|
US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
|
US4289872A
(en)
|
1979-04-06 |
1981-09-15 |
Allied Corporation |
Macromolecular highly branched homogeneous compound based on lysine units
|
|
US6410697B1
(en)
|
1979-04-20 |
2002-06-25 |
Schering Corporation |
Process for purifying human leukocyte interferon
|
|
US5554513A
(en)
|
1979-11-21 |
1996-09-10 |
Yeda Research & Development Co. Ltd. |
Production of recombinant human interferon-beta2
|
|
GR74498B
(US08114630-20120214-C00039.png)
|
1980-04-03 |
1984-06-28 |
Biogen Inc |
|
|
US6610830B1
(en)
|
1980-07-01 |
2003-08-26 |
Hoffman-La Roche Inc. |
Microbial production of mature human leukocyte interferons
|
|
US4414150A
(en)
|
1980-11-10 |
1983-11-08 |
Genentech, Inc. |
Hybrid human leukocyte interferons
|
|
US4456748A
(en)
|
1981-02-23 |
1984-06-26 |
Genentech, Inc. |
Hybrid human leukocyte interferons
|
|
FR2504010B1
(fr)
|
1981-04-15 |
1985-10-25 |
Sanofi Sa |
Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
|
|
US4551433A
(en)
|
1981-05-18 |
1985-11-05 |
Genentech, Inc. |
Microbial hybrid promoters
|
|
JPS57206622A
(en)
|
1981-06-10 |
1982-12-18 |
Ajinomoto Co Inc |
Blood substitute
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
US4614651A
(en)
|
1981-07-12 |
1986-09-30 |
Damon Biotech, Inc. |
Interferon epsilon
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4678751A
(en)
|
1981-09-25 |
1987-07-07 |
Genentech, Inc. |
Hybrid human leukocyte interferons
|
|
US5096705A
(en)
|
1981-10-19 |
1992-03-17 |
Genentech, Inc. |
Human immune interferon
|
|
AU561343B2
(en)
|
1981-10-19 |
1987-05-07 |
Genentech Inc. |
Human immune interferon by recombinant dna
|
|
US4672108A
(en)
|
1981-12-07 |
1987-06-09 |
Hoffmann-La Roche Inc. |
Crystalline human leukocyte interferon
|
|
JPS58110600A
(ja)
|
1981-12-25 |
1983-07-01 |
Kyowa Hakko Kogyo Co Ltd |
ヒトβ型インタ−フエロン遺伝子を含む組みかえ体プラスミド
|
|
US5098703A
(en)
|
1982-01-15 |
1992-03-24 |
Cetus Corporation |
Interferon-alpha 76
|
|
US4975276A
(en)
|
1982-01-15 |
1990-12-04 |
Cetus Corporation |
Interferon-alpha 54
|
|
US4973479A
(en)
|
1982-01-15 |
1990-11-27 |
Cetus Corporation |
Interferon-α61
|
|
EP0098876A1
(en)
|
1982-01-19 |
1984-01-25 |
Cetus Corporation |
Multiclass hybrid interferons
|
|
EP0088046B1
(de)
|
1982-02-17 |
1987-12-09 |
Ciba-Geigy Ag |
Lipide in wässriger Phase
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
US6936694B1
(en)
|
1982-05-06 |
2005-08-30 |
Intermune, Inc. |
Manufacture and expression of large structural genes
|
|
DE3218121A1
(de)
|
1982-05-14 |
1983-11-17 |
Leskovar, Peter, Dr.-Ing., 8000 München |
Arzneimittel zur tumorbehandlung
|
|
US4462940A
(en)
|
1982-09-23 |
1984-07-31 |
Cetus Corporation |
Process for the recovery of human β-interferon-like polypeptides
|
|
US5702699A
(en)
|
1982-09-23 |
1997-12-30 |
Cetus Corporation |
Process for the recovery of lipophilic proteins
|
|
US4588585A
(en)
|
1982-10-19 |
1986-05-13 |
Cetus Corporation |
Human recombinant cysteine depleted interferon-β muteins
|
|
US4966843A
(en)
|
1982-11-01 |
1990-10-30 |
Cetus Corporation |
Expression of interferon genes in Chinese hamster ovary cells
|
|
US4512922A
(en)
|
1982-12-22 |
1985-04-23 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511502A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4511503A
(en)
|
1982-12-22 |
1985-04-16 |
Genentech, Inc. |
Purification and activity assurance of precipitated heterologous proteins
|
|
US4820352A
(en)
|
1983-01-10 |
1989-04-11 |
Bausch & Lomb Incorporated |
Cleaning and conditioning solutions for contact lenses and methods of use
|
|
US4876197A
(en)
|
1983-02-22 |
1989-10-24 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
US5089398A
(en)
|
1983-02-22 |
1992-02-18 |
Chiron Corporation |
Enhanced yeast transcription employing hybrid GAPDH promoter region constructs
|
|
US4518584A
(en)
|
1983-04-15 |
1985-05-21 |
Cetus Corporation |
Human recombinant interleukin-2 muteins
|
|
US4755465A
(en)
|
1983-04-25 |
1988-07-05 |
Genentech, Inc. |
Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
|
|
US4859600A
(en)
|
1983-04-25 |
1989-08-22 |
Genentech, Inc. |
Recombinant procaryotic cell containing correctly processed human growth hormone
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
GB8317880D0
(en)
|
1983-07-01 |
1983-08-03 |
Searle & Co |
Structure and synthesis of interferons
|
|
US4689406A
(en)
|
1983-08-10 |
1987-08-25 |
Amgen |
Enhancement of microbial expression of polypeptides
|
|
US4681930A
(en)
|
1983-09-20 |
1987-07-21 |
Hoffmann-La Roche Inc. |
Immune interferon and a method for its extraction and purification
|
|
DE3486459D1
(de)
|
1983-09-26 |
1997-12-11 |
Udo Dr Med Ehrenfeld |
Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
|
|
US4855238A
(en)
|
1983-12-16 |
1989-08-08 |
Genentech, Inc. |
Recombinant gamma interferons having enhanced stability and methods therefor
|
|
US4880734A
(en)
|
1984-05-11 |
1989-11-14 |
Chiron Corporation |
Eukaryotic regulatable transcription
|
|
GB8412564D0
(en)
|
1984-05-17 |
1984-06-20 |
Searle & Co |
Structure and properties
|
|
CA1302320C
(en)
|
1984-06-11 |
1992-06-02 |
Hideo Niwa |
Expression of human cromosomal interferon-_ in animal cells
|
|
US5120832A
(en)
|
1984-08-27 |
1992-06-09 |
Genentech, Inc. |
Distinct family of human leukocyte interferons
|
|
JPS6156199A
(ja)
|
1984-08-27 |
1986-03-20 |
Shionogi & Co Ltd |
新規ヒトインタ−フエロンα類
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4675483A
(en)
|
1984-09-10 |
1987-06-23 |
Siemens Aktiengesellschaft |
Contact arrangement for vacuum switches
|
|
US4738921A
(en)
|
1984-09-27 |
1988-04-19 |
Eli Lilly And Company |
Derivative of the tryptophan operon for expression of fused gene products
|
|
US4659839A
(en)
|
1984-10-10 |
1987-04-21 |
Mallinckrodt, Inc. |
Coupling agents for radiolabeled antibody fragments
|
|
US4837148A
(en)
|
1984-10-30 |
1989-06-06 |
Phillips Petroleum Company |
Autonomous replication sequences for yeast strains of the genus pichia
|
|
US4959314A
(en)
|
1984-11-09 |
1990-09-25 |
Cetus Corporation |
Cysteine-depleted muteins of biologically active proteins
|
|
US4885166A
(en)
|
1985-06-11 |
1989-12-05 |
Ciba-Geigy Corporation |
Hybrid interferons
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4766106A
(en)
|
1985-06-26 |
1988-08-23 |
Cetus Corporation |
Solubilization of proteins for pharmaceutical compositions using polymer conjugation
|
|
US4917888A
(en)
|
1985-06-26 |
1990-04-17 |
Cetus Corporation |
Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
|
|
US4810643A
(en)
|
1985-08-23 |
1989-03-07 |
Kirin- Amgen Inc. |
Production of pluripotent granulocyte colony-stimulating factor
|
|
US6004548A
(en)
|
1985-08-23 |
1999-12-21 |
Amgen, Inc. |
Analogs of pluripotent granulocyte colony-stimulating factor
|
|
US4680338A
(en)
|
1985-10-17 |
1987-07-14 |
Immunomedics, Inc. |
Bifunctional linker
|
|
EP0243465A1
(en)
|
1985-10-25 |
1987-11-04 |
Vivian L. Mackay |
Method of using bar1 for secreting foreign proteins
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
DE3683910D1
(de)
|
1986-09-05 |
1992-03-26 |
Cetus Corp |
Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.
|
|
US4894330A
(en)
|
1986-12-23 |
1990-01-16 |
Cetus Corporation |
Purification of recombinant beta-interferon incorporating RP-HPLC
|
|
US5186933A
(en)
|
1986-12-30 |
1993-02-16 |
Baylor College Of Medicine |
Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system
|
|
US4908432A
(en)
|
1987-01-09 |
1990-03-13 |
New York University |
Novel polypeptide having gamma-interferon activity
|
|
EP0349594A4
(en)
|
1987-03-16 |
1990-09-26 |
American Biogenetic Sciences, Inc. |
Recombinant baculovirus occlusion bodies in vaccines and biological insecticides
|
|
DE3712564A1
(de)
|
1987-04-14 |
1988-11-24 |
Bioferon Biochem Substanz |
Verfahren zur konstruktion einer animalen zellinie fuer die herstellung von humanem interferon-beta
|
|
US5229490A
(en)
|
1987-05-06 |
1993-07-20 |
The Rockefeller University |
Multiple antigen peptide system
|
|
CA1317244C
(en)
|
1987-07-24 |
1993-05-04 |
Ernest Seigo Kawasaki |
Production of biologically active forms of csf using a baculovirus (acnpv)-insect cell expression system
|
|
AU2136788A
(en)
|
1987-07-24 |
1989-03-01 |
Cetus Corporation |
Production of ricin toxins in a baculovirus-insect cell expression system
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US4929555A
(en)
|
1987-10-19 |
1990-05-29 |
Phillips Petroleum Company |
Pichia transformation
|
|
GB8725529D0
(en)
|
1987-10-30 |
1987-12-02 |
Delta Biotechnology Ltd |
Polypeptides
|
|
US4904584A
(en)
|
1987-12-23 |
1990-02-27 |
Genetics Institute, Inc. |
Site-specific homogeneous modification of polypeptides
|
|
CA1340772C
(en)
|
1987-12-30 |
1999-09-28 |
Patricia Tekamp-Olson |
Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
|
|
CA1324969C
(en)
|
1988-05-06 |
1993-12-07 |
Jeffrey R. Shuster |
High level expression of proteins in yeast
|
|
US5674706A
(en)
|
1988-05-06 |
1997-10-07 |
Chiron Corporation |
High level expression of proteins in yeast
|
|
FR2631974B1
(fr)
|
1988-05-31 |
1992-12-11 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede de preparation et son application en tant que vecteur d'expression de genes
|
|
AU4197389A
(en)
|
1988-08-05 |
1990-03-05 |
Mount Sinai School Of Medicine Of The City University Of New York, The |
In vivo infection of live insects with a recombinant baculovirus
|
|
GB8819453D0
(en)
|
1988-08-16 |
1988-09-21 |
Roy P |
Production of bluetongue virus non-structural proteins using baculovirus expression vector
|
|
NZ230425A
(en)
|
1988-09-02 |
1992-07-28 |
Molecular Eng Ass |
Production of paramyxovirus fusion (f) protein using recombinant baculovirus expression vector
|
|
US5218092A
(en)
|
1988-09-29 |
1993-06-08 |
Kyowa Hakko Kogyo Co., Ltd. |
Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
|
|
US5997856A
(en)
|
1988-10-05 |
1999-12-07 |
Chiron Corporation |
Method and compositions for solubilization and stabilization of polypeptides, especially proteins
|
|
WO1990004788A1
(en)
|
1988-10-28 |
1990-05-03 |
Genentech, Inc. |
Method for identifying active domains and amino acid residues in polypeptides and hormone variants
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
WO1990005785A1
(en)
|
1988-11-18 |
1990-05-31 |
The Regents Of The University Of California |
Method for site-specifically incorporating unnatural amino acids into proteins
|
|
US5047335A
(en)
|
1988-12-21 |
1991-09-10 |
The Regents Of The University Of Calif. |
Process for controlling intracellular glycosylation of proteins
|
|
JP2989002B2
(ja)
|
1988-12-22 |
1999-12-13 |
キリン―アムジエン・インコーポレーテツド |
化学修飾顆粒球コロニー刺激因子
|
|
US4902502A
(en)
|
1989-01-23 |
1990-02-20 |
Cetus Corporation |
Preparation of a polymer/interleukin-2 conjugate
|
|
WO1990010078A1
(en)
|
1989-02-23 |
1990-09-07 |
University Of Ottawa |
Improved baculovirus expression system capable of producing foreign gene proteins at high levels
|
|
CA2045614C
(en)
|
1989-02-24 |
1997-09-30 |
James W. Bacus |
Method and apparatus for determining a proliferation index of a cell sample
|
|
US5705363A
(en)
|
1989-03-02 |
1998-01-06 |
The Women's Research Institute |
Recombinant production of human interferon τ polypeptides and nucleic acids
|
|
US6372206B1
(en)
|
1989-03-02 |
2002-04-16 |
University Of Florida |
Orally-administered interferon-TAU compositions and methods
|
|
US5122614A
(en)
|
1989-04-19 |
1992-06-16 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
ATE300519T1
(de)
|
1989-04-19 |
2005-08-15 |
Enzon Inc |
Verfahren zum herstellen von modifizierten polypeptiden die eine polypeptid und ein polyalkylenoxid enthalten
|
|
US5324844A
(en)
|
1989-04-19 |
1994-06-28 |
Enzon, Inc. |
Active carbonates of polyalkylene oxides for modification of polypeptides
|
|
ATE92107T1
(de)
|
1989-04-29 |
1993-08-15 |
Delta Biotechnology Ltd |
N-terminale fragmente von menschliches serumalbumin enthaltenden fusionsproteinen.
|
|
US5766883A
(en)
|
1989-04-29 |
1998-06-16 |
Delta Biotechnology Limited |
Polypeptides
|
|
JPH04501065A
(ja)
|
1989-05-17 |
1992-02-27 |
ユニバーシティ オブ ジョージア リサーチ ファウンデーション インコーポレイテッド |
改良されたバキュロウイルス発現ベクター
|
|
FR2649120B1
(fr)
|
1989-06-30 |
1994-01-28 |
Cayla |
Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede
|
|
IL91562A0
(en)
|
1989-09-07 |
1990-04-29 |
Yeda Res & Dev |
Interferon-gamma receptor fragment and its production
|
|
US5889151A
(en)
|
1989-10-20 |
1999-03-30 |
Societe Leb-Tech |
Purified human alpha interferon receptor
|
|
US5162601A
(en)
|
1989-11-22 |
1992-11-10 |
The Upjohn Company |
Plant potyvirus expression vector with a gene for protease
|
|
US5312808A
(en)
|
1989-11-22 |
1994-05-17 |
Enzon, Inc. |
Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
|
|
US5219564A
(en)
|
1990-07-06 |
1993-06-15 |
Enzon, Inc. |
Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
|
|
FR2664905B1
(fr)
|
1990-07-18 |
1994-08-12 |
Agronomique Inst Nat Rech |
Baculovirus modifie, son procede d'obtention, et vecteurs d'expression obtenus a partir dudit baculovirus.
|
|
WO1992001800A1
(en)
|
1990-07-20 |
1992-02-06 |
Chiron Corporation |
Method for integrative transformation of yeast using dispersed repetitive elements
|
|
WO1992002628A1
(en)
|
1990-08-02 |
1992-02-20 |
Chiron Corporation |
Expression of human cmv glycoprotein-h using the baculovirus-insect cell expression system
|
|
JPH06500470A
(ja)
|
1990-09-04 |
1994-01-20 |
メルク エンド カンパニー インコーポレーテッド |
メチロトローフ酵母細胞におけるインスリン様成長因子の産生
|
|
CA2073511A1
(en)
|
1990-11-14 |
1992-05-29 |
Matthew R. Callstrom |
Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins
|
|
US5252714A
(en)
|
1990-11-28 |
1993-10-12 |
The University Of Alabama In Huntsville |
Preparation and use of polyethylene glycol propionaldehyde
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
US5231178A
(en)
|
1991-01-16 |
1993-07-27 |
The Salk Institute Biotechnology/Industrial Associates, Inc. |
Method for the purification of intact, correctly-folded insulin-like growth factor-1
|
|
JPH06506217A
(ja)
|
1991-03-18 |
1994-07-14 |
エンゾン，インコーポレーテッド |
ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
|
|
WO1992016619A1
(en)
|
1991-03-19 |
1992-10-01 |
Us Army |
Expression of influenza nucleoprotein antigens in baculovirus
|
|
US5595732A
(en)
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US6013433A
(en)
|
1991-04-26 |
2000-01-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
US5290686A
(en)
|
1991-07-31 |
1994-03-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Expression of influenza a M2 protein in baculovirus
|
|
DE4128319A1
(de)
|
1991-08-27 |
1993-03-04 |
Bioferon Biochem Substanz |
Neues rekombinantes human-ifn-beta, verfahren zu dessen herstellung und dieses enthaltende pharmazeutische zubereitungen
|
|
US5540923A
(en)
|
1991-12-06 |
1996-07-30 |
Landsforeningen Til Kraeftens Bekaemplse |
Interferon proteins
|
|
IT1260468B
(it)
|
1992-01-29 |
1996-04-09 |
|
Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
DE69312700T2
(de)
|
1992-04-14 |
1998-02-19 |
Cornell Res Foundation Inc |
Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung
|
|
US5516657A
(en)
|
1992-05-11 |
1996-05-14 |
Cambridge Biotech Corporation |
Baculovirus vectors for expression of secretory and membrane-bound proteins
|
|
ZA933926B
(en)
|
1992-06-17 |
1994-01-03 |
Amgen Inc |
Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules
|
|
AU5006993A
(en)
|
1992-08-21 |
1994-03-15 |
Enzon, Inc. |
Novel attachment of polyalkylene oxides to bio-effecting substances
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
US5298643A
(en)
|
1992-12-22 |
1994-03-29 |
Enzon, Inc. |
Aryl imidate activated polyalkylene oxides
|
|
AU6029594A
(en)
|
1993-01-15 |
1994-08-15 |
Enzon, Inc. |
Factor viii - polymeric conjugates
|
|
US5349001A
(en)
|
1993-01-19 |
1994-09-20 |
Enzon, Inc. |
Cyclic imide thione activated polyalkylene oxides
|
|
US5321095A
(en)
|
1993-02-02 |
1994-06-14 |
Enzon, Inc. |
Azlactone activated polyalkylene oxides
|
|
US5532142A
(en)
|
1993-02-12 |
1996-07-02 |
Board Of Regents, The University Of Texas System |
Method of isolation and purification of fusion polypeptides
|
|
IL104734A0
(en)
|
1993-02-15 |
1993-06-10 |
Univ Bar Ilan |
Bioactive conjugates of cellulose with amino compounds
|
|
US5441734A
(en)
|
1993-02-25 |
1995-08-15 |
Schering Corporation |
Metal-interferon-alpha crystals
|
|
EP0626448A3
(de)
|
1993-05-26 |
1998-01-14 |
BOEHRINGER INGELHEIM INTERNATIONAL GmbH |
Verfahren zur Herstellung und Reinigung von alpha-Interferon
|
|
AU7097094A
(en)
|
1993-06-01 |
1994-12-20 |
Enzon, Inc. |
Carbohydrate-modified polymer conjugates with erythropoietic activity
|
|
US5789551A
(en)
|
1993-06-11 |
1998-08-04 |
Pestka Biomedical Laboratories, Inc. |
Human leukocyte interferon Hu-IFN-α001
|
|
AU7113594A
(en)
|
1993-06-21 |
1995-01-17 |
Enzon, Inc. |
Site specific synthesis of conjugated peptides
|
|
GB9317618D0
(en)
|
1993-08-24 |
1993-10-06 |
Royal Free Hosp School Med |
Polymer modifications
|
|
US5762939A
(en)
|
1993-09-13 |
1998-06-09 |
Mg-Pmc, Llc |
Method for producing influenza hemagglutinin multivalent vaccines using baculovirus
|
|
US5919455A
(en)
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5643575A
(en)
|
1993-10-27 |
1997-07-01 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5491076A
(en)
|
1993-11-01 |
1996-02-13 |
The Texas A&M University System |
Expression of foreign genes using a replicating polyprotein producing virus vector
|
|
US5605792A
(en)
|
1993-11-04 |
1997-02-25 |
The Ohio State University Research Foundation |
Infectious bursal disease virus VP2 fusion protein expressed by baculovirus, use as diagnostic
|
|
US5951974A
(en)
|
1993-11-10 |
1999-09-14 |
Enzon, Inc. |
Interferon polymer conjugates
|
|
WO1995013090A1
(en)
|
1993-11-10 |
1995-05-18 |
Enzon, Inc. |
Improved interferon polymer conjugates
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
FR2715664B1
(fr)
|
1994-01-31 |
1996-04-12 |
Proteine Performance Sa |
Baculovirus recombinant et son utilisation pour la production d'anticorps monoclonaux.
|
|
US5545723A
(en)
|
1994-03-15 |
1996-08-13 |
Biogen Inc. |
Muteins of IFN-β
|
|
JP3090586B2
(ja)
|
1994-03-15 |
2000-09-25 |
片倉工業株式会社 |
システインプロテアーゼ遺伝子欠損バキュロウイルスおよびその製造法並びにこれを利用する有用タンパク質の製造法
|
|
US5473034A
(en)
|
1994-03-18 |
1995-12-05 |
Hyogo Prefectural Government |
Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby
|
|
US5629384A
(en)
|
1994-05-17 |
1997-05-13 |
Consiglio Nazionale Delle Ricerche |
Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
|
|
AU2826495A
(en)
|
1994-06-02 |
1996-01-04 |
Enzon, Inc. |
Method of solubilizing substantially water insoluble materials
|
|
US5730990A
(en)
|
1994-06-24 |
1998-03-24 |
Enzon, Inc. |
Non-antigenic amine derived polymers and polymer conjugates
|
|
US6403375B1
(en)
|
1994-08-24 |
2002-06-11 |
Boyce Thompson Institute For Plant Research, Inc. |
Establishment of Trichoplusia ni cell lines in serum-free medium for recombinant protein and baculovirus production
|
|
US5650234A
(en)
|
1994-09-09 |
1997-07-22 |
Surface Engineering Technologies, Division Of Innerdyne, Inc. |
Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
|
|
US5871986A
(en)
|
1994-09-23 |
1999-02-16 |
The General Hospital Corporation |
Use of a baculovirus to express and exogenous gene in a mammalian cell
|
|
US5766582A
(en)
|
1994-10-11 |
1998-06-16 |
Schering Corporation |
Stable, aqueous alfa interferon solution formulations
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
WO1996041813A2
(en)
|
1994-11-09 |
1996-12-27 |
Offord Robin E |
Functionalized polymers for site-specific attachment
|
|
US5738846A
(en)
|
1994-11-10 |
1998-04-14 |
Enzon, Inc. |
Interferon polymer conjugates and process for preparing the same
|
|
IL116085A
(en)
|
1994-12-16 |
1999-12-31 |
Ortho Pharma Corp |
Spray dried erythropoietin
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
EP0842275A1
(en)
|
1995-02-17 |
1998-05-20 |
Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) |
PRODUCTION OF BIOLOGICALLY ACTIVE RECOMBINANT BOVINE FOLLICLE STIMULATING HORMONE (REC bFSH) IN THE BACULOVIRUS EXPRESSION SYSTEM
|
|
FR2732035B1
(fr)
|
1995-03-23 |
1997-05-30 |
Agronomique Inst Nat Rech |
Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede
|
|
US6184344B1
(en)
|
1995-05-04 |
2001-02-06 |
The Scripps Research Institute |
Synthesis of proteins by native chemical ligation
|
|
NZ308772A
(en)
|
1995-05-17 |
1999-04-29 |
Du Pont |
Recombinant baculovirus insecticides
|
|
US5814485A
(en)
|
1995-06-06 |
1998-09-29 |
Chiron Corporation |
Production of interferon-β (IFN-β) in E. coli
|
|
AU5893696A
(en)
|
1995-06-07 |
1996-12-30 |
Novo Nordisk A/S |
Modification of polypeptides
|
|
US5672662A
(en)
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US5840565A
(en)
|
1995-08-22 |
1998-11-24 |
The Regents Of The University Of California |
Methods for enhancing the production of viral vaccines in PKR-deficient cell culture
|
|
US5908621A
(en)
|
1995-11-02 |
1999-06-01 |
Schering Corporation |
Polyethylene glycol modified interferon therapy
|
|
US5861279A
(en)
|
1996-01-17 |
1999-01-19 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
|
|
WO1997026332A1
(en)
|
1996-01-17 |
1997-07-24 |
Schering Corporation |
Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists
|
|
US5747639A
(en)
|
1996-03-06 |
1998-05-05 |
Amgen Boulder Inc. |
Use of hydrophobic interaction chromatography to purify polyethylene glycols
|
|
SI0964702T1
(sl)
|
1996-08-02 |
2007-02-28 |
Ortho Mcneil Pharm Inc |
Polipeptidi, ki imajo posamezen kovalentno vezan N-terminalni vodotopni polimer
|
|
US5980948A
(en)
|
1996-08-16 |
1999-11-09 |
Osteotech, Inc. |
Polyetherester copolymers as drug delivery matrices
|
|
US6214966B1
(en)
|
1996-09-26 |
2001-04-10 |
Shearwater Corporation |
Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
|
|
DE69738768D1
(de)
|
1996-12-13 |
2008-07-24 |
Novartis Vaccines & Diagnostic |
Analyse und separation von pdgf-proteinen
|
|
BR9606270A
(pt)
|
1996-12-18 |
1998-09-22 |
Univ Minas Gerais |
Processo para a produção da proteína do interferon beta-cis humano recombinante e proteína de interferon beta-cis humano recombinante
|
|
ATE200030T1
(de)
|
1997-01-29 |
2001-04-15 |
Polymasc Pharmaceuticals Plc |
Pegylationsverfahren
|
|
GB9703406D0
(en)
|
1997-02-19 |
1997-04-09 |
Chiron Spa |
Expression of heterologous proteins
|
|
US6188965B1
(en)
|
1997-04-11 |
2001-02-13 |
California Institute Of Technology |
Apparatus and method for automated protein design
|
|
DE19717864C2
(de)
|
1997-04-23 |
2001-05-17 |
Fraunhofer Ges Forschung |
Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung
|
|
WO1998049198A1
(en)
|
1997-04-30 |
1998-11-05 |
Enzon, Inc. |
Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof
|
|
US5990237A
(en)
|
1997-05-21 |
1999-11-23 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
|
|
US5965393A
(en)
|
1997-07-01 |
1999-10-12 |
National Institute Of Immunology |
Method for enhancing foreign gene expression in baculovirus expression vector system
|
|
BR9812267B1
(pt)
|
1997-07-14 |
2013-11-26 |
|
Hormônio de crescimento recombinante.
|
|
US7270809B2
(en)
*
|
1997-07-14 |
2007-09-18 |
Bolder Biotechnology, Inc. |
Cysteine variants of alpha interferon-2
|
|
GB9715660D0
(en)
|
1997-07-25 |
1997-10-01 |
Zeneca Ltd |
Proteins
|
|
WO1999007862A1
(en)
|
1997-08-05 |
1999-02-18 |
Chiron Corporation |
Novel pichia pastoris gene sequences and methods for their use
|
|
DE19735593C2
(de)
|
1997-08-15 |
1999-08-26 |
Hepavec Ag Fuer Gentherapie |
Hüllprotein-modifizierter Baculovirus-Vektor für die Gentherapie
|
|
US6090584A
(en)
|
1997-08-21 |
2000-07-18 |
University Technologies International Inc. |
Baculovirus artificial chromosomes and methods of use
|
|
US5989868A
(en)
|
1997-09-12 |
1999-11-23 |
The Board Of Regents Of The University Of Oklahoma |
Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
|
|
EP1015576B1
(en)
|
1997-09-16 |
2005-05-04 |
Egea Biosciences, LLC |
Method for the complete chemical synthesis and assembly of genes and genomes
|
|
EP1032268A4
(en)
|
1997-09-26 |
2003-08-20 |
Uab Research Foundation |
REDUCED ANTIGENS CELLS AND THEIR USE
|
|
US6201072B1
(en)
|
1997-10-03 |
2001-03-13 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
US6004573A
(en)
|
1997-10-03 |
1999-12-21 |
Macromed, Inc. |
Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
|
|
DE19748489A1
(de)
|
1997-11-03 |
1999-05-06 |
Roche Diagnostics Gmbh |
Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
|
|
US6448369B1
(en)
|
1997-11-06 |
2002-09-10 |
Shearwater Corporation |
Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
|
|
EP1037995A1
(en)
|
1997-12-08 |
2000-09-27 |
Genentech, Inc. |
Human interferon-epsilon: a type 1 interferon
|
|
ZA9811070B
(en)
|
1997-12-08 |
2000-07-03 |
Genentech Inc |
Type I interferons.
|
|
EP0924298A1
(en)
|
1997-12-18 |
1999-06-23 |
Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) |
Protein expression in baculovirus vector expression systems
|
|
US5985263A
(en)
|
1997-12-19 |
1999-11-16 |
Enzon, Inc. |
Substantially pure histidine-linked protein polymer conjugates
|
|
US5981709A
(en)
|
1997-12-19 |
1999-11-09 |
Enzon, Inc. |
α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
|
|
WO1999045130A1
(en)
|
1998-03-04 |
1999-09-10 |
Onyx Pharmaceuticals, Inc. |
Baculovirus expression system and method for high throughput expression of genetic material
|
|
JP2002505338A
(ja)
|
1998-03-05 |
2002-02-19 |
カイロン コーポレイション |
生物学的に活性な分子の血清半減期を増加するための方法
|
|
EP1061954B1
(en)
|
1998-03-12 |
2004-06-09 |
Nektar Therapeutics Al, Corporation |
Poly(ethylene glycol) derivatives with proximal reactive groups
|
|
US6180096B1
(en)
|
1998-03-26 |
2001-01-30 |
Schering Corporation |
Formulations for protection of peg-interferon alpha conjugates
|
|
KR100264953B1
(ko)
|
1998-04-03 |
2001-03-02 |
박현우 |
재조합 베큘로바이러스, 이의 제조방법 및 이를 포함하는 미생물 살충제
|
|
IL139286A
(en)
|
1998-04-28 |
2005-12-18 |
Applied Research Systems |
Polyol-ifn-beta conjugates, their preparation and use
|
|
CA2328476A1
(en)
|
1998-05-07 |
1999-11-11 |
Transkaryotic Therapies, Inc. |
Genomic sequences upstream of the coding region of the g-csf gene for protein production and delivery
|
|
US6451986B1
(en)
|
1998-06-22 |
2002-09-17 |
Immunex Corporation |
Site specific protein modification
|
|
US6168932B1
(en)
|
1998-07-13 |
2001-01-02 |
Parker Hughes Institute |
Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system
|
|
US6472512B1
(en)
|
1998-07-21 |
2002-10-29 |
Human Genome Sciences, Inc. |
Keratinocyte derived interferon
|
|
US6245528B1
(en)
|
1998-07-28 |
2001-06-12 |
Academia Sinica |
Latent baculovirus expression system
|
|
US6368825B1
(en)
|
1998-08-10 |
2002-04-09 |
Academia Sinica |
Baculovirus containing minimal CMV promoter
|
|
JP2002528562A
(ja)
|
1998-08-28 |
2002-09-03 |
グリフォン サイエンシーズ |
長さのばらつきが小さいポリアミド連鎖、その連鎖の製造方法およびその連鎖とタンパク質の複合体
|
|
WO2000020032A1
(en)
|
1998-10-06 |
2000-04-13 |
Trustees Of Dartmouth College |
RECOMBINANT CAT ALLERGEN, Fel dI, EXPRESSED IN BACULOVIRUS FOR DIAGNOSIS AND TREATMENT OF CAT ALLERGY
|
|
US6420339B1
(en)
|
1998-10-14 |
2002-07-16 |
Amgen Inc. |
Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
|
|
EE04967B1
(et)
|
1998-10-16 |
2008-02-15 |
Biogen, Incorporated |
Glkoslitud interferoon-beeta, selle kasutamineja seda sisaldav farmatseutiline kompositsioon, meetod interferoon-beeta-1a aktiivsuse pikendamiseks ja leiutisekohase valgu valmistamiseks
|
|
US6403312B1
(en)
|
1998-10-16 |
2002-06-11 |
Xencor |
Protein design automatic for protein libraries
|
|
MXPA01003790A
(es)
|
1998-10-16 |
2002-09-18 |
Biogen Inc |
Proteinas de fusion beta - interferon y sus usos.
|
|
CN1325443A
(zh)
|
1998-10-30 |
2001-12-05 |
诺沃奇梅兹有限公司 |
具有减弱的变应原性的糖基化蛋白
|
|
US6451346B1
(en)
|
1998-12-23 |
2002-09-17 |
Amgen Inc |
Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents
|
|
US6433144B1
(en)
|
1999-01-12 |
2002-08-13 |
Viragen, Inc. |
Compositions of highly-purified natural mixtures of type I Interferon derived from leukocytes and methods
|
|
US6350589B1
(en)
|
1998-12-31 |
2002-02-26 |
Viragen, Inc. |
Compositions of highly-purified natural mixtures of type I interferon derived from leukocytes and methods
|
|
US6703225B1
(en)
|
1999-01-12 |
2004-03-09 |
Sumitomo Pharmaceuticals Company, Limited |
Interferon-α
|
|
US6281211B1
(en)
|
1999-02-04 |
2001-08-28 |
Euro-Celtique S.A. |
Substituted semicarbazides and the use thereof
|
|
US6342216B1
(en)
|
1999-03-17 |
2002-01-29 |
The Board Of Regents, The University Of Texas System |
Therapy of cancer by insect cells containing recombinant baculovirus encoding genes
|
|
US6994986B2
(en)
|
1999-03-17 |
2006-02-07 |
The Board Of Trustees Of The Leland Stanford University |
In vitro synthesis of polypeptides by optimizing amino acid metabolism
|
|
EP1177311B1
(en)
|
1999-03-17 |
2014-11-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
In vitro macromolecule biosynthesis methods using exogenous amino acids and a novel atp regeneration system
|
|
US6337191B1
(en)
|
1999-03-22 |
2002-01-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Vitro protein synthesis using glycolytic intermediates as an energy source
|
|
WO2000062630A1
(en)
|
1999-04-16 |
2000-10-26 |
Wm. Marsh Rice University |
Functionalized poly(propylene fumarate) and poly(propylene fumarate-co-ethylene glycol)
|
|
US6514729B1
(en)
|
1999-05-12 |
2003-02-04 |
Xencor, Inc. |
Recombinant interferon-beta muteins
|
|
EP1987847A1
(en)
|
1999-05-21 |
2008-11-05 |
Micro Therapeutics, Inc. |
Novel high viscosity embolizing compositions
|
|
EP1156771A2
(en)
|
1999-06-22 |
2001-11-28 |
The University Of Maryland |
Interferon tau mutants and methods for making them
|
|
US6261805B1
(en)
|
1999-07-15 |
2001-07-17 |
Boyce Thompson Institute For Plant Research, Inc. |
Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
|
|
US7144574B2
(en)
|
1999-08-27 |
2006-12-05 |
Maxygen Aps |
Interferon β variants and conjugates
|
|
US6531122B1
(en)
|
1999-08-27 |
2003-03-11 |
Maxygen Aps |
Interferon-β variants and conjugates
|
|
WO2001027301A2
(en)
|
1999-10-15 |
2001-04-19 |
The Rockefeller University |
System for rapid generation of recombinant baculovirus-based expression vectors for silkworm larvae
|
|
US6348558B1
(en)
|
1999-12-10 |
2002-02-19 |
Shearwater Corporation |
Hydrolytically degradable polymers and hydrogels made therefrom
|
|
DK1259563T4
(en)
|
1999-12-22 |
2016-11-21 |
Nektar Therapeutics |
PROCEDURE FOR PREPARING 1-BENZOTRIAZOLYL CARBONATE ESTERS OF WATER SOLUBLE POLYMERS
|
|
DK1259562T3
(da)
|
1999-12-22 |
2006-04-18 |
Nektar Therapeutics Al Corp |
Sterisk hindrede derivater af vandoplöselige polymerer
|
|
US6413507B1
(en)
|
1999-12-23 |
2002-07-02 |
Shearwater Corporation |
Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
|
|
US6646110B2
(en)
|
2000-01-10 |
2003-11-11 |
Maxygen Holdings Ltd. |
G-CSF polypeptides and conjugates
|
|
WO2001062827A2
(en)
|
2000-02-22 |
2001-08-30 |
Shearwater Corporation |
N-maleimidyl polymer derivatives
|
|
AU780270B2
(en)
|
2000-02-23 |
2005-03-10 |
Association Francaise Contre Les Myopathies |
Treatment of immune diseases
|
|
AU2001257577A1
(en)
|
2000-02-28 |
2001-09-03 |
Shearwater Corporation |
Water-soluble polymer conjugates of artelinic acid
|
|
US6586207B2
(en)
|
2000-05-26 |
2003-07-01 |
California Institute Of Technology |
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
|
|
GB0012997D0
(en)
|
2000-05-26 |
2000-07-19 |
Eurogene Limited |
Gene delivery
|
|
JP2002030098A
(ja)
|
2000-07-17 |
2002-01-29 |
Institute Of Immunology Co Ltd |
バキュロウィルスの発芽ウイルスからウイルスエンベロープを回収する方法
|
|
KR100396983B1
(ko)
|
2000-07-29 |
2003-09-02 |
이강춘 |
고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체
|
|
WO2002019963A2
(en)
|
2000-09-08 |
2002-03-14 |
Gryphon Therapeutics, Inc. |
Synthetic erythropoiesis stimulating proteins
|
|
US7118737B2
(en)
*
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
US7544354B2
(en)
|
2000-10-27 |
2009-06-09 |
Novartis Vaccines And Diagnostics |
Methods of protein purification and recovery
|
|
PL209928B1
(pl)
|
2000-11-07 |
2011-11-30 |
Novartis Vaccines & Diagnostic |
Kompozycja farmaceutyczna zawierająca biologicznie aktywny IFN-β i mannitol, wstępnie napełniona strzykawka zawierająca tę kompozycję oraz sposób wytwarzania preparatu IFN-β
|
|
US6436386B1
(en)
|
2000-11-14 |
2002-08-20 |
Shearwater Corporation |
Hydroxyapatite-targeting poly (ethylene glycol) and related polymers
|
|
TW593427B
(en)
|
2000-12-18 |
2004-06-21 |
Nektar Therapeutics Al Corp |
Synthesis of high molecular weight non-peptidic polymer derivatives
|
|
TWI246524B
(en)
|
2001-01-19 |
2006-01-01 |
Shearwater Corp |
Multi-arm block copolymers as drug delivery vehicles
|
|
BR0208041A
(pt)
|
2001-03-15 |
2004-02-25 |
Merck Patent Gmbh |
Interferon beta modificado com imunogenicidade reduzida
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
WO2002080959A1
(en)
|
2001-04-03 |
2002-10-17 |
Universitair Medisch Centrum Utrecht |
Method of treatment of hypoxia/ischaemia blutflusswiderstand
|
|
US6887462B2
(en)
|
2001-04-09 |
2005-05-03 |
Chiron Corporation |
HSA-free formulations of interferon-beta
|
|
DK2322631T3
(en)
|
2001-04-19 |
2015-01-12 |
Scripps Research Inst |
Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA syntetasepar
|
|
US6566132B1
(en)
|
2001-04-26 |
2003-05-20 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Interferon gamma receptor 1 expression
|
|
GB0113657D0
(en)
|
2001-06-05 |
2001-07-25 |
Geneprot Inc |
Improved native chemical ligation with three or more components
|
|
US20040138412A1
(en)
|
2001-09-07 |
2004-07-15 |
Paolo Botti |
Extended native chemical ligation
|
|
US6908963B2
(en)
|
2001-10-09 |
2005-06-21 |
Nektar Therapeutics Al, Corporation |
Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
|
|
JP4758608B2
(ja)
|
2001-11-07 |
2011-08-31 |
ネクター セラピューティックス |
分枝ポリマーおよびそれらの結合体
|
|
WO2003042235A2
(en)
|
2001-11-14 |
2003-05-22 |
Geneprot, Inc. |
Extended native chemical ligation of three or more peptide fragments
|
|
ES2545090T3
(es)
*
|
2001-12-21 |
2015-09-08 |
Human Genome Sciences, Inc. |
Proteínas de fusión de albúmina y GCSF
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
CA2476425C
(en)
|
2002-02-15 |
2012-04-17 |
The Research Foundation Of State University Of New York At Buffalo |
Ribozymes with broad trna aminoacylation activity
|
|
CA2477577A1
(en)
|
2002-03-12 |
2003-09-18 |
Maxygen Aps |
Interferon beta-like molecules for treatment of stroke
|
|
US7375234B2
(en)
|
2002-05-30 |
2008-05-20 |
The Scripps Research Institute |
Copper-catalysed ligation of azides and acetylenes
|
|
WO2004002500A1
(en)
|
2002-06-28 |
2004-01-08 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method of treating autoimmune diseases with interferon-beta and il-2r antagonist
|
|
JP2006501242A
(ja)
|
2002-08-23 |
2006-01-12 |
ザイモジェネティクス， インク． |
炎症性腸疾患の治療方法
|
|
EP1581631A4
(en)
|
2002-10-01 |
2007-09-05 |
Xencor Inc |
INTERFERON VARIANTS HAVING IMPROVED PROPERTIES
|
|
US20050054053A1
(en)
|
2002-10-01 |
2005-03-10 |
Xencor, Inc. |
Interferon variants with improved properties
|
|
JP4752001B2
(ja)
|
2002-10-16 |
2011-08-17 |
ザ スクリプス リサーチ インスティチュート |
糖蛋白質合成
|
|
MXPA05003983A
(es)
|
2002-10-16 |
2005-06-22 |
Scripps Research Inst |
Incorporacion en sitio especifico de cetoaminoacidos en proteinas.
|
|
US7314613B2
(en)
*
|
2002-11-18 |
2008-01-01 |
Maxygen, Inc. |
Interferon-alpha polypeptides and conjugates
|
|
EP1583816A4
(en)
|
2002-12-22 |
2007-06-13 |
Scripps Research Inst |
PROTEIN NETWORKS
|
|
UA90654C2
(ru)
*
|
2002-12-26 |
2010-05-25 |
Маунтин Вью Фармасьютикалз, Инк. |
Полимерные конъюгаты интерферона-бета с повышенной биологической активностью
|
|
EP1667708B9
(en)
*
|
2002-12-26 |
2012-10-31 |
Mountain View Pharmaceuticals, Inc. |
POLYETHYLENE GLYCOL CONJUGATES OF INTERFERON-BETA-1b WITH ENHANCED IN VITRO BIOLOGICAL POTENCY
|
|
EA010801B1
(ru)
|
2003-02-25 |
2008-12-30 |
Лаборатуар Сероно Са |
Комбинированное применение рибавирина и бета-интерферона при демиелинизирующих заболеваниях
|
|
CN101223272B
(zh)
|
2003-04-17 |
2013-04-03 |
斯克利普斯研究院 |
扩展真核生物遗传密码
|
|
US20060160175A1
(en)
|
2003-07-07 |
2006-07-20 |
The Scripps Research Institute |
Compositions of orthogonal leucyl-trna and aminoacyl-trna synthetase pairs and uses thereof
|
|
US7527943B2
(en)
|
2003-07-07 |
2009-05-05 |
The Scripps Research Institute |
Compositions of orthogonal glutamyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
|
|
JP5192150B2
(ja)
|
2003-07-07 |
2013-05-08 |
ザ スクリプス リサーチ インスティチュート |
直交リシルｔＲＮＡとアミノアシルｔＲＮＡシンテターゼの対の組成物及びその使用
|
|
CN100408090C
(zh)
|
2003-07-11 |
2008-08-06 |
舍林股份公司 |
改良的重组人干扰素-β-1b多肽
|
|
SG143252A1
(en)
|
2003-10-09 |
2008-06-27 |
Ambrx Inc |
Polymer derivatives
|
|
ATE526032T1
(de)
|
2003-12-11 |
2011-10-15 |
Ares Trading Sa |
Stabilisierte flüssige interferon-formulierungen
|
|
NZ586034A
(en)
|
2004-02-02 |
2011-10-28 |
Ambrx Inc |
Modified human growth hormone polypeptides and their uses
|
|
EP1735340A2
(en)
|
2004-03-17 |
2006-12-27 |
Eli Lilly And Company |
Glycol linked fgf-21 compounds
|
|
EP1748788A1
(en)
|
2004-05-17 |
2007-02-07 |
Ares Trading S.A. |
Hydrogel interferon formulations
|
|
WO2005120551A1
(en)
|
2004-06-07 |
2005-12-22 |
Nastech Pharmaceutical Company Inc. |
Intranasal formulations of interferon beta free of stabilizers that are proteins or polypeptides
|
|
US7670595B2
(en)
|
2004-06-28 |
2010-03-02 |
Merck Patent Gmbh |
Fc-interferon-beta fusion proteins
|
|
JP2008507297A
(ja)
|
2004-07-26 |
2008-03-13 |
エンゾン ファーマシューティカルズ，インコーポレーテッド |
最適化されたインターフェロンβ遺伝子
|
|
KR100781666B1
(ko)
|
2004-11-02 |
2007-12-03 |
신영기 |
인간 인터페론-베타 변이체
|
|
CN101056890B
(zh)
|
2004-11-10 |
2012-05-09 |
诺华疫苗和诊断公司 |
脱酰胺基干扰素-β
|
|
TW200633718A
(en)
|
2004-12-16 |
2006-10-01 |
Applied Research Systems |
Treatment of hepatitis c in the asian population
|
|
WO2006069246A2
(en)
|
2004-12-22 |
2006-06-29 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
US7736872B2
(en)
|
2004-12-22 |
2010-06-15 |
Ambrx, Inc. |
Compositions of aminoacyl-TRNA synthetase and uses thereof
|
|
JP2008541769A
(ja)
|
2005-06-03 |
2008-11-27 |
アンブレツクス・インコーポレイテツド |
改善されたヒトインターフェロン分子及びそれらの使用
|
|
JP4829969B2
(ja)
|
2005-08-18 |
2011-12-07 |
アンブルックス，インコーポレイテッド |
ｔＲＮＡ組成物、およびその使用
|
|
RS57549B1
(sr)
|
2005-08-26 |
2018-10-31 |
Ares Trading Sa |
Proces za pripremu glikoziliranog interferona beta
|
|
KR20080050591A
(ko)
|
2005-09-01 |
2008-06-09 |
아레스 트레이딩 에스.에이. |
시신경염 치료
|
|
FI20051003A0
(fi)
|
2005-10-07 |
2005-10-07 |
Faron Pharmaceuticals Oy |
Menetelmä iskemiareperfuusiovaurion tai monielinhäiriön hoitamiseksi tai estämiseksi
|
|
NZ580686A
(en)
*
|
2007-05-02 |
2012-11-30 |
Ambrx Inc |
Modified interferon beta polypeptides and their uses
|
