DK304382A - Fremgangsmaade til fremstilling af substituerede imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents
Fremgangsmaade til fremstilling af substituerede imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf Download PDFInfo
- Publication number
- DK304382A DK304382A DK304382A DK304382A DK304382A DK 304382 A DK304382 A DK 304382A DK 304382 A DK304382 A DK 304382A DK 304382 A DK304382 A DK 304382A DK 304382 A DK304382 A DK 304382A
- Authority
- DK
- Denmark
- Prior art keywords
- compounds
- procedure
- acid addition
- addition salts
- acceptable acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/213—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C49/217—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8121333 | 1981-07-10 | ||
GB08121333A GB2101114B (en) | 1981-07-10 | 1981-07-10 | Substituted imidazole derivatives and their preparation and use |
Publications (3)
Publication Number | Publication Date |
---|---|
DK304382A true DK304382A (da) | 1983-01-11 |
DK158307B DK158307B (da) | 1990-04-30 |
DK158307C DK158307C (da) | 1990-10-08 |
Family
ID=10523160
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK304382A DK158307C (da) | 1981-07-10 | 1982-07-07 | Analogifremgangsmaade til fremstilling af 4-(fenylalkyl)-imidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
DK630486A DK160610C (da) | 1981-07-10 | 1986-12-29 | Analogifremgangsmaade til fremstilling af 4-fenylalkyl- eller 4-fenylalkenylimidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK630486A DK160610C (da) | 1981-07-10 | 1986-12-29 | Analogifremgangsmaade til fremstilling af 4-fenylalkyl- eller 4-fenylalkenylimidazolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
Country Status (23)
Country | Link |
---|---|
US (3) | US4544664A (da) |
EP (1) | EP0072615B1 (da) |
JP (1) | JPS5818365A (da) |
KR (1) | KR860001864B1 (da) |
AT (1) | ATE17121T1 (da) |
AU (1) | AU554125B2 (da) |
BG (1) | BG60763B2 (da) |
CA (1) | CA1184559A (da) |
DD (1) | DD207713A1 (da) |
DE (1) | DE3268111D1 (da) |
DK (2) | DK158307C (da) |
FI (1) | FI77858C (da) |
GB (1) | GB2101114B (da) |
HK (1) | HK8289A (da) |
HU (1) | HU187773B (da) |
IE (1) | IE53244B1 (da) |
IL (1) | IL66271A (da) |
NO (1) | NO160439C (da) |
NZ (1) | NZ201176A (da) |
SG (1) | SG65388G (da) |
SU (1) | SU1241990A3 (da) |
UA (1) | UA5557A1 (da) |
ZA (1) | ZA824875B (da) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2069481B (en) * | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
US4482723A (en) * | 1983-04-11 | 1984-11-13 | Pfizer Inc. | Process for preparation of 4-acetyl-2-substituted-imidazoles |
CA1238640A (en) * | 1984-06-18 | 1988-06-28 | Kenneth S. Hirsch | 4(5)-substituted imidazoles |
US4661508A (en) * | 1984-06-18 | 1987-04-28 | Eli Lilly And Company | Aromatase inhibiting α,α-diphenyl-4(5)imidazole-methanes or -ethanes |
US4605661A (en) * | 1984-06-18 | 1986-08-12 | Eli Lilly And Company | Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles |
FI844786A0 (fi) * | 1984-12-04 | 1984-12-04 | Farmos Oy | Terapeutiskt utnyttjbar foerening. |
US4600683A (en) * | 1985-04-22 | 1986-07-15 | International Business Machines Corp. | Cross-linked polyalkenyl phenol based photoresist compositions |
GB8626287D0 (en) * | 1986-11-04 | 1986-12-03 | Ucb Sa | Substituted 1h-imidazoles |
FI864570A0 (fi) * | 1986-11-11 | 1986-11-11 | Farmos Oy | Terapeutiskt anvaendbar foerening. |
GB2206880B (en) * | 1987-07-16 | 1991-04-24 | Farmos Oy | Optical isomers of an imidazole derivative |
GB2210875B (en) * | 1987-10-09 | 1991-05-29 | Farmos Oy | Aromatase inhibiting 4(5)-imidazoles |
GB2215206B (en) | 1988-02-29 | 1991-07-03 | Farmos Oy | 4-substituted imidazole derivatives useful in perioperative care |
GB8810067D0 (en) * | 1988-04-28 | 1988-06-02 | Ucb Sa | Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides |
US5439928A (en) * | 1989-03-30 | 1995-08-08 | Orion-Yhtyma Oy | Aromatase inhibiting 4(5)-imidazoles |
GB2229719B (en) * | 1989-03-30 | 1992-04-29 | Farmos Oy | Novel aromatase inhibiting 4(5)-imidazoles |
US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
US5151526A (en) * | 1990-10-11 | 1992-09-29 | The United States Of America As Represented By The Secretary Of The Army | 4-[1-(1-naphthalenyl)ethyl]-1H-imidazole, method of making and use as an anesthetic |
DE4042492C2 (de) * | 1990-10-18 | 1995-04-13 | Heinz W Dr Joseph | Verwendung von 4,5-Di-n-hexylimidazol zur Herstellung von fungiziden Mitteln |
GB2256135B (en) | 1991-05-31 | 1995-01-18 | Orion Yhtymae Oy | Transdermal administration of 4-substituted imidazoles |
GB9111732D0 (en) * | 1991-05-31 | 1991-07-24 | Orion Yhtymae Oy | The use of certain salts of medetomidine and its optically active enantiomers to regulate the rate of transdermal administration of the drugs |
US5401851A (en) * | 1992-06-03 | 1995-03-28 | Eli Lilly And Company | Angiotensin II antagonists |
SE9302333D0 (sv) * | 1993-07-06 | 1993-07-06 | Ab Astra | New compounds |
GB9521680D0 (en) * | 1995-10-23 | 1996-01-03 | Orion Yhtymo Oy | New use of imidazole derivatives |
UA64751C2 (uk) | 1997-06-25 | 2004-03-15 | Пфайзер Продактс Інк. | Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти) |
AR015744A1 (es) * | 1998-04-01 | 2001-05-16 | Orion Corp | Uso de dexmedetomidina para sedacion en terapia intensiva |
US6231594B1 (en) | 1999-08-11 | 2001-05-15 | Radiant Medical, Inc. | Method of controlling body temperature while reducing shivering |
DE60027034T2 (de) * | 1999-10-22 | 2006-11-09 | Takeda Pharmaceutical Co. Ltd. | 1-substituierte-phenyl-1-(1h-imidazol-4-yl)alkohole, verfahren zu deren herstellung sowie deren verwendung |
US6582457B2 (en) * | 2001-02-15 | 2003-06-24 | Radiant Medical, Inc. | Method of controlling body temperature while reducing shivering |
ZA200507486B (en) | 2003-03-07 | 2007-03-28 | Astellas Pharma Inc | Nitrogenous heterocyclic derivative having 2,6-disubstituted styryl |
CA2637308C (en) * | 2006-01-27 | 2014-02-25 | F. Hoffmann-La Roche Ag | Use of 4-imidazole derivatives for cns disorders |
EP1918282A1 (en) | 2006-11-06 | 2008-05-07 | "Joint Stock Company Grindeks" | Method for preparing medetomidine and its salts |
US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
WO2008144623A1 (en) | 2007-05-23 | 2008-11-27 | Allergan, Inc. | Cyclic lactams for the treatment of glaucoma or elevated intraocular pressure |
ES2390323T3 (es) | 2007-05-23 | 2012-11-08 | Allergan, Inc. | Compuestos terapéuticos de ((fenil)imidazolil)metilquinolinilo |
GB2453982B (en) * | 2007-10-24 | 2009-09-16 | Norbrook Lab Ltd | Chemical process for the preparation of Medetomidine |
US7902247B2 (en) | 2008-01-09 | 2011-03-08 | Allergan, Inc. | Substituted-aryl-2-phenylethyl-1H-imidazole compounds as subtype selective modulators of alpha 2B and/or alpha 2C adrenergic receptors |
EP2250153B1 (en) * | 2008-01-18 | 2013-06-19 | Allergan, Inc. | Substituted-aryl-(imidazole)-methyl)-phenyl compounds as subtype selective modulators of alpha 2b and/or alpha 2c adrenergic receptors |
US7795263B2 (en) * | 2008-07-08 | 2010-09-14 | Wildlife Laboratories, Inc. | Pharmaceutical combination for and method of anesthetizing and immobilizing non-domesticated mammals |
US8555875B2 (en) | 2008-12-23 | 2013-10-15 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
CN101921234B (zh) * | 2009-06-12 | 2012-05-30 | 中国中化股份有限公司 | 一种制备美托咪啶的方法 |
WO2011070069A1 (en) | 2009-12-09 | 2011-06-16 | I-Tech Ab | Process for preparation of medetomidine |
CN101805294B (zh) * | 2010-01-12 | 2015-06-10 | 北京华禧联合科技发展有限公司 | 盐酸右美托咪定关键中间体的制备 |
RU2448095C1 (ru) * | 2010-12-09 | 2012-04-20 | Олег Геннадьевич Еремин | Способ получения детомидина или его нетоксичных фармацевтически приемлемых солей |
RU2448094C1 (ru) * | 2010-12-09 | 2012-04-20 | Олег Геннадьевич Еремин | Улучшенный способ получения медетомидина или его нетоксичных фармацевтически приемлемых солей |
CN103748077B (zh) | 2011-07-22 | 2016-08-17 | 坎布雷卡尔斯库加公司 | 用于制备4-取代咪唑类的方法 |
WO2013069025A1 (en) | 2011-11-11 | 2013-05-16 | Neon Laboratories Ltd. | "process for the preparation of dexmedetomidine" |
US8242158B1 (en) | 2012-01-04 | 2012-08-14 | Hospira, Inc. | Dexmedetomidine premix formulation |
WO2012172119A2 (en) * | 2012-05-08 | 2012-12-20 | Lonza Ltd | Method for the preparation of medetomidine |
IN2014DN07983A (da) * | 2012-05-08 | 2015-05-01 | Lonza Ag | |
EA029130B1 (ru) * | 2012-05-08 | 2018-02-28 | Лонца Лтд | Применение соединения для получения медетомидина |
DK2867195T3 (da) | 2012-06-28 | 2016-04-04 | Lonza Ag | Fremgangsmåde til fremstilling af 2-(2,3-dimethylphenyl)-1- propanal med chloracetone |
WO2013011157A1 (en) | 2012-06-28 | 2013-01-24 | Lonza Ltd | Method for preparation of medetomidine with chloroacetone |
EP3054930B1 (en) | 2013-10-07 | 2020-12-02 | Teikoku Pharma USA, Inc. | Methods and compositions for transdermal delivery of a non-sedative amount of dexmedetomidine |
US10772871B2 (en) | 2013-10-07 | 2020-09-15 | Teikoku Pharma Usa, Inc. | Dexmedetomidine transdermal delivery devices and methods for using the same |
TWI709417B (zh) | 2013-10-07 | 2020-11-11 | 美商帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
CN104447562A (zh) * | 2014-03-27 | 2015-03-25 | 宁波天衡药业股份有限公司 | 一种制备盐酸右美托咪定关键中间体的新方法 |
DK179655B1 (da) | 2015-05-06 | 2019-03-13 | I-Tech Ab | Medetomidine for use in controlling parasitic crustaceans on fish |
US9717796B1 (en) | 2016-04-20 | 2017-08-01 | Slypharma, Llc | Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container |
CN105884691B (zh) * | 2016-06-02 | 2017-08-25 | 江苏恒瑞医药股份有限公司 | 一种制备右美托咪定及其中间体的方法 |
WO2018065288A1 (de) | 2016-10-07 | 2018-04-12 | Bayer Cropscience Aktiengesellschaft | 2-[2-phenyl-1-(sulfonylmethyl)vinyl]-imidazo[4,5-b]pyridin-derivate und verwandte verbindungen als schädlingsbekämpfungsmittel im pflanzenschutz |
AR113206A1 (es) | 2017-01-10 | 2020-02-19 | Bayer Cropscience Ag | Derivados heterocíclicos como pesticidas |
CN110382485B (zh) | 2017-01-10 | 2022-05-10 | 拜耳公司 | 作为害虫防治剂的杂环烯衍生物 |
ES2882193T3 (es) | 2017-03-29 | 2021-12-01 | I Tech Ab | Artículo antiincrustante |
CN108872431B (zh) * | 2018-07-09 | 2021-03-23 | 成都倍特药业股份有限公司 | 一种检测4-(1-(2,5-二甲基苯基)乙基)-1h-咪唑或/和其盐酸盐的方法 |
US11160791B2 (en) | 2018-11-01 | 2021-11-02 | Medefil, Inc. | Dexmedetomidine injection premix formulation in ready to use (RTU) bags |
CN111217756B (zh) * | 2019-12-11 | 2022-03-11 | 南京亿华药业有限公司 | 一种盐酸右美托咪定的制备方法 |
CN113896684A (zh) * | 2020-07-06 | 2022-01-07 | 复旦大学 | 一种美托咪定的制备方法 |
CN117295718A (zh) | 2022-03-22 | 2023-12-26 | 维科-兹多洛夫希沃特尼赫有限责任公司 | 美托咪定及其衍生物的制备方法 |
CN114671811A (zh) * | 2022-04-14 | 2022-06-28 | 南京正科医药股份有限公司 | 一种右美托咪定拆分副产物的外消旋化回收方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2946804A (en) * | 1958-12-29 | 1960-07-26 | Abbott Lab | (5-methyl-4-imidazolyl)-diphenyl carbinol salts and lower alkyl quaternaries |
BE793407A (fr) * | 1971-12-28 | 1973-06-28 | Hoechst Ag | Imidazolyl - (2) -carbinols ayant une activite hypolipidemique et leur procede de preparation |
AU518569B2 (en) * | 1979-08-07 | 1981-10-08 | Farmos-Yhtyma Oy | 4-benzyl- and 4-benzoyl imidazole derivatives |
GB2069481B (en) * | 1980-02-13 | 1983-07-27 | Farmos Oy | Substituted imidazole derivatives |
GB2092569B (en) * | 1981-02-05 | 1984-09-19 | Farmos Oy | Substituted imidazole derivatives and their preparation and use |
GB2101114B (en) * | 1981-07-10 | 1985-05-22 | Farmos Group Ltd | Substituted imidazole derivatives and their preparation and use |
-
1981
- 1981-07-10 GB GB08121333A patent/GB2101114B/en not_active Expired
-
1982
- 1982-06-15 FI FI822140A patent/FI77858C/fi not_active IP Right Cessation
- 1982-06-28 NO NO822183A patent/NO160439C/no not_active IP Right Cessation
- 1982-06-30 IE IE1602/82A patent/IE53244B1/en not_active IP Right Cessation
- 1982-07-02 DE DE8282303496T patent/DE3268111D1/de not_active Expired
- 1982-07-02 AT AT82303496T patent/ATE17121T1/de not_active IP Right Cessation
- 1982-07-02 EP EP82303496A patent/EP0072615B1/en not_active Expired
- 1982-07-06 NZ NZ201176A patent/NZ201176A/en unknown
- 1982-07-06 AU AU85628/82A patent/AU554125B2/en not_active Expired
- 1982-07-06 CA CA000406694A patent/CA1184559A/en not_active Expired
- 1982-07-07 US US06/396,000 patent/US4544664A/en not_active Expired - Lifetime
- 1982-07-07 KR KR828203024A patent/KR860001864B1/ko active
- 1982-07-07 DK DK304382A patent/DK158307C/da not_active IP Right Cessation
- 1982-07-08 IL IL66271A patent/IL66271A/xx not_active IP Right Cessation
- 1982-07-08 JP JP57119692A patent/JPS5818365A/ja active Granted
- 1982-07-08 ZA ZA824875A patent/ZA824875B/xx unknown
- 1982-07-09 DD DD82241554A patent/DD207713A1/de not_active IP Right Cessation
- 1982-07-09 UA UA3463047A patent/UA5557A1/uk unknown
- 1982-07-09 HU HU822248A patent/HU187773B/hu unknown
- 1982-07-09 SU SU823463047A patent/SU1241990A3/ru active
-
1985
- 1985-03-19 US US06/713,654 patent/US4639464A/en not_active Expired - Lifetime
-
1986
- 1986-12-29 DK DK630486A patent/DK160610C/da not_active IP Right Cessation
-
1988
- 1988-01-11 US US07/141,810 patent/US4826864A/en not_active Expired - Lifetime
- 1988-09-30 SG SG653/88A patent/SG65388G/en unknown
-
1989
- 1989-01-26 HK HK82/89A patent/HK8289A/xx not_active IP Right Cessation
-
1994
- 1994-01-18 BG BG98382A patent/BG60763B2/bg unknown
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Date | Code | Title | Description |
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PUP | Patent expired |