869C2 (uk) | Нафтил-заміщені похідні бензимідазолу, фармацевтична композиція, спосіб лікування (варіанти) та спосіб інгібування людського фактора | |
DK0396184T3 (da) | Anvendelse af ketoconazol og et retinoid til behandling af acne vulgaris | |
BR0316458A (pt) | Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto | |
RU94044454A (ru) | Ингибитор аутоимунных заболеваний | |
DE68912195D1 (de) | Verwendung von Pyrrolicloncarbonsäurealkylestern zur Herstellung eines Arzneimittels zur Behandlung von Ichtyosis. | |
DE69424777T2 (de) | 3,4-diarylchromane zur behandlung von dermatitis | |
RU94036771A (ru) | Ингибиторы ангиогенеза и ангиогенных заболеваний | |
DE60220055D1 (de) | 4-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)harnstoff und dessen verwendung bei der behandlung von mit glycogensynthasekinase-3 (gsk3) assoziierten leiden | |
RU94045271A (ru) | Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера | |
SE0004101D0 (sv) | New use | |
CA2289017A1 (en) | The use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer | |
BR0212249A (pt) | Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, e, uso de um composto | |
IT1288399B1 (it) | Medicamento per il trattamento terapeutico della maculopatia legata all'eta', della maculopatia non legata all'eta' e per la profilassi | |
DE69200840T2 (de) | Harnstoff- und Thioharnstoffderivate, Herstellung und therapeutische Verwendung. | |
DK0673646T3 (da) | Anvendelse af deoxyspergualin til fremstilling af et lægemiddel til behandling af inflammatorisk-hyperreaktive sygdomme | |
DE69421705D1 (de) | Verwendung von Efaroxan und dessen Derivaten zur Herstellung eines Arzneimittels zur Behandlung neurogenerativer Erkrankungen | |
RU94044455A (ru) | Средство для усиления функции макрофага и лечения человека с ослабленным иммунитетом | |
ATE139702T1 (de) | Die freisetzung des histamin hemmenden faktors sowie diesen enthaltende präparate |